{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:00:02Z","timestamp":1793826002837,"version":"4.6.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP0033-110737"],"award-info":[{"award-number":["PP0033-110737"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-14-CE14-0030-01"],"award-info":[{"award-number":["ANR-14-CE14-0030-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-19- CE18-0021-02"],"award-info":[{"award-number":["ANR-19- CE18-0021-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-10-LABX-69-01"],"award-info":[{"award-number":["ANR-10-LABX-69-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009396","name":"Universit\u00e4tsspital Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012453","name":"Providence Health Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000045","name":"Aetna Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ebiom.2022.103852","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T02:01:56Z","timestamp":1643680916000},"page":"103852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old"],"prefix":"10.1016","volume":"76","author":[{"given":"Francesco","family":"Nicoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Clave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Wanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrei","family":"von Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bondet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Alanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Douay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Baque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lependu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-8674","authenticated-orcid":false,"given":"Karin","family":"Stiasny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Muetsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Boddaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Sauce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Toubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Karrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Appay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ebiom.2022.103852_bib0001","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3201\/eid1108.050289a","article-title":"Epidemiology and transmission dynamics of West Nile virus disease","volume":"11","author":"Hayes","year":"2005","journal-title":"Emerg Infect Dis"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2022.103852_bib0002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-3156.2008.02147.x","article-title":"Case fatality of SARS in mainland China and associated risk factors","volume":"14","author":"Jia","year":"2009","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.ebiom.2022.103852_bib0003","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mib.2015.11.003","article-title":"Infection in an aging population","volume":"29","author":"Kline","year":"2016","journal-title":"Curr Opin Microbiol"},{"issue":"18","key":"10.1016\/j.ebiom.2022.103852_bib0004","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.ebiom.2022.103852_bib0005","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103852_bib0006","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.jaci.2020.03.017","article-title":"Influence of immune aging on vaccine responses","volume":"145","author":"Gustafson","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"7872","key":"10.1016\/j.ebiom.2022.103852_bib0007","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-021-03739-1","article-title":"Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2","volume":"596","author":"Collier","year":"2021","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0008","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/infdis\/jiw047","article-title":"Declining effectiveness of herpes zoster vaccine in adults aged >\/=60 years","volume":"213","author":"Tseng","year":"2016","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103852_bib0009","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.1700290","article-title":"Varicella-zoster virus-specific cellular immune responses to the live attenuated zoster vaccine in young and older adults","volume":"199","author":"Weinberg","year":"2017","journal-title":"J Immunol"},{"issue":"43","key":"10.1016\/j.ebiom.2022.103852_bib0010","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1016\/j.vaccine.2008.07.071","article-title":"Pneumococcal vaccination in older adults induces antibodies with low opsonic capacity and reduced antibody potency","volume":"26","author":"Schenkein","year":"2008","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0011","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/cid\/civ686","article-title":"The impact of age on the efficacy of 13-valent pneumococcal conjugate vaccine in elderly","volume":"61","author":"Van Werkhoven","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0012","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12979-016-0081-0","article-title":"Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults","volume":"13","author":"Grasse","year":"2016","journal-title":"Immun Ageing"},{"key":"10.1016\/j.ebiom.2022.103852_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2019.103998","article-title":"Aging and influenza vaccine-induced immunity","volume":"348","author":"Dugan","year":"2020","journal-title":"Cell Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0014","doi-asserted-by":"crossref","first-page":"e27753","DOI":"10.1371\/journal.pone.0027753","article-title":"Elderly subjects have a delayed antibody response and prolonged viraemia following yellow fever vaccination: a prospective controlled cohort study","volume":"6","author":"Roukens","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103852_bib0015","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.4049\/jimmunol.1500598","article-title":"Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans","volume":"195","author":"Schulz","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2022.103852_bib0016","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3389\/fimmu.2018.01035","article-title":"Impaired immune response to primary but not to booster vaccination against hepatitis B in older adults","volume":"9","author":"Weinberger","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0017","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1038\/s41598-018-28111-8","article-title":"Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules","volume":"8","author":"Wagner","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103852_bib0018","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s11357-020-00217-w","article-title":"Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity","volume":"42","author":"Nicoli","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.ebiom.2022.103852_bib0019","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exger.2014.01.003","article-title":"Naive T cells: the crux of cellular immune aging?","volume":"54","author":"Appay","year":"2014","journal-title":"Exp Gerontol"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103852_bib0020","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/nm.2963","article-title":"Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity","volume":"18","author":"Li","year":"2012","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0021","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/acel.12384","article-title":"Reduced naive CD8(+) T-cell priming efficacy in elderly adults","volume":"15","author":"Briceno","year":"2016","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0022","doi-asserted-by":"crossref","first-page":"e12879","DOI":"10.1111\/acel.12879","article-title":"Functional pathways regulated by microRNA networks in CD8 T-cell aging","volume":"18","author":"Gustafson","year":"2019","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103852_bib0023","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri.2016.38","article-title":"T cell responses to cytomegalovirus","volume":"16","author":"Klenerman","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103852_bib0024","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41590-018-0049-7","article-title":"Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors","volume":"19","author":"Patin","year":"2018","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103852_bib0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.vaccine.2012.11.041","article-title":"Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination","volume":"31","author":"Derhovanessian","year":"2013","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0026","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.vaccine.2015.01.071","article-title":"Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine","volume":"33","author":"Frasca","year":"2015","journal-title":"Vaccine"},{"issue":"25-26","key":"10.1016\/j.ebiom.2022.103852_bib0027","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/S0264-410X(03)00309-8","article-title":"Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination\u2013an impact of immunosenescence","volume":"21","author":"Trzonkowski","year":"2003","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.ebiom.2022.103852_bib0028","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.4049\/jimmunol.1303361","article-title":"Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly","volume":"193","author":"Derhovanessian","year":"2014","journal-title":"J Immunol"},{"issue":"29-30","key":"10.1016\/j.ebiom.2022.103852_bib0029","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1016\/j.vaccine.2011.03.086","article-title":"Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities","volume":"29","author":"den Elzen","year":"2011","journal-title":"Vaccine"},{"issue":"281","key":"10.1016\/j.ebiom.2022.103852_bib0030","doi-asserted-by":"crossref","first-page":"281ra43","DOI":"10.1126\/scitranslmed.aaa2293","article-title":"Cytomegalovirus infection enhances the immune response to influenza","volume":"7","author":"Furman","year":"2015","journal-title":"Sci Transl Med"},{"issue":"29","key":"10.1016\/j.ebiom.2022.103852_bib0031","doi-asserted-by":"crossref","first-page":"E6817","DOI":"10.1073\/pnas.1719451115","article-title":"Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection","volume":"115","author":"Smithey","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103852_bib0032","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcv.2012.02.016","article-title":"Quantitative determination of IgM antibodies reduces the pitfalls in the serodiagnosis of tick-borne encephalitis","volume":"54","author":"Stiasny","year":"2012","journal-title":"J Clin Virol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103852_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003458","article-title":"Dissection of antibody specificities induced by yellow fever vaccination","volume":"9","author":"Vratskikh","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103852_bib0034","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41541-019-0133-5","article-title":"Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination","volume":"4","author":"Bradt","year":"2019","journal-title":"npj Vaccines"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103852_bib0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2310\/7060.2005.12205","article-title":"Protection against tick-borne encephalitis with a new vaccine formulation free of protein-derived stabilizers","volume":"12","author":"Zent","year":"2005","journal-title":"J Travel Med"},{"key":"10.1016\/j.ebiom.2022.103852_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155533","article-title":"Differential levels of IFNalpha subtypes in autoimmunity and viral infection","volume":"144","author":"Bondet","year":"2021","journal-title":"Cytokine"},{"issue":"50","key":"10.1016\/j.ebiom.2022.103852_bib0037","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1016\/j.vaccine.2009.09.069","article-title":"Characteristics of antibody responses in tick-borne encephalitis vaccination breakthroughs","volume":"27","author":"Stiasny","year":"2009","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0038","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/(SICI)1096-9071(199601)48:1<102::AID-JMV16>3.0.CO;2-I","article-title":"Correlation between ELISA, hemagglutination inhibition, and neutralization tests after vaccination against tick-borne encephalitis","volume":"48","author":"Holzmann","year":"1996","journal-title":"J Med Virol"},{"issue":"457","key":"10.1016\/j.ebiom.2022.103852_bib0039","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao2966","article-title":"Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus","volume":"10","author":"Clave","year":"2018","journal-title":"Sci Transl Med"},{"issue":"13","key":"10.1016\/j.ebiom.2022.103852_bib0040","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1039\/c1lc20126c","article-title":"Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR","volume":"11","author":"Zhong","year":"2011","journal-title":"Lab Chip"},{"key":"10.1016\/j.ebiom.2022.103852_bib0041","series-title":"R: A Language and Environment for Statistical Computing","year":"2019"},{"key":"10.1016\/j.ebiom.2022.103852_bib0042","series-title":"RStudio: integrated development environment for R","year":"2016"},{"issue":"43","key":"10.1016\/j.ebiom.2022.103852_bib0043","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"Journal of Open Source Software"},{"key":"10.1016\/j.ebiom.2022.103852_bib0044","unstructured":"https:\/\/scales.r-lib.org\/, Accessed 17 July 2018"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103852_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000383","article-title":"Cell generation dynamics underlying naive T-cell homeostasis in adult humans","volume":"17","author":"Mold","year":"2019","journal-title":"PLoS Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103852_bib0046","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11357-010-9170-8","article-title":"Age-related deregulation of naive T cell homeostasis in elderly humans","volume":"33","author":"Ferrando-Martinez","year":"2011","journal-title":"Age"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103852_bib0047","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1172\/JCI39269","article-title":"Evidence of premature immune aging in patients thymectomized during early childhood","volume":"119","author":"Sauce","year":"2009","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0048","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.4049\/jimmunol.1201235","article-title":"Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults","volume":"189","author":"Sauce","year":"2012","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103852_bib0049","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.4049\/jimmunol.1301721","article-title":"Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans","volume":"192","author":"Wertheimer","year":"2014","journal-title":"J Immunol"},{"issue":"36","key":"10.1016\/j.ebiom.2022.103852_bib0050","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1073\/pnas.1409155111","article-title":"Diversity and clonal selection in the human T-cell repertoire","volume":"111","author":"Qi","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2022.103852_bib0051","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3389\/fimmu.2018.01618","article-title":"The changing landscape of naive T cell receptor repertoire with human aging","volume":"9","author":"Egorov","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2022.103852_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.693054","article-title":"Impaired priming of SARS-CoV-2-specific naive CD8(+) T cells in older subjects","volume":"12","author":"Gallerani","year":"2021","journal-title":"Front Immunol"},{"issue":"18","key":"10.1016\/j.ebiom.2022.103852_bib0053","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1182\/blood-2009-10-251124","article-title":"Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies","volume":"115","author":"Alanio","year":"2010","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103852_bib0054","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2012.10.021","article-title":"Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults","volume":"38","author":"Su","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103852_bib0055","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.164.4.2180","article-title":"Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy","volume":"164","author":"Sempowski","year":"2000","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2022.103852_bib0056","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.18632\/oncotarget.14886","article-title":"Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection","volume":"8","author":"Carbajosa","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.ebiom.2022.103852_bib0057","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/jmv.23642","article-title":"Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults","volume":"85","author":"Wald","year":"2013","journal-title":"J Med Virol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103852_bib0058","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/21645515.2015.1105413","article-title":"Aging, cytomegalovirus (CMV) and influenza vaccine responses","volume":"12","author":"Frasca","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"23","key":"10.1016\/j.ebiom.2022.103852_bib0059","doi-asserted-by":"crossref","first-page":"33581","DOI":"10.18632\/oncotarget.9254","article-title":"Vaccine efficacy and T helper cell differentiation change with aging","volume":"7","author":"Lefebvre","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ebiom.2022.103852_bib0060","doi-asserted-by":"crossref","first-page":"25051","DOI":"10.1038\/srep25051","article-title":"Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses","volume":"6","author":"Lefebvre","year":"2016","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.ebiom.2022.103852_bib0061","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.4049\/jimmunol.1302503","article-title":"Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults","volume":"193","author":"Herati","year":"2014","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103852_bib0062","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1084\/jem.20041395","article-title":"Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses","volume":"200","author":"Eaton","year":"2004","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103852_bib0063","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/ar1180","article-title":"Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity","volume":"6","author":"Johnson","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ebiom.2022.103852_bib0064","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-065X.1997.tb01027.x","article-title":"Age-related changes in antibody repertoire: contribution from T cells","volume":"160","author":"Song","year":"1997","journal-title":"Immunol Rev"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103852_bib0065","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.4049\/jimmunol.180.5.2741","article-title":"Mechanisms for decreased function of B cells in aged mice and humans","volume":"180","author":"Frasca","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2022.103852_bib0066","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70554","article-title":"Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans","volume":"10","author":"Hill","year":"2021","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103852_bib0067","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13054-020-03440-1","article-title":"Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome","volume":"25","author":"Cuvelier","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2022.103852_bib0068","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12979-020-00185-x","article-title":"The ancient and the new\": is there an interaction between cytomegalovirus and SARS-CoV-2 infection?","volume":"17","author":"Moss","year":"2020","journal-title":"Immun Ageing"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103852_bib0069","doi-asserted-by":"crossref","first-page":"e2144","DOI":"10.1002\/rmv.2144","article-title":"Why the elderly appear to be more severely affected by COVID-19: the potential role of immunosenescence and CMV","volume":"30","author":"Kadambari","year":"2020","journal-title":"Rev Med Virol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:34:42Z","timestamp":1778873682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422000366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":69,"alternative-id":["S2352396422000366"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103852","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103852"}}