{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:35:39Z","timestamp":1789778139636,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ebiom.2017.03.023","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T10:46:36Z","timestamp":1489833996000},"page":"157-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome"],"prefix":"10.1016","volume":"18","author":[{"given":"Yuehui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanci","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Njomeza","family":"Morina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Br\u00e4nnstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Billig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2017.03.023_bb0005","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0026-0495(99)90196-8","article-title":"Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat","volume":"48","author":"Bogovich","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0015","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0020","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1093\/humrep\/det116","article-title":"Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients","volume":"28","author":"Carvajal","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0025","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0030","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.fertnstert.2008.08.073","article-title":"Selective impairment in glycogen synthase kinase-3 and mitogen-activated protein kinase phosphorylation: comparisons with the hyperandrogenic and the hyperinsulinemic rats","volume":"92","author":"Chen","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0040","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.mce.2011.06.031","article-title":"The role of androgens and the androgen receptor in cycling endometrium","volume":"358","author":"Cloke","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0045","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S0026-0495(00)90110-0","article-title":"Synergistic effects of insulin-like growth factor-I and human chorionic gonadotropin in the rat ovary","volume":"49","author":"Damario","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0050","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1101\/gad.1662308","article-title":"Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and raptor in association with IKK","volume":"22","author":"Dan","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0055","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.fertnstert.2004.11.070","article-title":"Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment","volume":"83","author":"DeUgarte","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0060","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/molehr\/gap033","article-title":"The effects of metformin on uterine tissue of hyperandrogenized BALB\/c mice","volume":"15","author":"Elia","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0065","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.mce.2010.02.029","article-title":"Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males","volume":"321","author":"Feng","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0070","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3109\/09513590.2015.1041906","article-title":"Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis","volume":"31","author":"Feng","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0075","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ejogrb.2014.01.009","article-title":"Metformin modulates PI3K and GLUT4 expression and Akt\/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin","volume":"175","author":"Ferreira","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0080","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: from mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0085","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.rbmo.2010.11.006","article-title":"Metformin modulates IL-8, IL-1beta, ICAM and IGFBP-1 expression in human endometrial stromal cells","volume":"22","author":"Germeyer","year":"2011","journal-title":"Reprod. BioMed. Online"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0090","doi-asserted-by":"publisher","first-page":"19970","DOI":"10.1038\/srep19970","article-title":"Intracrine androgens enhance decidualization and modulate expression of human endometrial receptivity genes","volume":"6","author":"Gibson","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0095","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0100","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.mce.2011.06.010","article-title":"Interaction between sex hormones and WNT\/beta-catenin signal transduction in endometrial physiology and disease","volume":"358","author":"van der Horst","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0105","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3109\/09513590.2014.951321","article-title":"Effects of metformin on endocrine, metabolic milieus and endometrial expression of androgen receptor in patients with polycystic ovary syndrome","volume":"31","author":"Ito-Yamaguchi","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0110","first-page":"1126","article-title":"Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome","volume":"86","author":"Jakubowicz","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0115","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/humrep\/der115","article-title":"Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium","volume":"26","author":"Keator","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0120","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1093\/humrep\/der436","article-title":"High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples","volume":"27","author":"Leach","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0125","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s12020-012-9739-3","article-title":"Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS","volume":"43","author":"Li","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0130","doi-asserted-by":"publisher","first-page":"173","DOI":"10.7150\/jca.8009","article-title":"Combination of Diane-35 and metformin to treat early endometrial carcinoma in PCOS women with insulin resistance","volume":"5","author":"Li","year":"2014","journal-title":"J. Cancer"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0135","first-page":"574","article-title":"Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action","volume":"7","author":"Li","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0140","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.7150\/ijbs.13109","article-title":"Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: in vivo and in vitro studies in women with polycystic ovary syndrome","volume":"11","author":"Li","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0145","doi-asserted-by":"publisher","first-page":"38134","DOI":"10.1038\/srep38134","article-title":"Impaired receptivity and decidualization in DHEA-induced PCOS mice","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0150","article-title":"Role of the PI3K-Akt signaling pathway in the pathogenesis of polycystic ovary syndrome","author":"Li","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0155","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1677\/joe.1.06226","article-title":"Up-regulation of the phosphatidylinositol 3-kinase\/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin","volume":"190","author":"Lima","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0160","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/cen.12951","article-title":"Serum levels of TSP-1, NF-kappaB and TGF-beta1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation","volume":"83","author":"Liu","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0165","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1016\/j.fertnstert.2010.01.049","article-title":"Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary syndrome","volume":"94","author":"Matteo","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0170","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0180","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007506.pub3","article-title":"Lifestyle changes in women with polycystic ovary syndrome","volume":"7","author":"Moran","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0185","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jsbmb.2010.02.015","article-title":"Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome","volume":"119","author":"Motta","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0190","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/humupd\/dmv025","article-title":"Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis","volume":"21","author":"Naderpoor","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0200","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1056\/NEJMct0707092","article-title":"Metformin for the treatment of the polycystic ovary syndrome","volume":"358","author":"Nestler","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0205","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1038\/ijo.2016.154","article-title":"Proinflammatory environment and role of TNF-alpha in endometrial function of obese women having polycystic ovarian syndrome","volume":"40","author":"Orostica","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0210","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/humrep\/dei351","article-title":"Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0215","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0220","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1073\/pnas.98.3.1047","article-title":"Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors","volume":"98","author":"Paria","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0225","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.steroids.2016.09.011","article-title":"Autophagic regulation in steroid hormone-responsive systems","volume":"115","author":"Park","year":"2016","journal-title":"Steroids"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0230","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrendo.2013.256","article-title":"Metformin-mode of action and clinical implications for diabetes and cancer","volume":"10","author":"Pernicova","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0235","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bpobgyn.2016.03.008","article-title":"Polycystic ovary syndrome: endometrial markers","volume":"37","author":"Piltonen","year":"2016","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0240","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1210\/jc.2013-1923","article-title":"Mesenchymal stem\/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential","volume":"98","author":"Piltonen","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0245","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/humrep\/dev055","article-title":"Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro","volume":"30","author":"Piltonen","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0250","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/0026-0495(92)90175-A","article-title":"Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats","volume":"41","author":"Poretsky","year":"1992","journal-title":"Metabolism"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0255","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.mce.2010.08.002","article-title":"The role of low-grade inflammation in the polycystic ovary syndrome","volume":"335","author":"Repaci","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0260","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0265","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1756-9966-33-41","article-title":"Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma","volume":"33","author":"Shao","year":"2014","journal-title":"J. Exp. Clin. Cancer. Res."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0270","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1210\/en.2015-2032","article-title":"A role for androgens in epithelial proliferation and formation of glands in the mouse uterus","volume":"157","author":"Simitsidellis","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0275","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/humupd\/dmu037","article-title":"Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications","volume":"20","author":"Sivalingam","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0280","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.mce.2016.11.009","article-title":"Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome","volume":"440","author":"Sumarac-Dumanovic","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0285","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1210\/jc.2006-2486","article-title":"Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells","volume":"92","author":"Takemura","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0290","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1530\/JME-11-0094","article-title":"Effect of single post-ovulatory administration of levonorgestrel on gene expression profile during the receptive period of the human endometrium","volume":"48","author":"Vargas","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0295","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.atherosclerosis.2015.07.017","article-title":"Metformin modulates human leukocyte\/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients","volume":"242","author":"Victor","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ebiom.2017.03.023_bb0300","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/nm1104","article-title":"Aberrant cannabinoid signaling impairs oviductal transport of embryos","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0305","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1016\/j.fertnstert.2009.01.096","article-title":"Effects of testosterone and metformin on glucose metabolism in endometrium","volume":"93","author":"Zhang","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0310","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00404-010-1765-x","article-title":"Up-regulated monoamine oxidase in the mouse uterus during the peri-implantation period","volume":"284","author":"Zhang","year":"2011","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0315","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","article-title":"Physiological and molecular determinants of embryo implantation","volume":"34","author":"Zhang","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0320","doi-asserted-by":"publisher","first-page":"30679","DOI":"10.1038\/srep30679","article-title":"Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ebiom.2017.03.023_bb0325","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1210\/jc.2014-2419","article-title":"Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K\/AKT\/NF-kappaB signaling in the granulosa cells of PCOS patients","volume":"100","author":"Zhao","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417301196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417301196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T07:54:48Z","timestamp":1535961288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396417301196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":61,"alternative-id":["S2352396417301196"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.03.023","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}