{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:58:16Z","timestamp":1762455496083,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ebiom.2018.11.052","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T09:46:16Z","timestamp":1543830376000},"page":"7-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models"],"prefix":"10.1016","volume":"38","author":[{"given":"Aubryanna","family":"Hettinghouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-8032","authenticated-orcid":false,"given":"Chuan-ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2018.11.052_bb0005","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/humu.20676","article-title":"Gaucher disease: Mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)","volume":"29","author":"Hruska","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrd.2017.214","article-title":"Emptying the stores: Lysosomal diseases and therapeutic strategies","volume":"17","author":"Platt","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cytogfr.2018.04.003","article-title":"Molecular regulations and therapeutic targets of Gaucher disease","volume":"41","author":"Chen","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"issue":"7280","key":"10.1016\/j.ebiom.2018.11.052_bb0020","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature08710","article-title":"Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology","volume":"463","author":"Kirkegaard","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0025","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ebiom.2016.10.010","article-title":"Progranulin recruits HSP70 to \u03b2-glucocerebrosidase and is therapeutic against Gaucher disease","volume":"13","author":"Jian","year":"2016","journal-title":"EBioMedicine"},{"issue":"355","key":"10.1016\/j.ebiom.2018.11.052_bb0030","doi-asserted-by":"crossref","first-page":"355ra118","DOI":"10.1126\/scitranslmed.aad9823","article-title":"Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses","volume":"8","author":"Kirkegaard","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2018.11.037","article-title":"The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase","author":"Fog","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ebiom.2016.08.004","article-title":"Association between Progranulin and Gaucher disease","volume":"11","author":"Jian","year":"2016","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.ebiom.2018.11.052_bb0045","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1242\/dmm.008185","article-title":"Animal models for Gaucher disease research","volume":"4","author":"Farfel-Becker","year":"2011","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.ebiom.2018.11.052_bb0050","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ebiom.2018.01.022","article-title":"Chitinase-3-like PROTEIN 1: A Progranulin downstream molecule and potential biomarker for Gaucher disease","volume":"28","author":"Jian","year":"2018","journal-title":"EBioMedicine"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418305565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396418305565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:51:27Z","timestamp":1762455087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396418305565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":10,"alternative-id":["S2352396418305565"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.052","relation":{},"ISSN":["2352-3964"],"issn-type":[{"type":"print","value":"2352-3964"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.037","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}