{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:28Z","timestamp":1777870828084,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2026YFHZ0054"],"award-info":[{"award-number":["2026YFHZ0054"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC1667"],"award-info":[{"award-number":["2025ZNSFSC1667"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020440","name":"Beijing Health Promotion Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704000"],"award-info":[{"award-number":["2022YFC2704000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705502"],"award-info":[{"award-number":["2023YFC2705502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.earlhumdev.2026.106506","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:12:44Z","timestamp":1769818364000},"page":"106506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolomic insights into potential early neurodevelopment in offspring of women with polycystic ovary syndrome: Maternal and fetal serum metabolomics based on a prospective birth cohort study"],"prefix":"10.1016","volume":"216","author":[{"given":"Qi","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-588X","authenticated-orcid":false,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0005","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106506_bb0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1514250","article-title":"Global burden of polycystic ovary syndrome among women of childbearing age, 1990-2021: a systematic analysis using the global burden of disease study 2021","volume":"13","author":"Meng","year":"2025","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106506_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106506_bb0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41574-020-00456-z","article-title":"The importance of metabolic dysfunction in polycystic ovary syndrome","volume":"17","author":"Visser","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0030","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis","volume":"26","author":"Wekker","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"9398","key":"10.1016\/j.earlhumdev.2026.106506_bb0035","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(03)14942-2","article-title":"Hormones and insulin resistance during pregnancy","volume":"362","author":"Ryan","year":"2003","journal-title":"Lancet (London, England)"},{"issue":"7","key":"10.1016\/j.earlhumdev.2026.106506_bb0040","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/humrep\/deaa099","article-title":"Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies","volume":"35","author":"Mills","year":"2020","journal-title":"Hum. Reprod. (Oxford, England)"},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d6309","article-title":"Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study","volume":"343","author":"Roos","year":"2011","journal-title":"BMJ (Clin. Res. ed)."},{"issue":"12","key":"10.1016\/j.earlhumdev.2026.106506_bb0050","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1038\/s41591-019-0666-1","article-title":"Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome","volume":"25","author":"Risal","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106506_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01699-8","article-title":"A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children","volume":"11","author":"Dubey","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2024.106984","article-title":"The early development of offspring born to women with polycystic ovary syndrome: insights from a prospective birth cohort study in southwestern China","volume":"163","author":"Cao","year":"2024","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0065","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/pr3000317","article-title":"Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients","volume":"11","author":"Sun","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-10-153","article-title":"Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis","volume":"10","author":"Zhao","year":"2012","journal-title":"BMC Med."},{"issue":"8","key":"10.1016\/j.earlhumdev.2026.106506_bb0075","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4103\/0366-6999.229899","article-title":"Identification of potential biomarkers for urine metabolomics of polycystic ovary syndrome based on gas chromatography-mass spectrometry","volume":"131","author":"Zou","year":"2018","journal-title":"Chin. Med. J."},{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/09513590.2019.1698026","article-title":"Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics","volume":"36","author":"Jiang","year":"2020","journal-title":"Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol."},{"issue":"83","key":"10.1016\/j.earlhumdev.2026.106506_bb0085","doi-asserted-by":"crossref","first-page":"52923","DOI":"10.1039\/C6RA27357B","article-title":"Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study","volume":"7","author":"Feng","year":"2017","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.earlhumdev.2026.106506_bb0090","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/GRF.0b013e31815a5494","article-title":"Metabolic changes in pregnancy","volume":"50","author":"Lain","year":"2007","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.638727","article-title":"Metabolomic profiling of pregnancies with polycystic ovary syndrome identifies a unique metabolic signature and potential predictive biomarkers of low birth weight","volume":"12","author":"Diboun","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"Suppl. 1","key":"10.1016\/j.earlhumdev.2026.106506_bb0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12859-019-3310-7","article-title":"So you think you can PLS-DA?","volume":"21","author":"Ruiz-Perez","year":"2020","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2105-8-207","article-title":"Orthogonal projections to latent structures as a strategy for microarray data normalization","volume":"8","author":"Bylesj\u00f6","year":"2007","journal-title":"BMC Bioinform."},{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0110","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1021\/ci060087t","article-title":"Genetic algorithm-optimized QSPR models for bioavailability, protein binding, and urinary excretion","volume":"46","author":"Wang","year":"2006","journal-title":"J. Chem. Inf. Model."},{"issue":"9","key":"10.1016\/j.earlhumdev.2026.106506_bb0115","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s10815-020-01896-2","article-title":"1H NMR-based metabonomics for infertility diagnosis in men with varicocele","volume":"37","author":"Neto","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113745","article-title":"Chemometrics-based LC-UV-ESIMS analyses of 50 Salvia species for detecting their antioxidant constituents","volume":"193","author":"Shojaeifard","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"21","key":"10.1016\/j.earlhumdev.2026.106506_bb0125","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1021\/ac980451q","article-title":"Genetic algorithm-based wavelength selection for the near-infrared determination of glucose in biological matrixes: initialization strategies and effects of spectral resolution","volume":"70","author":"Ding","year":"1998","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0130","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.talanta.2005.08.042","article-title":"Metabolic profiling using principal component analysis, discriminant partial least squares, and genetic algorithms","volume":"68","author":"Ramadan","year":"2006","journal-title":"Talanta"},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jceh.2019.04.053","article-title":"Mass spectrometry: a guide for the clinician","volume":"9","author":"Alsaleh","year":"2019","journal-title":"J. Clin. Exp. Hepatol."},{"issue":"8","key":"10.1016\/j.earlhumdev.2026.106506_bb0140","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC\u2013HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0145","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41380-024-02433-8","article-title":"Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics","volume":"29","author":"Hill","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.earlhumdev.2026.106506_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000193","article-title":"Analysis of gene regulatory networks in the mammalian circadian rhythm","volume":"4","author":"Yan","year":"2008","journal-title":"PLoS Comput. Biol."},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0155","doi-asserted-by":"crossref","DOI":"10.1097\/TEN.0b013e3181f661d2","article-title":"Polymorphisms in genes involved in testosterone metabolism in Slovak autistic boys","volume":"20","author":"Schmidtova","year":"2010","journal-title":"Endocrinologist"},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106506_bb0160","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2012.10.015","article-title":"Placental steroidogenesis in pregnant women with polycystic ovary syndrome","volume":"166","author":"Maliqueo","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"10","key":"10.1016\/j.earlhumdev.2026.106506_bb0165","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0170","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1097\/AOG.0000000000000852","article-title":"Implications of polycystic ovary syndrome for pregnancy and for the health of offspring","volume":"125","author":"Doherty","year":"2015","journal-title":"Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.earlhumdev.2026.106506_bb0175","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/mp.2015.183","article-title":"Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden","volume":"21","author":"Kosidou","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/srep10232","article-title":"Genetic association study of circadian genes with seasonal pattern in bipolar disorders","volume":"5","author":"Geoffroy","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106506_bb0185","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/ajmg.b.31021","article-title":"PER2 variantion is associated with depression vulnerability","volume":"153B","author":"Lavebratt","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106506_bb0190","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/aur.73","article-title":"Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism","volume":"2","author":"Hu","year":"2009","journal-title":"Autism Res."},{"issue":"5","key":"10.1016\/j.earlhumdev.2026.106506_bb0195","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1523\/JNEUROSCI.4636-05.2006","article-title":"Retinoid-related orphan receptor alpha controls the early steps of Purkinje cell dendritic differentiation","volume":"26","author":"Boukhtouche","year":"2006","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106506_bb0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-3806(01)00095-5","article-title":"Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+\/sg))","volume":"126","author":"Hadj-Sahraoui","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"issue":"6","key":"10.1016\/j.earlhumdev.2026.106506_bb0205","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/j.1471-4159.2006.03708.x","article-title":"Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis","volume":"96","author":"Boukhtouche","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.earlhumdev.2026.106506_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2005.11.080","article-title":"ROR alpha in genetic control of cerebellum development: 50 staggering years","volume":"1140","author":"Gold","year":"2007","journal-title":"Brain Res."},{"issue":"8","key":"10.1016\/j.earlhumdev.2026.106506_bb0215","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1096\/fj.10-154484","article-title":"Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain","volume":"24","author":"Nguyen","year":"2010","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.earlhumdev.2026.106506_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008517","article-title":"Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria","volume":"15","author":"Day","year":"2019","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.earlhumdev.2026.106506_bb0225","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/humupd\/dmx013","article-title":"Is foetal hyperexposure to androgens a cause of PCOS?","volume":"23","author":"Filippou","year":"2017","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.earlhumdev.2026.106506_bb0230","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.fertnstert.2020.08.1425","article-title":"Association between circadian rhythm disruption and polycystic ovary syndrome","volume":"115","author":"Wang","year":"2021","journal-title":"Fertil. Steril."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378226000290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378226000290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:03Z","timestamp":1777567503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378226000290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"alternative-id":["S0378378226000290"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2026.106506","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic insights into potential early neurodevelopment in offspring of women with polycystic ovary syndrome: Maternal and fetal serum metabolomics based on a prospective birth cohort study","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2026.106506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106506"}}