{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:13:49Z","timestamp":1791947629615,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18bm0204002h0006"],"award-info":[{"award-number":["18bm0204002h0006"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ebiom.2018.11.028","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:32:02Z","timestamp":1543365122000},"page":"562-574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":137,"special_numbering":"C","title":["Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration"],"prefix":"10.1016","volume":"39","author":[{"given":"Hung-Ya","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-843X","authenticated-orcid":false,"given":"Masaharu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Onoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Take","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Eiraku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Suzuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kitaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Mandai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.stem.2008.10.015","article-title":"Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice","volume":"4","author":"Lamba","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"7396","key":"10.1016\/j.ebiom.2018.11.028_bb0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10997","article-title":"Restoration of vision after transplantation of photoreceptors","volume":"485","author":"Pearson","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.028_bb0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.preteyeres.2012.06.003","article-title":"Cell replacement and visual restoration by retinal sheet transplants","volume":"31","author":"Seiler","year":"2012","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"10.1016\/j.ebiom.2018.11.028_bb0020","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nbt.2643","article-title":"Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina","volume":"31","author":"Gonzalez-Cordero","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10.1016\/j.ebiom.2018.11.028_bb0025","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.stemcr.2014.03.011","article-title":"Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice","volume":"2","author":"Assawachananont","year":"2014","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/srep29784","article-title":"Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice","volume":"6","author":"Barnea-Cramer","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0035","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1073\/pnas.1512590113","article-title":"Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration","volume":"113","author":"Shirai","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.028_bb0040","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.stemcr.2018.01.032","article-title":"Establishment of immunodeficient retinal degeneration model mice and functional maturation of human ESC-derived retinal sheets after transplantation","volume":"10","author":"Iraha","year":"2018","journal-title":"Stem Cell Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.028_bb0045","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","article-title":"Self-formation of optic cups and storable stratified neural retina from human ESCs","volume":"10","author":"Nakano","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0050","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1038\/ncomms7286","article-title":"Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue","volume":"6","author":"Kuwahara","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0055","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1038\/ncomms5047","article-title":"Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs","volume":"5","author":"Zhong","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13029","article-title":"Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors","volume":"7","author":"Pearson","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13028","article-title":"Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange","volume":"7","author":"Santos-Ferreira","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13537","article-title":"Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion","volume":"7","author":"Singh","year":"2016","journal-title":"Nat Commun"},{"issue":"9549","key":"10.1016\/j.ebiom.2018.11.028_bb0075","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0080","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stemcr.2016.12.008","article-title":"iPSC-derived retina transplants improve vision in rd1 end-stage retinal-degeneration mice","volume":"8","author":"Mandai","year":"2017","journal-title":"Stem Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0090","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41467-017-00926-5","article-title":"MHC matching improves engraftment of iPSC-derived neurons in non-human primates","volume":"8","author":"Morizane","year":"2017","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.ebiom.2018.11.028_bb0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.stemcr.2016.08.011","article-title":"Lack of T cell response to iPSC-derived retinal pigment epithelial cells from HLA homozygous donors","volume":"7","author":"Sugita","year":"2016","journal-title":"Stem Cell Rep"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.028_bb0100","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00417-014-2638-y","article-title":"A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression","volume":"252","author":"Seiler","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0105","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1038\/srep03594","article-title":"A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells","volume":"4","author":"Nakagawa","year":"2014","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0952523800008798","article-title":"Perceptual filling-in at the scotoma following a monocular retinal lesion in the monkey","volume":"14","author":"Murakami","year":"1997","journal-title":"Vis Neurosci"},{"key":"10.1016\/j.ebiom.2018.11.028_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.24459","article-title":"Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys","volume":"6","author":"Takakuwa","year":"2017","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.028_bb0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3727\/215517912X639315","article-title":"Adequate time window and environmental factors supporting retinal graft cell survival in rd mice","volume":"4","author":"Mandai","year":"2012","journal-title":"Cell Med"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.028_bb0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrn2636","article-title":"The diverse functional roles and regulation of neuronal gap junctions in the retina","volume":"10","author":"Bloomfield","year":"2009","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.028_bb0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.exer.2010.12.001","article-title":"Retinal degeneration in two lines of transgenic S334ter rats","volume":"92","author":"Martinez-Navarrete","year":"2011","journal-title":"Exp Eye Res"},{"issue":"2","key":"10.1016\/j.ebiom.2018.11.028_bb0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.eye.6703077","article-title":"Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa","volume":"23","author":"Oishi","year":"2009","journal-title":"Eye (Lond)"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418305322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418305322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T07:45:10Z","timestamp":1565250310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396418305322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":27,"alternative-id":["S2352396418305322"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.028","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}