{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:37:48Z","timestamp":1789148268472,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ebiom.2021.103601","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T18:51:31Z","timestamp":1633373491000},"page":"103601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia"],"prefix":"10.1016","volume":"72","author":[{"given":"David","family":"Carreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J","family":"Wanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zydrune","family":"Jasiunaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Hames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0970-0639","authenticated-orcid":false,"given":"Wen Y","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Dennison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelis","family":"Straatman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Martinez-Pomares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Pareek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-4069","authenticated-orcid":false,"given":"Carlos J.","family":"Orihuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos I.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Shen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Richard","family":"Moxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-793X","authenticated-orcid":false,"given":"Marco R","family":"Oggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10053","key":"10.1016\/j.ebiom.2021.103601_bib0001","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Wang","year":"2016","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103601_bib0002","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1473-3099(18)30310-4","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Troeger","year":"2018","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103601_bib0003","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/thoraxjnl-2015-206881","article-title":"British Thoracic Society community acquired pneumonia guideline and the NICE pneumonia guideline: how they fit together","volume":"70","author":"Lim","year":"2015","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0004","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/thorax.58.5.377","article-title":"Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study","volume":"58","author":"Lim","year":"2003","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103601_bib0005","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America","volume":"200","author":"Metlay","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ebiom.2021.103601_bib0006","first-page":"140115","article-title":"Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia","author":"Arnold","year":"2018","journal-title":"Respir Med"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103601_bib0007","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/CCM.0b013e3182a66b9b","article-title":"Macrolides and mortality in critically ill patients with community-acquired pneumonia: a systematic review and meta-analysis","volume":"42","author":"Sligl","year":"2014","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0008","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0009","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41564-018-0147-1","article-title":"Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia","volume":"3","author":"Ercoli","year":"2018","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103601_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.14573\/altex.1805131","article-title":"An ex vivo porcine spleen perfusion as a model of bacterial sepsis","volume":"36","author":"Chung","year":"2019","journal-title":"Altex"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103601_bib0011","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s40262-017-0572-y","article-title":"Intracellular Pharmacokinetics of Antibacterials and Their Clinical Implications","volume":"57","author":"Pea","year":"2018","journal-title":"Clin Pharmacokinet"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0012","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/imm.12469","article-title":"Human spleen microanatomy: why mice do not suffice","volume":"145","author":"Steiniger","year":"2015","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103601_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166092","article-title":"A Non-Human Primate Model of Severe Pneumococcal Pneumonia","volume":"11","author":"Reyes","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ebiom.2021.103601_bib0014","unstructured":"Carreno D, Wanford JJ, Restrepo MI, Orihuela CJ, Andrew PW, Moxon ER, et\u00a0al. Streptococcus pneumoniae inside splenic macrophages as the source of bacteraemia during invasive disease. The UK Cellular Microbiology Network: Exploring the Host-Bacterial Interface 2019."},{"key":"10.1016\/j.ebiom.2021.103601_bib0015","doi-asserted-by":"crossref","unstructured":"Carreno D, Wanford JJ, Jasiunaite Z, Hames R, Restrepo MI, Orihuela CJ, et\u00a0al. Pneumococcal invasive disease preceded by intracellular replication within splenic macrophages. The Microbiology Society Annual Conference 2019.","DOI":"10.1099\/acmi.ac2019.po0352"},{"key":"10.1016\/j.ebiom.2021.103601_bib0016","unstructured":"Carreno D, Wanford JJ, Restrepo MI, Orihuela CJ, Andrew PW, Moxon ER, et\u00a0al. Splenic macrophages as the source of bacteraemia during invasive pneumococcal disease. 29th ECCMID European Congress of Clinical Microbiology & Infectious Diseases 2019."},{"key":"10.1016\/j.ebiom.2021.103601_bib0017","unstructured":"Carreno D, Wanford JJ, Restrepo MI, Orihuela CJ, Andrew PW, Moxon ER, et\u00a0al. Intracellular replication of Streptococcus pneumoniae in a subset population of splenic macrophages as the source of bacteraemia during invasive disease. 14th Europneumo 2019."},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004026","article-title":"The Role of Host and Microbial Factors in the Pathogenesis of Pneumococcal Bacteraemia Arising from a Single Bacterial Cell Bottleneck","volume":"10","author":"Gerlini","year":"2014","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103601_bib0019","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.79.2.137","article-title":"Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus Type III","volume":"79","author":"Avery","year":"1944","journal-title":"J Exp Med"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103601_bib0020","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/infdis\/jir657","article-title":"Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice","volume":"204","author":"Kadioglu","year":"2011","journal-title":"J Infect Dis"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103601_bib0021","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/598483","article-title":"Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host","volume":"199","author":"Trappetti","year":"2009","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103601_bib0022","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2180-3-14","article-title":"The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice","volume":"3","author":"Chiavolini","year":"2003","journal-title":"BMC Microbiol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0023","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1365-2958.2003.03596.x","article-title":"Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia","volume":"49","author":"Oggioni","year":"2003","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0024","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/j.1365-2958.2006.05310.x","article-title":"Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis","volume":"61","author":"Oggioni","year":"2006","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0025","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1128\/AAC.46.5.1340-1344.2002","article-title":"Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of beta-lactams in a mouse sepsis model","volume":"46","author":"Casal","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2021.103601_bib0026","first-page":"3315","article-title":"A simple and effective heat induced antigen retrieval method","author":"Vinod","year":"2016","journal-title":"MethodsX"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103601_bib0027","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"5-6","key":"10.1016\/j.ebiom.2021.103601_bib0028","first-page":"211","article-title":"Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture","volume":"16","author":"Carlier","year":"1994","journal-title":"Int J Tissue React"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0029","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0891-5520(03)00066-7","article-title":"Intracellular pharmacodynamics of antibiotics","volume":"17","author":"Carryn","year":"2003","journal-title":"Infect Dis Clin North Am"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103601_bib0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jac\/dki241","article-title":"Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models","volume":"56","author":"Girard","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0031","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2017.02.016","article-title":"Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages","volume":"46","author":"Sabatel","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2021.103601_bib0032","first-page":"9302","article-title":"The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms","author":"Zimmermann","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103601_bib0033","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jinf.2018.01.003","article-title":"Effectiveness of combination therapy versus monotherapy with a third-generation cephalosporin in bacteraemic pneumococcal pneumonia: A propensity score analysis","volume":"76","author":"De la Calle","year":"2018","journal-title":"J Infect"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103601_bib0034","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.chest.2018.11.006","article-title":"Effect of Combined \u03b2-Lactam\/Macrolide Therapy on Mortality According to the Microbial Etiology and Inflammatory Status of Patients With Community-Acquired Pneumonia","volume":"155","author":"Ceccato","year":"2019","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1128\/CMR.00058-15","article-title":"Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective","volume":"29","author":"Kim","year":"2016","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103601_bib0036","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/AAC.00161-18","article-title":"Mechanism of Macrolide-Induced Inhibition of Pneumolysin Release Involves Impairment of Autolysin Release in Macrolide-Resistant Streptococcus pneumoniae","volume":"62","author":"Domon","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103601_bib0037","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1172\/JCI110148","article-title":"The role of the spleen in experimental pneumococcal bacteremia","volume":"67","author":"Brown","year":"1981","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103601_bib0038","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/cid\/civ1195","article-title":"Overwhelming Postsplenectomy Infection: A Prospective Multicenter Cohort Study","volume":"62","author":"Theilacker","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0039","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00281-013-0378-4","article-title":"Macrophage heterogeneity in lymphoid tissues","volume":"35","author":"den Haan","year":"2013","journal-title":"Semin Immunopathol"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103601_bib0040","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.exphem.2006.06.016","article-title":"Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human","volume":"34","author":"Dor","year":"2006","journal-title":"Exp Hematol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0041","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1164\/rccm.201903-0607OC","article-title":"Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens","volume":"201","author":"Mitsi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103601_bib0042","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/aor.12003","article-title":"The Development of a Multiorgan Ex Vivo Perfused Model: Results With the Porcine Liver-Kidney Circuit Over 24 Hours","volume":"37","author":"Chung","year":"2013","journal-title":"Artif Organs"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103601_bib0043","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1096\/fj.03-1450fje","article-title":"Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection","volume":"18","author":"Marriott","year":"2004","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103601_bib0044","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1164\/rccm.201705-0903OC","article-title":"Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists","volume":"198","author":"Bewley","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ebiom.2021.103601_bib0045","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3389\/fimmu.2020.00786","article-title":"Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance","volume":"11","author":"Watson","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103601_bib0046","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.it.2011.11.001","article-title":"CD169+ macrophages at the crossroads of antigen presentation","volume":"33","author":"Martinez-Pomares","year":"2012","journal-title":"Trends Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103601_bib0047","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/eji.201444983","article-title":"Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses","volume":"45","author":"Veninga","year":"2015","journal-title":"Eur J Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103601_bib0048","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S0950268810002402","article-title":"Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by Streptococcus pneumoniae","volume":"139","author":"Lin","year":"2011","journal-title":"Epidemiol Infect"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103601_bib0049","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1128\/AAC.44.9.2561-2563.2000","article-title":"Activities of Antimicrobial Agents against Intracellular Pneumococci","volume":"44","author":"Mandell","year":"2000","journal-title":"Antimicrob Agents Chemother"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421003947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421003947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:12:15Z","timestamp":1762456335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421003947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":49,"alternative-id":["S2352396421003947"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103601","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103601"}}