{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:27:45Z","timestamp":1789993665733,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ebiom.2021.103239","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:20:31Z","timestamp":1612984831000},"page":"103239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia"],"prefix":"10.1016","volume":"64","author":[{"given":"Xuhan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoping","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0001","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuron.2006.09.015","article-title":"Neurobiology of schizophrenia","volume":"52","author":"Ross","year":"2006","journal-title":"Neuron"},{"issue":"18","key":"10.1016\/j.ebiom.2021.103239_bib0002","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJMra035458","volume":"349","author":"Schizophrenia","year":"2003","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0003","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.biopsych.2013.06.010","article-title":"Immune system disturbances in schizophrenia","volume":"75","author":"Horvath","year":"2014","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0004","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/acps.12265","article-title":"Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity","volume":"130","author":"Assies","year":"2014","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0006-3223(02)01443-9","article-title":"Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients","volume":"53","author":"Arvindakshan","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0006","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0920-9964(94)90043-4","article-title":"The membrane hypothesis of schizophrenia","volume":"13","author":"Horrobin","year":"1994","journal-title":"Schizophr Res"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0278-5846(00)00181-0","article-title":"Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia","volume":"25","author":"Mahadik","year":"2001","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0008","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bst0180503","article-title":"Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction","volume":"18","author":"Axelrod","year":"1990","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0009","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0920-9964(94)90045-0","article-title":"Red blood cell membrane dynamics in schizophrenia. II. Fatty acid composition","volume":"13","author":"Yao","year":"1994","journal-title":"Schizophr Res"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0920-9964(97)00151-5","article-title":"The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia","volume":"30","author":"Horrobin","year":"1998","journal-title":"Schizophr Res"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103239_bib0011","doi-asserted-by":"crossref","first-page":"e1176","DOI":"10.1038\/tp.2017.152","article-title":"Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study","volume":"7","author":"Yang","year":"2017","journal-title":"Transl Psychiatry"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103239_bib0012","first-page":"862","article-title":"Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro","volume":"23","author":"Agro","year":"1996","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103239_bib0013","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0952-3278(93)90176-W","article-title":"Arachidonic acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a prostacyclin-dependent mechanism","volume":"49","author":"Holladay","year":"1993","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0014","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0920-9964(99)00171-1","article-title":"Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics","volume":"44","author":"Kim","year":"2000","journal-title":"Schizophr Res"},{"key":"10.1016\/j.ebiom.2021.103239_bib0015","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pnpbp.2012.06.010","article-title":"Polyunsaturated fatty acids and their metabolites in the pathobiology of schizophrenia","volume":"42","author":"Das","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0016","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/2211556011302010073","article-title":"Polyunsaturated fatty acids and their metabolites in neural development and implications for psychiatric disorders","volume":"2","author":"Sakayori","year":"2013","journal-title":"Current Psychopharmacology"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103239_bib0017","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.plefa.2003.08.015","article-title":"Membrane polyunsaturated fatty acids and CSF cytokines in patients with schizophrenia","volume":"69","author":"Yao","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0018","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/schbul\/sbv130","article-title":"Prevalence and Specificity of the Abnormal Niacin Response: A Potential Endophenotype Marker in Schizophrenia","volume":"42","author":"Yao","year":"2016","journal-title":"Schizophr Bull"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0019","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/schbul\/sbx150","article-title":"Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population","volume":"44","author":"Sun","year":"2018","journal-title":"Schizophr Bull"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103239_bib0020","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0278-5846(03)00152-0","article-title":"On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis","volume":"27","author":"Maclean","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0021","doi-asserted-by":"crossref","DOI":"10.1186\/s12865-020-0334-8","article-title":"Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus","volume":"21","author":"Roy","year":"2020","journal-title":"BMC Immunology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"Yong","year":"2005","journal-title":"Cell research"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103239_bib0023","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00406-007-0736-0","article-title":"Association between BanI genotype and increased phospholipase A2 activity in schizophrenia","volume":"257","author":"Barbosa","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0024","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.plefa.2003.12.013","article-title":"The investigation of cytosolic phospholipase A2 using ELISA","volume":"70","author":"Macdonald","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.b.20156","article-title":"Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema","volume":"127B","author":"Covault","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1-2","key":"10.1016\/j.ebiom.2021.103239_bib0026","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0952-3278(96)90154-4","article-title":"Phospholipase A2 and the hypofrontality hypothesis of schizophrenia","volume":"55","author":"Gattaz","year":"1996","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103239_bib0027","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1007\/s12035-015-9355-3","article-title":"Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System","volume":"53","author":"Yagami","year":"2016","journal-title":"Mol Neurobiol"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103239_bib0028","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1007\/s12035-015-9355-3","article-title":"Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System","volume":"53","author":"Yagami","year":"2016","journal-title":"Molecular Neurobiology"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103239_bib0029","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/nn.4399","article-title":"Gene expression elucidates functional impact of polygenic risk for schizophrenia","volume":"19","author":"Fromer","year":"2016","journal-title":"Nat Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0030","doi-asserted-by":"crossref","first-page":"e32618","DOI":"10.1371\/journal.pone.0032618","article-title":"Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients","volume":"7","author":"van Beveren","year":"2012","journal-title":"PLoS One"},{"issue":"2-3","key":"10.1016\/j.ebiom.2021.103239_bib0031","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.psychres.2011.09.026","article-title":"Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia","volume":"196","author":"Tang","year":"2012","journal-title":"Psychiatry Res"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103239_bib0032","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/schbul\/sbt070","article-title":"Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials","volume":"39","author":"Nitta","year":"2013","journal-title":"Schizophr Bull"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103239_bib0033","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/schbul\/sby024","article-title":"Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations","volume":"44","author":"M\u00fcller","year":"2018","journal-title":"Schizophr Bull"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103239_bib0034","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.bbamcr.2007.09.001","article-title":"Regulation of cyclooxygenase-2 expression by cyclic AMP","volume":"1773","author":"Klein","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0035","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/endo.143.3.8680","article-title":"Inhibition of Cyclooxygenase-2 by Natriuretic Peptides","volume":"143","author":"Kiemer","year":"2002","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0036","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/imm.12309","article-title":"Calcium\/calmodulin-dependent protein kinase II regulates cyclooxygenase-2 expression and prostaglandin E2 production by activating cAMP-response element-binding protein in rat peritoneal macrophages","volume":"143","author":"Zhou","year":"2014","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0037","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.gpb.2014.09.005","article-title":"Lipidomic and Metabolomic Analysis of Cyclooxygenase-null Cells: Eicosanoid Storm, Cross Talk, and Compensation by COX-1","volume":"14","author":"Islam","year":"2016","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.ebiom.2021.103239_bib0038","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-2094-5-17","article-title":"Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2","volume":"5","author":"Aid","year":"2008","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ebiom.2021.103239_bib0039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1741-7015-11-74","article-title":"Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0952-3278(98)90109-0","article-title":"Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects","volume":"58","author":"Das","year":"1998","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0041","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01255817","article-title":"Elevated plasma prostaglandin E2 levels in schizophrenia","volume":"77","author":"Kaiya","year":"1989","journal-title":"J Neural Transm"},{"key":"10.1016\/j.ebiom.2021.103239_bib0042","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.eurpsy.2017.09.007","article-title":"Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls","volume":"47","author":"Garc\u00eda-\u00c1lvarez","year":"2020","journal-title":"European Psychiatry"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0043","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1471-4159.1997.68020704.x","article-title":"Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells","volume":"68","author":"Fiebich","year":"1997","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0044","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.bjp.0704705","article-title":"Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts","volume":"136","author":"Inoue","year":"2002","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103239_bib0045","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1471-4159.2005.03050.x","article-title":"Up-regulation of interleukin-6 induced by prostaglandin E from invading macrophages following nerve injury: an in vivo and in vitro study","volume":"93","author":"Ma","year":"2005","journal-title":"J Neurochem"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103239_bib0046","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1073\/pnas.93.10.4885","article-title":"Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2","volume":"93","author":"Hinson","year":"1996","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0047","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuroscience.2006.10.055","article-title":"Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS","volume":"145","author":"Oka","year":"2007","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103239_bib0048","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/jnr.21620","article-title":"Ciliary neurotrophic factor and interleukin-6 differentially activate microglia","volume":"86","author":"Krady","year":"2008","journal-title":"J Neurosci Res"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103239_bib0049","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.imbio.2011.07.006","article-title":"Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets","volume":"216","author":"Aravena","year":"2011","journal-title":"Immunobiology"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0050","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1073\/pnas.94.4.1500","article-title":"Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain","volume":"94","author":"Heyser","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103239_bib0051","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3389\/fphar.2019.01244","article-title":"Measurement of Thromboxane Biosynthesis in Health and Disease","volume":"10","author":"Patrono","year":"2019","journal-title":"Front Pharmacol"},{"issue":"9-10","key":"10.1016\/j.ebiom.2021.103239_bib0052","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0028-3908(96)00059-7","article-title":"Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2","volume":"35","author":"Schwartz-Bloom","year":"1996","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103239_bib0053","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1460-9568.2011.07774.x","article-title":"Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake","volume":"34","author":"Mitsumori","year":"2011","journal-title":"European Journal of Neuroscience"},{"issue":"1-2","key":"10.1016\/j.ebiom.2021.103239_bib0054","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0952-3278(96)90139-8","article-title":"Membrane fatty acids, niacin flushing and clinical parameters","volume":"55","author":"Glen","year":"1996","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(02)00281-5","article-title":"Increased phospholipase A2 activity in schizophrenia with absent response to niacin","volume":"61","author":"Tavares","year":"2003","journal-title":"Schizophr Res"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103239_bib0056","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.plefa.2006.02.002","article-title":"Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls","volume":"74","author":"Nilsson","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103239_bib0057","doi-asserted-by":"crossref","first-page":"898","DOI":"10.2146\/ajhp160219","article-title":"Randomized controlled trial of different aspirin regimens for reduction of niacin-induced flushing","volume":"74","author":"Banka","year":"2017","journal-title":"Am J Health Syst Pharm"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0058","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jacl.2011.01.002","article-title":"Persistent erythema with niacin is not attributable to aspirin resistance","volume":"5","author":"Babcock","year":"2011","journal-title":"J Clin Lipidol"},{"issue":"16","key":"10.1016\/j.ebiom.2021.103239_bib0059","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103239_bib0060","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41467-019-09492-4","article-title":"The cyclooxygenase-1\/mPGES-1\/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103239_bib0061","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.plefa.2012.11.005","article-title":"The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients","volume":"88","author":"Nadalin","year":"2013","journal-title":"Prostaglandins Leukot Essent Fatty Acids"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:00:59Z","timestamp":1762455659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421000323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":61,"alternative-id":["S2352396421000323"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103239","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103239"}}