{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:04:22Z","timestamp":1792425862523,"version":"4.5.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ebiom.2021.103474","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T11:30:00Z","timestamp":1625916600000},"page":"103474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Energy metabolism in childhood neurodevelopmental disorders"],"prefix":"10.1016","volume":"69","author":[{"given":"Oyarz\u00e1bal","family":"A","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musokhranova","family":"U","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barros","family":"LF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garc\u00eda-Cazorla","family":"A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0301-0082(94)90015-9","article-title":"Ions and energy in mammalian brain","volume":"43","author":"Ereci\u0144ska","year":"1994","journal-title":"Prog Neurobiol"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103474_bib0002","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J Cereb blood flow Metab"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103474_bib0003","article-title":"The astrocyte: powerhouse and recycling center","volume":"7","author":"Weber","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ebiom.2021.103474_bib0004","series-title":"Joint FAO\/WHO\/UNU expert consultation on energy and protein requirements","article-title":"Basal metabolic rate in man","year":"1981"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103474_bib0005","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1096\/fj.11-183822","article-title":"Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans","volume":"25","author":"Rasmussen","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.ebiom.2021.103474_bib0006","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-0-387-85998-9_45","article-title":"Ketones suppress brain glucose consumption","volume":"645","author":"LaManna","year":"2009","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0007","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/jcbfm.2013.87","article-title":"Ketosis proportionately spares glucose utilization in brain","volume":"33","author":"Zhang","year":"2013","journal-title":"J Cereb blood flow Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0008","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/sp.2000.6361","article-title":"Glucose metabolism in the developing brain","volume":"24","author":"Vannucci","year":"2000","journal-title":"Semin Perinatol"},{"issue":"5930","key":"10.1016\/j.ebiom.2021.103474_bib0009","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2013.11.020","article-title":"Aerobic glycolysis in the human brain is associated with development and neotenous gene expression","volume":"19","author":"Goyal","year":"2014","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103474_bib0011","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-\u03b2 deposition","volume":"14","author":"Bero","year":"2011","journal-title":"Nat Neurosci"},{"issue":"4864","key":"10.1016\/j.ebiom.2021.103474_bib0012","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1126\/science.3260686","article-title":"Nonoxidative glucose consumption during focal physiologic neural activity","volume":"241","author":"Fox","year":"1988","journal-title":"Science"},{"issue":"35","key":"10.1016\/j.ebiom.2021.103474_bib0013","doi-asserted-by":"crossref","first-page":"11090","DOI":"10.1073\/pnas.1508259112","article-title":"NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting","volume":"112","author":"Lerchundi","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"10.1016\/j.ebiom.2021.103474_bib0014","doi-asserted-by":"crossref","first-page":"9432","DOI":"10.1074\/jbc.M117.777243","article-title":"Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism","volume":"292","author":"San Mart\u00edn","year":"2017","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103474_bib0015","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1073\/pnas.1716469115","article-title":"Neuronal control of astrocytic respiration through a variant of the Crabtree effect","volume":"115","author":"Fern\u00e1ndez-Moncada","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103474_bib0016","article-title":"Aerobic glycolysis in the brain: warburg and crabtree contra pasteur","author":"Barros","year":"2020","journal-title":"Neurochem Res"},{"issue":"22","key":"10.1016\/j.ebiom.2021.103474_bib0017","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1073\/pnas.91.22.10625","article-title":"Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization","volume":"91","author":"Pellerin","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0018","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1113\/JP274944","article-title":"CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain","volume":"596","author":"Barros","year":"2018","journal-title":"J Physiol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0019","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1113\/JP274945","article-title":"CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain","volume":"596","author":"Bak","year":"2018","journal-title":"J Physiol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn.2018.19","article-title":"Lactate in the brain: from metabolic end-product to signalling molecule","volume":"19","author":"Magistretti","year":"2018","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0021","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/physrev.00062.2017","article-title":"Brain glucose metabolism: integration of energetics with function","volume":"99","author":"Dienel","year":"2019","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103474_bib0022","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.tins.2013.04.002","article-title":"Metabolic signaling by lactate in the brain","volume":"36","author":"Barros","year":"2013","journal-title":"Trends Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0023","first-page":"511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ebiom.2021.103474_bib0024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuint.2015.02.002","article-title":"Glucose metabolism and astrocyte\u2013neuron interactions in the neonatal brain","volume":"82","author":"Brekke","year":"2015","journal-title":"Neurochem Int"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1025503115837","article-title":"Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain","volume":"18","author":"Lust","year":"2003","journal-title":"Metab Brain Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0026","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuroscience.2003.08.040","article-title":"Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain","volume":"122","author":"Rafiki","year":"2003","journal-title":"Neuroscience"},{"issue":"4\u20135","key":"10.1016\/j.ebiom.2021.103474_bib0027","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000017324","article-title":"Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle","volume":"20","author":"Pellerin","year":"1998","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.ebiom.2021.103474_bib0028","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.exer.2016.10.019","article-title":"Differential expression of endothelial nutrient transporters (MCT1 and GLUT1) in the developing eyes of mice","volume":"153","author":"Kishimoto","year":"2016","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0029","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1651-2227.1975.tb04375.x","article-title":"Oxidation of glucose and d-B-OH-butyrate by the early human fetal brain","volume":"64","author":"Adam","year":"1975","journal-title":"Acta Paediatr Scand"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103474_bib0030","first-page":"2352","article-title":"Preferential utilization of ketone bodies in the brain and lung of newborn rats","volume":"44","author":"Yeh","year":"1985","journal-title":"Fed Proc"},{"key":"10.1016\/j.ebiom.2021.103474_bib0031","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnene.2011.00002","article-title":"Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices","volume":"3","author":"Ivanov","year":"2011","journal-title":"Front Neuroenergetics"},{"key":"10.1016\/j.ebiom.2021.103474_bib0032","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnene.2011.00004","article-title":"Lactate Fuels the Neonatal Brain","volume":"3","author":"Kasischke","year":"2011","journal-title":"Front Neuroenergetics"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0033","first-page":"23","article-title":"Reactive oxygen species: physiological and physiopathological effects on synaptic plasticity","volume":"10","author":"Beckhauser","year":"2016","journal-title":"J Exp Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0034","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000439271","article-title":"Pyruvate to lactate metabolic changes during neurodevelopment measured dynamically using hyperpolarized 13C imaging in juvenile murine brain","volume":"38","author":"Chen","year":"2016","journal-title":"Dev Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0035","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/pmed.1998.0274","article-title":"A critical period of brain development: studies of cerebral glucose utilization with PET","volume":"27","author":"Chugani","year":"1998","journal-title":"Prev Med"},{"issue":"13","key":"10.1016\/j.ebiom.2021.103474_bib0036","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/0883073818792308","article-title":"Imaging brain metabolism in the newborn","volume":"33","author":"Chugani","year":"2018","journal-title":"J Child Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0037","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ana.410220408","article-title":"Positron emission tomography study of human brain functional development","volume":"22","author":"Chugani","year":"1987","journal-title":"Ann Neurol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103474_bib0038","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/0271678X15625349","article-title":"Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: no evidence of regional differences of aerobic glycolysis","volume":"36","author":"Hyder","year":"2016","journal-title":"J Cereb blood flow Metab"},{"key":"10.1016\/j.ebiom.2021.103474_bib0039","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3389\/fnins.2018.00631","article-title":"Trajectories of brain lactate and re-visited oxygen-glucose index calculations do not support elevated non-oxidative metabolism of glucose across childhood","volume":"12","author":"Benveniste","year":"2018","journal-title":"Front Neurosci"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/jcbfm.2014.8","article-title":"The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury","volume":"34","author":"Brekke","year":"2014","journal-title":"J Cereb blood flow Metab"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0041","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s11064-013-1014-3","article-title":"Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain","volume":"39","author":"Morken","year":"2014","journal-title":"Neurochem Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0042","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1471-4159.2009.06115.x","article-title":"Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons","volume":"110","author":"Lund","year":"2009","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0043","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1523\/JNEUROSCI.3516-10.2011","article-title":"Regulation of oligodendrocyte development and myelination by glucose and lactate","volume":"31","author":"Rinholm","year":"2011","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0044","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.wnr.0000192733.00535.b6","article-title":"Hypoglycemia influences oligodendrocyte development and myelin formation","volume":"17","author":"Yan","year":"2006","journal-title":"Neuroreport"},{"issue":"22","key":"10.1016\/j.ebiom.2021.103474_bib0045","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1523\/JNEUROSCI.1352-11.2012","article-title":"Critical time window of neuronal cholesterol synthesis during neurite outgrowth","volume":"32","author":"F\u00fcnfschilling","year":"2012","journal-title":"J Neurosci"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182372","article-title":"Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions","volume":"12","author":"Rao","year":"2017","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0047","first-page":"334","article-title":"Oligodendrocyte bioenergetics in health and disease","volume":"25","author":"Rosko","year":"2019","journal-title":"Neurosci."},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0048","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/jcbfm.2009.97","article-title":"Neuroprotective role of lactate after cerebral ischemia","volume":"29","author":"Berthet","year":"2009","journal-title":"J Cereb blood flow Metab"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0049","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000486411","article-title":"Exogenous \u03b2-hydroxybutyrate treatment and neuroprotection in a suckling rat model of hypoxic-ischemic encephalopathy","volume":"40","author":"Lee","year":"2018","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.ebiom.2021.103474_bib0050","article-title":"Neuroprotective role of lactate in rat neonatal hypoxia-ischemia","author":"Roumes","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ebiom.2021.103474_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2020.09.006","article-title":"Lactate administration reduces brain injury and ameliorates behavioral outcomes following neonatal hypoxia-ischemia","author":"Tassinari","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.ebiom.2021.103474_bib0052","doi-asserted-by":"crossref","first-page":"15557","DOI":"10.1038\/ncomms15557","article-title":"Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1","volume":"8","author":"Morland","year":"2017","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103474_bib0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0113-2","article-title":"Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage","volume":"50","author":"Zhou","year":"2018","journal-title":"Exp Mol Med"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0054","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00134-008-1283-5","article-title":"Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients","volume":"35","author":"Ichai","year":"2009","journal-title":"Intensiv Care Med"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2008.01821.x","article-title":"History of the ketogenic diet","volume":"49","author":"Wheless","year":"2008","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0056","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/epi4.12414","article-title":"Glut1 deficiency syndrome (Glut1DS): state of the art in 2020 and recommendations of the international Glut1DS study group","volume":"5","author":"Klepper","year":"2020","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.ebiom.2021.103474_bib0057","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijdevneu.2018.04.005","article-title":"The ketogenic diet in disease and development","volume":"68","author":"Barry","year":"2018","journal-title":"Int J Dev Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0058","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jimd.12071","article-title":"Synaptic energy metabolism and neuronal excitability, in sickness and health","volume":"42","author":"Oyarzabal","year":"2019","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.ebiom.2021.103474_bib0059","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.seizure.2016.01.011","article-title":"Use of dietary therapies amongst patients with GLUT1 deficiency syndrome","volume":"35","author":"Kass","year":"2016","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/nyas.12314","article-title":"Issues in the timing of integrated early interventions: contributions from nutrition, neuroscience, and psychological research","volume":"1308","author":"Wachs","year":"2014","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0061","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S0954579415000061","article-title":"Early life nutrition and neural plasticity","volume":"27","author":"Georgieff","year":"2015","journal-title":"Dev Psychopathol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0062","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3716","article-title":"Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health","volume":"141","author":"Schwarzenberg","year":"2018","journal-title":"Pediatrics"},{"issue":"14","key":"10.1016\/j.ebiom.2021.103474_bib0063","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1074\/jbc.R117.809194","article-title":"Mitochondrial energy generation disorders: genes, mechanisms, and clues to pathology","volume":"294","author":"Frazier","year":"2019","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0064","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jimd.12086","article-title":"Proposal for a simplified classification of IMD based on a pathophysiological approach: a practical guide for clinicians","volume":"42","author":"Saudubray","year":"2019","journal-title":"J Inherit Metab Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0065","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ana.410370311","article-title":"Positron emission tomography and magnetic resonance spectroscopy of cerebral glycolysis in children with congenital lactic acidosis","volume":"37","author":"Duncan","year":"1995","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0066","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11689-019-9268-y","article-title":"Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk","volume":"11","author":"Kumar","year":"2019","journal-title":"J Neurodev Disord"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01837894","article-title":"Autism and lactic acidosis","volume":"15","author":"Coleman","year":"1985","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.ebiom.2021.103474_bib0068","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnmol.2017.00034","article-title":"Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches","volume":"10","author":"Cheng","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103474_bib0069","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021429118","article-title":"An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes","volume":"118","author":"Yardeni","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103474_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104544","article-title":"Metabolic interventions in autism spectrum disorder","volume":"132","author":"Mierau","year":"2019","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ebiom.2021.103474_bib0071","article-title":"Mitochondrial dysfunction in autism spectrum disorder: unique abnormalities and targeted treatments","volume":"35","author":"Frye","year":"2020","journal-title":"Semin Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0072","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1096\/fj.201601004R","article-title":"Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study","volume":"31","author":"Rose","year":"2017","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0073","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1038\/tp.2014.15","article-title":"Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines","volume":"4","author":"Rose","year":"2014","journal-title":"Transl Psychiatry"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0074","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jand.2015.03.026","article-title":"Dietary supplementation in children with autism spectrum disorders: common, insufficient, and excessive","volume":"115","author":"Stewart","year":"2015","journal-title":"J Acad Nutr Diet"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0075","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.biopsych.2012.01.014","article-title":"A randomized controlled pilot trial of oral N-acetylcysteine in children with autism","volume":"71","author":"Hardan","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"43","key":"10.1016\/j.ebiom.2021.103474_bib0076","doi-asserted-by":"crossref","first-page":"15550","DOI":"10.1073\/pnas.1416940111","article-title":"Sulforaphane treatment of autism spectrum disorder (ASD)","volume":"111","author":"Singh","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2021.103474_bib0077","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fnins.2017.00493","article-title":"The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence","volume":"11","author":"Zuccoli","year":"2017","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0078","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0920-9964(00)00075-X","article-title":"Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia","volume":"48","author":"Maurer","year":"2001","journal-title":"Schizophr Res"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0079","doi-asserted-by":"crossref","first-page":"e967","DOI":"10.1038\/tp.2016.239","article-title":"Elevated brain lactate in schizophrenia: a 7\u2009T magnetic resonance spectroscopy study","volume":"6","author":"Rowland","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103474_bib0080","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1089\/ars.2010.3459","article-title":"The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics","volume":"15","author":"Martins-de-Souza","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103474_bib0081","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.biopsych.2017.10.014","article-title":"Defects in bioenergetic coupling in schizophrenia","volume":"83","author":"Sullivan","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0082","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S2215-0366(19)30416-X","article-title":"Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis","volume":"7","author":"Pillinger","year":"2020","journal-title":"Lancet Psychiatry"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103474_bib0083","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/sj.mp.4001116","article-title":"State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophrenia","volume":"7","author":"Dror","year":"2002","journal-title":"Mol Psychiatry"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0084","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0278-5846(00)00181-0","article-title":"Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia","volume":"25","author":"Mahadik","year":"2001","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000063573","article-title":"Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder","volume":"46","author":"Kuloglu","year":"2002","journal-title":"Neuropsychobiology"},{"issue":"2\u20133","key":"10.1016\/j.ebiom.2021.103474_bib0086","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4927(97)00064-4","article-title":"Multiple regression analysis of relationship between frontal lobe phosphorus metabolism and clinical symptoms in patients with schizophrenia","volume":"76","author":"Shioiri","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.ebiom.2021.103474_bib0087","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2020.09.003","article-title":"Evidence for altered energy metabolism, increased lactate, and decreased pH in schizophrenia brain: a focused review and meta-analysis of human postmortem and magnetic resonance spectroscopy studies","volume":"223","author":"Pruett","year":"2020","journal-title":"Schizophr Res"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103474_bib0088","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.15252\/embr.201642951","article-title":"The economic costs of mental disorders","volume":"17","author":"Trautmann","year":"2016","journal-title":"EMBO Rep"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103474_bib0089","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4088\/JCP.10m06634","article-title":"Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression","volume":"72","author":"Sublette","year":"2011","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0090","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1176\/appi.ajp.159.3.477","article-title":"Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder","volume":"159","author":"Nemets","year":"2002","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0091","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5080067","article-title":"Supplementation with omega-3 fatty acids in psychiatric disorders: a review of literature data","volume":"5","author":"Bozzatello","year":"2016","journal-title":"J Clin Med"},{"key":"10.1016\/j.ebiom.2021.103474_bib0092","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6154080","article-title":"Developmental dynamics of rett syndrome","volume":"2016","author":"Feldman","year":"2016","journal-title":"Neural Plast"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0093","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrneurol.2016.186","article-title":"Clinical and biological progress over 50 years in Rett syndrome","volume":"13","author":"Leonard","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"46","key":"10.1016\/j.ebiom.2021.103474_bib0094","doi-asserted-by":"crossref","first-page":"E7287","DOI":"10.1073\/pnas.1615330113","article-title":"Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome","volume":"113","author":"Banerjee","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0387-7604(93)90045-A","article-title":"Mitochondrial dysfunction in Rett syndrome. An ultrastructural and biochemical study","volume":"15","author":"Dotti","year":"1993","journal-title":"Brain Dev"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0096","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.freeradbiomed.2009.05.016","article-title":"Systemic oxidative stress in classic Rett syndrome","volume":"47","author":"De Felice","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ebiom.2021.103474_bib0097","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/195935","article-title":"Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome","volume":"2014","author":"Signorini","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ebiom.2021.103474_bib0098","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fphys.2019.00479","article-title":"Neuronal redox-imbalance in rett syndrome affects mitochondria as well as cytosol, and is accompanied by intensified mitochondrial O2 consumption and ROS release","volume":"10","author":"Can","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.ebiom.2021.103474_bib0099","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuropharm.2017.04.024","article-title":"Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome","volume":"121","author":"Valenti","year":"2017","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103474_bib0100","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/cge.13094","article-title":"Mining for mitochondrial mechanisms: linking known syndromes to mitochondrial function","volume":"93","author":"Panneman","year":"2018","journal-title":"Clin Genet"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0101","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(20)30217-9","article-title":"Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies","volume":"19","author":"Sandweiss","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ebiom.2021.103474_bib0102","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fncel.2017.00058","article-title":"Mitochondrial dysfunction in the pathogenesis of rett syndrome: implications for mitochondria-targeted therapies","volume":"11","author":"Shulyakova","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0103","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1038\/npp.2014.105","article-title":"Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome","volume":"39","author":"De Filippis","year":"2014","journal-title":"Neuropsychopharmacol"},{"issue":"6972","key":"10.1016\/j.ebiom.2021.103474_bib0104","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.310.6972.83","article-title":"13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years","volume":"310","year":"1995","journal-title":"BMJ"},{"issue":"9131","key":"10.1016\/j.ebiom.2021.103474_bib0105","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group","volume":"352","year":"1998","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103474_bib0106","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103474_bib0107","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/jcm9061669","article-title":"The anti-diabetic drug metformin rescues aberrant mitochondrial activity and restrains oxidative stress in a female mouse model of rett syndrome","volume":"9","author":"Zuliani","year":"2020","journal-title":"J Clin Med"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0108","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/hmg\/ddu737","article-title":"The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice","volume":"24","author":"Lumaban","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0109","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41593-019-0338-y","article-title":"Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice","volume":"22","author":"Shen","year":"2019","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/hmg\/ddx387","article-title":"Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function","volume":"27","author":"Weisz","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103474_bib0111","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1515\/hsz-2019-0221","article-title":"Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome","volume":"401","author":"D'Antoni","year":"2020","journal-title":"Biol Chem"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103474_bib0112","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.devcel.2011.08.008","article-title":"The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation","volume":"21","author":"Hom","year":"2011","journal-title":"Dev Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103474_bib0113","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cell.2020.07.008","article-title":"ATP synthase c-subunit leak causes aberrant cellular metabolism in fragile X syndrome","volume":"182","author":"Licznerski","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2021.103474_bib0114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molmet.2019.01.002","article-title":"The translational regulator FMRP controls lipid and glucose metabolism in mice and humans","volume":"21","author":"Leboucher","year":"2019","journal-title":"Mol Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103474_bib0115","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0292-20.2021","article-title":"Distinct basal metabolism in three mouse models of neurodevelopmental disorders","volume":"8","author":"Menzies","year":"2021","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0116","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21429-4","article-title":"Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance","volume":"12","author":"Vita","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2021.103474_bib0117","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105036","article-title":"Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model","volume":"146","author":"Vandenberg","year":"2021","journal-title":"Neurochem Int"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103474_bib0118","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010410","article-title":"Depletion of mitochondrial components from extracellular vesicles secreted from astrocytes in a mouse model of fragile X syndrome","volume":"22","author":"Ha","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0119","doi-asserted-by":"crossref","first-page":"e956","DOI":"10.1002\/mgg3.956","article-title":"Metformin treatment in young children with fragile X syndrome","volume":"7","author":"Biag","year":"2019","journal-title":"Mol Genet genomic Med"},{"key":"10.1016\/j.ebiom.2021.103474_bib0120","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3389\/fnins.2020.00670","article-title":"Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions","volume":"14","author":"Dierssen","year":"2020","journal-title":"Front Neurosci"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103474_bib0121","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1038\/s41380-018-0200-8","article-title":"Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders","volume":"25","author":"Yu","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103474_bib0122","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.celrep.2019.10.059","article-title":"Suppressing aneuploidy-associated phenotypes improves the fitness of trisomy 21 cells","volume":"29","author":"Hwang","year":"2019","journal-title":"Cell Rep"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642100267X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642100267X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:05:17Z","timestamp":1762455917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642100267X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":122,"alternative-id":["S235239642100267X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103474","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Energy metabolism in childhood neurodevelopmental disorders","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103474"}}