{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:55:44Z","timestamp":1790819744269,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ebiom.2015.11.019","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T11:03:09Z","timestamp":1447758189000},"page":"2037-2045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis"],"prefix":"10.1016","volume":"2","author":[{"given":"Gabriele","family":"Di Sante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tolusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Laura","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gremese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Alivernini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Nicol\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Ferraccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ebiom.2015.11.019_bb0005","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid Arthritis Classification Criteria: an American College of Rheumatology\/European League Against Rheumatism Collaborative Initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0010","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrrheum.2009.80","article-title":"Type 17T helper cells-origins, features and possible roles in rheumatic disease","volume":"5","author":"Annunziato","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 Revised Criteria for the Classification of Rheumatoid Arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"issue":"15","key":"10.1016\/j.ebiom.2015.11.019_bb0020","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.132254199","article-title":"Predominant selection of T cells specific for the glycosylated collagen type II epitope (263\u2013270) in humanized transgenic mice and in rheumatoid arthritis","volume":"99","author":"Backlund","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.ebiom.2015.11.019_bb0025","doi-asserted-by":"crossref","first-page":"13108","DOI":"10.1073\/pnas.93.23.13108","article-title":"Molecular basis for the recognition of two structurally different Major histocompatibility complex\/peptide complexes by a single T-cell receptor","volume":"93","author":"Brock","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semarthrit.2012.12.003","article-title":"Genetics in rheumatoid arthritis beyond HLA genes: what meta-analyses have shown?","volume":"43","author":"Chatzikyriakidou","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/BOR.0b013e32834518a3","article-title":"Pathophysiology of rheumatoid arthritis","volume":"23","author":"Cooles","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"issue":"7","key":"10.1016\/j.ebiom.2015.11.019_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011550","article-title":"Modeling the ternary complex TCR-Vbeta\/COLLAGENII(261\u2013273)\/HLA-DR4 associated with rheumatoid arthritis","volume":"5","author":"De Rosa","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0045","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1399-0004.1989.tb03185.x","article-title":"The contribution of HLA to rheumatoid arthritis","volume":"36","author":"Deighton","year":"1989","journal-title":"Clin. Genet."},{"issue":"5","key":"10.1016\/j.ebiom.2015.11.019_bb0050","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1084\/jem.178.5.1675","article-title":"Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease","volume":"178","author":"Deng","year":"1993","journal-title":"J. Exp. Med."},{"issue":"Suppl. 3","key":"10.1016\/j.ebiom.2015.11.019_bb0055","doi-asserted-by":"crossref","first-page":"iii61","DOI":"10.1136\/ard.2008.098509","article-title":"Protection against rheumatoid arthritis by HLA: nature and nurture","volume":"67","author":"Feitsma","year":"2008","journal-title":"Ann. Rheum. Dis."},{"issue":"60","key":"10.1016\/j.ebiom.2015.11.019_bb0060","first-page":"413","article-title":"The potential role of Th17 in mediating the transition from acute to chronic autoimmune inflammation: rheumatoid arthritis as a model","volume":"11","author":"Ferraccioli","year":"2011","journal-title":"Discov. Med."},{"issue":"5 Suppl. 39","key":"10.1016\/j.ebiom.2015.11.019_bb0065","first-page":"S93","article-title":"The disease activity score and the EULAR response criteria","volume":"23","author":"Fransen","year":"2005","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.ebiom.2015.11.019_bb0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaut.2010.12.004","article-title":"Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes","volume":"36","author":"Ge","year":"2011","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/sarh.2002.32552","article-title":"Influence of human leukocyte antigen-DRB1 on the susceptibility and severity of rheumatoid arthritis","volume":"31","author":"Gonzalez-Gay","year":"2002","journal-title":"Semin. Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.ebiom.2015.11.019_bb0080","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0085","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/art.20289","article-title":"T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage","volume":"50","author":"He","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.ebiom.2015.11.019_bb0090","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/ard.2010.143768","article-title":"Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes","volume":"70","author":"Hot","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/ard.2010.135376","article-title":"The need for personalised medicine for rheumatoid arthritis","volume":"70","author":"Isaacs","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0100","doi-asserted-by":"crossref","first-page":"937","DOI":"10.7326\/0003-4819-78-6-937","article-title":"Rheumatoid arthritis, 1970\u20131972","volume":"78","author":"Johnson","year":"1973","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ebiom.2015.11.019_bb0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1196\/annals.1361.067","article-title":"Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary","volume":"1051","author":"Kapitany","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.ebiom.2015.11.019_bb0110","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nri959","article-title":"Progressive differentiation and selection of the fittest in the immune response","volume":"2","author":"Lanzavecchia","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.ebiom.2015.11.019_bb0115","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1002\/art.27622","article-title":"Role of Th17 cells in human autoimmune arthritis","volume":"62","author":"Leipe","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0120","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1172\/JCI117624","article-title":"CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response","volume":"94","author":"Li","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"2\u20133","key":"10.1016\/j.ebiom.2015.11.019_bb0125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.clim.2005.09.020","article-title":"Altered collagen II peptides inhibited T-cell activation in rheumatoid arthritis","volume":"118","author":"Li","year":"2006","journal-title":"Clin. Immunol."},{"issue":"11","key":"10.1016\/j.ebiom.2015.11.019_bb0130","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1002\/eji.201344424","article-title":"DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells","volume":"44","author":"Luckey","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1084\/jem.187.3.379","article-title":"Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities","volume":"187","author":"Luhder","year":"1998","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.ebiom.2015.11.019_bb0140","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/art.24410","article-title":"Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis","volume":"60","author":"Lundstrom","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.ebiom.2015.11.019_bb0145","doi-asserted-by":"crossref","first-page":"513","DOI":"10.4049\/jimmunol.1201891","article-title":"HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile","volume":"190","author":"Mangalam","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2015.11.019_bb0150","first-page":"15","article-title":"Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets","volume":"3","author":"Mesko","year":"2010","journal-title":"BMC Med. Genet."},{"issue":"9\u201310","key":"10.1016\/j.ebiom.2015.11.019_bb0155","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2119\/molmed.2011.00034","article-title":"B-cell subsets in the joint compartments of seropositive and seronegative rheumatoid arthritis (RA) and no-RA arthritides express memory markers and ZAP70 and characterize the aggregate pattern irrespectively of the autoantibody status","volume":"17","author":"Michelutti","year":"2011","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.ebiom.2015.11.019_bb0160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/intimm\/dxh376","article-title":"Mycobacterium tuberculosis in the adjuvant modulates the balance of Th immune response to self-antigen of the CNS without influencing a \u201cCore\u201d repertoire of specific T cells","volume":"18","author":"Nicolo","year":"2006","journal-title":"Int. Immunol."},{"issue":"11","key":"10.1016\/j.ebiom.2015.11.019_bb0165","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/rheumatology\/35.11.1101","article-title":"Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatism Association Preliminary Remission Criteria in Relation to the Disease Activity Score","volume":"35","author":"Prevoo","year":"1996","journal-title":"Br. J. Rheumatol."},{"issue":"4","key":"10.1016\/j.ebiom.2015.11.019_bb0170","doi-asserted-by":"crossref","first-page":"R784","DOI":"10.1186\/ar1733","article-title":"Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin","volume":"7","author":"Raza","year":"2005","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00002281-199805000-00007","article-title":"The genetic contribution to the pathogenesis of rheumatoid arthritis","volume":"10","author":"Reveille","year":"1998","journal-title":"Curr. Opin. Rheumatol."},{"issue":"6","key":"10.1016\/j.ebiom.2015.11.019_bb0180","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1186\/ar2553","article-title":"Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis","volume":"10","author":"Ria","year":"2008","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.168.1.253","article-title":"HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen","volume":"168","author":"Rosloniec","year":"2002","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.ebiom.2015.11.019_bb0190","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1084\/jem.186.7.1059","article-title":"A mechanism for the major histocompatibility complex-linked resistance to autoimmunity","volume":"186","author":"Schmidt","year":"1997","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.ebiom.2015.11.019_bb0195","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/art.39054","article-title":"Autoantigen BiP-derived HLA-DR4 epitopes differentially recognized by effector and regulatory T cells in rheumatoid arthritis","volume":"67","author":"Shoda","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"8","key":"10.1016\/j.ebiom.2015.11.019_bb0200","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/art.34459","article-title":"Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis","volume":"64","author":"Snir","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ebiom.2015.11.019_bb0205","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4049\/jimmunol.1500267","article-title":"Cutting edge: chronic NF-kappaB activation in CD4+ T cells in rheumatoid arthritis is genetically determined by HLA risk alleles","volume":"195","author":"Spurlock","year":"2015","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.ebiom.2015.11.019_bb0210","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.4049\/jimmunol.181.4.2869","article-title":"Delineating the role of the HLA-DR4 \u201cshared epitope\u201d in susceptibility versus resistance to develop arthritis","volume":"181","author":"Taneja","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0215","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.clim.2008.11.011","article-title":"Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype","volume":"131","author":"Tolusso","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ebiom.2015.11.019_bb0220","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fimmu.2013.00321","article-title":"MHC class II polymorphisms, autoreactive T-cells, and autoimmunity","volume":"4","author":"Tsai","year":"2013","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.ebiom.2015.11.019_bb0225","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ng1010-814","article-title":"Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis","volume":"42","author":"van der Woude","year":"2010","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0230","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/art.1780390105","volume":"39","author":"van Gestel","year":"1996","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.ebiom.2015.11.019_bb0235","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/rheumatology\/39.11.1189","article-title":"Skewed T-cell receptor variable gene usage in the synovium of early and chronic rheumatoid arthritis patients and persistence of clonally expanded T cells in a chronic patient","volume":"39","author":"VanderBorght","year":"2000","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.ebiom.2015.11.019_bb0240","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/00325481.1973.11713616","article-title":"Rheumatologic disorders due to immune complexes","volume":"54","author":"Vaughan","year":"1973","journal-title":"Postgrad. Med."},{"issue":"24","key":"10.1016\/j.ebiom.2015.11.019_bb0245","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.95.24.14447","article-title":"Perturbation of the T cell repertoire in rheumatoid arthritis","volume":"95","author":"Wagner","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.ebiom.2015.11.019_bb0250","first-page":"392","article-title":"New biomarkers in rheumatoid arthritis","volume":"70","author":"Willemze","year":"2012","journal-title":"Neth. J. Med."},{"issue":"2","key":"10.1016\/j.ebiom.2015.11.019_bb0255","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1074\/jbc.M111.289488","article-title":"A single autoimmune T cell receptor recognizes more than a million different peptides","volume":"287","author":"Wooldridge","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00296-008-0634-4","article-title":"Mucosal administration of an altered CII263-272 peptide inhibits collagen-induced arthritis by suppression of Th1\/Th17 cells and expansion of regulatory T cells","volume":"29","author":"Zhao","year":"2008","journal-title":"Rheumatol. Int."},{"issue":"2","key":"10.1016\/j.ebiom.2015.11.019_bb0265","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15321819.2013.841192","article-title":"Skewness of TCR Vbeta of peripheral blood and synovial fluid of patients with rheumatoid arthritis","volume":"35","author":"Zhou","year":"2014","journal-title":"J. Immunoass. Immunochem."},{"issue":"1","key":"10.1016\/j.ebiom.2015.11.019_bb0270","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.clim.2010.10.002","article-title":"Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis","volume":"138","author":"Zizzo","year":"2011","journal-title":"Clin. Immunol."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396415302036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396415302036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:25:38Z","timestamp":1748679938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396415302036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S2352396415302036"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2015.11.019","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2015.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}