{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:59Z","timestamp":1786987799844,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ebiom.2022.103843","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T07:42:10Z","timestamp":1643787730000},"page":"103843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Inhibition of caspase-1-mediated inflammasome activation reduced blood coagulation in cerebrospinal fluid after subarachnoid haemorrhage"],"prefix":"10.1016","volume":"76","author":[{"given":"Yuanjian","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4458-0559","authenticated-orcid":false,"given":"Reng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Lenahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-136X","authenticated-orcid":false,"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ebiom.2022.103843_bib0001","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJMcp1605827","article-title":"Subarachnoid hemorrhage","volume":"377","author":"Lawton","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103843_bib0002","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/ene.12686","article-title":"Predictors and impact of early cerebral infarction after aneurysmal subarachnoid hemorrhage","volume":"22","author":"Jabbarli","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.ebiom.2022.103843_bib0003","first-page":"1","article-title":"Thick and diffuse cisternal clot independently predicts vasospasm-related morbidity and poor outcome after aneurysmal subarachnoid hemorrhage","author":"Aldrich","year":"2020","journal-title":"J Neurosurg"},{"issue":"13","key":"10.1016\/j.ebiom.2022.103843_bib0004","first-page":"226","article-title":"Aneurysmal Subarachnoid Hemorrhage","volume":"114","author":"Petridis","year":"2017","journal-title":"Dtsch Arztebl Int"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10143-019-01116-1","article-title":"The effectiveness of lumbar cerebrospinal fluid drainage in aneurysmal subarachnoid hemorrhage with different bleeding amounts","volume":"43","author":"Fang","year":"2020","journal-title":"Neurosurg Rev"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103843_bib0006","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3109\/02688697.2010.505989","article-title":"External ventricular drainage following aneurysmal subarachnoid haemorrhage","volume":"24","author":"Gigante","year":"2010","journal-title":"Br J Neurosurg"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103843_bib0007","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1227\/00006123-198304000-00011","article-title":"Disturbances of cerebrospinal fluid circulation during the acute stage of subarachnoid hemorrhage","volume":"12","author":"Doczi","year":"1983","journal-title":"Neurosurgery"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103843_bib0008","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/STROKEAHA.114.006617","article-title":"Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?","volume":"45","author":"Gaberel","year":"2014","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0009","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12975-014-0329-y","article-title":"Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice","volume":"5","author":"Siler","year":"2014","journal-title":"Transl Stroke Res"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1227\/00006123-198701000-00004","article-title":"Acute hydrocephalus after aneurysmal subarachnoid hemorrhage","volume":"20","author":"Milhorat","year":"1987","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103843_bib0011","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/0271678X17701157","article-title":"Subarachnoid hemorrhage - Induced block of cerebrospinal fluid flow: role of brain coagulation factor III (tissue factor)","volume":"38","author":"Golanov","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0012","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11910-010-0086-6","article-title":"Management of intraventricular hemorrhage","volume":"10","author":"Hinson","year":"2010","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103843_bib0013","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1590\/S0004-282X1993000400005","article-title":"Arachnoid granulation affected by subarachnoid hemorrhage","volume":"51","author":"Chopard","year":"1993","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.ebiom.2022.103843_bib0014","doi-asserted-by":"crossref","first-page":"e2160","DOI":"10.1038\/cddis.2016.63","article-title":"Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control","volume":"7","author":"Luo","year":"2016","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103843_bib0015","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s004010000219","article-title":"Morphological changes following experimental intraventricular haemorrhage and intraventricular fibrinolytic treatment with recombinant tissue plasminogen activator","volume":"100","author":"Mayfrank","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0016","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5607\/en.2019.28.1.104","article-title":"Persistent malfunction of glymphatic and meningeal lymphatic drainage in a mouse model of subarachnoid hemorrhage","volume":"28","author":"Pu","year":"2019","journal-title":"Exp Neurobiol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103843_bib0017","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.STR.31.6.1256","article-title":"Urokinase cisternal irrigation therapy for prevention of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage: a study of urokinase concentration and the fibrinolytic system","volume":"31","author":"Sasaki","year":"2000","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1227\/01.NEU.0000370920.44359.91","article-title":"Intraventricular tissue plasminogen activator for the prevention of vasospasm and hydrocephalus after aneurysmal subarachnoid hemorrhage","volume":"67","author":"Ramakrishna","year":"2010","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0019","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s13311-019-00829-x","article-title":"Aneurysmal subarachnoid hemorrhage: an overview of inflammation-induced cellular changes","volume":"17","author":"Coulibaly","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41419-020-2248-z","article-title":"Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0021","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrn3638","article-title":"Inflammasomes in the CNS","volume":"15","author":"Walsh","year":"2014","journal-title":"Nat Rev Neurosci"},{"issue":"2 Suppl","key":"10.1016\/j.ebiom.2022.103843_bib0022","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ebiom.2022.103843_bib0023","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fcell.2020.00073","article-title":"Understanding inflammatory responses in the manifestation of prothrombotic phenotypes","volume":"8","author":"Chanchal","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0024","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vph.2014.05.005","article-title":"Regulation of tissue factor gene expression in monocytes and endothelial cells: thromboxane A2 as a new player","volume":"62","author":"Bode","year":"2014","journal-title":"Vascul Pharmacol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103843_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2019.04.003","article-title":"Inflammasome activation triggers blood clotting and host death through pyroptosis","volume":"50","author":"Wu","year":"2019","journal-title":"Immunity"},{"issue":"Suppl 2","key":"10.1016\/j.ebiom.2022.103843_bib0026","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/S0049-3848(16)30369-3","article-title":"Astrocyte tissue factor controls CNS hemostasis and autoimmune inflammation","volume":"141","author":"Wang","year":"2016","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103843_bib0027","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1007\/s13311-020-00925-3","article-title":"Pituitary adenylate cyclase-activating polypeptide attenuates brain edema by protecting blood-brain barrier and glymphatic system after subarachnoid hemorrhage in rats","volume":"17","author":"Fang","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103843_bib0028","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s00330-020-07242-5","article-title":"Deep venous drainage variant rate and degree may be higher in patients with perimesencephalic than in non-perimesencephalic angiogram-negative subarachnoid hemorrhage","volume":"31","author":"Fang","year":"2021","journal-title":"Eur Radiol"},{"key":"10.1016\/j.ebiom.2022.103843_bib0029","unstructured":"Niknejad SIaMT. Sentinel clot sign; 2021. [Available from: https:\/\/radiopaedia.org\/articles\/sentinel-clot-sign?lang=us."},{"issue":"10","key":"10.1016\/j.ebiom.2022.103843_bib0030","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/s41418-018-0137-0","article-title":"A connexin43\/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation","volume":"25","author":"Yang","year":"2018","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0031","first-page":"165","article-title":"Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models","volume":"52","author":"Prunell","year":"2003","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0032","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","article-title":"A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model","volume":"167","author":"Sugawara","year":"2008","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0033","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jneumeth.2010.05.004","article-title":"Digitally quantifying cerebral hemorrhage using Photoshop and Image J","volume":"190","author":"Tang","year":"2010","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.ebiom.2022.103843_bib0034","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainresbull.2018.10.009","article-title":"Evaluation of intranasal delivery route of drug administration for brain targeting","volume":"143","author":"Erdo","year":"2018","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.ebiom.2022.103843_bib0035","article-title":"PubChem Compound Summary for CID 11398092","year":"2021","journal-title":"Belnacasan. Nat Center Biotechnol Inf"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0036","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1038\/s41467-018-06449-x","article-title":"Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model","volume":"9","author":"Flores","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2022.103843_bib0037","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jneumeth.2018.09.031","article-title":"Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin","volume":"311","author":"Wolf","year":"2019","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0038","doi-asserted-by":"crossref","first-page":"e2579","DOI":"10.1038\/cddis.2016.460","article-title":"NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2022.103843_bib0039","unstructured":"Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF ClinicalTrials.gov; 2022. [Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04938414."},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/neuros\/nyx364","article-title":"The subarachnoid hemorrhage early brain edema score predicts delayed cerebral ischemia and clinical outcomes","volume":"83","author":"Ahn","year":"2018","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0041","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12987-019-0129-6","article-title":"Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases","volume":"16","author":"Bothwell","year":"2019","journal-title":"Fluids Barriers CNS"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0042","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3171\/2016.9.JNS16615","article-title":"Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study","volume":"128","author":"Galea","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ebiom.2022.103843_bib0043","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3389\/fnins.2019.00541","article-title":"Fibrinogen chains intrinsic to the brain","volume":"13","author":"Golanov","year":"2019","journal-title":"Front Neurosci"},{"issue":"68","key":"10.1016\/j.ebiom.2022.103843_bib0044","article-title":"Programmed cell deaths and potential crosstalk with blood\u2013brain barrier dysfunction after hemorrhagic stroke","volume":"14","author":"Fang","year":"2020","journal-title":"Front. Cell Neurosci."},{"issue":"3","key":"10.1016\/j.ebiom.2022.103843_bib0045","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12028-020-01113-z","article-title":"Inflammasome caspase-1 activity is elevated in cerebrospinal fluid after aneurysmal subarachnoid hemorrhage and predicts functional outcome","volume":"34","author":"Hirsch","year":"2021","journal-title":"Neurocrit Care"},{"issue":"9","key":"10.1016\/j.ebiom.2022.103843_bib0046","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1161\/01.STR.28.9.1666","article-title":"Cerebrospinal fluid tissue factor and thrombin-antithrombin III complex as indicators of tissue injury after subarachnoid hemorrhage","volume":"28","author":"Hirashima","year":"1997","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0047","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-018-1282-6","article-title":"Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia\/reperfusion injury","volume":"15","author":"Gong","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"26","key":"10.1016\/j.ebiom.2022.103843_bib0048","doi-asserted-by":"crossref","first-page":"E6065","DOI":"10.1073\/pnas.1722041115","article-title":"Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis","volume":"115","author":"McKenzie","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103843_bib0049","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.bbrc.2019.03.202","article-title":"Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia\/macrophage and suppressing NF-kappaB activation","volume":"513","author":"Li","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ebiom.2022.103843_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7879629","article-title":"VX765 attenuates pyroptosis and HMGB1\/TLR4\/NF-kappaB pathways to improve functional outcomes in TBI mice","volume":"2020","author":"Sun","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103843_bib0051","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI116573","article-title":"Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis","volume":"92","author":"Eddleston","year":"1993","journal-title":"J Clin Invest"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:12:07Z","timestamp":1762456327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":51,"alternative-id":["S2352396422000275"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103843","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of caspase-1-mediated inflammasome activation reduced blood coagulation in cerebrospinal fluid after subarachnoid haemorrhage","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103843"}}