{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:00:44Z","timestamp":1784818844871,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970525"],"award-info":[{"award-number":["81970525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013ZX10005002"],"award-info":[{"award-number":["2013ZX10005002"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018ZX10725506"],"award-info":[{"award-number":["2018ZX10725506"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ebiom.2021.103389","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T02:45:32Z","timestamp":1621219532000},"page":"103389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["A novel nomogram to predict evident histological liver injury in patients with HBeAg-positive chronic hepatitis B virus infection"],"prefix":"10.1016","volume":"67","author":[{"given":"Xiujuan","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laicheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zujiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ebiom.2021.103389_bib0001","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S2468-1253(18)30056-6","article-title":"Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study","volume":"3","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103389_bib0002","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103389_bib0003","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/hep.22518","article-title":"Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection?","volume":"48","author":"Papatheodoridis","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103389_bib0004","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","year":"2017","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103389_bib0005","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1053\/j.gastro.2008.02.075","article-title":"Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT","volume":"134","author":"Kumar","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103389_bib0006","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jhep.2007.07.022","article-title":"The clinical significance of persistently normal ALT in chronic hepatitis B infection","volume":"47","author":"Lai","year":"2007","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103389_bib0007","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/ajg.2009.248","article-title":"Histological disease in Asian-Americans with chronic hepatitis B, high hepatitis B virus DNA, and normal alanine aminotransferase levels","volume":"104","author":"Nguyen","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2021.103389_bib0008","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2893.2010.01270.x","article-title":"Significant histopathology in Chinese chronic hepatitis B patients with persistently high-normal alanine aminotransferase","volume":"17","author":"Gui","year":"2010","journal-title":"J Viral Hepat"},{"issue":"10161","key":"10.1016\/j.ebiom.2021.103389_bib0009","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0140-6736(18)31865-8","article-title":"Chronic hepatitis B virus infection","volume":"392","author":"Seto","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103389_bib0010","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/hep.30417","article-title":"Entecavir and Peginterferon alfa-2a in adults with hepatitis B e antigen-positive immune-tolerant chronic hepatitis B virus infection","volume":"69","author":"Feld","year":"2019","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103389_bib0011","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.22742","article-title":"Liver biopsy","volume":"49","author":"Rockey","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103389_bib0012","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2015.04.006","article-title":"EASL-ALEH clinical practice guidelines: non-invasive tests for evaluation of liver disease severity and prognosis","volume":"63","year":"2015","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103389_bib0013","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/apt.16067","article-title":"Very low probability of significant liver inflammation in chronic hepatitis B patients with low ALT levels in the absence of liver fibrosis","volume":"52","author":"Sonneveld","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103389_bib0014","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0168-8278(02)00357-4","article-title":"Histopathological study of chronic hepatitis B and C: a comparison of two scoring systems","volume":"38","author":"Rozario","year":"2003","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103389_bib0015","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103389_bib0016","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1111\/j.1365-2893.2010.01360.x","article-title":"Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection","volume":"18","author":"Liu","year":"2011","journal-title":"J Viral Hepat"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103389_bib0017","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/jvh.12044","article-title":"Quantification of hepatitis B surface antigen and E antigen: correlation between Elecsys and architect assays","volume":"20","author":"Zhou","year":"2013","journal-title":"J Viral Hepat"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103389_bib0018","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/hep.20772","article-title":"Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort","volume":"42","author":"Lok","year":"2005","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103389_bib0019","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103389_bib0020","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/gutjnl-2015-309260","article-title":"The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in west Africa","volume":"65","author":"Lemoine","year":"2016","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103389_bib0021","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D'Amico","year":"2006","journal-title":"J Hepatol"},{"issue":"35","key":"10.1016\/j.ebiom.2021.103389_bib0022","doi-asserted-by":"crossref","first-page":"59257","DOI":"10.18632\/oncotarget.19501","article-title":"A novel predictive model using routinely clinical parameters to predict liver fibrosis in patients with chronic hepatitis B","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103389_bib0023","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2015.11.012","article-title":"Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients","volume":"64","author":"Kim","year":"2016","journal-title":"J Hepatol"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421001821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421001821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:05:17Z","timestamp":1762455917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421001821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":23,"alternative-id":["S2352396421001821"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103389","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel nomogram to predict evident histological liver injury in patients with HBeAg-positive chronic hepatitis B virus infection","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103389"}}