{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:01:18Z","timestamp":1787234478471,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2016R1A2B4016318"],"award-info":[{"award-number":["NRF-2016R1A2B4016318"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012147","name":"Royal Brompton and Harefield NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1061"],"award-info":[{"award-number":["HI14C1061"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ebiom.2018.01.038","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T09:50:30Z","timestamp":1517478630000},"page":"303-310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-2293","authenticated-orcid":false,"given":"Joseph","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Ling","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kokosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Renzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby M.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athol U.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ebiom.2018.01.038_bb0005","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.ebiom.2018.01.038_bb0010","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/resp.12154","article-title":"Smoking-related emphysema is associated with idiopathic pulmonary fibrosis and rheumatoid lung","volume":"18","author":"Antoniou","year":"2013","journal-title":"Respirology"},{"issue":"4","key":"10.1016\/j.ebiom.2018.01.038_bb0015","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/art.39528","article-title":"Combined pulmonary fibrosis and emphysema in scleroderma lung disease has a major confounding effect on lung physiology and screening for pulmonary hypertension","volume":"68","author":"Antoniou","year":"2015","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.ebiom.2018.01.038_bb0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/resp.12234","article-title":"Predictors of mortality in rheumatoid arthritis-related interstitial lung disease","volume":"19","author":"Assayag","year":"2014","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.ebiom.2018.01.038_bb0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12026-013-8395-x","article-title":"Autoimmune smoke and fire\u2014coexisting rheumatoid arthritis and chronic obstructive pulmonary disease: a cross-sectional analysis","volume":"56","author":"Bieber","year":"2013","journal-title":"Immunol. Res."},{"issue":"11","key":"10.1016\/j.ebiom.2018.01.038_bb0030","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.rmed.2013.08.039","article-title":"Influence of radiological emphysema on lung function test in idiopathic pulmonary fibrosis","volume":"107","author":"Bodlet","year":"2013","journal-title":"Respir. Med."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0035","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1183\/09031936.05.00021005","article-title":"Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity","volume":"26","author":"Cottin","year":"2005","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.ebiom.2018.01.038_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/art.30077","article-title":"Combined pulmonary fibrosis and emphysema syndrome in connective tissue disease","volume":"63","author":"Cottin","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ebiom.2018.01.038_bb0045","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1378\/chest.13-2408","article-title":"A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease","volume":"145","author":"Doyle","year":"2014","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.ebiom.2018.01.038_bb0050","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1164\/rccm.200701-014OC","article-title":"Autoantibodies in patients with chronic obstructive pulmonary disease","volume":"177","author":"Feghali-Bostwick","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.ebiom.2018.01.038_bb0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/archinternmed.2007.59","article-title":"Progressive preclinical interstitial lung disease in rheumatoid arthritis","volume":"168","author":"Gochuico","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1471-2466-14-104","article-title":"An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features","volume":"14","author":"Inomata","year":"2014","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.ebiom.2018.01.038_bb0065","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00379-2017","article-title":"Functional and prognostic effects when emphysema complicates idiopathic pulmonary fibrosis","volume":"50","author":"Jacob","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0070","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/rheumatology\/keu165","article-title":"Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics\u2014a large multicentre UK study","volume":"53","author":"Kelly","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.ebiom.2018.01.038_bb0075","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00092309","article-title":"Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease","volume":"35","author":"Kim","year":"2010","journal-title":"Eur. Respir. J."},{"issue":"10","key":"10.1016\/j.ebiom.2018.01.038_bb0080","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1136\/ard.2007.075192","article-title":"Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells","volume":"67","author":"Makrygiannakis","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0085","article-title":"Risk of Incident Chronic Obstructive Pulmonary Disease (COPD) in Rheumatoid Arthritis: A Population Based Cohort Study","author":"McGuire","year":"2017","journal-title":"Arthritis Care Res."},{"issue":"1","key":"10.1016\/j.ebiom.2018.01.038_bb0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1378\/chest.08-2306","article-title":"Idiopathic pulmonary fibrosis and emphysema: Decreased survival associated with severe pulmonary arterial hypertension","volume":"136","author":"Mej\u00eda","year":"2009","journal-title":"CHEST Journal"},{"issue":"3","key":"10.1016\/j.ebiom.2018.01.038_bb0095","first-page":"257","article-title":"The presence of emphysema further impairs physiologic function in patients with idiopathic pulmonary fibrosis","volume":"51","author":"Mura","year":"2006","journal-title":"RespirCare"},{"issue":"1","key":"10.1016\/j.ebiom.2018.01.038_bb0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12026-012-8347-x","article-title":"COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype","volume":"55","author":"Packard","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0110","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis\u2014evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.ebiom.2018.01.038_bb0115","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1172\/JCI28756","article-title":"Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis","volume":"116","author":"Rangel-Moreno","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0120","doi-asserted-by":"crossref","first-page":"151626","DOI":"10.1155\/2015\/151626","article-title":"Anti-cyclic citrullinated peptide antibodies and severity of interstitial lung disease in women with rheumatoid arthritis","volume":"2015","author":"Rocha-Mu\u00f1oz","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.ebiom.2018.01.038_bb0125","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1378\/chest.12-2403","article-title":"Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis","volume":"144","author":"Ryerson","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.ebiom.2018.01.038_bb0130","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/art.1780391014","article-title":"Rheumatoid arthritis lung disease. Determinants of radiographic and physiologic abnormalities","volume":"39","author":"Saag","year":"1996","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.ebiom.2018.01.038_bb0135","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1084\/jem.20131241","article-title":"A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis","volume":"210","author":"Scally","year":"2013","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.ebiom.2018.01.038_bb0140","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/qjmed\/hcu027","article-title":"Increased risk of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: a population-based cohort study","volume":"107","author":"Shen","year":"2014","journal-title":"QJM"},{"issue":"6","key":"10.1016\/j.ebiom.2018.01.038_bb0145","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1183\/09031936.00019210","article-title":"Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome","volume":"37","author":"Tsuchiya","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.ebiom.2018.01.038_bb0150","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1074\/jbc.C800225200","article-title":"Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway","volume":"284","author":"Volonte","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.ebiom.2018.01.038_bb0155","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1369\/jhc.2008.951806","article-title":"Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis","volume":"56","author":"Vuorinen","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ebiom.2018.01.038_bb0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.rmed.2017.03.027","article-title":"High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival","volume":"126","author":"Yunt","year":"2017","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.ebiom.2018.01.038_bb0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1465-9921-9-83","article-title":"Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD","volume":"9","author":"Zandvoort","year":"2008","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.ebiom.2018.01.038_bb0170","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/resp.12240","article-title":"Hypomethylation of perforin regulatory elements in CD4+T cells from rat spleens contributes to the development of autoimmune emphysema","volume":"19","author":"Zhang","year":"2014","journal-title":"Respirology"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418300422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418300422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:47:48Z","timestamp":1762454868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396418300422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":33,"alternative-id":["S2352396418300422"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.01.038","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.01.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}