{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:30:54Z","timestamp":1785047454335,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Biotechnology, Govt. of India","award":["BT\/PR8591"],"award-info":[{"award-number":["BT\/PR8591"]}]},{"name":"Department of Biotechnology, Govt. of India","award":["BT\/PR22985"],"award-info":[{"award-number":["BT\/PR22985"]}]},{"name":"Tata Innovation Fellowship","award":["BT\/HRD\/35\/01\/02\/2014"],"award-info":[{"award-number":["BT\/HRD\/35\/01\/02\/2014"]}]}],"content-domain":{"domain":["ebiomedicine.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ebiom.2018.11.049","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T10:28:55Z","timestamp":1544005735000},"page":"332-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses"],"prefix":"10.1016","volume":"39","author":[{"given":"Amrita","family":"Ojha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angika","family":"Bhasym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriparna","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowtham K.","family":"Annarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Bhakuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naval K.","family":"Vikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhanshu","family":"Vrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankar","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Guchhait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ebiom.2018.11.049_bb0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/ATVBAHA.114.303287","article-title":"Human cytomegalovirus-platelet interaction triggers toll-like receptor 2-dependent proinflammatory and proangiogenic responses","volume":"34","author":"Assinger","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.049_bb0010","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2008.03.009","article-title":"Thrombocytopenia associated with chronic liver disease","volume":"48","author":"Afdhal","year":"2008","journal-title":"J Hepatol"},{"issue":"18","key":"10.1016\/j.ebiom.2018.11.049_bb0015","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1128\/JVI.00136-06","article-title":"DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets","volume":"80","author":"Chaipan","year":"2006","journal-title":"J Virol"},{"issue":"9400","key":"10.1016\/j.ebiom.2018.11.049_bb0020","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(03)15012-X","article-title":"Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa\/tissue factor: a study in rhesus monkeys","volume":"362","author":"Geisbert","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2018.11.049_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/srep41697","article-title":"Platelet activation determines the severity of thrombocytopenia in dengue infection","volume":"7","author":"Ojha","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.049_bb0030","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1182\/blood-2014-09-598029","article-title":"Dengue virus binding and replication by platelets","volume":"126","author":"Simon","year":"2015","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.ebiom.2018.11.049_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2036.2007.03512.x","article-title":"Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease","volume":"26","author":"Weksler","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.ebiom.2018.11.049_bb0040","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1046\/j.1365-2362.2002.01041.x","article-title":"Procoagulant and inflammatory response of virus-infected monocytes","volume":"32","author":"Bouwman","year":"2002","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.049_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002858","article-title":"The role of platelets in the pathogenesis of viral hemorrhagic fevers","volume":"8","author":"Zapata","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.049_bb0050","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/s41598-018-22285-x","article-title":"A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection","volume":"8","author":"Malavige","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ebiom.2018.11.049_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006385","article-title":"Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue","volume":"13","author":"Trugilho","year":"2017","journal-title":"PLoS Pathog"},{"issue":"24","key":"10.1016\/j.ebiom.2018.11.049_bb0060","doi-asserted-by":"crossref","first-page":"9569","DOI":"10.1073\/pnas.1207314109","article-title":"Identification of the platelet-derived chemokine CXCL4\/PF-4 as a broad-spectrum HIV-1 inhibitor","volume":"109","author":"Auerbach","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.049_bb0065","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1753425909106171","article-title":"Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replication","volume":"15","author":"Schwartzkopff","year":"2009","journal-title":"Innate Immun"},{"issue":"4","key":"10.1016\/j.ebiom.2018.11.049_bb0070","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/hep.23435","article-title":"CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis","volume":"51","author":"Zaldivar","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.049_bb0075","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/mi.2017.1","article-title":"Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection","volume":"10","author":"Guo","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"5243","key":"10.1016\/j.ebiom.2018.11.049_bb0080","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ebiom.2018.11.049_bb0085","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1189\/jlb.1203644","article-title":"Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza a virus infection in mice","volume":"76","author":"Wareing","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"5\u20136","key":"10.1016\/j.ebiom.2018.11.049_bb0090","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/08830185.2011.593105","article-title":"CCL5: a double-edged sword in host defense against the hepatitis C virus","volume":"30","author":"Katsounas","year":"2011","journal-title":"Int Rev Immunol"},{"issue":"24","key":"10.1016\/j.ebiom.2018.11.049_bb0095","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1016\/j.jmb.2013.09.038","article-title":"Antiviral mechanisms of human defensins","volume":"425","author":"Wilson","year":"2013","journal-title":"J Mol Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.049_bb0100","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.antiviral.2010.03.012","article-title":"Antiviral activity of selected antimicrobial peptides against vaccinia virus","volume":"86","author":"Mohan","year":"2010","journal-title":"Antiviral Res"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.049_bb0105","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nm1780","article-title":"Aggravation of viral hepatitis by platelet-derived serotonin","volume":"14","author":"Lang","year":"2008","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2018.11.049_bb0110","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2013-11-536003","article-title":"Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis","volume":"124","author":"Koupenova","year":"2014","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.049_bb0115","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1182\/blood-2006-06-032524","article-title":"Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance","volume":"109","author":"Othman","year":"2007","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.ebiom.2018.11.049_bb0120","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.4049\/jimmunol.144.8.3183","article-title":"Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection","volume":"144","author":"Littaua","year":"1990","journal-title":"J Immunol"},{"issue":"16","key":"10.1016\/j.ebiom.2018.11.049_bb0125","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00018-010-0357-z","article-title":"Dengue virus life cycle: viral and host factors modulating infectivity","volume":"67","author":"Rodenhuis-Zybert","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2018.11.049_bb0130","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.virol.2008.03.028","article-title":"Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever","volume":"376","author":"Durbin","year":"2008","journal-title":"Virology"},{"issue":"3\u20134","key":"10.1016\/j.ebiom.2018.11.049_bb0135","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0171-2985(11)80365-7","article-title":"Role of macrophage cytokines in influenza a virus infections","volume":"189","author":"Peschke","year":"1993","journal-title":"Immunobiology"},{"issue":"2\u20133","key":"10.1016\/j.ebiom.2018.11.049_bb0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0166-3542(94)90058-2","article-title":"The interferons: a biological system with therapeutic potential in viral infections","volume":"24","author":"Baron","year":"1994","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ebiom.2018.11.049_bb0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/jir.1992.1992.109","article-title":"Interferon treatments: how to use an endogenous system as a therapeutic agent","author":"Dianzani","year":"1992","journal-title":"J Interferon Res"},{"issue":"8","key":"10.1016\/j.ebiom.2018.11.049_bb0150","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/eji.201747449","article-title":"Engulfment of Hb-activated platelets differentiates monocytes into pro-inflammatory macrophages in PNH patients","volume":"48","author":"Singhal","year":"2018","journal-title":"Eur J Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2018.11.049_bb0155","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3324\/haematol.2015.132183","article-title":"Hemoglobin interaction with GP1balpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis","volume":"100","author":"Singhal","year":"2015","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.049_bb0160","doi-asserted-by":"crossref","first-page":"e2556","DOI":"10.1038\/cddis.2016.394","article-title":"Japanese encephalitis virus induces human neural stem\/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress","volume":"8","author":"Mukherjee","year":"2017","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.049_bb0165","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1194\/jlr.D012807","article-title":"Detergent-free isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles","volume":"52","author":"Waugh","year":"2011","journal-title":"J Lipid Res"},{"issue":"4","key":"10.1016\/j.ebiom.2018.11.049_bb0170","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1074\/mcp.RA117.000461","article-title":"Quantitative Proteomics of strong and Weak Biofilm Formers of Enterococcus faecalis reveals Novel regulators of Biofilm Formation","volume":"17","author":"Suriyanarayanan","year":"2018","journal-title":"Mol Cell Proteomics"},{"issue":"5","key":"10.1016\/j.ebiom.2018.11.049_bb0175","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/pmic.201000595","article-title":"SearchGUI: an open-source graphical user interface for simultaneous OMSSA and X!Tandem searches","volume":"11","author":"Vaudel","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.ebiom.2018.11.049_bb0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-60761-444-9_5","article-title":"Target-decoy search strategy for mass spectrometry-based proteomics","volume":"604","author":"Elias","year":"2010","journal-title":"Methods Mol Biol"},{"issue":"Database issue","key":"10.1016\/j.ebiom.2018.11.049_bb0185","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.ebiom.2018.11.049_bb0190","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/pr060161n","article-title":"Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae","volume":"5","author":"Zybailov","year":"2006","journal-title":"J Proteome Res"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.049_bb0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nbt.3109","article-title":"PeptideShaker enables reanalysis of MS-derived proteomics data sets","volume":"33","author":"Vaudel","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"16","key":"10.1016\/j.ebiom.2018.11.049_bb0200","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1128\/MCB.24.16.7249-7259.2004","article-title":"Cluster analysis of mass spectrometry data reveals a novel component of SAGA","volume":"24","author":"Powell","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"10","key":"10.1016\/j.ebiom.2018.11.049_bb0205","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood-2003-11-3994","article-title":"Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin","volume":"104","author":"Eslin","year":"2004","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.049_bb0210","first-page":"281","article-title":"Characterization of a platelet derived factor modulating phagocyte functions and cooperating with interleukin 1","volume":"8","author":"Brandt","year":"1989","journal-title":"Lymphokine Res"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.049_bb0215","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1073\/pnas.78.7.4584","article-title":"Platelet factor 4 is chemotactic for neutrophils and monocytes","volume":"78","author":"Deuel","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.ebiom.2018.11.049_bb0220","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1089\/aid.2015.0344","article-title":"Platelet factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment","volume":"32","author":"Parker","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"3","key":"10.1016\/j.ebiom.2018.11.049_bb0225","first-page":"409","article-title":"Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestations","volume":"136","author":"Rhodes","year":"1973","journal-title":"Surg Gynecol Obstet"},{"issue":"5","key":"10.1016\/j.ebiom.2018.11.049_bb0230","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1471-4159.2008.05238.x","article-title":"Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis","volume":"105","author":"Mishra","year":"2008","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.049_bb0235","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/v4010062","article-title":"Animal models of dengue virus infection","volume":"4","author":"Zompi","year":"2012","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.ebiom.2018.11.049_bb0240","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ajpath.2016.10.009","article-title":"Critical Role of the CXCL10\/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush","volume":"187","author":"Ha","year":"2017","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2018.11.049_bb0245","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2015.09.005","article-title":"CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy","volume":"64","author":"Zhang","year":"2016","journal-title":"J Hepatol"},{"issue":"15","key":"10.1016\/j.ebiom.2018.11.049_bb0250","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1158\/0008-5472.CAN-06-0709","article-title":"Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer","volume":"66","author":"Walser","year":"2006","journal-title":"Cancer Res"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239641830553X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239641830553X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T17:05:07Z","timestamp":1694451907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239641830553X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":50,"alternative-id":["S235239641830553X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.049","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734615474.793567016","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}