{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:30:39Z","timestamp":1791289839497,"version":"4.3.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ebiom.2018.06.016","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:28:31Z","timestamp":1529540911000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting \u03b1-Type Phenol-Soluble Modulins and \u03b1-Hemolysin"],"prefix":"10.1016","volume":"33","author":[{"given":"Heidi","family":"Wolfmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo T.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-7505","authenticated-orcid":false,"given":"Daniel","family":"Pletzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Draeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard B.","family":"Babiychuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ebiom.2018.06.016_bb0005","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3201\/eid2111.150452","article-title":"USA300 methicillin-resistant Staphylococcus aureus, United States, 2000-2013","volume":"21","author":"Carrel","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2018.06.016_bb0010","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"David","year":"2010","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0015","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ajpath.2014.11.030","article-title":"Pathogenesis of Staphylococcus aureus abscesses","volume":"185","author":"Kobayashi","year":"2015","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.ebiom.2018.06.016_bb0020","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/1574-6976.12057","article-title":"Phenol-soluble modulins\u2014critical determinants of staphylococcal virulence","volume":"38","author":"Cheung","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ebiom.2018.06.016_bb0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fcimb.2012.00012","article-title":"Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?","volume":"2","author":"Vandenesch","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"10.1016\/j.ebiom.2018.06.016_bb0030","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nm1656","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA","volume":"13","author":"Wang","year":"2007","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.ebiom.2018.06.016_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007446","article-title":"Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells","volume":"4","author":"Craven","year":"2009","journal-title":"PLoS One."},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0040","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chom.2010.05.012","article-title":"Human Formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus","volume":"7","author":"Kretschmer","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"30","key":"10.1016\/j.ebiom.2018.06.016_bb0045","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.ebiom.2018.06.016_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075103","article-title":"Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model","volume":"8","author":"Tkaczyk","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ebiom.2018.06.016_bb0055","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1128\/IAI.00089-14","article-title":"The psm alpha locus regulates production of Staphylococcus aureus alpha-toxin during infection","volume":"82","author":"Berube","year":"2014","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0060","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/infdis\/jir441","article-title":"Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection","volume":"204","author":"Kobayashi","year":"2011","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2018.06.016_bb0065","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/infdis\/jir846","article-title":"Staphylococcus aureus alpha-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome","volume":"205","author":"Kebaier","year":"2012","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2018.06.016_bb0070","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/IAI.01313-06","article-title":"Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia","volume":"75","author":"Bubeck Wardenburg","year":"2007","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chom.2015.05.011","article-title":"Synergistic action of Staphylococcus aureus alpha-toxin on platelets and myeloid lineage cells contributes to lethal sepsis","volume":"17","author":"Powers","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0080","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/toxins5061140","article-title":"Staphylococcus aureus alpha-toxin: nearly a century of intrigue","volume":"5","author":"Berube","year":"2013","journal-title":"Toxins (Basel)"},{"issue":"5294","key":"10.1016\/j.ebiom.2018.06.016_bb0085","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","article-title":"Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore","volume":"274","author":"Song","year":"1996","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ebiom.2018.06.016_bb0090","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.chom.2017.10.008","article-title":"Staphylococcus aureus Virulent PSM alpha Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation","volume":"22","author":"Nakagawa","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"9","key":"10.1016\/j.ebiom.2018.06.016_bb0095","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1128\/IAI.00401-15","article-title":"Staphlyococcus aureus phenol-soluble modulins stimulate the release of proinflammatory cytokines from keratinocytes and are required for induction of skin inflammation","volume":"83","author":"Syed","year":"2015","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.ebiom.2018.06.016_bb0100","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1086\/605332","article-title":"Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-valentine leukocidin","volume":"200","author":"Hongo","year":"2009","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2018.06.016_bb0105","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1128\/IAI.00394-15","article-title":"Role of phenol-soluble modulins in formation of Staphylococcus aureus biofilms in synovial fluid","volume":"83","author":"Dastgheyb","year":"2015","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.ebiom.2018.06.016_bb0110","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molcel.2008.08.005","article-title":"RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus","volume":"32","author":"Queck","year":"2008","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.ebiom.2018.06.016_bb0115","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jinf.2015.06.005","article-title":"Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins","volume":"71","author":"Berlon","year":"2015","journal-title":"J Infect"},{"issue":"1","key":"10.1016\/j.ebiom.2018.06.016_bb0120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nbt.3037","article-title":"Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice","volume":"33","author":"Henry","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2018.06.016_bb0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF01279342","article-title":"Pathogens, toxins, and lipid rafts","volume":"212","author":"Fivaz","year":"2000","journal-title":"Protoplasma"},{"issue":"1","key":"10.1016\/j.ebiom.2018.06.016_bb0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0003-2697(81)90179-2","article-title":"Silver staining of proteins in polyacrylamide gels","volume":"118","author":"Wray","year":"1981","journal-title":"Anal Biochem"},{"issue":"5","key":"10.1016\/j.ebiom.2018.06.016_bb0135","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal Chem"},{"issue":"8","key":"10.1016\/j.ebiom.2018.06.016_bb0140","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ebiom.2018.06.016_bb0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ebiom.2016.09.015","article-title":"Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically","volume":"12","author":"Mansour","year":"2016","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2018.06.016_bb0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/pathogens1010003","article-title":"Interaction of phenol-soluble modulins with phosphatidylcholine vesicles","volume":"1","author":"Duong","year":"2012","journal-title":"Pathogens"},{"issue":"12","key":"10.1016\/j.ebiom.2018.06.016_bb0155","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1016\/j.bbamem.2014.08.026","article-title":"Investigating the lytic activity and structural properties of Staphylococcus aureus phenol soluble modulin (PSM) peptide toxins","volume":"1838","author":"Laabei","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.ebiom.2018.06.016_bb0160","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/656043","article-title":"Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model","volume":"202","author":"Kennedy","year":"2010","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2018.06.016_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002606","article-title":"Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles","volume":"8","author":"Surewaard","year":"2012","journal-title":"PLoS Pathog"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0170","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.celrep.2017.07.045","article-title":"Non-classical protein excretion is boosted by PSM alpha-induced cell leakage","volume":"20","author":"Ebner","year":"2017","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2018.06.016_bb0175","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nm.3047","article-title":"Essential Staphylococcus aureus toxin export system","volume":"19","author":"Chatterjee","year":"2013","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ebiom.2018.06.016_bb0180","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1128\/IAI.00115-09","article-title":"Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia","volume":"77","author":"Ragle","year":"2009","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.ebiom.2018.06.016_bb0185","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1517\/14728222.2012.682573","article-title":"The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections","volume":"16","author":"Cheung","year":"2012","journal-title":"Expert Opin Ther Tar"},{"issue":"11","key":"10.1016\/j.ebiom.2018.06.016_bb0190","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1056\/NEJMra1212788","article-title":"Management of skin abscesses in the era of methicillin-resistant Staphylococcus aureus","volume":"370","author":"Singer","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ebiom.2018.06.016_bb0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1128\/CMR.15.1.95-110.2002","article-title":"Modulation of release of proinflammatory bacterial compounds by antibacterials: potential impact on course of inflammation and outcome in sepsis and meningitis","volume":"15","author":"Nau","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ebiom.2018.06.016_bb0200","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1038\/ncomms6438","article-title":"The staphylococcal toxins gamma-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors","volume":"5","author":"Spaan","year":"2014","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.ebiom.2018.06.016_bb0205","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrmicro.2017.27","article-title":"Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors","volume":"15","author":"Spaan","year":"2017","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"10.1016\/j.ebiom.2018.06.016_bb0210","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chom.2013.04.006","article-title":"The staphylococcal toxin Panton-valentine Leukocidin targets human C5a receptors","volume":"13","author":"Spaan","year":"2013","journal-title":"Cell Host Microbe"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418302238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418302238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T09:47:43Z","timestamp":1551779263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396418302238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":42,"alternative-id":["S2352396418302238"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.06.016","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting \u03b1-Type Phenol-Soluble Modulins and \u03b1-Hemolysin","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}