{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:54:39Z","timestamp":1787165679403,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ebiom.2020.102645","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T23:54:30Z","timestamp":1580514870000},"page":"102645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A peptide derived from the core \u03b2-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models"],"prefix":"10.1016","volume":"52","author":[{"given":"Asma","family":"Achek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk-Kwon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh Chandra","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaud","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riwon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook-Young","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Seon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuong L.H.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hee","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyun","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangdun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2020.102645_bib0001","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102645_bib0002","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nri1916","article-title":"Toll-like receptors as molecular switches","volume":"6","author":"Gay","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102645_bib0003","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: tIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102645_bib0004","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nri3713","article-title":"Assembly and localization of Toll-like receptor signalling complexes","volume":"14","author":"Gay","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"7300","key":"10.1016\/j.ebiom.2020.102645_bib0005","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature09121","article-title":"Helical assembly in the MYD88-IRAK4-IRAK2 complex in TLR\/IL-1R signalling","volume":"465","author":"Lin","year":"2010","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0006","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.it.2010.12.005","article-title":"What the Myddosome structure tells us about the initiation of innate immunity","volume":"32","author":"Gay","year":"2011","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0007","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102645_bib0008","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/aps.2015.91","article-title":"Toll-like receptors: potential targets for lupus treatment","volume":"36","author":"Wu","year":"2015","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0009","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12969-017-0137-5","article-title":"TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population","volume":"15","author":"Wang","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autrev.2015.08.009","article-title":"The critical role of toll-like receptors\u2013From microbial recognition to autoimmunity: a comprehensive review","volume":"15","author":"Jimenez-Dalmaroni","year":"2016","journal-title":"Autoimmun Rev"},{"issue":"Pt A","key":"10.1016\/j.ebiom.2020.102645_bib0011","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.arr.2015.01.003","article-title":"DAMPs as mediators of sterile inflammation in aging-related pathologies","volume":"24","author":"Feldman","year":"2015","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102645_bib0012","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri1630","article-title":"Negative regulation of toll-like receptor-mediated immune responses","volume":"5","author":"Liew","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102645_bib0013","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1124\/pr.109.001073","article-title":"Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer","volume":"61","author":"O'Neill","year":"2009","journal-title":"Pharmacol Rev"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102645_bib0014","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s12272-016-0806-9","article-title":"Toll-like receptors: promising therapeutic targets for inflammatory diseases","volume":"39","author":"Achek","year":"2016","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.ebiom.2020.102645_bib0015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fimmu.2014.00334","article-title":"Multiple roles of toll-like receptor 4 in colorectal cancer","volume":"5","author":"Yesudhas","year":"2014","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0016","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrrheum.2014.209","article-title":"TLR4 signalling in osteoarthritis\u2013finding targets for candidate DMOADs","volume":"11","author":"Gomez","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102645_bib0017","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrrheum.2016.61","article-title":"Toll-like receptors and chronic inflammation in rheumatic diseases: new developments","volume":"12","author":"Joosten","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"10.1016\/j.ebiom.2020.102645_bib0018","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri1957","article-title":"Toll-like receptors in systemic autoimmune disease","volume":"6","author":"Marshak-Rothstein","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102645_bib0019","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102645_bib0020","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1002\/art.24140","article-title":"Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis","volume":"58","author":"Ospelt","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ebiom.2020.102645_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/132732","article-title":"Increased responsiveness to toll-like receptor 4 stimulation in peripheral blood mononuclear cells from patients with recent onset rheumatoid arthritis","volume":"2008","author":"Kowalski","year":"2008","journal-title":"Mediators Inflamm"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102645_bib0022","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.4049\/jimmunol.177.10.6880","article-title":"TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease","volume":"177","author":"Liu","year":"2006","journal-title":"J Immunol"},{"issue":"32","key":"10.1016\/j.ebiom.2020.102645_bib0023","doi-asserted-by":"crossref","first-page":"13064","DOI":"10.1073\/pnas.1120585109","article-title":"Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation","volume":"109","author":"Reynolds","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2020.102645_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2019.05.002","article-title":"Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases","author":"Patra","year":"2020","journal-title":"Semin Cancer Biol"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102645_bib0025","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nrd914","article-title":"Toll-like receptors as potential therapeutic targets for multiple diseases","volume":"1","author":"Zuany-Amorim","year":"2002","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0026","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting Toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0027","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1471-4892(03)00080-8","article-title":"Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases","volume":"3","author":"O'Neill","year":"2003","journal-title":"Curr Opin Pharmacol"},{"issue":"29","key":"10.1016\/j.ebiom.2020.102645_bib0028","doi-asserted-by":"crossref","first-page":"24641","DOI":"10.1074\/jbc.M112.360925","article-title":"Targeting Toll-like receptor (TLR) signaling by Toll\/interleukin-1 receptor (TIR) domain-containing adapter protein\/MyD88 adapter-like (TIRAP\/Mal)-derived decoy peptides","volume":"287","author":"Couture","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ebiom.2020.102645_bib0029","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biomaterials.2017.02.023","article-title":"TLR4\/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation","volume":"126","author":"Park","year":"2017","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102645_bib0030","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.4049\/jimmunol.1202703","article-title":"Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo","volume":"190","author":"Piao","year":"2013","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102645_bib0031","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.4049\/jimmunol.1002424","article-title":"Targeting TLR4 signaling by TLR4 Toll\/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll\/IL-1 receptor domain dimerization interface","volume":"186","author":"Toshchakov","year":"2011","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102645_bib0032","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.celrep.2015.05.035","article-title":"A decoy peptide that disrupts tirap recruitment to TLRs is protective in a murine model of influenza","volume":"11","author":"Piao","year":"2015","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0033","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cell.2014.01.019","article-title":"A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction","volume":"156","author":"Bonham","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102645_bib0034","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2006.03.047","article-title":"Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling","volume":"125","author":"Kagan","year":"2006","journal-title":"Cell"},{"issue":"32","key":"10.1016\/j.ebiom.2020.102645_bib0035","doi-asserted-by":"crossref","first-page":"E6480","DOI":"10.1073\/pnas.1701868114","article-title":"Solution structure of the TLR adaptor MAL\/TIRAP reveals an intact BB loop and supports MAL CYS91 glutathionylation for signaling","volume":"114","author":"Hughes","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0036","doi-asserted-by":"crossref","first-page":"e34202","DOI":"10.1371\/journal.pone.0034202","article-title":"Structural insights into TIR domain specificity of the bridging adaptor MAL in TLR4 signaling","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS ONE"},{"issue":"36","key":"10.1016\/j.ebiom.2020.102645_bib0037","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.1073\/pnas.1104780108","article-title":"Crystal structure of Toll-like receptor adaptor MAL\/TIRAP reveals the molecular basis for signal transduction and disease protection","volume":"108","author":"Valkov","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2020.102645_bib0038","doi-asserted-by":"crossref","first-page":"43043","DOI":"10.1038\/srep43043","article-title":"Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0039","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/toxsci\/kfv182","article-title":"Etoposide induces necrosis through p53-Mediated antiapoptosis in human kidney proximal tubule cells","volume":"148","author":"Kwon","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.ebiom.2020.102645_bib0040","doi-asserted-by":"crossref","first-page":"15623","DOI":"10.1038\/srep15623","article-title":"Structural and functional analysis of cell adhesion and nuclear envelope nano-topography in cell death","volume":"5","author":"Kwon","year":"2015","journal-title":"Sci Rep"},{"issue":"14","key":"10.1016\/j.ebiom.2020.102645_bib0041","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1111\/bph.12715","article-title":"Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice","volume":"171","author":"Xin","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102645_bib0042","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar2662","article-title":"Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models","volume":"11","author":"Bang","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0043","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1476-5381.2011.01353.x","article-title":"Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats","volume":"164","author":"Kim","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0044","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s12276-019-0244-0","article-title":"A cell-penetrating peptide blocks toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice","volume":"51","author":"Kwon","year":"2019","journal-title":"Exp Mol Med"},{"issue":"14","key":"10.1016\/j.ebiom.2020.102645_bib0045","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1016\/S0021-9258(17)34080-2","article-title":"The third helix of the antennapedia homeodomain translocates through biological membranes","volume":"269","author":"Derossi","year":"1994","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102645_bib0046","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0047","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nrrheum.2016.166","article-title":"Interleukin-1 function and role in rheumatic disease","volume":"12","author":"Schett","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0048","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejphar.2008.01.032","article-title":"Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-KAPPAB in raw 264.7 macrophages","volume":"584","author":"Kim","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0049","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1084\/jem.20061849","article-title":"Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock","volume":"204","author":"Yang","year":"2007","journal-title":"J Exp Med"},{"issue":"7344","key":"10.1016\/j.ebiom.2020.102645_bib0050","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102645_bib0051","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1136\/ard.2007.086421","article-title":"Type I interferons might form the link between Toll-like receptor (TLR) 3\/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)","volume":"68","author":"Roelofs","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"27","key":"10.1016\/j.ebiom.2020.102645_bib0052","first-page":"253","article-title":"Psoriasis: clinical manifestations, pathogenesis and therapeutic perspectives","volume":"5","author":"Schon","year":"2005","journal-title":"Discov Med"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0053","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1046\/j.1365-2133.2003.05287.x","article-title":"Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis","volume":"148","author":"Baker","year":"2003","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102645_bib0054","first-page":"497","article-title":"Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin","volume":"17","author":"Begon","year":"2007","journal-title":"Eur J Dermatol EJD"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102645_bib0055","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.4049\/jimmunol.1200901","article-title":"Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation","volume":"190","author":"Hirai","year":"2013","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0056","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.str.2015.12.018","article-title":"Reconstructing the TIR side of the myddosome: a paradigm for tir-tir interactions","volume":"24","author":"Vyncke","year":"2016","journal-title":"Structure"},{"issue":"17","key":"10.1016\/j.ebiom.2020.102645_bib0057","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1074\/jbc.M112.415810","article-title":"Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MYD88 adapter-like (Mal)","volume":"288","author":"Bovijn","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0058","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov Today"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0059","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4049\/jimmunol.1800194","article-title":"Blocking TIR domain interactions in TLR9 signaling","volume":"201","author":"Javmen","year":"2018","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102645_bib0060","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.178.5.2655","article-title":"Cutting edge: differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs","volume":"178","author":"Toshchakov","year":"2007","journal-title":"J Immunol"},{"issue":"47","key":"10.1016\/j.ebiom.2020.102645_bib0061","doi-asserted-by":"crossref","first-page":"19036","DOI":"10.1073\/pnas.1313575110","article-title":"Recruitment of tlr adapter trif to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain","volume":"110","author":"Piao","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102645_bib0062","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1038\/s41598-017-03447-9","article-title":"Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons","volume":"7","author":"Allette","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102645_bib0063","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","article-title":"TLR2 and TLR4 in autoimmune diseases: a comprehensive review","volume":"47","author":"Liu","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102645_bib0064","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00403-016-1620-4","article-title":"Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis","volume":"308","author":"Smith","year":"2016","journal-title":"Arch Dermatol Res"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102645_bib0065","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.4049\/jimmunol.0803219","article-title":"Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus","volume":"183","author":"Lartigue","year":"2009","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102645_bib0066","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/art.22848","article-title":"Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis","volume":"56","author":"Abdollahi-Roodsaz","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.ebiom.2020.102645_bib0067","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.4049\/jimmunol.176.11.7021","article-title":"Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis","volume":"176","author":"Roelofs","year":"2006","journal-title":"J Immunol"},{"issue":"3\u20134","key":"10.1016\/j.ebiom.2020.102645_bib0068","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12079-009-0075-1","article-title":"The role of tenascin-C in tissue injury and tumorigenesis","volume":"3","author":"Midwood","year":"2009","journal-title":"J Cell Commun Signal"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102645_bib0069","doi-asserted-by":"crossref","first-page":"R260","DOI":"10.1186\/ar4105","article-title":"Raised circulating tenascin-C in rheumatoid arthritis","volume":"14","author":"Page","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0070","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/eji.201444908","article-title":"HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1alpha activation","volume":"45","author":"Park","year":"2015","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102645_bib0071","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/art.10859","article-title":"High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine","volume":"48","author":"Taniguchi","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102645_bib0072","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1074\/jbc.M113.523274","article-title":"Mechanism of bacterial interference with TLR4 signaling by Brucella Toll\/interleukin-1 receptor domain-containing protein TCPB","volume":"289","author":"Alaidarous","year":"2014","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102645_bib0073","doi-asserted-by":"crossref","first-page":"E2046","DOI":"10.1073\/pnas.1621248114","article-title":"Multiple functional self-association interfaces in plant TIR domains","volume":"114","author":"Zhang","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"171","key":"10.1016\/j.ebiom.2020.102645_bib0074","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/stke.2003.171.re3","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: signal transduction during inflammation and host defense","volume":"2003","author":"Dunne","year":"2003","journal-title":"Sci STKE: Signal Transduct Knowl Environ"},{"issue":"40","key":"10.1016\/j.ebiom.2020.102645_bib0075","doi-asserted-by":"crossref","first-page":"30132","DOI":"10.1074\/jbc.M602057200","article-title":"Structural and functional evidence for the role of the TLR2 DD loop in TLR1\/TLR2 heterodimerization and signaling","volume":"281","author":"Gautam","year":"2006","journal-title":"J Biol Chem"},{"issue":"29","key":"10.1016\/j.ebiom.2020.102645_bib0076","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.0603804103","article-title":"Details of toll-like receptor:adapter interaction revealed by germ-line mutagenesis","volume":"103","author":"Jiang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"42","key":"10.1016\/j.ebiom.2020.102645_bib0077","doi-asserted-by":"crossref","first-page":"41443","DOI":"10.1074\/jbc.M301742200","article-title":"Structural complementarity of Toll\/Interleukin-1 receptor domains in Toll-like receptors and the adaptors MAL and MYD88","volume":"278","author":"Dunne","year":"2003","journal-title":"J Biol Chem"},{"issue":"28","key":"10.1016\/j.ebiom.2020.102645_bib0078","doi-asserted-by":"crossref","first-page":"26152","DOI":"10.1074\/jbc.M503262200","article-title":"Interactive sites in the MYD88 Toll\/Interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102645_bib0079","doi-asserted-by":"crossref","first-page":"e788","DOI":"10.1371\/journal.pone.0000788","article-title":"A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins","volume":"2","author":"Nunez Miguel","year":"2007","journal-title":"PLoS ONE"}],"updated-by":[{"DOI":"10.1016\/j.ebiom.2025.105953","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000}}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420300207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420300207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:35:27Z","timestamp":1763116527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396420300207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":79,"alternative-id":["S2352396420300207"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102645","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A peptide derived from the core \u03b2-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102645"}}