{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:23:35Z","timestamp":1781663015421,"version":"3.54.5"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010127","name":"J\u00fcrgen Manchot Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017147","name":"International Progressive MS Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ebiom.2021.103276","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T03:54:34Z","timestamp":1615434874000},"page":"103276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-427X","authenticated-orcid":false,"given":"Anastasia","family":"Manousi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-0956","authenticated-orcid":false,"given":"Peter","family":"G\u00f6ttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-9925","authenticated-orcid":false,"given":"Laura","family":"Reiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Ling","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9496-2216","authenticated-orcid":false,"given":"Luke M.","family":"Healy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Akkermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4894-4679","authenticated-orcid":false,"given":"Joel","family":"Gruchot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schira-Heinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack P.","family":"Antel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-1126","authenticated-orcid":false,"given":"Patrick","family":"K\u00fcry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0001","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.ebiom.2021.103276_bib0002","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00109-006-0065-1","article-title":"Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain","volume":"84","author":"Becher","year":"2006","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0003","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40478-014-0097-7","article-title":"Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?","volume":"2","author":"Lee","year":"2014","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0004","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103276_bib0005","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrn.2017.136","article-title":"Regenerating CNS myelin - from mechanisms to experimental medicines","volume":"18","author":"Franklin","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"Pt 7","key":"10.1016\/j.ebiom.2021.103276_bib0006","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/brain\/awr014","article-title":"Enhancing remyelination in disease\u2013can we wrap it up?","volume":"134","author":"Kotter","year":"2011","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0007","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.tins.2016.02.004","article-title":"Pushing forward: remyelination as the new frontier in CNS diseases","volume":"39","author":"Kremer","year":"2016","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.ebiom.2021.103276_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080825","article-title":"The molecular basis for remyelination failure in multiple sclerosis","volume":"8","author":"Gruchot","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0009","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.22415","article-title":"The complex world of oligodendroglial differentiation inhibitors","volume":"69","author":"Kremer","year":"2011","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1352458518800827","article-title":"Current advancements in promoting remyelination in multiple sclerosis","volume":"25","author":"Kremer","year":"2018","journal-title":"Multiple Sclerosis J"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0011","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/WCO.0000000000000692","article-title":"Remyelination in multiple sclerosis","volume":"32","author":"Kremer","year":"2019","journal-title":"Curr. Opin. Neurol."},{"issue":"6","key":"10.1016\/j.ebiom.2021.103276_bib0012","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.conb.2013.06.005","article-title":"Intrinsic and extrinsic control of oligodendrocyte development","volume":"23","author":"Zuchero","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"25","key":"10.1016\/j.ebiom.2021.103276_bib0013","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1073\/pnas.0802659105","article-title":"The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination","volume":"105","author":"Heinen","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"22","key":"10.1016\/j.ebiom.2021.103276_bib0014","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1073\/pnas.0900204106","article-title":"p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation","volume":"106","author":"Kremer","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"18","key":"10.1016\/j.ebiom.2021.103276_bib0015","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1242\/dev.074518","article-title":"p57kip2 regulates glial fate decision in adult neural stem cells","volume":"139","author":"Jadasz","year":"2012","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0016","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1523\/JNEUROSCI.1423-14.2015","article-title":"Oligodendroglial maturation is dependent on intracellular protein shuttling","volume":"35","author":"G\u00f6ttle","year":"2015","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103276_bib0017","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1358\/dnp.2009.22.2.1343228","article-title":"The value of drug repositioning in the current pharmaceutical market","volume":"22","author":"Tobinick","year":"2009","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.ebiom.2021.103276_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2019.01.009","article-title":"Drug repurposing: old drugs, new tricks to fast track drug development for the brain","volume":"147","author":"Gasparini","year":"2019","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103276_bib0019","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.4103\/1673-5374.235242","article-title":"Drug repurposing for neuroregeneration in multiple sclerosis","volume":"13","author":"K\u00fcry","year":"2018","journal-title":"Neural Regen Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0020","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1110-z","article-title":"Teriflunomide promotes oligodendroglial differentiation and myelination","volume":"15","author":"G\u00f6ttle","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"7471","key":"10.1016\/j.ebiom.2021.103276_bib0021","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12647","article-title":"A regenerative approach to the treatment of multiple sclerosis","volume":"502","author":"Deshmukh","year":"2013","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103276_bib0022","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.3618","article-title":"Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis","volume":"20","author":"Mei","year":"2014","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.ebiom.2021.103276_bib0023","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/glia.23306","article-title":"Vitamin C promotes oligodendrocytes generation and remyelination","volume":"66","author":"Guo","year":"2018","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103276_bib0024","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/glia.23606","article-title":"Inhibition of MAPK\/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases","volume":"67","author":"Suo","year":"2019","journal-title":"Glia"},{"issue":"7718","key":"10.1016\/j.ebiom.2021.103276_bib0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41586-018-0360-3","article-title":"Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination","volume":"560","author":"Hubler","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103276_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189380","article-title":"Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103276_bib0027","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/1352458514566419","article-title":"Promoting remyelination in multiple sclerosis: current drugs and future prospects","volume":"21","author":"Kremer","year":"2015","journal-title":"Multiple Sclerosis J"},{"key":"10.1016\/j.ebiom.2021.103276_bib0028","article-title":"Promoting remyelination in multiple sclerosis","author":"Cunniffe","year":"2019","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0029","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1083\/jcb.85.3.890","article-title":"Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue","volume":"85","author":"McCarthy","year":"1980","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.21227","article-title":"FTY720 modulates human oligodendrocyte progenitor process extension and survival","volume":"63","author":"Miron","year":"2008","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0031","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/glia.23233","article-title":"Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis","volume":"66","author":"Jadasz","year":"2018","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103276_bib0032","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/NEN.0b013e3181ef3be4","article-title":"Response of human oligodendrocyte progenitors to growth factors and axon signals","volume":"69","author":"Cui","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103276_bib0033","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1089\/scd.2011.0494","article-title":"Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate","volume":"21","author":"Cui","year":"2012","journal-title":"Stem Cells Dev."},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0034","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/acn3.55","article-title":"Heterogeneity of oligodendrocyte progenitor cells in adult human brain","volume":"1","author":"Leong","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.ebiom.2021.103276_bib0035","unstructured":"Franklin KBJ, Paxinos G. The mouse brain in stereotaxic coordinates. 3 ed. New York: Elsevier2008."},{"issue":"2","key":"10.1016\/j.ebiom.2021.103276_bib0036","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/acn3.159","article-title":"Cuprizone does not induce CNS demyelination in nonhuman primates","volume":"2","author":"Chen","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0037","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0038","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.chembiol.2019.01.004","article-title":"Diverse chemical scaffolds enhance oligodendrocyte formation by inhibiting CYP51, TM7SF2, or EBP","volume":"26","author":"Allimuthu","year":"2019","journal-title":"Cell Chemical Biology"},{"issue":"7555","key":"10.1016\/j.ebiom.2021.103276_bib0039","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature14335","article-title":"Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo","volume":"522","author":"Najm","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13104-016-2220-2","article-title":"A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells","volume":"9","author":"Lariosa-Willingham","year":"2016","journal-title":"BMC Res Notes"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0041","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuropharm.2010.04.014","article-title":"Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects","volume":"59","author":"Buckley","year":"2010","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146503","article-title":"CXCR7 is involved in human oligodendroglial precursor cell maturation","volume":"11","author":"Kremer","year":"2016","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0043","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1750-3639.2001.tb00385.x","article-title":"The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system","volume":"11","author":"Matsushima","year":"2001","journal-title":"Brain Pathol"},{"issue":"20","key":"10.1016\/j.ebiom.2021.103276_bib0044","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1128\/MCB.22.20.6931-6945.2002","article-title":"Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress","volume":"22","author":"Seternes","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"18","key":"10.1016\/j.ebiom.2021.103276_bib0045","doi-asserted-by":"crossref","first-page":"13872","DOI":"10.1074\/jbc.275.18.13872","article-title":"A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp","volume":"275","author":"G\u00f3mez del Arco","year":"2000","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103276_bib0046","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.onc.1209894","article-title":"Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation","volume":"26","author":"Ivanova","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.ebiom.2021.103276_bib0047","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2018.12.037","article-title":"Repurposing of omeprazole for oligodendrocyte differentiation and remyelination","volume":"1710","author":"Zhu","year":"2019","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0048","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/glia.23535","article-title":"Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination","volume":"67","author":"G\u00f6ttle","year":"2019","journal-title":"Glia"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103276_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144550","article-title":"Clobetasol and halcinonide act as smoothened agonists to promote myelin gene expression and RxR\u03b3 receptor activation","volume":"10","author":"Porcu","year":"2015","journal-title":"PLoS ONE"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103276_bib0050","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41401-018-0206-4","article-title":"Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination","volume":"40","author":"Cui","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ebiom.2021.103276_bib0051","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.22434","article-title":"Chemical inducers and transcriptional markers of oligodendrocyte differentiation","author":"Joubert","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0052","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1087057114559490","article-title":"High-content phenotypic screening and triaging strategy to identify small molecules driving oligodendrocyte progenitor cell differentiation","volume":"20","author":"Peppard","year":"2014","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.ebiom.2021.103276_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00007","article-title":"Aspirin promotes oligodendrocyte precursor cell proliferation and differentiation after white matter lesion","volume":"6","author":"Chen","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.ebiom.2021.103276_bib0054","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.expneurol.2014.12.012","article-title":"Voltage-gated Ca++ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro","volume":"265","author":"Cheli","year":"2015","journal-title":"Exp Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103276_bib0055","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jnc.12988","article-title":"Exposure to serotonin adversely affects oligodendrocyte development and myelinationin vitro","volume":"133","author":"Fan","year":"2015","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103276_bib0056","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00401-015-1426-z","article-title":"Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination","volume":"130","author":"Preisner","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ebiom.2021.103276_bib0057","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1016\/j.arabjc.2012.07.017","article-title":"Benzimidazoles: a biologically active compounds","volume":"10","author":"Salahuddin","year":"2017","journal-title":"Arabian J Chem"},{"key":"10.1016\/j.ebiom.2021.103276_bib0058","series-title":"Veterinary medicine: a textbook of the diseases of cattle, horses, sheep, pigs and goats","first-page":"674","author":"Radostits","year":"2007"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0059","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11508-2","article-title":"Computational cell cycle profiling of cancer cells for prioritizing FDA-approved drugs with repurposing potential","volume":"7","author":"Lo","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031062","article-title":"A role of microtubules in oligodendrocyte differentiation","volume":"21","author":"Lee","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0061","doi-asserted-by":"crossref","DOI":"10.1186\/s13321-018-0283-x","article-title":"ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database","volume":"10","author":"Dong","year":"2018","journal-title":"J Cheminform"},{"key":"10.1016\/j.ebiom.2021.103276_bib0062","series-title":"Congenital malformations in laboratory and farm animals \/Kalman T. Szabo","author":"Szabo","year":"1989"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0063","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0015-0282(16)37981-X","article-title":"Danazol\u2014a synthetic steroid derivative with interesting physiologic properties *\u2020","volume":"22","author":"Dmowski","year":"1971","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.ebiom.2021.103276_bib0064","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00277-015-2579-5","article-title":"Danazol induces apoptosis and cytotoxicity of leukemic cells alone and in combination with purine nucleoside analogs in chronic lymphocytic leukemia","volume":"95","author":"Podhorecka","year":"2015","journal-title":"Ann. Hematol."},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0065","article-title":"Danazol mediates collateral sensitivity via STAT3\/Myc related pathway in multidrug-resistant cancer cells","volume":"9","author":"Chang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2021.103276_bib0066","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44889","article-title":"Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant","volume":"8","author":"Diamantopoulou","year":"2019","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103276_bib0067","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/jps.20001","article-title":"Rapid dissolution of high-potency danazol particles produced by evaporative precipitation into aqueous solution","volume":"93","author":"Chen","year":"2004","journal-title":"J Pharm Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103276_bib0068","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/glia.22736","article-title":"Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex","volume":"63","author":"El-Etr","year":"2015","journal-title":"Glia"},{"issue":"Pt 1","key":"10.1016\/j.ebiom.2021.103276_bib0069","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/brain\/aws284","article-title":"The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination","volume":"136","author":"Hussain","year":"2013","journal-title":"Brain"},{"issue":"51","key":"10.1016\/j.ebiom.2021.103276_bib0070","doi-asserted-by":"crossref","first-page":"14829","DOI":"10.1073\/pnas.1614826113","article-title":"Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin","volume":"113","author":"Bielecki","year":"2016","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103276_bib0071","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1570159X15666170717120343","article-title":"Five decades of cuprizone, an updated model to replicate demyelinating diseases","volume":"17","author":"Vega-Riquer","year":"2019","journal-title":"Curr Neuropharmacol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103276_bib0072","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/ana.22214","article-title":"Activation of CXCR7 receptor promotes oligodendroglial cell maturation","volume":"68","author":"G\u00f6ttle","year":"2010","journal-title":"Ann. Neurol."}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421000694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:05:24Z","timestamp":1762455924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421000694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":72,"alternative-id":["S2352396421000694"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103276","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103276"}}