{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:06:25Z","timestamp":1778133985877,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009781","name":"Australian Centre for HIV and Hepatitis Virology Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002716","name":"Alfred Research Trusts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ebiom.2021.103252","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T05:16:17Z","timestamp":1614230177000},"page":"103252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-5572","authenticated-orcid":false,"given":"James H.","family":"McMahon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-661X","authenticated-orcid":false,"given":"Jennifer M.","family":"Zerbato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian S.Y.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn L.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Tumpach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashanti","family":"Dantanarayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajantha","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene A.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Alt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Hagenauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Roney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"O'Bryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Beech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme J.","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-8804","authenticated-orcid":false,"given":"Christian W.","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze-Ting","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Caskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel C.","family":"Nussenzweig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph E.","family":"Hagemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon R.","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2021.103252_bib0001","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/387183a0","article-title":"Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection","volume":"387","author":"Chun","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2021.103252_bib0002","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2021.103252_bib0003","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nm.4411","article-title":"Defining total-body AIDS-virus burden with implications for curative strategies","volume":"23","author":"Estes","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2021.103252_bib0004","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.1318249111","article-title":"Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues","volume":"111","author":"Fletcher","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103252_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007619","article-title":"Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection","volume":"15","author":"Pardons","year":"2019","journal-title":"PLoS pathogens"},{"key":"10.1016\/j.ebiom.2021.103252_bib0006","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41591-019-0412-8","article-title":"Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic","volume":"25","author":"Caskey","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2021.103252_bib0007","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2967\/jnumed.113.122630","article-title":"Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET","volume":"55","author":"Mortimer","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ebiom.2021.103252_bib0008","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12325-018-0711-3","article-title":"Application of Cu-64 NODAGA-PSMA PET in Prostate Cancer","volume":"35","author":"Sevcenco","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.ebiom.2021.103252_bib0009","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nmeth.3320","article-title":"Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques","volume":"12","author":"Santangelo","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.ebiom.2021.103252_bib0010","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.1207227","article-title":"Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding","volume":"333","author":"Scheid","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2021.103252_bib0011","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature14411","article-title":"Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117","volume":"522","author":"Caskey","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2021.103252_bib0012","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature18929","article-title":"HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption","volume":"535","author":"Scheid","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2021.103252_bib0013","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.aaf1279","article-title":"Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo","volume":"352","author":"Lu","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2021.103252_bib0014","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1742-4690-4-89","article-title":"Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS","volume":"4","author":"Sterjovski","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2021.103252_bib0015","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01736-19","article-title":"CXCR4-using HIV strains predominate in naive and central memory CD4(+) T cells in people living with HIV on antiretroviral therapy: implications for how latency is established and maintained","volume":"94","author":"Roche","year":"2020","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2021.103252_bib0016","series-title":"Proceedings of the 4th International Workshop on Targetry and Target Chemistry AIP Conf Proc","first-page":"114","article-title":"Automated production of 124 I and 64 Cu using IBA Terimo and Pinctada metal electroplating and processing modules","volume":"1509","author":"Ponigera","year":"2012"},{"key":"10.1016\/j.ebiom.2021.103252_bib0017","first-page":"1","article-title":"Using the Student's t-test with extremely small sample sizes","volume":"18","author":"de Winter","year":"2013","journal-title":"Pract Assess Res Eval"},{"key":"10.1016\/j.ebiom.2021.103252_bib0018","first-page":"3","article-title":"Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals","volume":"304","author":"Siliciano","year":"2005","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ebiom.2021.103252_bib0019","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ebiom.2018.09.036","article-title":"Improved assays to measure and characterize the inducible HIV reservoir","volume":"36","author":"Massanella","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2021.103252_bib0020","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1128\/JVI.79.16.10108-10125.2005","article-title":"Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies","volume":"79","author":"Li","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2021.103252_bib0021","unstructured":"Reeves J, Zheng Y, Olefsky M, et\u00a0al. Susceptibility to anti-HIV bnAbs is concordant in pre-ART plasma and on-ART PBMC samples: ACTG NWCS413. Conference for Retroviruses and Opportunistic Infections. Seattle, WA, USA2019."},{"key":"10.1016\/j.ebiom.2021.103252_bib0022","unstructured":"MIM Software Inc. https:\/\/www.mimsoftware.com 11 March 2020."},{"key":"10.1016\/j.ebiom.2021.103252_bib0023","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0146645316661077","article-title":"ICRP Publication 133: The ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions","volume":"45","author":"Bolch","year":"2016","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ebiom.2021.103252_bib0024","article-title":"1990 recommendations of the international commission on radiological protection. ICRP Publication 60","volume":"21","year":"1991","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ebiom.2021.103252_bib0025","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1021\/mp500209a","article-title":"Single-chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets","volume":"11","author":"Alt","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ebiom.2021.103252_bib0026","unstructured":"ARPANSA. Code of practice for exposure of humans to ionizing radiation for research purposes. 2015:1-36."},{"key":"10.1016\/j.ebiom.2021.103252_bib0027","series-title":"Handbook of anticancer pharmacokinetics and pharmacodynamics","article-title":"Pharmacokinetics of Antibodies and Immunotoxins in Mice and Humans","author":"Ghetie","year":"2004"},{"key":"10.1016\/j.ebiom.2021.103252_bib0028","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1208\/s12248-018-0203-z","article-title":"Receptor occupancy imaging studies in oncology drug development","volume":"20","author":"Burvenich","year":"2018","journal-title":"AAPS J"},{"key":"10.1016\/j.ebiom.2021.103252_bib0029","doi-asserted-by":"crossref","first-page":"15812","DOI":"10.1073\/pnas.2634931100","article-title":"Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions","volume":"100","author":"Zhu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103252_bib0030","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1128\/JVI.76.11.5315-5325.2002","article-title":"Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120\/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus","volume":"76","author":"Chertova","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2021.103252_bib0031","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4137\/BIC.S38542","article-title":"Selecting targets for tumor imaging: an overview of cancer-associated membrane proteins","volume":"8","author":"Boonstra","year":"2016","journal-title":"Biomark Cancer"},{"key":"10.1016\/j.ebiom.2021.103252_bib0032","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00895-18","article-title":"Susceptibility to neutralization by broadly neutralizing antibodies generally correlates with infected cell binding for a panel of clade B HIV reactivated from latent reservoirs","volume":"92","author":"Ren","year":"2018","journal-title":"J Virol"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:05:29Z","timestamp":1762455929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421000451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":32,"alternative-id":["S2352396421000451"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103252","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103252"}}