{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:42:25Z","timestamp":1792852945426,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013248","name":"Family Process Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BIO2016-77639-P"],"award-info":[{"award-number":["BIO2016-77639-P"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PCIN-2016 \u2013 082"],"award-info":[{"award-number":["PCIN-2016 \u2013 082"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ebiom.2020.102771","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T03:01:31Z","timestamp":1587783691000},"page":"102771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy"],"prefix":"10.1016","volume":"55","author":[{"given":"S\u00f3nia","family":"Castanheira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"L\u00f3pez-Escarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Graciela","family":"Pucciarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Cestero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Baquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-0530","authenticated-orcid":false,"given":"Francisco","family":"Garc\u00eda-del Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0001","first-page":"346","article-title":"The global burden of typhoid fever","volume":"82","author":"Crump","year":"2004","journal-title":"Bull World Health Organ"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0002","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MTBP-0009-2016","article-title":"Salmonella intracellular lifestyles and their impact on host-to-host transmission","volume":"5","author":"Pucciarelli","year":"2017","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.ebiom.2020.102771_bib0003","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fcimb.2017.00428","article-title":"Evolution of salmonella-host cell interactions through a dynamic bacterial genome","volume":"7","author":"Ilyas","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0004","first-page":"527","article-title":"Typhoidal Salmonella serovars: ecological opportunity and the evolution of a new pathovar","volume":"42","author":"Hiyoshi","year":"2018","journal-title":"FEMS Microbiol Rev"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102771_bib0005","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijantimicag.2014.02.009","article-title":"Nanocarriers for antibiotics: a promising solution to treat intracellular bacterial infections","volume":"43","author":"Abed","year":"2014","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102771_bib0006","article-title":"Intracellular penetration and effects of antibiotics on Staphylococcus aureus inside human neutrophils: a comprehensive review","volume":"8","author":"Bongers","year":"2019","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.ebiom.2020.102771_bib0007","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mib.2017.09.008","article-title":"Heterogeneity of Salmonella-Host interactions in infected host tissues","volume":"39","author":"Bumann","year":"2017","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ebiom.2020.102771_bib0008","first-page":"8","article-title":"Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues","author":"Bumann","year":"2019","journal-title":"F1000Res."},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0009","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.ARBA-0014-2017","article-title":"Antimicrobial resistance in nontyphoidal Salmonella","volume":"6","author":"McDermott","year":"2018","journal-title":"Microbiol Spectr"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102771_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006779","article-title":"A systematic review of antimicrobial resistance in Salmonella enterica serovar typhi, the etiological agent of typhoid","volume":"12","author":"Britto","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2020.102771_bib0011","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1469-0691.2011.03552.x","article-title":"Treatment of typhoid fever in the 21st century: promises and shortcomings","volume":"17","author":"Butler","year":"2011","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0012","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/clinids\/9.4.719","article-title":"Treatment of typhoid fever and other systemic salmonelloses with cefotaxime, ceftriaxone, cefoperazone, and other newer cephalosporins","volume":"9","author":"Soe","year":"1987","journal-title":"Rev Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102771_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1469-0691.2000.00036.x","article-title":"Relapse of multiresistant Salmonella typhi after combined therapy with ciprofloxacin and ceftriaxone","volume":"6","author":"Dragsted","year":"2000","journal-title":"Clin Microbiol Infect"},{"issue":"22","key":"10.1016\/j.ebiom.2020.102771_bib0014","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid fever","volume":"347","author":"Parry","year":"2002","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1473-3099(15)00530-7","article-title":"Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial","volume":"16","author":"Arjyal","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2020.102771_bib0016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4269\/ajtmh.15-0714","article-title":"Case series of imported enteric fever at a referral center in Tokyo, Japan: antibiotic susceptibility and risk factors for relapse","volume":"95","author":"Matono","year":"2016","journal-title":"Am J Trop Med Hyg."},{"issue":"3","key":"10.1016\/j.ebiom.2020.102771_bib0017","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1128\/JB.01206-07","article-title":"Modulation of horizontally acquired genes by the HHA-YDGT proteins in Salmonella enterica serovar Typhimurium","volume":"190","author":"Vivero","year":"2008","journal-title":"J Bacteriol"},{"issue":"4\u20135","key":"10.1016\/j.ebiom.2020.102771_bib0018","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<813::AID-ELPS813>3.0.CO;2-Q","article-title":"Regulation of virulence genes by environmental signals in Salmonella typhimurium","volume":"20","author":"Deiwick","year":"1999","journal-title":"Electrophoresis"},{"issue":"12","key":"10.1016\/j.ebiom.2020.102771_bib0019","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.ebiom.2020.102771_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0378-1119(02)00551-6","article-title":"Construction of targeted single copy lac fusions using lambda red and FLP-mediated site-specific recombination in bacteria","volume":"290","author":"Ellermeier","year":"2002","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.ebiom.2020.102771_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01685-17","article-title":"A specialized peptidoglycan synthase promotes Salmonella cell division inside host cells","volume":"8","author":"Castanheira","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.ebiom.2020.102771_bib0022","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1038\/srep09374","article-title":"Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells","volume":"5","author":"Lobato-Marquez","year":"2015","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.ebiom.2020.102771_bib0023","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1128\/jb.172.10.5863-5870.1990","article-title":"Differential effect of mutational impairment of penicillin-binding proteins 1A and 1B on Escherichia coli strains harboring thermosensitive mutations in the cell division genes ftsA, ftsQ, ftsZ, and pbpB","volume":"172","author":"Garcia del Portillo","year":"1990","journal-title":"J Bacteriol"},{"issue":"3","key":"10.1016\/j.ebiom.2020.102771_bib0024","doi-asserted-by":"crossref","first-page":"165","DOI":"10.15698\/mic2018.03.622","article-title":"Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles","volume":"5","author":"Castanheira","year":"2018","journal-title":"Microb Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2020.102771_bib0025","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.72.8.2999","article-title":"Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12","volume":"72","author":"Spratt","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6167","key":"10.1016\/j.ebiom.2020.102771_bib0026","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.1244705","article-title":"Internalization of Salmonella by macrophages induces formation of nonreplicating persisters","volume":"343","author":"Helaine","year":"2014","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0027","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cell.2014.06.045","article-title":"Phenotypic variation of Salmonella in host tissues delays eradication by antimicrobial chemotherapy","volume":"158","author":"Claudi","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ebiom.2020.102771_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001793","article-title":"Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment","volume":"12","author":"Kaiser","year":"2014","journal-title":"PLoS Biol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0029","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/AAC.43.5.1124","article-title":"BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins","volume":"43","author":"Zhao","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0030","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1128\/AAC.04552-14","article-title":"Profiling of beta-lactam selectivity for penicillin-binding proteins in Escherichia coli strain DC2","volume":"59","author":"Kocaoglu","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2020.102771_bib0031","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-4615-4143-1_28","article-title":"Of mice, calves, and men Comparison of the mouse typhoid model with other Salmonella infections","volume":"473","author":"Tsolis","year":"1999","journal-title":"Adv Exp Med Biol."},{"issue":"10","key":"10.1016\/j.ebiom.2020.102771_bib0032","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3855\/jidc.1192","article-title":"Factors associated with typhoid relapse in the era of multiple drug resistant strains","volume":"5","author":"Ahmad","year":"2011","journal-title":"J Infect Dev Ctries"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0033","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nrmicro.2016.34","article-title":"Distinguishing between resistance, tolerance and persistence to antibiotic treatment","volume":"14","author":"Brauner","year":"2016","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0034","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1128\/IAI.01033-10","article-title":"Dissemination of persistent intestinal bacteria via the mesenteric lymph nodes causes typhoid relapse","volume":"79","author":"Griffin","year":"2011","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.ebiom.2020.102771_bib0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/mi.2011.2","article-title":"Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda","volume":"4","author":"Griffin","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.102771_bib0036","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1462-5822.2006.00706.x","article-title":"Manipulating cellular transport and immune responses: dynamic interactions between intracellular Salmonella enterica and its host cells","volume":"8","author":"Abrahams","year":"2006","journal-title":"Cell Microbiol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420301468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420301468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:10:42Z","timestamp":1715044242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396420301468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":36,"alternative-id":["S2352396420301468"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102771","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.102771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102771"}}