{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:32:50Z","timestamp":1791829970811,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ebiom.2020.102635","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T06:53:14Z","timestamp":1580712794000},"page":"102635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1\/2 in polycystic ovary syndrome"],"prefix":"10.1016","volume":"52","author":[{"given":"Ruiqiong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasiximuke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-3390","authenticated-orcid":false,"given":"Yanzhi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0001","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril."},{"key":"10.1016\/j.ebiom.2020.102635_bib0002","article-title":"Recent advances in mammalian reproductive biology","author":"Wen","year":"2019","journal-title":"Sci China Life Sci"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0003","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102635_bib0004","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.ebiom.2020.102635_bib0005","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1385\/ENDO:30:1:27","article-title":"Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment","volume":"30","author":"Gorry","year":"2006","journal-title":"Endocrine"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0007","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00006254-198202000-00001","article-title":"Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called \"hyperthecosis\"","volume":"37","author":"Hughesdon","year":"1982","journal-title":"Obstet Gynecol Surv."},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2020.102635_bib0008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0303-7207(99)00239-7","article-title":"Follicular dynamics in the polycystic ovary syndrome","volume":"163","author":"Franks","year":"2000","journal-title":"Mol Cell Endocrinol."},{"issue":"5","key":"10.1016\/j.ebiom.2020.102635_bib0009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tem.2018.02.012","article-title":"Endocrine, paracrine, and autocrine signaling pathways that regulate ovulation","volume":"29","author":"Richards","year":"2018","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102635_bib0010","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1210\/me.2005-0504","article-title":"Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor","volume":"20","author":"Shimada","year":"2006","journal-title":"Mol Endocrinol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0011","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1210\/me.2005-0185","article-title":"Role of the epidermal growth factor network in ovarian follicles","volume":"20","author":"Conti","year":"2006","journal-title":"Mol Endocrinol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102635_bib0012","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1210\/endo.143.6.8845","article-title":"Mitogen-activated protein kinase activity in cumulus cells is essential for gonadotropin-induced oocyte meiotic resumption and cumulus expansion in the mouse","volume":"143","author":"Su","year":"2002","journal-title":"Endocrinology"},{"issue":"5658","key":"10.1016\/j.ebiom.2020.102635_bib0013","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.1092463","article-title":"EGF-like growth factors as mediators of LH action in the ovulatory follicle","volume":"303","author":"Park","year":"2004","journal-title":"Science"},{"issue":"5929","key":"10.1016\/j.ebiom.2020.102635_bib0014","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.1171396","article-title":"MAPK3\/1 (ERK1\/2) in ovarian granulosa cells are essential for female fertility","volume":"324","author":"Fan","year":"2009","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1210\/me.2010-0318","article-title":"CCAAT\/enhancer-binding proteins (C\/EBP)-alpha and -beta are essential for ovulation, luteinization, and the expression of key target genes","volume":"25","author":"Fan","year":"2011","journal-title":"Mol Endocrinol"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102635_bib0016","doi-asserted-by":"crossref","first-page":"E2016","DOI":"10.1210\/jc.2011-3441","article-title":"Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis","volume":"97","author":"Kaur","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0017","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/molehr\/gan082","article-title":"Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients","volume":"15","author":"Kenigsberg","year":"2009","journal-title":"Mol Hum Reprod"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102635_bib0018","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1210\/me.2004-0074","article-title":"Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients","volume":"18","author":"Jansen","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ebiom.2020.102635_bib0019","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ebiom.2018.09.046","article-title":"Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome","volume":"36","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102635_bib0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0168-9525(94)90034-5","article-title":"The Lim domain: a new structural motif found in zinc-finger-like proteins","volume":"10","author":"Sanchez-Garcia","year":"1994","journal-title":"Trends Genet"},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2020.102635_bib0021","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0925-4773(00)00341-5","article-title":"Expression patterns of FHL\/slim family members suggest important functional roles in skeletal muscle and cardiovascular system","volume":"95","author":"Chu","year":"2000","journal-title":"Mech Dev"},{"issue":"22","key":"10.1016\/j.ebiom.2020.102635_bib0022","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1128\/MCB.20.22.8613-8622.2000","article-title":"A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of Creb and Crem","volume":"20","author":"Fimia","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0023","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/dna.1997.16.433","article-title":"Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma","volume":"16","author":"Genini","year":"1997","journal-title":"DNA Cell Biol"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102635_bib0024","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1210\/me.2011-1347","article-title":"The Lim domain protein FHL2 interacts with the NR5A family of nuclear receptors and Creb to activate the inhibin-alpha subunit gene in ovarian granulosa cells","volume":"26","author":"Matulis","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/emboj\/21.4.736","article-title":"The transcriptional coactivator FHL2 transmits rho signals from the cell membrane into the nucleus","volume":"21","author":"Muller","year":"2002","journal-title":"Embo J"},{"issue":"22","key":"10.1016\/j.ebiom.2020.102635_bib0026","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1074\/jbc.M800708200","article-title":"The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation","volume":"283","author":"Labalette","year":"2008","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102635_bib0027","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1053\/j.gastro.2006.12.004","article-title":"Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis","volume":"132","author":"Wang","year":"2007","journal-title":"Gastroenterology"},{"issue":"17","key":"10.1016\/j.ebiom.2020.102635_bib0028","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1038\/sj.emboj.7600773","article-title":"Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts","volume":"24","author":"Gunther","year":"2005","journal-title":"Embo J"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0029","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00223-006-0074-7","article-title":"Disruption of four-and-a-half lim 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice","volume":"79","author":"Govoni","year":"2006","journal-title":"Calcif Tissue Int"},{"issue":"22","key":"10.1016\/j.ebiom.2020.102635_bib0030","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/01.CIR.103.22.2731","article-title":"Cardiac-specific Lim protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation","volume":"103","author":"Kong","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102635_bib0031","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1128\/MCB.24.3.1081-1095.2004","article-title":"Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes","volume":"24","author":"Purcell","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"20","key":"10.1016\/j.ebiom.2020.102635_bib0032","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1128\/MCB.20.20.7460-7462.2000","article-title":"FHL2 (SLIM3) is not essential for cardiac development and function","volume":"20","author":"Chu","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0033","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0167-4781(02)00414-1","article-title":"The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation","volume":"1577","author":"Du","year":"2002","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102635_bib0034","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/MED.0b013e32832afd4d","article-title":"Androgens and polycystic ovary syndrome","volume":"16","author":"Nisenblat","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0035","first-page":"18","article-title":"The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS","volume":"6","author":"Baculescu","year":"2013","journal-title":"J Med Life"},{"issue":"15","key":"10.1016\/j.ebiom.2020.102635_bib0036","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1073\/pnas.1418216112","article-title":"Alternative splicing of the androgen receptor in polycystic ovary syndrome","volume":"112","author":"Wang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2020.102635_bib0037","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jsbmb.2009.09.017","article-title":"Four and a half lim domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity","volume":"118","author":"Kollara","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102635_bib0038","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/emboj\/19.3.359","article-title":"FHL2, a novel tissue-specific coactivator of the androgen receptor","volume":"19","author":"Muller","year":"2000","journal-title":"Embo J"},{"issue":"48","key":"10.1016\/j.ebiom.2020.102635_bib0039","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1038\/onc.2015.41","article-title":"CCAAT\/Enhancer binding protein beta controls androgen-deprivation-induced senescence in prostate cancer cells","volume":"34","author":"Barakat","year":"2015","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ebiom.2020.102635_bib0041","doi-asserted-by":"crossref","first-page":"31675","DOI":"10.1038\/srep31675","article-title":"hCG-induced sprouty2 mediates amphiregulin-stimulated COX-2\/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0042","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/endo.133.2.8393774","article-title":"Hormone induction of luteinization and prostaglandin endoperoxide synthase-2 involves multiple cellular signaling pathways","volume":"133","author":"Morris","year":"1993","journal-title":"Endocrinology"},{"issue":"338","key":"10.1016\/j.ebiom.2020.102635_bib0043","doi-asserted-by":"crossref","first-page":"338ra68","DOI":"10.1126\/scitranslmed.aad2709","article-title":"The prostaglandin transporter (PGT) as a potential mediator of ovulation","volume":"8","author":"Yerushalmi","year":"2016","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102635_bib0044","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/med.21558","article-title":"A magic drug target: androgen receptor","volume":"39","author":"Li","year":"2019","journal-title":"Med Res Rev"},{"key":"10.1016\/j.ebiom.2020.102635_bib0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-61779-095-9_8","article-title":"Lentiviral vectors","volume":"737","author":"Giry-Laterriere","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0046","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/dbio.1996.0258","article-title":"Expression of CCAAT enhancer binding protein-alpha (C\/EBP alpha) in the rat ovary: implications for follicular development and ovulation","volume":"179","author":"Piontkewitz","year":"1996","journal-title":"Dev Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102635_bib0047","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrd.20971","article-title":"Targeted suppression of HAS2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression","volume":"76","author":"Sugiura","year":"2009","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.ebiom.2020.102635_bib0048","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fendo.2018.00669","article-title":"ATF4 contributes to ovulation via regulating COX2\/PGE2 expression: a potential role of ATF4 in PCOS","volume":"9","author":"Di","year":"2018","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0049","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mrd.10173","article-title":"Comparison between PMSG- and FSH-induced superovulation for the generation of transgenic rats","volume":"63","author":"Popova","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.ebiom.2020.102635_bib0050","doi-asserted-by":"crossref","first-page":"26691","DOI":"10.1038\/srep26691","article-title":"STMN1 promotes progesterone production via star up-regulation in mouse granulosa cells","volume":"6","author":"Dou","year":"2016","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102635_bib0051","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"issue":"16","key":"10.1016\/j.ebiom.2020.102635_bib0052","doi-asserted-by":"crossref","first-page":"E3334","DOI":"10.1073\/pnas.1616467114","article-title":"Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome","volume":"114","author":"Caldwell","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0053","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/humupd\/dmq032","article-title":"Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence","volume":"17","author":"Qiao","year":"2011","journal-title":"Hum Reprod Update"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102635_bib0054","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2015","journal-title":"Hum Reprod Update"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102635_bib0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00404-007-0462-x","article-title":"Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome","volume":"277","author":"Sahu","year":"2008","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0056","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1472-6483(10)61728-2","article-title":"IVF outcome in anovulatory infertility (WHO group 2)\u2013including polycystic ovary syndrome\u2013following previous unsuccessful ovulation induction","volume":"7","author":"Mulders","year":"2003","journal-title":"Reprod Biomed Online"},{"issue":"17","key":"10.1016\/j.ebiom.2020.102635_bib0057","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1101\/gad.11.17.2153","article-title":"An essential role for C\/EBPbeta in female reproduction","volume":"11","author":"Sterneck","year":"1997","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.ebiom.2020.102635_bib0058","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1095\/biolreprod.111.097808","article-title":"Rodent models for human polycystic ovary syndrome","volume":"86","author":"Walters","year":"2012","journal-title":"Biol Reprod."},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2020.102635_bib0059","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2012.10.005","article-title":"Sheep models of polycystic ovary syndrome phenotype","volume":"373","author":"Padmanabhan","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102635_bib0060","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1016\/j.fertnstert.2010.06.077","article-title":"Androgen excess down-regulates connexin43 in a human granulosa cell line","volume":"94","author":"Wu","year":"2010","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0061","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/en.2009-0751","article-title":"Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis","volume":"151","author":"Yang","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0062","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1757-2215-6-36","article-title":"Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model","volume":"6","author":"Hossain","year":"2013","journal-title":"J Ovarian Res"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0063","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1210\/en.2014-1887","article-title":"Haplosufficient genomic androgen receptor signaling is adequate to protect female mice from induction of polycystic ovary syndrome features by prenatal hyperandrogenization","volume":"156","author":"Caldwell","year":"2015","journal-title":"Endocrinology"},{"issue":"16","key":"10.1016\/j.ebiom.2020.102635_bib0064","doi-asserted-by":"crossref","first-page":"E3334","DOI":"10.1073\/pnas.1616467114","article-title":"Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome","volume":"114","author":"Caldwell","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2020.102635_bib0065","doi-asserted-by":"crossref","first-page":"14994","DOI":"10.1038\/srep14994","article-title":"Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK\/ERK signaling","volume":"5","author":"Lan","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0066","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/me.2004-0178","article-title":"Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome","volume":"19","author":"Nelson-Degrave","year":"2005","journal-title":"Mol Endocrinol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102635_bib0067","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1530\/REP-14-0517","article-title":"Role of androgens in normal and pathological ovarian function","volume":"149","author":"Walters","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.ebiom.2020.102635_bib0068","article-title":"A candidate pathogenic gene, zinc finger gene 217 (ZNF217) may contribute to polycystic ovary syndrome through prostaglandin E2","author":"Zhai","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102635_bib0069","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/humrep\/del408","article-title":"Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis","volume":"22","author":"Lindeberg","year":"2007","journal-title":"Hum Reprod"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102635_bib0070","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10815-011-9594-9","article-title":"Molecular characterization of the human ovulatory cascade-lesson from the IVF\/IVM model","volume":"28","author":"Yerushalmi","year":"2011","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102635_bib0071","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/endo.142.1.7862","article-title":"Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor","volume":"142","author":"Nishi","year":"2001","journal-title":"Endocrinology"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420300104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420300104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:57:33Z","timestamp":1762455453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396420300104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":71,"alternative-id":["S2352396420300104"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102635","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1\/2 in polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102635"}}