{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:10:46Z","timestamp":1783350646911,"version":"3.54.6"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T00:00:00Z","timestamp":1586563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ebiom.2020.102768","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:17:19Z","timestamp":1587043039000},"page":"102768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"special_numbering":"C","title":["Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-3701","authenticated-orcid":false,"given":"Ruklanthi","family":"de Alwis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther S.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-1544","authenticated-orcid":false,"given":"Eng Eong","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2020.102768_bib0001","series-title":"Coronavirus disease 2019 (COVID-19) situation report 72","year":"2020"},{"key":"10.1016\/j.ebiom.2020.102768_bib0002","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0003","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/infdis\/jiu396","article-title":"The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis","volume":"211","author":"Mair-Jenkins","year":"2015","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102768_bib0004","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1378\/chest.12-2907","article-title":"Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection","volume":"144","author":"Hung","year":"2013","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10096-004-1271-9","article-title":"Use of convalescent plasma therapy in SARS patients in Hong Kong","volume":"24","author":"Cheng","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ebiom.2020.102768_bib0006","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3389\/fmicb.2019.01781","article-title":"Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus","volume":"10","author":"Yong","year":"2019","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0007","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.virusres.2007.01.021","article-title":"Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease","volume":"133","author":"Enjuanes","year":"2008","journal-title":"Virus Res"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102768_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030623","article-title":"Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV): a systematic review","volume":"9","author":"Pang","year":"2020","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0009","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines - a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ebiom.2020.102768_bib0010","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.3389\/fimmu.2018.01963","article-title":"New vaccine technologies to combat outbreak situations","volume":"9","author":"Rauch","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(20)30141-9","article-title":"Convalescent plasma as a potential therapy for COVID-19","author":"Chen","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ebiom.2020.102768_bib0012","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.aivir.2016.08.002","article-title":"Feline coronaviruses: pathogenesis of feline infectious peritonitis","volume":"96","author":"Tekes","year":"2016","journal-title":"Adv Virus Res"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102768_bib0013","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/jvi.64.3.1407-1409.1990","article-title":"Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization","volume":"64","author":"Vennema","year":"1990","journal-title":"J Virol"},{"issue":"3 Suppl 4","key":"10.1016\/j.ebiom.2020.102768_bib0014","first-page":"25","article-title":"Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS","volume":"22","author":"Yip","year":"2016","journal-title":"Hong Kong Med J"},{"issue":"8589","key":"10.1016\/j.ebiom.2020.102768_bib0015","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0140-6736(88)91657-1","article-title":"Antibody-dependent enhancement of human immunodeficiency virus type 1 infection","volume":"1","author":"Robinson","year":"1988","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102768_bib0016","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1073\/pnas.86.12.4710","article-title":"Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees","volume":"86","author":"Robinson","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102768_bib0017","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.1890360312","article-title":"Infection enhancement of influenza a NWS virus in primary murine macrophages by anti-hemagglutinin monoclonal antibody","volume":"36","author":"Ochiai","year":"1992","journal-title":"J Med Virol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102768_bib0018","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/JVI.75.5.2324-2330.2001","article-title":"Infectivity-enhancing antibodies to Ebola virus glycoprotein","volume":"75","author":"Takada","year":"2001","journal-title":"J Virol"},{"issue":"13","key":"10.1016\/j.ebiom.2020.102768_bib0019","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1128\/JVI.77.13.7539-7544.2003","article-title":"Antibody-dependent enhancement of Ebola virus infection","volume":"77","author":"Takada","year":"2003","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102768_bib0020","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbrc.2014.07.090","article-title":"Antibody-dependent sars coronavirus infection is mediated by antibodies against spike proteins","volume":"451","author":"Wang","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102768_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02015-19","article-title":"Molecular mechanism for antibody-dependent enhancement of coronavirus entry","volume":"94","author":"Wan","year":"2020","journal-title":"J Virol"},{"issue":"20","key":"10.1016\/j.ebiom.2020.102768_bib0022","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1128\/JVI.00671-11","article-title":"Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent Fcgammar pathway","volume":"85","author":"Jaume","year":"2011","journal-title":"J Virol"},{"issue":"10169","key":"10.1016\/j.ebiom.2020.102768_bib0023","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Wilder-Smith","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0024","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.146.1.201","article-title":"Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody","volume":"146","author":"Halstead","year":"1977","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of dengue serostatus on dengue vaccine safety and efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0026","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/oxfordjournals.aje.a120954","article-title":"An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine","volume":"89","author":"Kapikian","year":"1969","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0027","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/oxfordjournals.aje.a120955","article-title":"Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine","volume":"89","author":"Kim","year":"1969","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0028","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/oxfordjournals.aje.a120956","article-title":"Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine","volume":"89","author":"Fulginiti","year":"1969","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0029","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/oxfordjournals.aje.a120957","article-title":"Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population","volume":"89","author":"Chin","year":"1969","journal-title":"Am J Epidemiol"},{"issue":"17","key":"10.1016\/j.ebiom.2020.102768_bib0030","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1128\/JVI.00593-06","article-title":"Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response","volume":"80","author":"Iankov","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0031","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1001\/archpedi.1965.02090020234007","article-title":"Measles immunization with killed virus vaccine. Serum antibody titers and experience with exposure to measles epidemic","volume":"109","author":"Rauh","year":"1965","journal-title":"Am J Dis Child"},{"issue":"11","key":"10.1016\/j.ebiom.2020.102768_bib0032","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3201\/eid1111.040659","article-title":"Neutralizing antibody response and SARS severity","volume":"11","author":"Ho","year":"2005","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102768_bib0033","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1084\/jem.20062545","article-title":"Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program","volume":"204","author":"Dhodapkar","year":"2007","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102768_bib0034","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1073\/pnas.1317454111","article-title":"Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue","volume":"111","author":"Chan","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102768_bib0035","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1073\/pnas.1324286111","article-title":"LILR-B1 blocks activating Fc\u03b3R signaling to allow antibody dependent enhancement of dengue virus infection","volume":"111","author":"Nimmerjahn","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2020.102768_bib0036","doi-asserted-by":"crossref","first-page":"40923","DOI":"10.1038\/srep40923","article-title":"Dengue virus compartmentalization during antibody-enhanced infection","volume":"7","author":"Ong","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102768_bib0037","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00528-19","article-title":"Antibody-Dependent dengue virus entry modulates cell intrinsic responses for enhanced infection","volume":"4","author":"Chan","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.ebiom.2020.102768_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0039","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.virusres.2004.09.004","article-title":"SARS-coronavirus replication in human peripheral monocytes\/macrophages","volume":"107","author":"Yilla","year":"2005","journal-title":"Virus Res"},{"issue":"9371","key":"10.1016\/j.ebiom.2020.102768_bib0040","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0140-6736(03)13412-5","article-title":"Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0041","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123158","article-title":"Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2020.102768_bib0042","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fimmu.2019.00548","article-title":"Fc-Mediated antibody effector functions during respiratory syncytial virus infection and disease","volume":"10","author":"van Erp","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0043","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/imcb.12324","article-title":"Antibody-mediated complement activation in pathology and protection","volume":"98","author":"Goldberg","year":"2020","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0044","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.coviro.2016.12.002","article-title":"Antibody-dependent cellular cytotoxicity and influenza virus","volume":"22","author":"Vanderven","year":"2017","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0045","doi-asserted-by":"crossref","first-page":"16164","DOI":"10.1038\/nmicrobiol.2016.164","article-title":"Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity","author":"Chan","year":"2016","journal-title":"Nat Microbiol"},{"issue":"7335","key":"10.1016\/j.ebiom.2020.102768_bib0046","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09737","article-title":"Programming the magnitude and persistence of antibody responses with innate immunity","volume":"470","author":"Kasturi","year":"2011","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102768_bib0047","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41591-019-0510-7","article-title":"Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection","volume":"25","author":"Chan","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2020.102768_bib0048","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1038\/cddis.2012.144","article-title":"ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation","volume":"3","author":"Riteau","year":"2012","journal-title":"Cell Death Dis"},{"issue":"104","key":"10.1016\/j.ebiom.2020.102768_bib0049","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.3104re1","article-title":"Basal release of ATP: an autocrine-paracrine mechanism for cell regulation","volume":"3","author":"Corriden","year":"2010","journal-title":"Sci Signal"},{"key":"10.1016\/j.ebiom.2020.102768_bib0050","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ebiom.2020.102768_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtho.2020.02.010","article-title":"Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer","author":"Tian","year":"2020","journal-title":"J Thorac Oncol"},{"issue":"15","key":"10.1016\/j.ebiom.2020.102768_bib0052","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1016\/j.vaccine.2006.10.031","article-title":"Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model","volume":"25","author":"Du","year":"2007","journal-title":"Vaccine"},{"issue":"23","key":"10.1016\/j.ebiom.2020.102768_bib0053","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1128\/JVI.06048-11","article-title":"A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge","volume":"85","author":"Bolles","year":"2011","journal-title":"J Virol"},{"issue":"22","key":"10.1016\/j.ebiom.2020.102768_bib0054","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1128\/JVI.78.22.12672-12676.2004","article-title":"Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets","volume":"78","author":"Weingartl","year":"2004","journal-title":"J Virol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0055","doi-asserted-by":"crossref","first-page":"e35421","DOI":"10.1371\/journal.pone.0035421","article-title":"Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus","volume":"7","author":"Tseng","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102768_bib0056","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1128\/JVI.02980-14","article-title":"Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology","volume":"89","author":"Honda-Okubo","year":"2015","journal-title":"J Virol"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102768_bib0057","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1080\/21645515.2016.1177688","article-title":"Immunization with inactivated middle east respiratory syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus","volume":"12","author":"Agrawal","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"15","key":"10.1016\/j.ebiom.2020.102768_bib0058","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1128\/JVI.00983-14","article-title":"Effects of toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB\/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine","volume":"88","author":"Iwata-Yoshikawa","year":"2014","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0059","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1348-0421.12754","article-title":"Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs","volume":"64","author":"Sekimukai","year":"2020","journal-title":"Microbiol Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102768_bib0060","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1371\/journal.pmed.0030525","article-title":"Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants","volume":"3","author":"Deming","year":"2006","journal-title":"PLoS Med"},{"issue":"Pt 3","key":"10.1016\/j.ebiom.2020.102768_bib0061","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1099\/vir.0.81579-0","article-title":"Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus","volume":"87","author":"See","year":"2006","journal-title":"J Gen Virol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102768_bib0062","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.immuni.2019.08.007","article-title":"Immunological lessons from respiratory syncytial virus vaccine development","volume":"51","author":"Ruckwardt","year":"2019","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102768_bib0063","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/infdis\/jiz137","article-title":"A highly immunogenic, protective, and safe adenovirus-based vaccine expressing middle east respiratory syndrome coronavirus S1-CD40L fusion protein in a transgenic human Dipeptidyl peptidase 4 mouse model","volume":"220","author":"Hashem","year":"2019","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0064","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/mi.2017.46","article-title":"Airway T cells protect against RSV infection in the absence of antibody","volume":"11","author":"Kinnear","year":"2018","journal-title":"Mucosal Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006810","article-title":"Memory CD8 t cells mediate severe immunopathology following respiratory syncytial virus infection","volume":"14","author":"Schmidt","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2020.102768_bib0066","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-0-387-34814-8_3","article-title":"Understanding the role of innate immunity in the mechanism of action of the live attenuated Yellow Fever Vaccine 17D","volume":"590","author":"Querec","year":"2007","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0067","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ni.1688","article-title":"Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans","volume":"10","author":"Querec","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ebiom.2020.102768_bib0068","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"47","key":"10.1016\/j.ebiom.2020.102768_bib0069","doi-asserted-by":"crossref","first-page":"14688","DOI":"10.1073\/pnas.1508114112","article-title":"Asymptomatic humans transmit dengue virus to mosquitoes","volume":"112","author":"Duong","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1084\/jem.20061788","article-title":"The antiinflammatory activity of IgG: the intravenous IgG paradox","volume":"204","author":"Nimmerjahn","year":"2007","journal-title":"J Exp Med"},{"issue":"Pt 6","key":"10.1016\/j.ebiom.2020.102768_bib0071","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1099\/vir.0.000079","article-title":"Anti-inflammatory activity of intravenous immunoglobulins protects against West Nile virus encephalitis","volume":"96","author":"Srivastava","year":"2015","journal-title":"J Gen Virol"},{"issue":"30","key":"10.1016\/j.ebiom.2020.102768_bib0072","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1073\/pnas.1106568108","article-title":"Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection","volume":"108","author":"Chan","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2020.102768_bib0073","first-page":"674","article-title":"Immunomodulation by IVIg and the role of Fc-gamma receptors: classic mechanisms of action after all","volume":"5","author":"Nagelkerke","year":"2014","journal-title":"Front Immunol"},{"issue":"25","key":"10.1016\/j.ebiom.2020.102768_bib0074","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1182\/blood-2014-05-576835","article-title":"Inhibition of Fc\u03b3R-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and Fc\u03b3RIIB in human macrophages","volume":"124","author":"Nagelkerke","year":"2014","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.ebiom.2020.102768_bib0075","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/intimm\/dxx039","article-title":"IVIG-mediated effector functions in autoimmune and inflammatory diseases","volume":"29","author":"Galeotti","year":"2017","journal-title":"Int Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102768_bib0076","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.4049\/jimmunol.181.9.6337","article-title":"Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV","volume":"181","author":"Yasui","year":"2008","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102768_bib0077","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.vaccine.2007.11.092","article-title":"Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoV","volume":"26","author":"Lokugamage","year":"2008","journal-title":"Vaccine"},{"issue":"Pt 9","key":"10.1016\/j.ebiom.2020.102768_bib0078","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1099\/vir.0.2008\/001891-0","article-title":"Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines","volume":"89","author":"See","year":"2008","journal-title":"J Gen Virol"},{"issue":"15","key":"10.1016\/j.ebiom.2020.102768_bib0079","doi-asserted-by":"crossref","first-page":"7721","DOI":"10.1128\/JVI.00304-08","article-title":"A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters","volume":"82","author":"Lamirande","year":"2008","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102768_bib0080","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/vim.2010.0028","article-title":"Immunogenicity and protective efficacy in mice and hamsters of a beta-propiolactone inactivated whole virus SARS-CoV vaccine","volume":"23","author":"Roberts","year":"2010","journal-title":"Viral Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102768_bib0081","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.vaccine.2006.08.011","article-title":"Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro","volume":"25","author":"Kam","year":"2007","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.ebiom.2020.102768_bib0082","doi-asserted-by":"crossref","DOI":"10.3390\/v10090480","article-title":"Improved immune responses against Zika virus after sequential dengue and Zika virus infection in humans","volume":"10","author":"Delgado","year":"2018","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102768_bib0083","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/1096-9071(20000201)63:2<150::AID-JMV1010>3.0.CO;2-A","article-title":"Antibody-dependent enhancement of heterotypic dengue infections involved in suppression of IFNgamma production","volume":"63","author":"Yang","year":"2001","journal-title":"J Med Virol"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102768_bib0084","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.4049\/jimmunol.1401597","article-title":"CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice","volume":"193","author":"Zellweger","year":"2014","journal-title":"J Immunol"},{"issue":"24","key":"10.1016\/j.ebiom.2020.102768_bib0085","doi-asserted-by":"crossref","first-page":"e94500","DOI":"10.1172\/jci.insight.94500","article-title":"Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies","volume":"2","author":"Lam","year":"2017","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102768_bib0086","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3851\/IMP2735","article-title":"Evaluation of protective efficacy of the synthetic peptide vaccine containing the T-helper 1 epitope with CpG oligodeoxynucleotide against feline infectious peritonitis virus infection in cats","volume":"19","author":"Takano","year":"2014","journal-title":"Antivir Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0087","doi-asserted-by":"crossref","DOI":"10.3390\/v10010038","article-title":"A built-in cpg adjuvant in RSV F protein DNA vaccine drives a Th1 polarized and enhanced protective immune response","volume":"10","author":"Ma","year":"2018","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102768_bib0088","doi-asserted-by":"crossref","first-page":"16648","DOI":"10.1038\/s41598-018-34999-z","article-title":"Targeting CD40 enhances antibody- and CD8-mediated protection against respiratory syncytial virus infection","volume":"8","author":"Muralidharan","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2020.102768_bib0089","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.imlet.2016.09.011","article-title":"DNA vaccine encoding central conserved region of G protein induces Th1 predominant immune response and protection from RSV infection in mice","volume":"179","author":"Hua","year":"2016","journal-title":"Immunol Lett"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420301432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420301432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:09:54Z","timestamp":1715044194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396420301432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":89,"alternative-id":["S2352396420301432"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102768","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102768"}}