{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:24:54Z","timestamp":1782257094931,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","award":["IRF-013-09"],"award-info":[{"award-number":["IRF-013-09"]}],"id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143326"],"award-info":[{"award-number":["FDN-143326"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN-126148"],"award-info":[{"award-number":["FRN-126148"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ebiom.2019.04.060","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T10:08:03Z","timestamp":1557396483000},"page":"54-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease"],"prefix":"10.1016","volume":"43","author":[{"given":"Brittany","family":"Balint","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxuan","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Michael","family":"Arpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"O'Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varinder K.","family":"Randhawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.A.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-3274","authenticated-orcid":false,"given":"J. Geoffrey","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.ebiom.2019.04.060_bb0005","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve","volume":"370","author":"Verma","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ebiom.2019.04.060_bb0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/CIRCULATIONAHA.113.003026","article-title":"Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy","volume":"129","author":"Mahadevia","year":"2014","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ebiom.2019.04.060_bb0015","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jacc.2015.06.1310","article-title":"Valve-related Hemodynamics mediate human bicuspid Aortopathy: insights from wall shear stress mapping","volume":"66","author":"Guzzardi","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"10.1016\/j.ebiom.2019.04.060_bb0020","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/ajmg.a.31872","article-title":"Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance","volume":"143A","author":"Loscalzo","year":"2007","journal-title":"Am J Med Genet A"},{"issue":"3","key":"10.1016\/j.ebiom.2019.04.060_bb0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.carpath.2016.03.002","article-title":"Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the association for European cardiovascular pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria","volume":"25","author":"Halushka","year":"2016","journal-title":"Cardiovasc Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2019.04.060_bb0030","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63464-5","article-title":"Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization","volume":"163","author":"Li","year":"2003","journal-title":"Am J Pathol"},{"issue":"7","key":"10.1016\/j.ebiom.2019.04.060_bb0035","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1161\/CIRCRESAHA.108.187302","article-title":"Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells","volume":"104","author":"Frontini","year":"2009","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.ebiom.2019.04.060_bb0040","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/CIRCRESAHA.114.304936","article-title":"Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections","volume":"116","author":"Humphrey","year":"2015","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0045","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/ATVBAHA.115.305310","article-title":"Collectivization of vascular smooth muscle cells via TGF-beta-Cadherin-11-dependent adhesive switching","volume":"35","author":"Balint","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.ebiom.2019.04.060_bb0050","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1172\/JCI1025","article-title":"Evidence for a role of collagen synthesis in arterial smooth muscle cell migration","volume":"101","author":"Rocnik","year":"1998","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.ebiom.2019.04.060_bb0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng1721","article-title":"Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm\/aortic dissection and patent ductus arteriosus","volume":"38","author":"Zhu","year":"2006","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.ebiom.2019.04.060_bb0060","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/ng.2007.6","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections","volume":"39","author":"Guo","year":"2007","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0065","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ajhg.2010.10.006","article-title":"Mutations in myosin light chain kinase cause familial aortic dissections","volume":"87","author":"Wang","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"16","key":"10.1016\/j.ebiom.2019.04.060_bb0070","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1161\/01.CIR.99.16.2138","article-title":"Mechanisms underlying aortic dilatation in congenital aortic valve malformation","volume":"99","author":"Bonderman","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ebiom.2019.04.060_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2007.09.009","article-title":"Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling","volume":"135","author":"Della Corte","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0080","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00380-015-0703-z","article-title":"Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?","volume":"31","author":"Grewal","year":"2016","journal-title":"Heart Vessels"},{"issue":"3","key":"10.1016\/j.ebiom.2019.04.060_bb0085","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0022-5223(03)00398-2","article-title":"Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation","volume":"126","author":"Fedak","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.ebiom.2019.04.060_bb0090","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.jtcvs.2014.01.027","article-title":"Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall","volume":"148","author":"Grewal","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0095","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/ejcts\/ezu319","article-title":"Bicuspid aortic valve: phosphorylation of c-kit and downstream targets are prognostic for future aortopathy","volume":"46","author":"Grewal","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0100","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ebiom.2016.06.045","article-title":"Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves","volume":"10","author":"Jiao","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0105","doi-asserted-by":"crossref","first-page":"35712","DOI":"10.1038\/srep35712","article-title":"Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves","volume":"6","author":"Maleki","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2019.04.060_bb0110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.athoracsur.2011.09.057","article-title":"Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors","volume":"93","author":"Ikonomidis","year":"2012","journal-title":"Ann Thorac Surg"},{"issue":"12","key":"10.1016\/j.ebiom.2019.04.060_bb0115","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.ebiom.2019.04.060_bb0120","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Coppe","year":"2008","journal-title":"PLoS Biol"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0125","first-page":"612","article-title":"Cellular senescence and vascular disease: novel routes to better understanding and therapy","volume":"32","author":"Yin","year":"2016","journal-title":"Can J Cardiol"},{"issue":"17","key":"10.1016\/j.ebiom.2019.04.060_bb0130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0960-9822(99)80420-5","article-title":"Microarray analysis of replicative senescence","volume":"9","author":"Shelton","year":"1999","journal-title":"Curr Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2019.04.060_bb0135","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0014-4827(92)90286-H","article-title":"Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts","volume":"201","author":"Millis","year":"1992","journal-title":"Exp Cell Res"},{"issue":"15","key":"10.1016\/j.ebiom.2019.04.060_bb0140","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1074\/jbc.C700018200","article-title":"Extension of human cell lifespan by nicotinamide phosphoribosyltransferase","volume":"282","author":"van der Veer","year":"2007","journal-title":"J Biol Chem"},{"issue":"18","key":"10.1016\/j.ebiom.2019.04.060_bb0145","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/01.CIR.0000093274.82929.22","article-title":"Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis","volume":"108","author":"Minamino","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ebiom.2019.04.060_bb0150","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.atherosclerosis.2011.11.035","article-title":"Characteristics of TAV- and BAV-associated thoracic aortic aneurysms--smooth muscle cell biology, expression profiling, and histological analyses","volume":"220","author":"Blunder","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.atherosclerosis.2018.02.007","article-title":"Targeted gene expression analyses and immunohistology suggest a pro-proliferative state in tricuspid aortic valve-, and senescence and viral infections in bicuspid aortic valve-associated thoracic aortic aneurysms","volume":"271","author":"Blunder","year":"2018","journal-title":"Atherosclerosis"},{"issue":"13","key":"10.1016\/j.ebiom.2019.04.060_bb0160","first-page":"e266","article-title":"ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ebiom.2019.04.060_bb0165","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","author":"Roman","year":"1989","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.ebiom.2019.04.060_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"22","key":"10.1016\/j.ebiom.2019.04.060_bb0175","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0002-9149(90)91361-9","article-title":"Measurement of intracardiac dimensions and structures in normal young adult subjects by transesophageal echocardiography","volume":"65","author":"Drexler","year":"1990","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.ebiom.2019.04.060_bb0180","doi-asserted-by":"crossref","first-page":"C66","DOI":"10.1152\/ajpcell.00357.2009","article-title":"Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase","volume":"298","author":"Borradaile","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.ebiom.2019.04.060_bb0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.201212110","article-title":"Lysosome-mediated processing of chromatin in senescence","volume":"202","author":"Ivanov","year":"2013","journal-title":"J Cell Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2019.04.060_bb0190","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1161\/atvb.26.6.1303","article-title":"Degenerative aortic valve stenosis, but not coronary disease, is associated with shorter telomere length in the elderly","volume":"26","author":"Kurz","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2019.04.060_bb0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2443.2003.00620.x","article-title":"Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway","volume":"8","author":"Iwasa","year":"2003","journal-title":"Genes Cells"},{"issue":"8","key":"10.1016\/j.ebiom.2019.04.060_bb0200","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.ebiom.2019.04.060_bb0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/path.1711300107","article-title":"The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta","volume":"130","author":"McCullagh","year":"1980","journal-title":"J Pathol"},{"issue":"45","key":"10.1016\/j.ebiom.2019.04.060_bb0210","doi-asserted-by":"crossref","first-page":"35384","DOI":"10.1074\/jbc.M005139200","article-title":"Cell surface-bound collagenase-1 and focal substrate degradation stimulate the rear release of motile vascular smooth muscle cells","volume":"275","author":"Li","year":"2000","journal-title":"J Biol Chem"},{"issue":"34","key":"10.1016\/j.ebiom.2019.04.060_bb0215","doi-asserted-by":"crossref","first-page":"35573","DOI":"10.1074\/jbc.M400711200","article-title":"Fibroblast growth factor-2 and remodeled type I collagen control membrane protrusion in human vascular smooth muscle cells: biphasic activation of Rac1","volume":"279","author":"Fera","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.ebiom.2019.04.060_bb0220","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.jtcvs.2014.07.015","article-title":"The aortic wall with bicuspid aortic valve: immature or prematurely aging?","volume":"148","author":"Forte","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"11","key":"10.1016\/j.ebiom.2019.04.060_bb0225","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1096\/fj.02-0042fje","article-title":"Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells","volume":"16","author":"Mayr","year":"2002","journal-title":"FASEB J"},{"issue":"12","key":"10.1016\/j.ebiom.2019.04.060_bb0230","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1161\/CIRCRESAHA.116.310022","article-title":"Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease","volume":"120","author":"Watson","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0235","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2019.04.060_bb0240","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s40256-014-0063-6","article-title":"Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease","volume":"14","author":"Fisk","year":"2014","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2019.04.060_bb0250","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396419302993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396419302993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:30:59Z","timestamp":1778873459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396419302993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":50,"alternative-id":["S2352396419302993"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2019.04.060","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2019.04.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}