{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:33:06Z","timestamp":1790940786636,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ebiom.2021.103464","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T23:59:59Z","timestamp":1625356799000},"page":"103464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss"],"prefix":"10.1016","volume":"69","author":[{"given":"Shue","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Dittmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengji","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-4997","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2021.103464_bib0001","series-title":"Global health sector strategy on viral hepatitis 2016\u20132021","year":"2016"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103464_bib0002","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0003","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","year":"2017","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0004","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/hep.23464","article-title":"Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus","volume":"51","author":"Simonetti","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0005","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1053\/j.gastro.2010.04.048","article-title":"Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study","volume":"139","author":"Liu","year":"2010","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0006","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/JVI.77.1.68-76.2003","article-title":"CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection","volume":"77","author":"Thimme","year":"2003","journal-title":"J Virol"},{"issue":"19","key":"10.1016\/j.ebiom.2021.103464_bib0007","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1128\/JVI.00867-09","article-title":"The size of the viral inoculum contributes to the outcome of hepatitis B virus infection","volume":"83","author":"Asabe","year":"2009","journal-title":"J Virol"},{"issue":"Pt 6","key":"10.1016\/j.ebiom.2021.103464_bib0008","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1099\/vir.0.81920-0","article-title":"The immune response during hepatitis B virus infection","volume":"87","author":"Bertoletti","year":"2006","journal-title":"J Gen Virol"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103464_bib0009","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1128\/JVI.78.11.5707-5719.2004","article-title":"Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy","volume":"78","author":"Webster","year":"2004","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103464_bib0010","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/S0016-5085(99)70289-1","article-title":"Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection","volume":"117","author":"Maini","year":"1999","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0011","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1172\/JCI92812","article-title":"Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation","volume":"128","author":"Rivino","year":"2018","journal-title":"J Clin Investig"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103464_bib0012","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/JVI.02844-06","article-title":"Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection","volume":"81","author":"Boni","year":"2007","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1172\/JCI115590","article-title":"Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion","volume":"89","author":"Tsai","year":"1992","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103464_bib0014","doi-asserted-by":"crossref","first-page":"963-73 e9","DOI":"10.1053\/j.gastro.2012.07.014","article-title":"Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues","volume":"143","author":"Boni","year":"2012","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103464_bib0015","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1172\/JCI118592","article-title":"Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection","volume":"97","author":"Rehermann","year":"1996","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103464_bib0016","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1053\/j.gastro.2012.07.014","article-title":"Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues","volume":"143","author":"Boni","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0017","first-page":"38","article-title":"Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients","volume":"38","author":"Vyas","year":"2018","journal-title":"Liver Int Off J Int Assoc Stud Liver"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0018","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1053\/jhep.2002.33161","article-title":"Clinical significance of hepatitis B virus genotypes","volume":"35","author":"Chu","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ebiom.2021.103464_bib0019","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fimmu.2018.00219","article-title":"Hepatitis B virus-specific CD8+ T cells maintain functional exhaustion after antigen reexposure in an acute activation immune environment","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2021.103464_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2019.05.013","article-title":"MMP2\/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance","author":"Yang","year":"2019","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0021","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hep.27771","article-title":"Adaptation of the hepatitis B virus core protein to CD8(+) T-cell selection pressure","volume":"62","author":"Kefalakes","year":"2015","journal-title":"Hepatology"},{"issue":"1 Suppl","key":"10.1016\/j.ebiom.2021.103464_bib0022","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.jhep.2016.01.026","article-title":"Adaptive immunity in HBV infection","volume":"64","author":"Bertoletti","year":"2016","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2021.103464_bib0023","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jvh.13150","article-title":"Effects of pegylated interferon-alpha based therapies on functional cure and the risk of hepatocellular carcinoma development in patients with chronic hepatitis B","volume":"26","author":"Ren","year":"2019","journal-title":"J Viral Hepat"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0024","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2016.08.009","article-title":"The role of quantitative hepatitis B surface antigen revisited","volume":"66","author":"Cornberg","year":"2017","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.gastro.2011.04.046","article-title":"Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters","volume":"141","author":"Tseng","year":"2011","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103464_bib0026","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2018.05.004","article-title":"Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B","volume":"69","author":"Rinker","year":"2018","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0027","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/j.gastro.2020.04.019","article-title":"Effects of hepatitis B surface antigen on virus-specific and global T cells in patients with chronic hepatitis B virus infection","volume":"159","author":"Le Bert","year":"2020","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103464_bib0028","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/infdis\/jir283","article-title":"Viral determinants of hepatitis B surface antigen seroclearance in hepatitis B e antigen-negative chronic hepatitis B patients","volume":"204","author":"Chan","year":"2011","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103464_bib0029","first-page":"297","article-title":"Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection","volume":"10","author":"Chen","year":"2012","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103464_bib0030","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/gutjnl-2013-305517","article-title":"HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability","volume":"63","author":"Kim","year":"2014","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0031","doi-asserted-by":"crossref","first-page":"25","DOI":"10.14218\/JCTH.2017.00072","article-title":"HBsAg loss with peg-interferon alfa-2a in hepatitis B patients with partial response to nucleos(t)ide analog: new switch study","volume":"6","author":"Hu","year":"2018","journal-title":"J Clin Transl Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0032","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jhep.2012.11.007","article-title":"Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B?","volume":"58","author":"Thimme","year":"2013","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jhep.2012.09.029","article-title":"Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B","volume":"58","author":"Micco","year":"2013","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103464_bib0034","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jhep.2011.12.032","article-title":"Peginterferon-\u03b1 does not improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis","volume":"56","author":"Penna","year":"2012","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2021.103464_bib0035","first-page":"79","article-title":"Treatment of hepatitis B: is there still a role for interferon?","volume":"38","author":"Vigano","year":"2018","journal-title":"Liver Int Off J Int Assoc Stud Liver"},{"key":"10.1016\/j.ebiom.2021.103464_bib0036","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1038\/ncomms15050","article-title":"TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation","volume":"8","author":"Wieland","year":"2017","journal-title":"Nat Commun"},{"issue":"7620","key":"10.1016\/j.ebiom.2021.103464_bib0037","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103464_bib0038","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.20162115","article-title":"IL-2(high) tissue-resident T cells in the human liver: sentinels for hepatotropic infection","volume":"214","author":"Pallett","year":"2017","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103464_bib0039","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20142237","article-title":"Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells","volume":"212","author":"Odorizzi","year":"2015","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0040","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gutjnl-2018-316641","article-title":"Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load","volume":"68","author":"Schuch","year":"2019","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103464_bib0041","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1053\/j.gastro.2008.03.037","article-title":"Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B","volume":"134","author":"Zhang","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103464_bib0042","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jhep.2009.01.026","article-title":"Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients","volume":"50","author":"Zhang","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.ebiom.2021.103464_bib0043","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1743-422X-8-113","article-title":"Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection","volume":"8","author":"Wu","year":"2011","journal-title":"Virol J"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0044","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/eji.201141852","article-title":"Blockade of tim-3 signaling restores the virus-specific CD8(+) T-cell response in patients with chronic hepatitis B","volume":"42","author":"Wu","year":"2012","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.23977","article-title":"Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients","volume":"53","author":"Zhang","year":"2011","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103464_bib0046","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/j.gastro.2009.09.052","article-title":"Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B","volume":"138","author":"Fisicaro","year":"2010","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0047","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103464_bib0048","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ng.348","article-title":"A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians","volume":"41","author":"Kamatani","year":"2009","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103464_bib0049","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1128\/JVI.00406-12","article-title":"A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection","volume":"86","author":"Thomas","year":"2012","journal-title":"J Virol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103464_bib0050","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/liv.14008","article-title":"Association of HLA-DPA1 and HLA-DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians","volume":"39","author":"Koukoulioti","year":"2019","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103464_bib0051","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1172\/JCI121957","article-title":"PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection","volume":"128","author":"Salimzadeh","year":"2018","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103464_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/cmi.2009.5","article-title":"Blockade of Tim-3 pathway ameliorates interferon-gamma production from hepatic CD8+ T cells in a mouse model of hepatitis B virus infection","volume":"6","author":"Ying","year":"2009","journal-title":"Cell Mol Immunol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421002577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421002577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:08:24Z","timestamp":1762456104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421002577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":52,"alternative-id":["S2352396421002577"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103464","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.16.382838","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103464"}}