{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:18:20Z","timestamp":1771024700457,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ebiom.2017.05.022","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T22:16:30Z","timestamp":1495059390000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy"],"prefix":"10.1016","volume":"20","author":[{"given":"Jie-Jie","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Lin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2017.05.022_bb0005","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1158\/1078-0432.CCR-07-0109","article-title":"Emmprin and survivin predict response and survival following cisplatin-containing chemotherapy in patients with advanced bladder cancer","volume":"13","author":"Als","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0010","first-page":"434","article-title":"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily","volume":"55","author":"Biswas","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0015","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.clim.2008.08.012","article-title":"Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients","volume":"129","author":"Cai","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0020","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1177\/002215549904701209","article-title":"Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions","volume":"47","author":"Caudroy","year":"1999","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.23.090506.123547","article-title":"The thymus as an inductive site for T lymphopoiesis","volume":"23","author":"Ciofani","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coi.2013.01.003","article-title":"Transcriptional regulation of the NKT cell lineage","volume":"25","author":"Constantinides","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ni1164","article-title":"Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance","volume":"6","author":"Duncan","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2014.02.008","article-title":"Novel regulators of spermatogenesis","volume":"29","author":"Fok","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0045","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1101\/gad.1249504","article-title":"LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis","volume":"18","author":"Galceran","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/JLB.0309135","article-title":"Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases","volume":"86","author":"Gao","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0055","doi-asserted-by":"crossref","first-page":"20100","DOI":"10.1073\/pnas.0806501105","article-title":"A gene regulatory network armature for T lymphocyte specification","volume":"105","author":"Georgescu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0060","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.7314\/APJCP.2012.13.11.5909","article-title":"Associations between infiltrating lymphocyte subsets and hepatocellular carcinoma","volume":"13","author":"Guo","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1189\/jlb.3RU0215-045R","article-title":"The role of EMMPRIN in T cell biology and immunological diseases","volume":"98","author":"Hahn","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.smim.2010.04.006","article-title":"Beyond alphabeta\/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate","volume":"22","author":"Hayes","year":"2010","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0075","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/hep.23054","article-title":"Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor","volume":"50","author":"Hoechst","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1188995","article-title":"An essential developmental checkpoint for production of the T cell lineage","volume":"329","author":"Ikawa","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0085","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/eji.200940258","article-title":"Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes","volume":"40","author":"Kastner","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0090","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.matbio.2015.01.018","article-title":"EMMPRIN, an upstream regulator of MMPs, in CNS biology","volume":"44\u201346","author":"Kaushik","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1399-0039.1997.tb02853.x","article-title":"The pattern of expression of CD147\/neurothelin during human T-cell ontogeny as defined by the monoclonal antibody 8D6","volume":"50","author":"Kirsch","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0100","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/intimm\/11.5.777","article-title":"T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density","volume":"11","author":"Koch","year":"1999","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0014-5793(98)00213-0","article-title":"Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily","volume":"425","author":"Kuno","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1188989","article-title":"An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1188063","article-title":"Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0120","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood-2008-06-163774","article-title":"Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation","volume":"113","author":"Luis","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0125","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1172\/JCI66381","article-title":"Liver-resident NK cells confer adaptive immunity in skin-contact inflammation","volume":"123","author":"Peng","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0130","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0034-1390001","article-title":"CD147 in cardiovascular disease and thrombosis","volume":"40","author":"Pennings","year":"2014","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0135","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.4049\/jimmunol.168.10.4946","article-title":"A role for CD147 in thymic development","volume":"168","author":"Renno","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0140","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S1074-7613(02)00474-0","article-title":"Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro","volume":"17","author":"Schmitt","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0145","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ni.2230","article-title":"Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling","volume":"13","author":"Seiler","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0150","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1038\/onc.2010.166","article-title":"EMMPRIN regulates the canonical Wnt\/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis","volume":"29","author":"Sidhu","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0155","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/modpathol.2008.102","article-title":"Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9","volume":"21","author":"Sienel","year":"2008","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0160","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2360","article-title":"WNT signaling in the immune system: WNT is spreading its wings","volume":"8","author":"Staal","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0165","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.oraloncology.2013.07.006","article-title":"A novel extracellular drug conjugate significantly inhibits head and neck squamous cell carcinoma","volume":"49","author":"Sweeny","year":"2013","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0170","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1101\/gad.1298305","article-title":"Delayed, asynchronous, and reversible T-lineage specification induced by Notch\/Delta signaling","volume":"19","author":"Taghon","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0175","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/0008-5472.CAN-04-3605","article-title":"Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases","volume":"65","author":"Tang","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0180","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.4049\/jimmunol.1301976","article-title":"TNF-alpha-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma","volume":"192","author":"Uddin","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/374070a0","article-title":"An HMG-box-containing T-cell factor required for thymocyte differentiation","volume":"374","author":"Verbeek","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0190","doi-asserted-by":"crossref","first-page":"19489","DOI":"10.1074\/jbc.M801037200","article-title":"Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta","volume":"283","author":"Vetrivel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10585-014-9689-7","article-title":"A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway","volume":"32","author":"Wang","year":"2015","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0200","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10279","article-title":"A critical role for TCF-1 in T-lineage specification and differentiation","volume":"476","author":"Weber","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2017.05.022_bb0205","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1101\/gad.1450406","article-title":"c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma","volume":"20","author":"Weng","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0210","doi-asserted-by":"crossref","first-page":"17,411","DOI":"10.3390\/ijms151017411","article-title":"The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature","volume":"15","author":"Xiong","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.2011.06302.x","article-title":"Regulation of mature T cell responses by the Wnt signaling pathway","volume":"1247","author":"Xue","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7150\/ijbs.6818","article-title":"Important functional roles of basigin in thymocyte development and T cell activation","volume":"10","author":"Yao","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nri3702","article-title":"Developmental gene networks: a triathlon on the course to T cell identity","volume":"14","author":"Yui","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0230","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1158\/1535-7163.MCT-14-0104","article-title":"Preclinical pharmacokinetics, tolerability, and pharmacodynamics of metuzumab, a novel CD147 human-mouse chimeric and glycoengineered antibody","volume":"14","author":"Zhang","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0235","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1073\/pnas.0502768102","article-title":"CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production","volume":"102","author":"Zhou","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ebiom.2017.05.022_bb0240","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.4161\/cbt.8.11.8531","article-title":"A novel antibody fragment targeting HAb18G\/CD147 with cytotoxicity and decreased immunogenicity","volume":"8","author":"Zhu","year":"2009","journal-title":"Cancer Biol. Ther."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417302207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396417302207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:46:55Z","timestamp":1762454815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396417302207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":48,"alternative-id":["S2352396417302207"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.05.022","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2017.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}