{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:22:45Z","timestamp":1771651365325,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007041","name":"Universidad de Zaragoza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ebiom.2020.103186","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T06:09:09Z","timestamp":1610950149000},"page":"103186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment"],"prefix":"10.1016","volume":"64","author":[{"given":"Raquel","family":"Taranc\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Uranga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Bel\u00e9n","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dessislava","family":"Marinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Otal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-9173","authenticated-orcid":false,"given":"Nacho","family":"Aguil\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6710","key":"10.1016\/j.ebiom.2020.103186_bib0001","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.ebiom.2020.103186_bib0002","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41591-019-0469-4","article-title":"Farm-like indoor microbiota in non-farm homes protects children from asthma development","volume":"25","author":"Kirjavainen","year":"2019","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2020.103186_bib0003","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1508749","article-title":"Innate immunity and asthma risk in Amish and Hutterite farm children","volume":"375","author":"Stein","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2020.103186_bib0004","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1038\/nrdp.2015.25","article-title":"Asthma","volume":"1","author":"Holgate","year":"2015","journal-title":"Nat Rev Dis Primers."},{"issue":"5","key":"10.1016\/j.ebiom.2020.103186_bib0005","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0006","doi-asserted-by":"crossref","first-page":"L358","DOI":"10.1152\/ajplung.00341.2014","article-title":"Distinct macrophage phenotypes in allergic and nonallergic lung inflammation","volume":"308","author":"Robbe","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ebiom.2020.103186_bib0007","first-page":"35","article-title":"FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma","volume":"74","author":"Chung","year":"2018","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0008","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1165\/rcmb.2015-0295OC","article-title":"Alternative macrophage activation is increased in asthma","volume":"55","author":"Girodet","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"12","key":"10.1016\/j.ebiom.2020.103186_bib0009","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2020.103186_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2017.09.002","article-title":"Macrophage polarization and allergic asthma","volume":"191","author":"Saradna","year":"2018","journal-title":"Transl Res"},{"issue":"3","key":"10.1016\/j.ebiom.2020.103186_bib0011","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1067\/mai.2001.117457","article-title":"Antigen-presenting cells in allergy","volume":"108","author":"von Bubnoff","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0012","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jaci.2010.06.010","article-title":"Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore-induced allergic airway disease","volume":"126","author":"Moreira","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2020.103186_bib0013","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/cea.13582","article-title":"GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1\u03b1-induced eosinophilic airway inflammation","volume":"50","author":"Sokulsky","year":"2020","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"10.1016\/j.ebiom.2020.103186_bib0014","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jaci.2013.08.007","article-title":"Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis","volume":"133","author":"Linehan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.103186_bib0015","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1067\/mai.2000.111241","article-title":"BCG scar diameter and asthma: a case-control study","volume":"106","author":"Sarinho","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.103186_bib0016","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S1081-1206(10)61890-X","article-title":"Therapeutic effects of BCG vaccination in adult asthmatic patients: a randomized, controlled trial","volume":"88","author":"Choi","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0017","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.187.4.561","article-title":"Infection of mice with mycobacterium bovis-bacillus calmette-guerin (BCG) suppresses allergen-induced airway eosinophilia","volume":"187","author":"Erb","year":"1998","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.ebiom.2020.103186_bib0018","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jaci.2007.09.033","article-title":"Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models","volume":"121","author":"Lagranderie","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2020.103186_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106807","article-title":"Effects of mycobacteria major secretion protein, Ag85B, on allergic inflammation in the lung","volume":"9","author":"Tsujimura","year":"2014","journal-title":"PLoS ONE"},{"issue":"42","key":"10.1016\/j.ebiom.2020.103186_bib0020","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.vaccine.2013.07.051","article-title":"Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials","volume":"31","author":"Arbues","year":"2013","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.ebiom.2020.103186_bib0021","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S2213-2600(15)00435-X","article-title":"Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial","volume":"3","author":"Spertini","year":"2015","journal-title":"Lancet Respir Med"},{"issue":"9","key":"10.1016\/j.ebiom.2020.103186_bib0022","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S2213-2600(19)30251-6","article-title":"Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial","volume":"7","author":"Tameris","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"40","key":"10.1016\/j.ebiom.2020.103186_bib0023","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1016\/j.vaccine.2014.07.047","article-title":"Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice","volume":"32","author":"Solans","year":"2014","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.ebiom.2020.103186_bib0024","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.4049\/jimmunol.1004227","article-title":"A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma","volume":"188","author":"Reber","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2020.103186_bib0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.smim.2017.07.005","article-title":"Windows of opportunity for tolerance induction for allergy by studying the evolution of allergic sensitization in birth cohorts","volume":"30","author":"Westman","year":"2017","journal-title":"Semin Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.103186_bib0026","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/14760584.2017.1324303","article-title":"MTBVAC from discovery to clinical trials in tuberculosis-endemic countries","volume":"16","author":"Marinova","year":"2017","journal-title":"Expert Rev Vaccines"},{"issue":"9","key":"10.1016\/j.ebiom.2020.103186_bib0027","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa030595","article-title":"Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland","volume":"350","author":"Mutsch","year":"2004","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ebiom.2020.103186_bib0028","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.103186_bib0029","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2222.2007.02859.x","article-title":"Bacille-Calmette-Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single-blind study","volume":"38","author":"Steenhuis","year":"2008","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.ebiom.2020.103186_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.07.039","article-title":"BCG vaccination and allergy: a systematic review and meta-analysis","volume":"127","author":"Arnoldussen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2020.103186_bib0031","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/thorax.55.6.449","article-title":"International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema","volume":"55","author":"von Mutius","year":"2000","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.ebiom.2020.103186_bib0032","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2222.2005.02408.x","article-title":"Mycobacterium tuberculosis infection may protect against allergy in a tuberculosis endemic area","volume":"36","author":"Obihara","year":"2006","journal-title":"Clin Exp Allergy"},{"issue":"12","key":"10.1016\/j.ebiom.2020.103186_bib0033","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/all.13923","article-title":"Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model","volume":"74","author":"Tarancon","year":"2019","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.ebiom.2020.103186_bib0034","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.5588\/ijtld.14.0018","article-title":"Value of adding an IGRA to the TST to screen for latent tuberculous infection in Greek health care workers","volume":"18","author":"Charisis","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2020.103186_bib0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/2229-5178.93479","article-title":"Mantoux test and its interpretation","volume":"3","author":"Surajit","year":"2012","journal-title":"Indian Dermatol Online J"},{"issue":"8","key":"10.1016\/j.ebiom.2020.103186_bib0036","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1034\/j.1398-9995.2001.056008788.x","article-title":"Asthma in pulmonary tuberculosis","volume":"56","author":"Koh","year":"2001","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.ebiom.2020.103186_bib0037","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jaci.2010.03.037","article-title":"Direct ex vivo analysis of allergen-specific CD4+ T cells","volume":"125","author":"Kwok","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2020.103186_bib0038","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11882-015-0587-0","article-title":"T cell epitope peptide therapy for allergic diseases","volume":"16","author":"O'Hehir","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2020.103186_bib0039","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri.2015.18","article-title":"Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease","volume":"16","author":"DuPage","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2020.103186_bib0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/0970-2113.92361","article-title":"Pulmonary drug delivery strategies: a concise, systematic review","volume":"29","author":"Patil","year":"2012","journal-title":"Lung India"},{"issue":"3","key":"10.1016\/j.ebiom.2020.103186_bib0041","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/trstmh\/tru206","article-title":"Aerosol immunisation for TB: matching route of vaccination to route of infection","volume":"109","author":"Manjaly Thomas","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"7788","key":"10.1016\/j.ebiom.2020.103186_bib0042","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41586-019-1817-8","article-title":"Prevention of tuberculosis in macaques after intravenous BCG immunization","volume":"577","author":"Darrah","year":"2020","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2020.103186_bib0043","article-title":"Protective Efficacy of Inhaled BCG Vaccination Against Ultra-Low Dose Aerosol M. tuberculosis Challenge in Rhesus Macaques","volume":"12","author":"AD","year":"2020","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0044","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/1097-0142(197504)35:4<1088::AID-CNCR2820350411>3.0.CO;2-2","article-title":"Aerosol BCG treatment of carcinoma metastatic to the lung: a phase I study","volume":"35","author":"Garner","year":"1975","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.ebiom.2020.103186_bib0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/02770906809100348","article-title":"Aerogenic BCG vaccination against tuberculosis in animal and human subjects","volume":"5","author":"Rosenthal","year":"1968","journal-title":"J Asthma Res"},{"issue":"9","key":"10.1016\/j.ebiom.2020.103186_bib0046","doi-asserted-by":"crossref","first-page":"e12978","DOI":"10.1371\/journal.pone.0012978","article-title":"Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages","volume":"5","author":"Ferrer","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2020.103186_bib0047","article-title":"A human lung challenge model to evaluate the safety and immunogenicity of PPD and Live BCG","author":"Davids","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"9842","key":"10.1016\/j.ebiom.2020.103186_bib0048","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420305624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396420305624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:01:24Z","timestamp":1762455684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396420305624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":48,"alternative-id":["S2352396420305624"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.103186","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2020.103186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103186"}}