{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:45:12Z","timestamp":1776437112467,"version":"3.51.2"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL098166"],"award-info":[{"award-number":["U01HL098166"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000967","name":"American Health Assistance Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY029238"],"award-info":[{"award-number":["R01EY029238"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY030140"],"award-info":[{"award-number":["R01EY030140"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EBioMedicine"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ebiom.2021.103632","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T04:06:01Z","timestamp":1634875561000},"page":"103632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3"],"prefix":"10.1016","volume":"73","author":[{"given":"Tianxi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingzhu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-6365","authenticated-orcid":false,"given":"Demetrios","family":"Tsirukis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enton","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo Robert","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-9056","authenticated-orcid":false,"given":"Ye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0001","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nri3459","article-title":"Immunology of age-related macular degeneration","volume":"13","author":"Ambati","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103632_bib0002","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/bjo.2009.165563","article-title":"Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration","volume":"94","author":"Cherepanoff","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ebiom.2021.103632_bib0003","doi-asserted-by":"crossref","first-page":"16754","DOI":"10.1038\/srep16754","article-title":"Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration","volume":"5","author":"Lechner","year":"2015","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103632_bib0004","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1172\/JCI76492","article-title":"Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk","volume":"124","author":"Dejda","year":"2014","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103632_bib0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/bjo.81.5.396","article-title":"Macrophages and MHC class II positive cells in the choroid during endotoxin induced uveitis","volume":"81","author":"Yang","year":"1997","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103632_bib0006","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/bjo.83.5.598","article-title":"Dendritic cells and macrophages in the uveal tract of the normal mouse eye","volume":"83","author":"McMenamin","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0007","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.0105-2896.2009.00873.x","article-title":"Dendritic cell physiology and function in the eye","volume":"234","author":"Forrester","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ebiom.2021.103632_bib0008","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ebiom.2021.103632_bib0009","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2015.07.012","article-title":"In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization","volume":"139","author":"Crespo-Garcia","year":"2015","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ebiom.2021.103632_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/705783","article-title":"The role of microglia in diabetic retinopathy","volume":"2014","author":"Grigsby","year":"2014","journal-title":"J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0011","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/ATVBAHA.115.307080","article-title":"Inhibition of the Nuclear Receptor RORgamma and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia","volume":"36","author":"Talia","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ebiom.2021.103632_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia-neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2006.09.002","article-title":"Myeloid cell trafficking and tumor angiogenesis","volume":"250","author":"Schmid","year":"2007","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103632_bib0014","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1167\/iovs.14-16250","article-title":"Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia\/Macrophage in Ischemia\/Reperfusion Mouse Retina","volume":"56","author":"Kambhampati","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ebiom.2021.103632_bib0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4614-3209-8_26","article-title":"The role of monocytes and macrophages in age-related macular degeneration","volume":"801","author":"Grunin","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103632_bib0016","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.imbio.2013.06.010","article-title":"The role of immune-related myeloid cells in angiogenesis","volume":"218","author":"Chambers","year":"2013","journal-title":"Immunobiology"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0017","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.molmed.2011.07.009","article-title":"Metchnikoff's policemen: macrophages in development, homeostasis and regeneration","volume":"17","author":"Stefater","year":"2011","journal-title":"Trends Mol Med"},{"issue":"7352","key":"10.1016\/j.ebiom.2021.103632_bib0018","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature10085","article-title":"Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells","volume":"474","author":"Stefater","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103632_bib0019","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(93)80047-I","article-title":"Macrophages are required for cell death and tissue remodeling in the developing mouse eye","volume":"74","author":"Lang","year":"1993","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0020","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1172\/JCI29683","article-title":"Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy","volume":"116","author":"Ritter","year":"2006","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103632_bib0021","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2013.02.003","article-title":"Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1alpha degradation of netrin-1","volume":"17","author":"Binet","year":"2013","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103632_bib0022","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.4049\/jimmunol.1201168","article-title":"SOCS3 deficiency promotes M1 macrophage polarization and inflammation","volume":"189","author":"Qin","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0023","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2012.09.013","article-title":"Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization","volume":"38","author":"Spence","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2021.103632_bib0024","article-title":"A critical role for SOCS3 in promoting M1 macrophage activation and function in vitro and in vivo","author":"Arnold","year":"2013","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103632_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162111","article-title":"Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells","volume":"11","author":"Ushiki","year":"2016","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.ebiom.2021.103632_bib0026","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1182\/blood-2012-04-422527","article-title":"SOCS3 is an endogenous inhibitor of pathologic angiogenesis","volume":"120","author":"Stahl","year":"2012","journal-title":"Blood"},{"issue":"395","key":"10.1016\/j.ebiom.2021.103632_bib0027","doi-asserted-by":"crossref","first-page":"ra94","DOI":"10.1126\/scisignal.aaa8695","article-title":"SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth","volume":"8","author":"Sun","year":"2015","journal-title":"Sci Signal"},{"issue":"33","key":"10.1016\/j.ebiom.2021.103632_bib0028","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1073\/pnas.1504387112","article-title":"Nuclear receptor RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation","volume":"112","author":"Sun","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0029","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1566524016666160324130031","article-title":"STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration","volume":"16","author":"Chen","year":"2016","journal-title":"Curr Mol Med"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103632_bib0030","first-page":"3158","article-title":"VEGF is major stimulator in model of choroidal neovascularization","volume":"41","author":"Kwak","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103632_bib0031","first-page":"899","article-title":"Pathogenesis of laser-induced choroidal subretinal neovascularization","volume":"31","author":"Miller","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0032","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni938","article-title":"IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages","volume":"4","author":"Yasukawa","year":"2003","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0033","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2337\/db09-1024","article-title":"Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis","volume":"59","author":"Reed","year":"2010","journal-title":"Diabetes"},{"issue":"7297","key":"10.1016\/j.ebiom.2021.103632_bib0034","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09002","article-title":"Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis","volume":"465","author":"Wang","year":"2010","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103632_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132643","article-title":"Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice","volume":"10","author":"Gong","year":"2015","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.ebiom.2021.103632_bib0036","doi-asserted-by":"crossref","first-page":"24652","DOI":"10.18632\/oncotarget.15629","article-title":"SOCS3 inhibits the pathological effects of IL-22 in non-melanoma skin tumor-derived keratinocytes","volume":"8","author":"Madonna","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193543","article-title":"Comparison of two cannulation methods for assessment of intracavernosal pressure in a rat model","volume":"13","author":"Zhao","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2021.103632_bib0038","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/978-1-62703-496-8_24","article-title":"Generation of bone marrow and fetal liver chimeric mice","volume":"1032","author":"Holl","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"7","key":"10.1016\/j.ebiom.2021.103632_bib0039","doi-asserted-by":"crossref","first-page":"e69552","DOI":"10.1371\/journal.pone.0069552","article-title":"Choroid sprouting assay: an ex vivo model of microvascular angiogenesis","volume":"8","author":"Shao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2021.103632_bib0040","first-page":"prot5080","article-title":"Bone Marrow-Derived Macrophages (BMM): Isolation and Applications","volume":"2008","author":"Weischenfeldt","year":"2008","journal-title":"CSH Protoc"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0041","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1080\/02713680601100459","article-title":"The dynamic conduct of bone marrow-derived cells in the choroidal neovascularization microenvironment","volume":"31","author":"Hou","year":"2006","journal-title":"Curr Eye Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0042","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1634\/stemcells.22-1-21","article-title":"Choroidal neovascularization is provided by bone marrow cells","volume":"22","author":"Tomita","year":"2004","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0043","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/cne.21538","article-title":"Embryonic and postnatal development of microglial cells in the mouse retina","volume":"506","author":"Santos","year":"2008","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0044","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1076\/ocii.10.1.27.10328","article-title":"Distribution, markers, and functions of retinal microglia","volume":"10","author":"Chen","year":"2002","journal-title":"Ocul Immunol Inflamm"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103632_bib0045","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1167\/iovs.05-1522","article-title":"Potential role of microglia in retinal blood vessel formation","volume":"47","author":"Checchin","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ebiom.2021.103632_bib0046","first-page":"414","article-title":"Neutrophils promote experimental choroidal neovascularization","volume":"11","author":"Zhou","year":"2005","journal-title":"Mol Vis"},{"issue":"11","key":"10.1016\/j.ebiom.2021.103632_bib0047","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/nprot.2013.135","article-title":"Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice","volume":"8","author":"Lambert","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ebiom.2021.103632_bib0048","article-title":"Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production","volume":"5","author":"Yan","year":"2019","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0049","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1074-7613(04)00022-6","article-title":"SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis","volume":"20","author":"Croker","year":"2004","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0050","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s12035-014-9042-9","article-title":"Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression","volume":"53","author":"Wu","year":"2016","journal-title":"Mol Neurobiol"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0051","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/BJ20130481","article-title":"Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells","volume":"454","author":"Wiejak","year":"2013","journal-title":"Biochem J"},{"issue":"28","key":"10.1016\/j.ebiom.2021.103632_bib0052","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.2174\/1381612822666160530150936","article-title":"Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise","volume":"22","author":"Rani","year":"2016","journal-title":"Curr Pharm Des"},{"issue":"9","key":"10.1016\/j.ebiom.2021.103632_bib0053","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1002\/ijc.31594","article-title":"Mimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer","volume":"143","author":"La Manna","year":"2018","journal-title":"Int J Cancer"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0054","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ng.976","article-title":"A rare penetrant mutation in CFH confers high risk of age-related macular degeneration","volume":"43","author":"Raychaudhuri","year":"2011","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103632_bib0055","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1167\/iovs.13-13522","article-title":"Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change","volume":"55","author":"Kumar","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7726","key":"10.1016\/j.ebiom.2021.103632_bib0056","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41586-018-0552-x","article-title":"Erythro-myeloid progenitors contribute endothelial cells to blood vessels","volume":"562","author":"Plein","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0057","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.PRS.0000091169.51035.A5","article-title":"Selective recruitment of endothelial progenitor cells to ischemic tissues with increased neovascularization","volume":"113","author":"Park","year":"2004","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0058","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0092-8674(00)00025-8","article-title":"A role for hematopoietic stem cells in promoting angiogenesis","volume":"102","author":"Takakura","year":"2000","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.ebiom.2021.103632_bib0059","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1093\/emboj\/18.14.3964","article-title":"VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells","volume":"18","author":"Asahara","year":"1999","journal-title":"EMBO J"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0060","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.RES.86.12.1198","article-title":"Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects","volume":"86","author":"Kalka","year":"2000","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0061","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/7434","article-title":"Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization","volume":"5","author":"Takahashi","year":"1999","journal-title":"Nat Med"},{"issue":"35","key":"10.1016\/j.ebiom.2021.103632_bib0062","doi-asserted-by":"crossref","first-page":"13156","DOI":"10.1073\/pnas.0604203103","article-title":"Myeloid lineage progenitors give rise to vascular endothelium","volume":"103","author":"Bailey","year":"2006","journal-title":"PNAS"},{"issue":"5302","key":"10.1016\/j.ebiom.2021.103632_bib0063","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0064","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1172\/JCI8071","article-title":"Origins of circulating endothelial cells and endothelial outgrowth from blood","volume":"105","author":"Lin","year":"2000","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0065","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/blood.V95.2.581","article-title":"Enhanced endothelialization and microvessel formation in polyester grafts seeded with CD34(+) bone marrow cells","volume":"95","author":"Bhattacharya","year":"2000","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103632_bib0066","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"Asahara","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.ebiom.2021.103632_bib0067","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54257","article-title":"Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration","volume":"9","author":"Baba","year":"2020","journal-title":"eLife"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103632_bib0068","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/CIRCRESAHA.120.317442","article-title":"No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs","volume":"127","author":"Feng","year":"2020","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.ebiom.2021.103632_bib0069","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0344-0338(11)80727-2","article-title":"The use of CD31 and collagen IV as vascular markers. A study of 56 vascular lesions","volume":"191","author":"Schmidt","year":"1995","journal-title":"Pathol Res Pract"},{"issue":"34","key":"10.1016\/j.ebiom.2021.103632_bib0070","doi-asserted-by":"crossref","first-page":"22777","DOI":"10.1016\/S0021-9258(18)54418-5","article-title":"von Willebrand factor","volume":"266","author":"Sadler","year":"1991","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0071","doi-asserted-by":"crossref","first-page":"E1101","DOI":"10.1073\/pnas.1314505111","article-title":"CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells","volume":"111","author":"Clement","year":"2014","journal-title":"PNAS"},{"issue":"12","key":"10.1016\/j.ebiom.2021.103632_bib0072","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.4049\/jimmunol.1900059","article-title":"CD31 Acts as a Checkpoint Molecule and Is Modulated by FcgammaR-Mediated Signaling in Monocytes","volume":"203","author":"Merchand-Reyes","year":"2019","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0073","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF00489554","article-title":"Lectin histochemistry of mammalian endothelium","volume":"86","author":"Alroy","year":"1987","journal-title":"Histochemistry"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0074","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/jnc.12209","article-title":"The isolectin IB4 binds RET receptor tyrosine kinase in microglia","volume":"126","author":"Boscia","year":"2013","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.ebiom.2021.103632_bib0075","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stem.2018.04.014","article-title":"Single-Cell Transcriptomics Meets Lineage Tracing","volume":"23","author":"Kester","year":"2018","journal-title":"Cell stem cell"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0076","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105123","article-title":"Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling","volume":"40","author":"Wieghofer","year":"2021","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0077","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res"},{"key":"10.1016\/j.ebiom.2021.103632_bib0078","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.exer.2017.10.013","article-title":"Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy","volume":"166","author":"Vahatupa","year":"2018","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0079","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/ATVBAHA.115.306681","article-title":"Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization\u2013Brief Report","volume":"36","author":"Liyanage","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.22727","article-title":"Genetic targeting of microglia","volume":"63","author":"Wieghofer","year":"2015","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0081","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.0903563","article-title":"Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages","volume":"185","author":"Akhtar","year":"2010","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103632_bib0082","doi-asserted-by":"crossref","first-page":"670","DOI":"10.15252\/emmm.201505994","article-title":"Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization","volume":"8","author":"Luckoff","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.ebiom.2021.103632_bib0083","doi-asserted-by":"crossref","DOI":"10.3390\/ph12010011","article-title":"The Therapeutic Potential of Naringenin: A Review of Clinical Trials","volume":"12","author":"Salehi","year":"2019","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.ebiom.2021.103632_bib0084","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fitote.2016.04.015","article-title":"Naringenin exerts anti-angiogenic effects in human endothelial cells: Involvement of ERRalpha\/VEGF\/KDR signaling pathway","volume":"111","author":"Li","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ebiom.2021.103632_bib0085","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.31594","article-title":"Mimetics of Suppressor of cytokine signalling 3: novel potential therapeutics in triple breast cancer","author":"La Manna","year":"2018","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.ebiom.2021.103632_bib0086","first-page":"583","article-title":"Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities","volume":"90","author":"Quijano","year":"2017","journal-title":"Yale J Biol Med"}],"container-title":["EBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421004254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421004254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:15:48Z","timestamp":1762456548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421004254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":86,"alternative-id":["S2352396421004254"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103632","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3","name":"articletitle","label":"Article Title"},{"value":"EBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103632"}}