{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:34:47Z","timestamp":1789648487030,"version":"4.0.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ebiom.2016.06.026","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T01:13:32Z","timestamp":1466730812000},"page":"65-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Infectivity of Immature Neurons to Zika Virus: A Link to Congenital Zika Syndrome"],"prefix":"10.1016","volume":"10","author":[{"given":"Brandon W.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna C.","family":"Addanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahila N.","family":"Sriskanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewen","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Bagasra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2016.06.026_bb0005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0035-9203(56)90090-6","article-title":"Zika virus infection experimentally induced in a human volunteer","volume":"50","author":"Bearcroft","year":"1956","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"2","key":"10.1016\/j.ebiom.2016.06.026_bb0010","first-page":"183e93","article-title":"Zika virus infection of the central nervous system of mice","volume":"35","author":"Bell","year":"1971","journal-title":"Arch. Gesamte Virusforsch."},{"issue":"5","key":"10.1016\/j.ebiom.2016.06.026_bb0015","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1073\/pnas.77.5.2936","article-title":"Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid","volume":"77","author":"Breitman","year":"1980","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2015.12.006","article-title":"Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus","author":"Carneiro","year":"2016","journal-title":"Microbes Infect."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(16)00651-6","article-title":"Association between Zika virus and microcephaly in French Polynesia, 2013\u201315: a retrospective study","author":"Cauchemez","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ebiom.2016.06.026_bb0030","first-page":"124","article-title":"Clinical manifestations of Zika virus infection, Rio de Janeiro, Brazil, 2015","volume":"22","author":"Cerbino-Neto","year":"2016","journal-title":"Emerg. Infect. Dis."},{"issue":"5","key":"10.1016\/j.ebiom.2016.06.026_bb0035","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jinf.2016.02.011","article-title":"Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease","volume":"72","author":"Chan","year":"2016","journal-title":"J. Infect."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0040","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0035-9203(83)90106-2","article-title":"Sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan","volume":"77","author":"Darwish","year":"1983","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0045","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0050","author":"European Centre for Disease Prevention and Control (ECDC)"},{"issue":"17","key":"10.1016\/j.ebiom.2016.06.026_bb0055","doi-asserted-by":"crossref","first-page":"8880e96","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0060","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3201\/eid1509.090442","article-title":"Zika virus outside Africa","volume":"15","author":"Hayes","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0065","series-title":"Virus Research Institute Annual Report","first-page":"48","article-title":"Serology of wild mammals","author":"Henderson","year":"1968"},{"key":"10.1016\/j.ebiom.2016.06.026_bb0070","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.5897\/AJB2015.14474","article-title":"High proportion of mosquito vectors in Zika forest, Uganda, feeding on humans has implications for the spread of new arbovirus pathogens","volume":"14","author":"Kaddumukasa","year":"2015","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-62703-640-5_2","article-title":"Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology","volume":"1078","author":"Kovalevich","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0080","doi-asserted-by":"crossref","first-page":"e08347","DOI":"10.7554\/eLife.08347","article-title":"The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus","volume":"4","author":"Kraemer","year":"2015","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.ebiom.2016.06.026_bb0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/CMR.13.4.571","article-title":"Rubella virus replication and links to teratogenicity","volume":"13","author":"Lee","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ebiom.2016.03.046","article-title":"Climate change and Aedes vectors: 21st century projections for dengue transmission in Europe","volume":"7","author":"Liu-Helmersson","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2016.06.026_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0035-9203(54)90006-1","article-title":"Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria","volume":"48","author":"MacNamara","year":"1954","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0100","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chom.2012.08.009","article-title":"The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry","volume":"12","author":"Meertens","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.ebiom.2016.06.026_bb0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/2049-632X.12178","article-title":"The role of viral persistence in flavivirus biology","volume":"71","author":"Mlera","year":"2014","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0110","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00401-003-0768-0","article-title":"Inflammatory infiltrates in the spinal cord of patients with Guillain-Barre syndrome","volume":"106","author":"M\u00fcller","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jped.2016.02.009","article-title":"Microcephaly and Zika virus: a clinical and epidemiological analysis of the current outbreak in Brazil","author":"Nunes","year":"2016","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0120","doi-asserted-by":"crossref","first-page":"e537","DOI":"10.1542\/peds.2005-2024","article-title":"Birth outcomes following West Nile virus infection of pregnant women in the United States: 2003\u20132004","volume":"117","author":"O'Leary","year":"2006","journal-title":"Pediatrics"},{"issue":"7","key":"10.1016\/j.ebiom.2016.06.026_bb0125","doi-asserted-by":"crossref","DOI":"10.3201\/eid2207.151990","article-title":"A literature review of Zika virus","volume":"22","author":"Plourde","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0130","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects - reviewing the evidence for causality","author":"Rasmussen","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ebiom.2016.06.026_bb0135","doi-asserted-by":"crossref","first-page":"e60874","DOI":"10.1371\/journal.pone.0060874","article-title":"Climate change and range expansion of the Asian tiger mosquito (Aedes albopictus) in northeastern USA: implications for public health practitioners","volume":"8","author":"Rochlin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2016.06.026_bb0140","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.coi.2010.10.001","article-title":"TAM receptor signaling and autoimmune disease","volume":"22","author":"Rothlin","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0145","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1182\/blood-2011-08-372425","article-title":"Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells","volume":"119","author":"Simhadri","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ebiom.2016.06.026_bb0150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0035-9203(64)90201-9","article-title":"Zika virus infection in man","volume":"58","author":"Simpson","year":"1964","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"3","key":"10.1016\/j.ebiom.2016.06.026_bb0155","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1073\/pnas.93.3.1038","article-title":"Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma","volume":"93","author":"Sorensen","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0160","first-page":"351872","article-title":"West Nile virus infection in pregnancy","volume":"2013","author":"Stewart","year":"2013","journal-title":"Case Rep. Infect. Dis."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2016.06.026_bb0170","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.8.30148","article-title":"An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014","volume":"21","author":"Venturi","year":"2016","journal-title":"Euro Surveill."},{"issue":"14","key":"10.1016\/j.ebiom.2016.06.026_bb0175","doi-asserted-by":"crossref","first-page":"e3257.30","DOI":"10.1097\/MD.0000000000003257","article-title":"Guillain-Barre syndrome (42 cases) occurring during a Zika virus outbreak in French Polynesia","volume":"95","author":"Watrin","year":"2016","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.ebiom.2016.06.026_bb0180","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pneurobio.2009.07.003","article-title":"Adult neurogenesis and the olfactory system","volume":"89","author":"Whitman","year":"2009","journal-title":"Prog. Neurobiol."},{"issue":"8","key":"10.1016\/j.ebiom.2016.06.026_bb0185","doi-asserted-by":"crossref","first-page":"e2348","DOI":"10.1371\/journal.pntd.0002348","article-title":"Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika virus in Singapore","volume":"7","author":"Wong","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0190","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcv.2014.12.005","article-title":"Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications","volume":"63","author":"Zammarchi","year":"2015","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.ebiom.2016.06.026_bb0195","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1038\/emi.2016.48","article-title":"Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic","volume":"5","author":"Zhu","year":"2016","journal-title":"Emerg. Microbes Infect."}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396416302821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396416302821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:45:09Z","timestamp":1762454709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396416302821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":39,"alternative-id":["S2352396416302821"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2016.06.026","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infectivity of Immature Neurons to Zika Virus: A Link to Congenital Zika Syndrome","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2016.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}