{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:20:54Z","timestamp":1778862054783,"version":"3.51.4"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006282","name":"King Baudouin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/19\/101"],"award-info":[{"award-number":["C14\/19\/101"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G081821N"],"award-info":[{"award-number":["G081821N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ebiom.2021.103741","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T06:38:51Z","timestamp":1639118331000},"page":"103741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Keeping an eye on Ca2+ signalling to tackle dry eye diseases"],"prefix":"10.1016","volume":"74","author":[{"given":"Flore","family":"Sneyers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-9009","authenticated-orcid":false,"given":"Jens","family":"Loncke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-4828","authenticated-orcid":false,"given":"Geert","family":"Bultynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ebiom.2021.103741_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.118954","article-title":"CISD2 maintains cellular homeostasis","volume":"1868","author":"Shen","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"702","key":"10.1016\/j.ebiom.2021.103741_bib0002","doi-asserted-by":"crossref","first-page":"eabc6165","DOI":"10.1126\/scisignal.abc6165","article-title":"Uniting the divergent Wolfram syndrome-linked proteins WFS1 and CISD2 as modulators of Ca2+ signaling","volume":"14","author":"Loncke","year":"2021","journal-title":"Sci Signal"},{"issue":"10","key":"10.1016\/j.ebiom.2021.103741_bib0003","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1101\/gad.1779509","article-title":"Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.ebiom.2021.103741_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103654","article-title":"Cisd2 plays an essential role in corneal epithelial regeneration","volume":"73","author":"Sun","year":"2021","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.ebiom.2021.103741_bib0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/ICO.0b013e3181702d0c","article-title":"Outcome of treatment of mooren ulcer with topical cyclosporine a 2%","volume":"27","author":"Tandon","year":"2008","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.ebiom.2021.103741_bib0006","doi-asserted-by":"crossref","first-page":"e99205","DOI":"10.1371\/journal.pone.0099205","article-title":"Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye","volume":"9","author":"Inaba","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2021.103741_bib0007","doi-asserted-by":"crossref","first-page":"13953","DOI":"10.1038\/srep13953","article-title":"IP3R deficit underlies loss of salivary fluid secretion in Sjogren's Syndrome","volume":"5","author":"Teos","year":"2015","journal-title":"Sci Rep"},{"issue":"49","key":"10.1016\/j.ebiom.2021.103741_bib0008","doi-asserted-by":"crossref","first-page":"E5292","DOI":"10.1073\/pnas.1421055111","article-title":"A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome","volume":"111","author":"Lu","year":"2014","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.ebiom.2021.103741_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030700","article-title":"Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model","volume":"11","author":"Lin","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ebiom.2021.103741_bib0010","article-title":"Reduced Corneal Sensitivity with Neuronal Degeneration is a Novel Clinical Feature in Wolfram Syndrome","author":"Waszczykowska","year":"2021","journal-title":"Am J Ophthalmol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421005351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396421005351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:37:55Z","timestamp":1764866275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396421005351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":10,"alternative-id":["S2352396421005351"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103741","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keeping an eye on Ca2+ signalling to tackle dry eye diseases","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2021.103654","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103741"}}