{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:52:01Z","timestamp":1778676721939,"version":"3.51.4"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008391","name":"UBS Optimus Foundation","doi-asserted-by":"publisher","award":["2007-00206"],"award-info":[{"award-number":["2007-00206"]}],"id":[{"id":"10.13039\/501100008391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008777","name":"Fundaci\u00f3n Bunge y Born","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 0118"],"award-info":[{"award-number":["PIP 0118"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2008-1073"],"award-info":[{"award-number":["PICT 2008-1073"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ebiom.2017.04.033","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T01:32:34Z","timestamp":1493256754000},"page":"202-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The Role of Heterotypic DENV-specific CD8+T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-474X","authenticated-orcid":false,"given":"Laura B.","family":"Talarico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Batalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana B.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge M.","family":"Brahamian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayel\u00e9n G.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldana","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Simonetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego R.","family":"Hijano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio L.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio T.","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u00e9sica","family":"Paredes Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena I.","family":"Iba\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermina A.","family":"Melendi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix A.","family":"Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa B.","family":"Damonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando P.","family":"Polack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2017.04.033_bb0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.virol.2015.10.006","article-title":"Antibodies are not required to a protective immune response against dengue virus elicited in a mouse encephalitis model","volume":"487","author":"Amorim","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0010","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1017\/S0950268804003541","article-title":"Serological and virological features of dengue fever and dengue haemorrhagic fever in Thailand from 1999 to 2002","volume":"133","author":"Anantapreecha","year":"2005","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.chom.2010.10.007","article-title":"Mouse STAT2 restricts early dengue virus replication","volume":"8","author":"Ashour","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0020","doi-asserted-by":"crossref","first-page":"313842","DOI":"10.1155\/2015\/313842","article-title":"Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators","volume":"2015","author":"de Azeredo","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000790","article-title":"Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification","volume":"6","author":"Balsitis","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0030","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.4049\/jimmunol.176.5.2817","article-title":"Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes","volume":"176","author":"Bashyam","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3787","article-title":"Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination","volume":"7","author":"Beatty","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0040","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/vim.2008.0089","article-title":"Cross-reactive memory CD4+ T cells alter the CD8+ T-cell response to heterologous secondary dengue virus infections in mice in a sequence-specific manner","volume":"22","author":"Beaumier","year":"2009","journal-title":"Viral Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0045","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"issue":"39","key":"10.1016\/j.ebiom.2017.04.033_bb0050","article-title":"Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2","volume":"4","author":"Blaney","year":"2004","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1743-422X-4-23","article-title":"Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1","volume":"4","author":"Blaney","year":"2007","journal-title":"Virol. J."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0060","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1128\/JCM.39.11.4119-4124.2001","article-title":"Development and evaluation of serotype- and group-specific fluorogenic reverse transcriptase PCR (TaqMan) assays for dengue virus","volume":"39","author":"Callahan","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0065","doi-asserted-by":"crossref","first-page":"901276","DOI":"10.1155\/2014\/901276","article-title":"Elevated dengue virus nonstructural protein 1 serum levels and altered toll-like receptor 4 expression, nitric oxide, and tumor necrosis factor alpha production in dengue hemorrhagic fever patients","volume":"2014","author":"Carvalho","year":"2014","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0070","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/jmv.20108","article-title":"Lymphocyte activation and hepatic cellular infiltration in immunocompetent mice infected by dengue virus","volume":"73","author":"Chen","year":"2004","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0075","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.trstmh.2007.06.019","article-title":"Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency","volume":"101","author":"Chen","year":"2007","journal-title":"Trans. R Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0080","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiv258","article-title":"CD8+ T cell responses in Flavivirus-naive individuals following immunization with a live-attenuated tetravalent dengue vaccine candidate","author":"Chu","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0085","first-page":"917143","article-title":"Vascular leakage in dengue hemorrhagic fever is associated with dengue infected monocytes, monocyte activation\/exhaustion, and cytokines production","volume":"2015","author":"Chunhakan","year":"2015","journal-title":"Int. J. Vasc. Med."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jcv.2014.04.002","article-title":"A strong interferon response correlates with a milder dengue clinical condition","volume":"60","author":"De La Cruz Hernandez","year":"2014","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm.1894","article-title":"Lack of antibody affinity maturation due to poor toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease","volume":"15","author":"Delgado","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0100","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1073\/pnas.1010867107","article-title":"Immunodominant T-cell responses to dengue virus NS3 are associated with DHF","volume":"107","author":"Duangchinda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0105","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ebiom.2016.10.006","article-title":"Protective role of cross-reactive CD8 T cells against dengue virus infection","volume":"13","author":"Elong Ngono","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0110","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/1521-4141(200109)31:9<2603::AID-IMMU2603>3.0.CO;2-8","article-title":"Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs","volume":"31","author":"Finke","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.yexmp.2010.07.007","article-title":"A BALB\/c mouse model shows that liver involvement in dengue disease is immune-mediated","volume":"89","author":"Franca","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/srep00051","article-title":"Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans","volume":"1","author":"Friberg","year":"2011","journal-title":"Sci. Report."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/icb.2010.61","article-title":"Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive","volume":"89","author":"Friberg","year":"2011","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000617","article-title":"Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006","volume":"4","author":"Fried","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0255-0857.148369","article-title":"Dengue vaccines: challenges, development, current status and prospects","volume":"33","author":"Ghosh","year":"2015","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0140","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.324.7353.1563","article-title":"Dengue: an escalating problem","volume":"324","author":"Gibbons","year":"2002","journal-title":"BMJ"},{"issue":"Pt 6","key":"10.1016\/j.ebiom.2017.04.033_bb0145","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1099\/0022-1317-69-6-1391","article-title":"Partial nucleotide sequence and deduced amino acid sequence of the structural proteins of dengue virus type 2, New Guinea C and PUO-218 strains","volume":"69","author":"Gruenberg","year":"1988","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0150","doi-asserted-by":"crossref","first-page":"743","DOI":"10.4269\/ajtmh.2012.12-0157","article-title":"The economic burden of dengue","volume":"86","author":"Gubler","year":"2012","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4269\/ajtmh.1978.27.581","article-title":"Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga","volume":"27","author":"Gubler","year":"1978","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1590\/S0074-02761991000300011","article-title":"Sequential infection as risk factor for dengue hemorrhagic fever\/dengue shock syndrome (DHF\/DSS) during the 1981 dengue hemorrhagic Cuban epidemic","volume":"86","author":"Guzman","year":"1991","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0170","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"Guzman","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0175","first-page":"301","article-title":"Immune enhancement of viral infection","volume":"31","author":"Halstead","year":"1982","journal-title":"Prog. Allergy"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0180","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.239.4839.476","article-title":"Pathogenesis of dengue: challenges to molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0185","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0065-3527(03)60011-4","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume":"60","author":"Halstead","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0190","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3201\/eid0812.020170","article-title":"Dengue hemorrhagic fever in infants: research opportunities ignored","volume":"8","author":"Halstead","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0195","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/514047","article-title":"Early clinical and laboratory indicators of acute dengue illness","volume":"176","author":"Kalayanarooj","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0200","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/viro.1997.8500","article-title":"Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53","volume":"230","author":"Kinney","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0205","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jmv.21051","article-title":"Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells","volume":"80","author":"Kou","year":"2008","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0210","first-page":"375","article-title":"Dengue haemorrhagic fever\/dengue shock syndrome: lessons from the Cuban epidemic, 1981","volume":"67","author":"Kouri","year":"1989","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0215","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cimid.2007.05.010","article-title":"Dengue hemorrhagic fever with special emphasis on immunopathogenesis","volume":"30","author":"Kurane","year":"2007","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0220","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1086\/431520","article-title":"Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection","volume":"192","author":"Laoprasopwattana","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0225","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/340365","article-title":"Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections","volume":"185","author":"Libraty","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0230","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1034\/j.1600-065X.2003.00044.x","article-title":"Granzyme B: a natural born killer","volume":"193","author":"Lord","year":"2003","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0235","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0240","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1128\/JVI.01826-10","article-title":"An in-depth analysis of original antigenic sin in dengue virus infection","volume":"85","author":"Midgley","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125476","article-title":"A dengue virus type 4 model of disseminated lethal infection in AG129 mice","volume":"10","author":"Milligan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0250","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm887","article-title":"Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever","volume":"9","author":"Mongkolsapaya","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0255","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.4049\/jimmunol.176.6.3821","article-title":"T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?","volume":"176","author":"Mongkolsapaya","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0260","article-title":"STAT2 signaling and dengue virus infection","volume":"3","author":"Morrison","year":"2014","journal-title":"JAKSTAT"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1086\/380762","article-title":"Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles","volume":"189","author":"Nguyen","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0270","first-page":"392","article-title":"Clinical spectrum and management of dengue haemorrhagic fever","volume":"18","author":"Nimmannitya","year":"1987","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0275","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4269\/ajtmh.2003.68.191","article-title":"Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999","volume":"68","author":"Nisalak","year":"2003","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0280","doi-asserted-by":"crossref","first-page":"164878","DOI":"10.1155\/2010\/164878","article-title":"Cells in dengue virus infection in vivo","volume":"2010","author":"Noisakran","year":"2010","journal-title":"Adv. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0285","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1099\/vir.0.045088-0","article-title":"Characterization of a model of lethal dengue virus 2 infection in C57BL\/6 mice deficient in the alpha\/beta interferon receptor","volume":"93","author":"Orozco","year":"2012","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0290","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.virol.2005.04.042","article-title":"Liver injury and viremia in mice infected with dengue-2 virus","volume":"338","author":"Paes","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0295","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.icb.7100008","article-title":"Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF\/DSS)","volume":"85","author":"Pang","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0300","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.2004.70.172","article-title":"Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful?","volume":"70","author":"Phuong","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0305","series-title":"Fields Virology","first-page":"747","article-title":"Flaviviruses","author":"Pierson","year":"2013"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0310","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jim.2014.01.001","article-title":"Mouse models for dengue vaccines and antivirals","volume":"410","author":"Plummer","year":"2014","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0315","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm918","article-title":"A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles","volume":"9","author":"Polack","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0320","doi-asserted-by":"crossref","first-page":"12561","DOI":"10.1128\/JVI.06743-11","article-title":"Gamma interferon (IFN-gamma) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-alpha\/beta receptor-deficient mice","volume":"86","author":"Prestwood","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0325","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0065-3527(03)59009-1","article-title":"Microevolution and virulence of dengue viruses","volume":"59","author":"Rico-Hesse","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0330","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1128\/JVI.02675-12","article-title":"Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection","volume":"87","author":"Rivino","year":"2013","journal-title":"J. Virol."},{"issue":"Suppl. 1","key":"10.1016\/j.ebiom.2017.04.033_bb0335","first-page":"E36","article-title":"T lymphocyte responses to heterologous secondary dengue virus infections","volume":"1171","author":"Rothman","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0340","first-page":"83","article-title":"Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis","volume":"338","author":"Rothman","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0345","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms","volume":"11","author":"Rothman","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002194","article-title":"Review of dengue hemorrhagic fever fatal cases seen among adults: a retrospective study","volume":"7","author":"Sam","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0355","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/oxfordjournals.aje.a113932","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak","volume":"120","author":"Sangkawibha","year":"1984","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004541","article-title":"Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for dengue virus replication","volume":"10","author":"Schmid","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0365","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","article-title":"Murine model for dengue virus-induced lethal disease with increased vascular permeability","volume":"80","author":"Shresta","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0370","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cellimm.2010.02.005","article-title":"Secondary heterologous dengue infection risk: disequilibrium between immune regulation and inflammation?","volume":"262","author":"Sierra","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046292","article-title":"Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection","volume":"7","author":"Sung","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0380","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/trstmh\/trt044","article-title":"T helper type 2 bias and type 17 suppression in primary dengue virus infection in infants and young children","volume":"107","author":"Talarico","year":"2013","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0385","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0390","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1128\/JVI.00216-15","article-title":"Dengue virus infection with highly neutralizing levels of cross-reactive antibodies causes acute lethal small intestinal pathology without a high level of viremia in mice","volume":"89","author":"Watanabe","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0395","doi-asserted-by":"crossref","first-page":"E2046","DOI":"10.1073\/pnas.1305227110","article-title":"Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells","volume":"110","author":"Weiskopf","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0400","doi-asserted-by":"crossref","first-page":"E4256","DOI":"10.1073\/pnas.1505956112","article-title":"Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity","volume":"112","author":"Weiskopf","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0405","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1182\/blood-2002-05-1470","article-title":"Protection against thrombosis in mice lacking PAR3","volume":"100","author":"Weiss","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0410","doi-asserted-by":"crossref","unstructured":"Whitehead, S.S., Falgout, B., Hanley, K.A., Blaney Jr, J.E., Jr., Markoff, L., and Murphy, B.R. (2003). A live, attenuated dengue virus type 1 vaccine candidate with a 30-nucleotide deletion in the 3\u2032 untranslated region is highly attenuated and immunogenic in monkeys. J. Virol. 77, 1653\u20131657.","DOI":"10.1128\/JVI.77.2.1653-1657.2003"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0415","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/QCO.0b013e32835fb938","article-title":"The pathogenesis of dengue","volume":"26","author":"Yacoub","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0420","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.4049\/jimmunol.0801974","article-title":"A protective role for dengue virus-specific CD8+ T cells","volume":"182","author":"Yauch","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0425","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.4049\/jimmunol.1001709","article-title":"CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination","volume":"185","author":"Yauch","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0430","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fimmu.2014.00151","article-title":"Mouse models to study dengue virus immunology and pathogenesis","volume":"5","author":"Zellweger","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0435","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.chom.2010.01.004","article-title":"Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease","volume":"7","author":"Zellweger","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0440","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.4049\/jimmunol.1401597","article-title":"CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice","volume":"193","author":"Zellweger","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0445","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1128\/JVI.00036-15","article-title":"CD8+ T cells can mediate short-term protection against heterotypic dengue virus reinfection in mice","volume":"89","author":"Zellweger","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0450","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.4049\/jimmunol.168.11.5959","article-title":"T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity","volume":"168","author":"Zivna","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.04.033_bb0455","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/v4010062","article-title":"Animal models of dengue virus infection","volume":"4","author":"Zompi","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.ebiom.2017.04.033_bb0460","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.1102124","article-title":"Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells","volume":"188","author":"Zompi","year":"2012","journal-title":"J. Immunol."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417301883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417301883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:46:28Z","timestamp":1762454788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396417301883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":92,"alternative-id":["S2352396417301883"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.04.033","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Heterotypic DENV-specific CD8+T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.04.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}