{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:39:59Z","timestamp":1788176399674,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902828"],"award-info":[{"award-number":["81902828"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002928"],"award-info":[{"award-number":["82002928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["B2019039"],"award-info":[{"award-number":["B2019039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["y2syD2192230"],"award-info":[{"award-number":["y2syD2192230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["DFJH201921"],"award-info":[{"award-number":["DFJH201921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["81902828"],"award-info":[{"award-number":["81902828"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["82002928"],"award-info":[{"award-number":["82002928"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2019039"],"award-info":[{"award-number":["B2019039"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["y2syD2192230"],"award-info":[{"award-number":["y2syD2192230"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["DFJH201921"],"award-info":[{"award-number":["DFJH201921"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["81902828"],"award-info":[{"award-number":["81902828"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["82002928"],"award-info":[{"award-number":["82002928"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["B2019039"],"award-info":[{"award-number":["B2019039"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["y2syD2192230"],"award-info":[{"award-number":["y2syD2192230"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DFJH201921"],"award-info":[{"award-number":["DFJH201921"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["81902828"],"award-info":[{"award-number":["81902828"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["82002928"],"award-info":[{"award-number":["82002928"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["B2019039"],"award-info":[{"award-number":["B2019039"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["y2syD2192230"],"award-info":[{"award-number":["y2syD2192230"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["DFJH201921"],"award-info":[{"award-number":["DFJH201921"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ebiom.2021.103542","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T23:51:53Z","timestamp":1629935513000},"page":"103542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Genetic and immune characteristics of sentinel lymph node metastases and multiple lymph node metastases compared to their matched primary breast tumours"],"prefix":"10.1016","volume":"71","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheukfai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiaopei","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangnan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Balch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-5652","authenticated-orcid":false,"given":"Ning","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ebiom.2021.103542_bib0001","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1470-2045(06)70975-5","article-title":"Immunobiology of the sentinel lymph node and its potential role for antitumour immunity","volume":"7","author":"Kim","year":"2006","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103542_bib0002","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1245\/s10434-018-6486-6","article-title":"Eighth Edition of the AJCC Cancer Staging Manual: Breast Cancer","volume":"25","author":"Giuliano","year":"2018","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103542_bib0003","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/cncr.21729","article-title":"Maturation of dendritic cells and T-cell responses in sentinel lymph nodes from patients with breast carcinoma","volume":"106","author":"Matsuura","year":"2006","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103542_bib0004","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10555-006-8503-7","article-title":"Immune responses in the draining lymph nodes against cancer: implications for immunotherapy","volume":"25","author":"Shu","year":"2006","journal-title":"Cancer Metastasis Rev"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103542_bib0005","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1002\/ijc.27933","article-title":"Altered local and systemic immune profiles underlie lymph node metastasis in breast cancer patients","volume":"132","author":"Zuckerman","year":"2013","journal-title":"Int J Cancer"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103542_bib0006","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb3015","article-title":"The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis","volume":"16","author":"McAllister","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103542_bib0007","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00109-013-1021-5","article-title":"The metastasis-promoting roles of tumor-associated immune cells","volume":"91","author":"Smith","year":"2013","journal-title":"J Mol Med"},{"key":"10.1016\/j.ebiom.2021.103542_bib0008","article-title":"Frequent molecular subtype switching and gene expression alterations in lung and pleural metastasis from luminal A-type breast cancer","volume":"4","author":"Klebe","year":"2020","journal-title":"JCO Precision Oncol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103542_bib0009","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/bcr2771","article-title":"Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS)","volume":"12","author":"Thompson","year":"2010","journal-title":"Breast Cancer Res"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103542_bib0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nm.3886","article-title":"Subclonal diversification of primary breast cancer revealed by multiregion sequencing","volume":"21","author":"Yates","year":"2015","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103542_bib0011","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1158\/0008-5472.CAN-16-2717","article-title":"Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer","volume":"77","author":"Cejalvo","year":"2017","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103542_bib0012","first-page":"828","article-title":"Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases. Modern pathology: an official journal of the United States and Canadian Academy of Pathology","volume":"25","author":"Koh","year":"2012","journal-title":"Inc"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0013","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1158\/1078-0432.107.11.1","article-title":"Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodes","volume":"11","author":"Lee","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"3 Suppl","key":"10.1016\/j.ebiom.2021.103542_bib0014","doi-asserted-by":"crossref","first-page":"137S","DOI":"10.1245\/ASO.2004.01.902","article-title":"Sentinel node mapping and an International Sentinel Node Society: current issues and future directions","volume":"11","author":"Morton","year":"2004","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103542_bib0015","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/01.sla.0000086543.45557.cb","article-title":"Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases","volume":"238","author":"Morton","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.ebiom.2021.103542_bib0016","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-19-0414","article-title":"Heterogeneity of genomic profile in patients with HER2-positive breast cancer","author":"Chen","year":"2020","journal-title":"Endocr Relat Cancer"},{"issue":"15","key":"10.1016\/j.ebiom.2021.103542_bib0017","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.ebiom.2021.103542_bib0018","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103542_bib0019","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103542_bib0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103542_bib0021","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0022","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/bioinformatics\/btp612","article-title":"DEGseq: an R package for identifying differentially expressed genes from RNA-seq data","volume":"26","author":"Wang","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2021.103542_bib0023","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0024","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103542_bib0025","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cell.2017.01.010","article-title":"Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma","volume":"168","author":"Hugo","year":"2017","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103542_bib0026","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103542_bib0027","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/annonc\/mdu191","article-title":"Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients","volume":"25","author":"Ali","year":"2014","journal-title":"Ann Oncol"},{"issue":"7403","key":"10.1016\/j.ebiom.2021.103542_bib0028","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature11154","article-title":"Sequence analysis of mutations and translocations across breast cancer subtypes","volume":"486","author":"Banerji","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103542_bib0029","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1530\/ERC-19-0019","article-title":"PIK3CA mutations in ductal carcinoma in situ and adjacent invasive breast cancer","volume":"26","author":"Agahozo","year":"2019","journal-title":"Endocr Relat Cancer"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103542_bib0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/jamasurg.2013.3028","article-title":"Correlation of breast cancer axillary lymph node metastases with stem cell mutations","volume":"148","author":"Donovan","year":"2013","journal-title":"JAMA Surgery"},{"key":"10.1016\/j.ebiom.2021.103542_bib0031","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12907-015-0020-6","article-title":"Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer","volume":"15","author":"Arsenic","year":"2015","journal-title":"BMC Clin Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0032","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13046-016-0370-7","article-title":"The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR","volume":"35","author":"Zhao","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103542_bib0033","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1091\/mbc.e02-10-0703","article-title":"Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells","volume":"14","author":"Huang","year":"2003","journal-title":"Mol Biol Cell"},{"issue":"20","key":"10.1016\/j.ebiom.2021.103542_bib0034","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1056\/NEJMoa1810527","article-title":"Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer","volume":"379","author":"Turner","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(14)71159-3","article-title":"The cyclin-dependent kinase 4\/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1\/TRIO-18): a randomised phase 2 study","volume":"16","author":"Finn","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ebiom.2021.103542_bib0036","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ctrv.2017.09.003","article-title":"CDK4\/6 inhibition in early and metastatic breast cancer: A review","volume":"60","author":"de Groot","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ebiom.2021.103542_bib0037","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2020.1831217","article-title":"CDKN1B\/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cells","author":"Nowosad","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ebiom.2021.103542_bib0038","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fendo.2018.00393","article-title":"Landscape of CDKN1B mutations in luminal breast cancer and other hormone-driven human tumors","volume":"9","author":"Cusan","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103542_bib0039","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-\u03baB, inflammation, immunity and cancer: coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2021.103542_bib0040","doi-asserted-by":"crossref","DOI":"10.1172\/JCI98882","article-title":"Dominant-negative NFKBIA mutation promotes IL-1beta production causing hepatic disease with severe immunodeficiency","author":"Tan","year":"2020","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103542_bib0041","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1023\/A:1023033708204","article-title":"Cyclin D1, EMS1 and 11q13 amplification in breast cancer","volume":"78","author":"Ormandy","year":"2003","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103542_bib0042","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/annonc\/mdt419","article-title":"Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors","volume":"25","author":"Dienstmann","year":"2014","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103542_bib0043","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1158\/1541-7786.MCR-20-0067","article-title":"Epithelial-Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance","volume":"18","author":"Gooding","year":"2020","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.ebiom.2021.103542_bib0044","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-bioeng-112315-031200","article-title":"The lymphatic system in disease processes and cancer progression","volume":"18","author":"Padera","year":"2016","journal-title":"Annu Rev Biomed Eng"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103542_bib0045","doi-asserted-by":"crossref","first-page":"e80063","DOI":"10.1371\/journal.pone.0080063","article-title":"The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer","volume":"8","author":"Preston","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103542_bib0046","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1134412","article-title":"The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder","volume":"5","author":"Baras","year":"2016","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0047","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/cmi.2010.56","article-title":"A reversed CD4\/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix","volume":"8","author":"Shah","year":"2011","journal-title":"Cellular Mol Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103542_bib0048","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1200\/JCO.2008.18.7229","article-title":"Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer","volume":"27","author":"Salama","year":"2009","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0049","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s40425-019-0758-y","article-title":"Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition","volume":"7","author":"Mao","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.ebiom.2021.103542_bib0050","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1038\/ncomms6241","article-title":"Metastasis is regulated via microRNA-200\/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression","volume":"5","author":"Chen","year":"2014","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103542_bib0051","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2016.02.065","article-title":"Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma","volume":"165","author":"Hugo","year":"2016","journal-title":"Cell"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421003352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421003352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:05:20Z","timestamp":1762455920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421003352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":51,"alternative-id":["S2352396421003352"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103542","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic and immune characteristics of sentinel lymph node metastases and multiple lymph node metastases compared to their matched primary breast tumours","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103542"}}