{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:34:58Z","timestamp":1791196498683,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ebiom.2015.01.015","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T07:40:04Z","timestamp":1422430804000},"page":"244-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba"],"prefix":"10.1016","volume":"2","author":[{"given":"Vivian","family":"Kouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-4436","authenticated-orcid":false,"given":"Ricardo","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoan","family":"Alem\u00e1n\u202c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeissel","family":"Abrahantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Vercauteren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea-Clemencia","family":"Pineda-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Theys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Megens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Moutschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3234-8426","authenticated-orcid":false,"given":"Johan","family":"Van Weyenbergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissette","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Van Laethem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mieke","family":"Vandamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2015.01.015_bb0030","first-page":"146","article-title":"Factors linked to rapid progression to AIDS in Cuban subjects","volume":"62","author":"Abrahantes Rodr\u00edguez","year":"2010","journal-title":"Rev. Cubana Med. Trop."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-3305-6-18","article-title":"Effect of malaria on HIV\/AIDS transmission and progression","volume":"6","author":"Alemu","year":"2013","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0280","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1182\/blood.V95.4.1167.004k11_1167_1174","article-title":"Limited expression of R5-tropic HIV-1 in CCR5-positive type 1-polarized T cells explained by their ability to produce RANTES, MIP-1alpha, and MIP-1beta","volume":"95","author":"Annunziato","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ebiom.2015.01.015_bb9995","author":"Eberle"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0135","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/512682","article-title":"HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads","volume":"195","author":"Baeten","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0115","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1097\/QAD.0b013e328332d5e1","article-title":"Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man","volume":"23","author":"B\u00e1rtolo","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0200","doi-asserted-by":"crossref","first-page":"e4724","DOI":"10.1371\/journal.pone.0004724","article-title":"Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update","volume":"4","author":"Bennett","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/01.qai.0000186363.27587.c0","article-title":"Identification of a novel HIV-1 circulating ADG intersubtype recombinant form (CRF19_cpx) in Cuba","volume":"40","author":"Casado","year":"2005","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0035","doi-asserted-by":"crossref","first-page":"e11079","DOI":"10.1371\/journal.pone.0011079","article-title":"Host and viral genetic correlates of clinical definitions of HIV-1 disease progression","volume":"5","author":"Casado","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0180","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1093\/bioinformatics\/bti607","article-title":"An automated genotyping system for analysis of HIV-1 and other microbial sequences","volume":"21","author":"De Oliveira","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0315","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.270.5238.988","article-title":"Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients","volume":"270","author":"Deacon","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0265","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/bioinformatics\/btl508","article-title":"Analysis of HIV-1 pol sequences using Bayesian Networks: implications for drug resistance","volume":"22","author":"Deforche","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0020","doi-asserted-by":"crossref","first-page":"e72448","DOI":"10.1371\/journal.pone.0072448","article-title":"Phylodynamics of the HIV-1 epidemic in Cuba","volume":"8","author":"Delatorre","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0105","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/08892220152596597","article-title":"Immunologic and virologic analyses of an acutely HIV type 1-infected patient with extremely rapid disease progression","volume":"17","author":"Demarest","year":"2001","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0230","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0150","series-title":"Frequent CXCR4 Tropism of HIV-1 Subtype A and CRF02_AG During Late-stage Disease \u2014 Indication of an Evolving Epidemic in West Africa","first-page":"1","author":"Esbj\u00f6rnsson","year":"2010"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0290","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1128\/JVI.78.5.2187-2200.2004","article-title":"Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities","volume":"78","author":"Frahm","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0255","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1742-4690-10-36","article-title":"Limited cross-border infections in patients newly diagnosed with HIV in Europe","volume":"10","author":"Frentz","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0270","series-title":"UAI'99 Proceedings of the Fifteenth Conference on Uncertainty in Artificial Intelligence","first-page":"196","article-title":"Data analysis with bayesian networks: a bootstrap approach","author":"Friedman","year":"1999"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0095","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1086\/314660","article-title":"Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine co-receptor usage","volume":"179","author":"Giorgi","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0055","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/cid\/cis933","article-title":"Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study","volume":"56","author":"Helleberg","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0085","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/COH.0b013e32834bd365","article-title":"HIV\/hepatitis C coinfection natural history and disease progression","volume":"6","author":"Hernandez","year":"2011","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0285","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1086\/315250","article-title":"Stimulation of macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES by Candida albicans and Cryptococcus neoformans in peripheral blood mononuclear cells from persons with and without human immunodeficiency virus infec","volume":"181","author":"Huang","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0215","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1128\/JVI.77.24.13376-13388.2003","article-title":"Improved co-receptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences","volume":"77","author":"Jensen","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0140","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1086\/340130","article-title":"Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda","volume":"185","author":"Kaleebu","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/QAI.0b013e3180385aa0","article-title":"Relation between chemokine receptor use, disease stage, and HIV-1 subtypes A and D: results from a rural Ugandan cohort","volume":"45","author":"Kaleebu","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0145","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1086\/527416","article-title":"Effect of human immunodeficiency virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infection","volume":"197","author":"Kiwanuka","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0120","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/QAD.0b013e32832d0825","article-title":"Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection","volume":"23","author":"Lajoie","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0125","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1086\/605892","article-title":"Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)","volume":"200","author":"Le Clerc","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0260","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/infdis\/jir550","article-title":"Transmission network parameters estimated from HIV sequences for a nationwide epidemic","volume":"204","author":"Leigh Brown","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0240","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1128\/JVI.79.18.11981-11989.2005","article-title":"Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain","volume":"79","author":"Lemey","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0045","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.pcbi.0030029","article-title":"Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics","volume":"3","author":"Lemey","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0205","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nbt1371","article-title":"Bioinformatics prediction of HIV co-receptor usage","volume":"25","author":"Lengauer","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0295","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm992","article-title":"HIV evolution: CTL escape mutation and reversion after transmission","volume":"10","author":"Leslie","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0300","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1742-4690-10-126","article-title":"Functional conservation of HIV-1 Gag: implications for rational drug design","volume":"10","author":"Li","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0155","doi-asserted-by":"crossref","first-page":"e89462","DOI":"10.1371\/journal.pone.0089462","article-title":"Evidence that HIV-1 CRF01_AE is associated with low CD4+ T cell count and CXCR4 co-receptor usage in recently infected young men who have sex with men (MSM) in Shanghai, China","volume":"9","author":"Li","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0130","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1086\/596067","article-title":"Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)","volume":"199","author":"Limou","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0090","doi-asserted-by":"crossref","first-page":"e46143","DOI":"10.1371\/journal.pone.0046143","article-title":"Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection","volume":"7","author":"Liovat","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0320","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-4690-10-100","article-title":"Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes","volume":"10","author":"Mann","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0305","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1128\/JVI.80.7.3617-3623.2006","article-title":"Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1","volume":"80","author":"Martinez-Picado","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0060","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1097\/01.aids.0000432537.92958.73","article-title":"Association of self-reported race with AIDS death in continuous HAART users in a cohort of HIV-infected women in the United States","volume":"27","author":"Murphy","year":"2013","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/infdis\/jit425","article-title":"HIV type 1 polymerase gene polymorphisms are associated with phenotypic differences in replication capacity and disease progression","volume":"209","author":"Ng","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0075","doi-asserted-by":"crossref","first-page":"e1002464","DOI":"10.1371\/journal.ppat.1002464","article-title":"Tuberculosis and HIV co-infection","volume":"8","author":"Pawlowski","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0190","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1089\/aid.2006.22.724","article-title":"HIV type 1 molecular epidemiology in Cuba: high genetic diversity, frequent mosaicism, and recent expansion of BG intersubtype recombinant forms","volume":"22","author":"P\u00e9rez","year":"2006","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0165","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.meegid.2013.02.002","article-title":"Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba","volume":"16","author":"P\u00e9rez","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0185","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.meegid.2013.04.032","article-title":"Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: performance evaluation of the new REGA version 3 and seven other tools","volume":"19","author":"Pineda-Pe\u00f1a","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0245","doi-asserted-by":"crossref","first-page":"e9490","DOI":"10.1371\/journal.pone.0009490","article-title":"FastTree 2\u2014approximately maximum-likelihood trees for large alignments","volume":"5","author":"Price","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0040","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1128\/JVI.01959-09","article-title":"Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression","volume":"84","author":"Pushker","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0250","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1471-2105-14-317","article-title":"Automated analysis of phylogenetic clusters","volume":"14","author":"Ragonnet-Cronin","year":"2013","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0100","first-page":"819","article-title":"Disease progression","volume":"24","author":"Roberts","year":"2011"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0160","series-title":"Morbidity and Mortality Weekly Report Revised Surveillance Case Definitions for HIV Infection Among Adults, Adolescents, and Children Aged <18Months and for HIV Infection and AIDS Among Children Aged 18 Months to <13Years \u2014 United States","first-page":"57","author":"Rutledge","year":"2008"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0110","doi-asserted-by":"crossref","first-page":"e53920","DOI":"10.1371\/journal.pone.0053920","article-title":"CRF01_AE-specific neutralizing activity observed in plasma derived from HIV-1-infected Thai patients residing in northern Thailand: comparison of neutralizing breadth and potency between plasma derived from rapid and slow progressors","volume":"8","author":"Sapsutthipas","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0070","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/COH.0b013e328351b9e3","article-title":"The effects of schistosomiasis on HIV\/AIDS infection, progression and transmission","volume":"7","author":"Secor","year":"2012","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/QAI.0b013e318046ea47","article-title":"Identification of 3 phylogenetically related HIV-1 BG intersubtype circulating recombinant forms in Cuba","volume":"45","author":"Sierra","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0195","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1093\/bioinformatics\/btl446","article-title":"RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models","volume":"22","author":"Stamatakis","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0175","series-title":"8th European HIV Drug Resistance Workshop","article-title":"COMET: a novel approach to HIV-1 subtype prediction","author":"Struck","year":"2010"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0235","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1742-4690-9-81","article-title":"Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients","volume":"9","author":"Theys","year":"2012","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0005","first-page":"210","article-title":"Molecular epidemiology of HIV-1 variants in the global AIDS pandemic: an update","volume":"7","author":"Thomson","year":"2005","journal-title":"AIDS Rev."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0275","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/viro.1997.8980","article-title":"Differences in chemokine co-receptor usage between genetic subtypes of HIV-1","volume":"241","author":"Tscherning","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0170","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jviromet.2004.09.003","article-title":"A genotypic resistance assay for the detection of drug resistance in the human immunodeficiency virus type 1 envelope gene","volume":"123","author":"Van Laethem","year":"2005","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0210","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1473-3099(10)70319-4","article-title":"European guidelines on the clinical management of HIV-1 tropism testing","volume":"11","author":"Vandekerckhove","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ebiom.2015.01.015_bb0025","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1089\/088922203322493120","article-title":"Characterization of HIV type 1 clades in the Caribbean using pol gene sequences","volume":"19","author":"Vaughan","year":"2003","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.ebiom.2015.01.015_bb0310","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fimmu.2013.00355","article-title":"Viral factors in non-progression","volume":"4","author":"Wang","year":"2013","journal-title":"Front. Immunol."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396415000389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396415000389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T11:26:00Z","timestamp":1598700360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396415000389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S2352396415000389"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2015.01.015","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2015.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}