{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:28Z","timestamp":1790621008538,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ebiom.2019.07.016","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T08:07:01Z","timestamp":1563350821000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome: findings from a randomised phase 2 trial"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-9234","authenticated-orcid":false,"given":"Rahim Mohammad","family":"Naimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hvistendahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj","family":"Nerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Ambrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Patrick","family":"Achiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Bo","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger Jon","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Vilstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Steensberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle Bekker","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ebiom.2019.07.016_bb0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7326\/0003-4819-132-7-200004040-00003","article-title":"Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure","volume":"132","author":"Cavicchi","year":"2000","journal-title":"Ann. Intern. Med."},{"issue":"2 Suppl 1","key":"10.1016\/j.ebiom.2019.07.016_bb0010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.gastro.2005.10.066","article-title":"Intestinal failure-associated liver disease : what do we know today?","volume":"130","author":"Kelly","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/0148607114551968","article-title":"Glucagon-like peptide 2 improves cholestasis in parenteral nutrition-associated liver disease","volume":"40","author":"Lim","year":"2016","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"issue":"5","key":"10.1016\/j.ebiom.2019.07.016_bb0020","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jhep.2014.06.025","article-title":"Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease","volume":"61","author":"Pereira-Fantini","year":"2014","journal-title":"J. Hepatol."},{"issue":"18","key":"10.1016\/j.ebiom.2019.07.016_bb0025","first-page":"30170","article-title":"Assessment of intestinal failure associated liver disease according to different diagnostic criteria","volume":"S0261\u20135614","author":"Sasdelli","year":"2018","journal-title":"Clin. Nutr."},{"issue":"6","key":"10.1016\/j.ebiom.2019.07.016_bb0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/0148607114538057","article-title":"Transient Elastography (FibroScan) is not correlated with liver fibrosis but with cholestasis in patients with long-term home parenteral nutrition","volume":"39","author":"Van","year":"2015","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"issue":"3","key":"10.1016\/j.ebiom.2019.07.016_bb0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/liv.12887","article-title":"Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in paediatric intestinal failure","volume":"36","author":"Hukkinen","year":"2016","journal-title":"Liver Int."},{"issue":"7","key":"10.1016\/j.ebiom.2019.07.016_bb0040","first-page":"431","article-title":"Meal ingestion markedly increases liver stiffness suggesting the need for liver stiffness determination in fasting conditions","volume":"38","author":"Alvarez","year":"2015","journal-title":"Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.ebiom.2019.07.016_bb0045","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3109\/00365521.2014.1003396","article-title":"Liver stiffness and portal blood flow modifications induced by a liquid meal consumption: Pathogenetic mechanisms and clinical relevance","volume":"50","author":"Barone","year":"2015","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0050","first-page":"49","article-title":"Current use and perspective of indocyanine green clearance in liver diseases","volume":"35","author":"Levesque","year":"2016","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.ebiom.2019.07.016_bb0055","first-page":"1","article-title":"Indocyanine green retention test in cirrhosis and portal hypertension. Accuracy and relation to severity of disease","author":"M\u00f8ller","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10096-013-1936-3","article-title":"Macrophage-related serum biomarkers soluble CD163 (sCD163) and soluble mannose receptor (sMR) to differentiate mild liver fibrosis from cirrhosis in patients with chronic hepatitis C: a pilot study","volume":"33","author":"Andersen","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/0148607115595596","article-title":"Glucagon-like Peptide-2 alters bile acid metabolism in parenteral nutrition\u2013associated liver disease","volume":"40","author":"Lim","year":"2016","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/j.gastro.2005.11.005","article-title":"GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow","volume":"130","author":"Guan","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0075","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0016-5085(03)00667-X","article-title":"GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets","volume":"125","author":"Guan","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ebiom.2019.07.016_bb0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.regpep.2012.10.002","article-title":"Glucagon-like peptide-2 stimulates mucosal microcirculation measured by laser Doppler flowmetry in end-jejunostomy short bowel syndrome patients","volume":"180","author":"H\u00f8yerup","year":"2013","journal-title":"Regul. Pept."},{"issue":"6","key":"10.1016\/j.ebiom.2019.07.016_bb0085","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2012.09.007","article-title":"Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure","volume":"143","author":"Jeppesen","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ebiom.2019.07.016_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.69","article-title":"Long-term Teduglutide for the treatment of patients with intestinal failure associated with short bowel syndrome","volume":"7","author":"Schwartz","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.ebiom.2019.07.016_bb0095","first-page":"1","article-title":"Glepaglutide, a novel long-acting glucagon-like peptide-2 analogueue, for patients with short bowel syndrome: a randomised phase 2 trial","volume":"1253","author":"Naimi","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.ebiom.2019.07.016_bb0100","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jhep.2008.02.008","article-title":"Non-invasive evaluation of liver fibrosis using transient elastography","volume":"48","author":"Castera","year":"2008","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ebiom.2019.07.016_bb0105","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/hep.25993","article-title":"Determination of reliability criteria for liver stiffness evaluation by transient elastography","volume":"57","author":"Boursier","year":"2013","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ebiom.2019.07.016_bb0110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1499-3872(12)60159-3","article-title":"Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with child-Pugh a cirrhosis before hepatectomy for hepatocellular carcinoma","volume":"11","author":"Cheung","year":"2012","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2019.07.016_bb0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1445-2197.2006.03643.x","article-title":"Indocyanine green elimination: a comparison of the LiMON and serial blood sampling methods","volume":"76","author":"Purcell","year":"2006","journal-title":"ANZ J. Surg."},{"issue":"10","key":"10.1016\/j.ebiom.2019.07.016_bb0120","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s001340000639","article-title":"Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics","volume":"26","author":"Sakka","year":"2000","journal-title":"Intensive Care Med."},{"issue":"4","key":"10.1016\/j.ebiom.2019.07.016_bb0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/003655102760145852","article-title":"Characterization of an enzyme-linked immunosorbent assay for soluble CD163","volume":"62","author":"M\u00f8ller","year":"2002","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"3","key":"10.1016\/j.ebiom.2019.07.016_bb0130","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1515\/cclm-2013-0451","article-title":"A soluble form of the macrophage-related mannose receptor (MR\/CD206) is present in human serum and elevated in critical illness","volume":"52","author":"R\u00f8dgaard-Hansen","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"10.1016\/j.ebiom.2019.07.016_bb0135","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jhep.2016.12.022","article-title":"Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis","volume":"66","author":"Karlas","year":"2017","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365513.2011.626868","article-title":"Soluble CD163","volume":"72","author":"M\u00f8ller","year":"2012","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"10","key":"10.1016\/j.ebiom.2019.07.016_bb0145","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1097\/TP.0b013e31816dd513","article-title":"Collaborative strategies to reduce mortality and morbidity in patients with chronic intestinal failure including those who are referred for small bowel transplantation","volume":"85","author":"Beath","year":"2008","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.ebiom.2019.07.016_bb0150","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults","volume":"34","author":"Pironi","year":"2015","journal-title":"Clin. Nutr."},{"issue":"4","key":"10.1016\/j.ebiom.2019.07.016_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173992","article-title":"High risk of misinterpreting liver and spleen stiffness using 2D shear-wave and transient elastography after a moderate or high calorie meal","volume":"12","author":"Kj\u00e6rgaard","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ebiom.2019.07.016_bb0160","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hep.25500","article-title":"Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury","volume":"55","author":"El","year":"2012","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ebiom.2019.07.016_bb0165","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/SLA.0000000000002187","article-title":"Liver inflammation relates to decreased Canalicular bile transporter expression in pediatric onset intestinal failure","volume":"268","author":"Mutanen","year":"2018","journal-title":"Ann. Surg."},{"issue":"6","key":"10.1016\/j.ebiom.2019.07.016_bb0170","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1189\/jlb.0410235","article-title":"Tumor necrosis factor \u03b1-converting enzyme (TACE\/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163","volume":"88","author":"Etzerodt","year":"2010","journal-title":"J. Leukoc. Biol."}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396419304517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396419304517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:53:56Z","timestamp":1762455236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396419304517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":34,"alternative-id":["S2352396419304517"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2019.07.016","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome: findings from a randomised phase 2 trial","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2019.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}