{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:43:19Z","timestamp":1776411799566,"version":"3.51.2"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.earlhumdev.2026.106535","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:42:39Z","timestamp":1773214959000},"page":"106535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Every second counts: Association between activated clotting time and neurologic injury in neonatal ECMO"],"prefix":"10.1016","volume":"218","author":[{"given":"Eitan","family":"Keizman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evyatar","family":"Hubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Sadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Skourikhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Dumanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itai","family":"Pessach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mishaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reut Kassif","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106535_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.semtcvs.2015.07.005","article-title":"Trends in U.S. extracorporeal membrane oxygenation use and outcomes: 2002-2012","volume":"27","author":"McCarthy","year":"2015","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106535_bb0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.athoracsur.2018.07.040","article-title":"A single-center experience of 900 interhospital transports on extracorporeal membrane oxygenation","volume":"107","author":"Fletcher-Sandersj\u00f6\u00f6","year":"2019","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106535_bb0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jpedsurg.2007.09.021","article-title":"A 22-year experience in global transport extracorporeal membrane oxygenation","volume":"43","author":"Coppola","year":"2008","journal-title":"J. Pediatr. Surg."},{"issue":"9","key":"10.1016\/j.earlhumdev.2026.106535_bb0020","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1007\/s00134-013-2985-x","article-title":"Neurologic complications in neonates supported with extracorporeal membrane oxygenation. An analysis of ELSO registry data","volume":"39","author":"Polito","year":"2013","journal-title":"Intensive Care Med."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106535_bb0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000351033","article-title":"Cerebral aspects of neonatal extracorporeal membrane oxygenation: a review","volume":"104","author":"de Mol","year":"2013","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106535_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-46243-4","article-title":"Predictors of intracranial hemorrhage in neonatal patients on extracorporeal membrane oxygenation","volume":"13","author":"Wood","year":"2023","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.earlhumdev.2026.106535_bb0035","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3174\/ajnr.A5092","article-title":"Patterns of brain injury in newborns treated with extracorporeal membrane oxygenation","volume":"38","author":"Wien","year":"2017","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106535_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21749-5","article-title":"Incidence and predictors of brain infarction in neonatal patients on extracorporeal membrane oxygenation: an observational cohort study","volume":"12","author":"Kopfer","year":"2022","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.earlhumdev.2026.106535_bb0045","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1053\/j.jvca.2024.09.003","article-title":"Association of activated clotting time-guided anticoagulation with complications during extracorporeal membrane oxygenation support: a systematic review and meta-analysis","volume":"38","author":"Schwaiger","year":"2024","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.earlhumdev.2026.106535_bb0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.thromres.2018.05.009","article-title":"Anticoagulation during ECMO in neonatal and paediatric patients","volume":"173","author":"Barton","year":"2019","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.earlhumdev.2026.106535_bb0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0022-3468(92)90101-C","article-title":"Coagulation parameter instability as an early predictor of intracranial hemorrhage during extracorporeal membrane oxygenation","volume":"27","author":"Hirthler","year":"1992","journal-title":"J. Pediatr. Surg."},{"issue":"7","key":"10.1016\/j.earlhumdev.2026.106535_bb0060","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1177\/0885066618776937","article-title":"Anticoagulation monitoring under ECMO support: a comparative study between the activated coagulation time and the anti-Xa activity assay","volume":"35","author":"Delmas","year":"2020","journal-title":"J. Intensive Care Med."},{"issue":"2","key":"10.1016\/j.earlhumdev.2026.106535_bb0065","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1097\/PCC.0000000000000028","article-title":"Anti-factor Xa assay is a superior correlate of heparin dose than activated partial thromboplastin time or activated clotting time in pediatric extracorporeal membrane oxygenation*","volume":"15","author":"Liveris","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.earlhumdev.2026.106535_bb0070","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/pan.13046","article-title":"Congenital diaphragmatic hernia: outcomes of neonates treated at Mayo Clinic with and without extracorporeal membrane oxygenation","volume":"27","author":"Bojani\u0107","year":"2017","journal-title":"Paediatr. Anaesth."},{"issue":"4","key":"10.1016\/j.earlhumdev.2026.106535_bb0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/PCC.0000000000000103","article-title":"The association of carotid artery cannulation and neurologic injury in pediatric patients supported with venoarterial extracorporeal membrane oxygenation*","volume":"15","author":"Teele","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2026.106535_bb0080","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jss.2023.06.046","article-title":"A systematic review of clinical outcomes after carotid artery ligation versus carotid artery reconstruction following venoarterial extracorporeal membrane oxygenation in infants and children","volume":"291","author":"Gil","year":"2023","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.earlhumdev.2026.106535_bb0085","article-title":"Clinical profile and neurological outcomes of pediatric patients supported on venoarterial extracorporeal mechanical oxygenation in a cardiorespiratory pediatric intensive care unit: a single-center study","author":"Subhash","year":"2025","journal-title":"ASAIO J."},{"issue":"8","key":"10.1016\/j.earlhumdev.2026.106535_bb0090","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/PCC.0000000000001612","article-title":"Neurologic outcomes after extracorporeal membrane oxygenation: a systematic review","volume":"19","author":"Boyle","year":"2018","journal-title":"Pediatr. Crit. Care Med."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378226000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378226000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:47:43Z","timestamp":1776408463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378226000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":18,"alternative-id":["S0378378226000605"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2026.106535","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Every second counts: Association between activated clotting time and neurologic injury in neonatal ECMO","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2026.106535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106535"}}