{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:45Z","timestamp":1786987785107,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30-GM103335"],"award-info":[{"award-number":["P30-GM103335"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1539067"],"award-info":[{"award-number":["1539067"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.ebiom.2021.103487","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T01:17:40Z","timestamp":1626484660000},"page":"103487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Neuroinflammatory profiles regulated by the redox environment predicted cognitive dysfunction in people living with HIV: A cross-sectional study"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-4386","authenticated-orcid":false,"given":"Rachel K.","family":"Spooner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany K.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra M.","family":"Moshfegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman M.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey N.","family":"Dyball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Emanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Schlichte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikki","family":"Schantell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela E.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Kubat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Bares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Swindells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Stauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3404-1428","authenticated-orcid":false,"given":"Adam J.","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-9051","authenticated-orcid":false,"given":"Matthew C.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.ebiom.2021.103487_bib0001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","article-title":"Updated research nosology for HIV-associated neurocognitive disorders","volume":"69","author":"Antinori","year":"2007","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0002","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11065-009-9092-3","article-title":"Neuropsychological functioning and antiretroviral treatment in HIV\/AIDS: a review","volume":"19","author":"Cysique","year":"2009","journal-title":"Neuropsychol Rev"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13365-010-0006-1","article-title":"HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors","volume":"17","author":"Heaton","year":"2011","journal-title":"J Neurovirol"},{"issue":"23","key":"10.1016\/j.ebiom.2021.103487_bib0004","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"issue":"14","key":"10.1016\/j.ebiom.2021.103487_bib0005","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/QAD.0b013e32828e4e27","article-title":"The prevalence and incidence of neurocognitive impairment in the HAART era","volume":"21","author":"Robertson","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2021.103487_bib0006","first-page":"15","article-title":"HIV-associated neurocognitive disorder \u2014 pathogenesis and prospects for treatment","volume":"12","author":"Saylor","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103487_bib0007","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/QAD.0b013e3283354a7b","article-title":"Cognitive dysfunction in HIV patients despite long-standing suppression of viremia","volume":"24","author":"Simioni","year":"2010","journal-title":"AIDS"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0008","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.molcel.2016.03.019","article-title":"Methylome-wide analysis of chronic HIV infection reveals five-year increase in biological age and epigenetic targeting of HLA","volume":"62","author":"Gross","year":"2020","journal-title":"Mol Cell"},{"key":"10.1016\/j.ebiom.2021.103487_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.10.008","article-title":"Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications","volume":"45","author":"Hong","year":"2015","journal-title":"Brain Behav Immun"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0010","doi-asserted-by":"crossref","first-page":"A99","DOI":"10.1016\/j.antiviral.2008.12.013","article-title":"The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research","volume":"82","author":"Varatharajan","year":"2009","journal-title":"Antiviral Res"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103487_bib0011","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.4049\/jimmunol.1800753","article-title":"Increased mitochondrial biogenesis and reactive oxygen species production accompany prolonged CD4","volume":"201","author":"Akkaya","year":"2018","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103487_bib0012","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.it.2018.01.005","article-title":"Reactive oxygen species: involvement in T cell signaling and metabolism","volume":"39","author":"Franchina","year":"2018","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0014","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt","year":"2012","journal-title":"Immunity."},{"issue":"12","key":"10.1016\/j.ebiom.2021.103487_bib0015","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126675","article-title":"Effect of HIV infection and antiretroviral therapy on immune cellular functions","volume":"4","author":"Korencak","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0016","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13365-013-0227-1","article-title":"Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system","volume":"20","author":"Akay","year":"2014","journal-title":"J Neurovirol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103487_bib0017","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s13365-017-0573-5","article-title":"Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals","volume":"23","author":"Stauch","year":"2017","journal-title":"J Neurovirol"},{"key":"10.1016\/j.ebiom.2021.103487_bib0018","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1196\/annals.1354.003","article-title":"Free radical theory of aging: an update: increasing the functional life span","volume":"1067","author":"Harman","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ebiom.2021.103487_bib0019","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nicl.2018.07.009","article-title":"Aberrant oscillatory dynamics during somatosensory processing in HIV-infected adults","volume":"20","author":"Spooner","year":"2018","journal-title":"Neuroimage Clin"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103487_bib0020","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/brain\/awy097","article-title":"Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment","volume":"141","author":"Wiesman","year":"2018","journal-title":"Brain."},{"issue":"20","key":"10.1016\/j.ebiom.2021.103487_bib0021","doi-asserted-by":"crossref","first-page":"e1860","DOI":"10.1212\/WNL.0000000000006504","article-title":"Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder","volume":"91","author":"Lew","year":"2018","journal-title":"Neurology."},{"issue":"9","key":"10.1016\/j.ebiom.2021.103487_bib0022","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1002\/hbm.25408","article-title":"Impact of HIV-infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: a multimodal neuroimaging approach","volume":"42","author":"Casagrande","year":"2021","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103487_bib0023","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/13510002.2015.1101891","article-title":"Redox status in workers occupationally exposed to long-term low levels of ionizing radiation: a pilot study","volume":"21","author":"Ahmad","year":"2016","journal-title":"Redox Rep."},{"key":"10.1016\/j.ebiom.2021.103487_bib0024","series-title":"Wechsler Memory Scale - Third Edition","author":"Wechsler","year":"1997"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103487_bib0025","first-page":"8","article-title":"The California Verbal Learning Test \u2013 second edition: test-retest reliability, practice effects, and reliable change indices for the standard and alternate forms","volume":"21","author":"Woods","year":"2006","journal-title":"Arch Clin Neuropscyhol"},{"key":"10.1016\/j.ebiom.2021.103487_bib0026","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/00221325.1962.10533572","article-title":"Interference effects of Stroop color-word test in childhood, adulthood, and aging","volume":"100","author":"Comalli","year":"1962","journal-title":"J Genet Psychol"},{"key":"10.1016\/j.ebiom.2021.103487_bib0027","article-title":"Revised comprehensive norms for an expanded Halstead-Reitan battery","author":"Heaton","year":"2004","journal-title":"Demographically Adjusted Neuropsychological Norms for African American and Caucasian adults"},{"key":"10.1016\/j.ebiom.2021.103487_bib0028","series-title":"Wechsler Adult Intelligence Scale - Third Edition","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.ebiom.2021.103487_bib0029","series-title":"Grooved","author":"Klove","year":"1963"},{"key":"10.1016\/j.ebiom.2021.103487_bib0030","series-title":"Wide Range Achievement Test 4 professional manual","author":"Wilkinson","year":"2006"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103487_bib0031","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s12640-016-9608-6","article-title":"The HIV Protein gp120 alters mitochondrial dynamics in neurons","volume":"29","author":"Avdoshina","year":"2016","journal-title":"Neurotox Res"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0032","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12640-016-9619-3","article-title":"HIV-1 gp120-mediated mitochondrial dysfunction and HIV-associated neurological disorders","volume":"30","author":"Shah","year":"2016","journal-title":"Neurotox Res"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103487_bib0033","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1043-6618(02)00320-1","article-title":"Contribution to characterization of oxidative stress in HIV\/AIDS patients","volume":"47","author":"Gil","year":"2003","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103487_bib0034","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0009-8981(96)06394-2","article-title":"Oxidative stress in blood of HIV infected patients","volume":"255","author":"Repetto","year":"1996","journal-title":"Clin Chim Acta"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103487_bib0035","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0891-5849(95)00047-2","article-title":"The role of oxidative stress in HIV disease","volume":"19","author":"Pace","year":"1995","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103487_bib0036","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.freeradbiomed.2007.02.015","article-title":"The effects of superoxide dismutase on H2O2 formation","volume":"42","author":"Liochev","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ebiom.2021.103487_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101141","article-title":"Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4","volume":"27","author":"Moshfegh","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2021.103487_bib0038","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-med-042909-093756","article-title":"HIV infection, inflammation, immunosenescence, and aging","volume":"62","author":"Deeks","year":"2011","journal-title":"Ann Rev Med"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103487_bib0039","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jalz.2009.01.025","article-title":"Association of C-reactive protein with mild cognitive impairment","volume":"5","author":"Roberts","year":"2009","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/archneurol.2009.308","article-title":"Association of C-reactive protein to cognitive impairment","volume":"67","author":"Noble","year":"2010","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0041","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000442585","article-title":"Elevated C-reactive protein is associated with cognitive decline in outpatients of a general hospital: the Project in Sado for Total Health (PROST)","volume":"6","author":"Watanabe","year":"2016","journal-title":"Dement Geriatr Cogn Dis Extra"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0042","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s13365-017-0590-4","article-title":"Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study","volume":"24","author":"Rubin","year":"2018","journal-title":"J Neurovirol"},{"key":"10.1016\/j.ebiom.2021.103487_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.10.064","article-title":"Predictive biomarkers for cognitive decline during progressive HIV infection","author":"Gendelman","year":"2020","journal-title":"EBioMedicine [Internet]"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103487_bib0044","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103487_bib0045","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/jnnp.74.9.1200","article-title":"Intrathecal inflammation precedes development of Alzheimer's disease","volume":"74","author":"Tarkowski","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ebiom.2021.103487_bib0046","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neurobiolaging.2015.10.039","article-title":"The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function\u2014data from the Berlin Aging Study II","volume":"38","author":"Tegeler","year":"2016","journal-title":"Neurobiol Aging"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103487_bib0047","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8100390","volume":"8","author":"Kumar","year":"2020","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0048","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/archinte.166.1.64","article-title":"C-reactive protein is a marker for human immunodeficiency virus disease progression","volume":"166","author":"Lau","year":"2006","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103487_bib0049","first-page":"5","article-title":"Biomarkers of immune dysfunction in HIV","volume":"5","author":"Nixon","year":"2011","journal-title":"Curr Opin HIV AIDS"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103487_bib0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/QAD.0000000000000174","article-title":"Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients","volume":"28","author":"Noel","year":"2014","journal-title":"AIDS"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103487_bib0051","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/infdis\/jiu273","article-title":"Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of efavirenz","volume":"210","author":"Funes","year":"2014","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0052","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00126334-200309010-00004","article-title":"Factors associated with mitochondrial dysfunction in circulating peripheral blood lymphocytes from HIV-infected people","volume":"34","author":"Polo","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103487_bib0053","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2105\/AJPH.2012.301162","article-title":"Substance use among HIV-infected patients engaged in primary care in the United States: findings from the centers for AIDS research network of integrated clinical systems cohort","volume":"103","author":"Mimiaga","year":"2013","journal-title":"Am J Public Health"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103487_bib0054","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11904-008-0025-1","article-title":"HIV and depression: 2008 review and update","volume":"5","author":"Rabkin","year":"2008","journal-title":"Curr HIV\/AIDS Rep"},{"key":"10.1016\/j.ebiom.2021.103487_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/569819","article-title":"Monocytes as regulators of inflammation and HIV-related comorbidities during cART","volume":"2014","author":"Anzinger","year":"2014","journal-title":"Journal of Immunology Research"},{"issue":"6831","key":"10.1016\/j.ebiom.2021.103487_bib0056","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/35073667","article-title":"Pathways to neuronal injury and apoptosis in HIV-associated dementia","volume":"410","author":"Kaul","year":"2001","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103487_bib0057","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1212\/01.wnl.0000344404.12759.83","article-title":"HIV DNA and cognition in a Thai longitudinal HAART initiation cohort","volume":"72","author":"Valcour","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103487_bib0058","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/infdis\/jiw506","article-title":"Monocyte activation is associated with worse cognitive performance in HIV-infected women with virologic suppression","volume":"215","author":"Imp","year":"2017","journal-title":"J Infect Dis"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421002802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421002802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:06:20Z","timestamp":1762455980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421002802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":58,"alternative-id":["S2352396421002802"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103487","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinflammatory profiles regulated by the redox environment predicted cognitive dysfunction in people living with HIV: A cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103487"}}