{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:19:12Z","timestamp":1792981152838,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ebiom.2022.103882","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:32:47Z","timestamp":1644978767000},"page":"103882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-6628","authenticated-orcid":false,"given":"Tingting","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Uhlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-5344","authenticated-orcid":false,"given":"Sumonto","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Winn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ebiom.2022.103882_bib0001","doi-asserted-by":"crossref","first-page":"66","DOI":"10.13004\/kjnt.2014.10.2.66","article-title":"Clinical features of post-traumatic syringomyelia","volume":"10","author":"Kim","year":"2014","journal-title":"Korean J Neurotrauma"},{"issue":"9","key":"10.1016\/j.ebiom.2022.103882_bib0002","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/jnnp.57.9.1095","article-title":"Post-traumatic syringomyelia","volume":"57","author":"Squier","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41394-020-0264-y","article-title":"Silent post-traumatic syringomyelia and syringobulbia","volume":"6","author":"Scivoletto","year":"2020","journal-title":"Spinal Cord Ser Cases"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0004","first-page":"52","article-title":"Clinical manifestations and significance of post-traumatic thoracolumbar syringomyelia","volume":"7","author":"Qiu","year":"2004","journal-title":"Chin J Traumatol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103882_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s005860000197","article-title":"Comparison of different operative modalities in post-traumatic syringomyelia: preliminary report","volume":"10","author":"Schaan","year":"2001","journal-title":"Eur Spine J"},{"key":"10.1016\/j.ebiom.2022.103882_bib0006","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1038\/scsandc.2015.13","article-title":"Post-traumatic syringomyelia refractory to surgical intervention: a series of cases on recurrent syringomyelia","volume":"1","author":"Leahy","year":"2015","journal-title":"Spinal Cord Ser Cases"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103882_bib0007","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.stem.2018.05.014","article-title":"A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury","volume":"22","author":"Curtis","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103882_bib0008","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.stem.2020.07.007","article-title":"Neural stem cell grafts form extensive synaptic networks that integrate with host circuits after spinal cord injury","volume":"27","author":"Ceto","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103882_bib0009","first-page":"378","article-title":"Transplantation of neural precursor cells in the treatment of Parkinson disease: an efficacy and safety analysis","volume":"26","author":"Lige","year":"2016","journal-title":"Turk Neurosurg"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1089\/scd.2014.0096","article-title":"Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury","volume":"24","author":"Salewski","year":"2015","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ebiom.2022.103882_bib0011","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.expneurol.2013.12.022","article-title":"Neuroprotective effects of human spinal cord-derived neural precursor cells after transplantation to the injured spinal cord","volume":"253","author":"Emgard","year":"2014","journal-title":"Exp Neurol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103882_bib0012","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/cne.23578","article-title":"Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord","volume":"522","author":"Sareen","year":"2014","journal-title":"J Comp Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103882_bib0013","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4252\/wjsc.v6.i4.404","article-title":"Fetal stem cell transplantation: past, present, and future","volume":"6","author":"Ishii","year":"2014","journal-title":"World J Stem Cells"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103882_bib0014","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/MOO.0b013e328330345b","article-title":"Regeneration of the mammalian inner ear sensory epithelium","volume":"17","author":"Wei","year":"2009","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ebiom.2022.103882_bib0015","doi-asserted-by":"crossref","DOI":"10.1007\/s13311-020-00987-3","article-title":"Transplantation of human neural precursor cells reverses syrinx growth in a rat model of post-traumatic syringomyelia","author":"Xu","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103882_bib0016","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nm.4066","article-title":"Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration","volume":"22","author":"Kadoya","year":"2016","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.ebiom.2022.103882_bib0017","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41592-018-0074-3","article-title":"Generation and post-injury integration of human spinal cord neural stem cells","volume":"15","author":"Kumamaru","year":"2018","journal-title":"Nat Methods"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103882_bib0018","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.stemcr.2018.10.022","article-title":"Treatment with a gamma-secretase inhibitor promotes functional recovery in human iPSC- derived transplants for chronic spinal cord injury","volume":"11","author":"Okubo","year":"2018","journal-title":"Stem Cell Rep"},{"issue":"8","key":"10.1016\/j.ebiom.2022.103882_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182339","article-title":"Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury","volume":"12","author":"Suzuki","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ebiom.2022.103882_bib0020","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nm.4354","article-title":"Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury","volume":"23","author":"Hara","year":"2017","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0021","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12974-017-1008-1","article-title":"Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-kappaB signaling in an IL-6-dependent manner","volume":"14","author":"Sun","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"16","key":"10.1016\/j.ebiom.2022.103882_bib0022","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1089\/neu.2012.2614","article-title":"Aquaporin-4 expression in post-traumatic syringomyelia","volume":"30","author":"Hemley","year":"2013","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.ebiom.2022.103882_bib0023","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fncel.2020.00208","article-title":"Role of chondroitin sulfation following spinal cord injury","volume":"14","author":"Hussein","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ebiom.2022.103882_bib0024","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuroscience.2021.05.031","article-title":"The function of NG2\/CSPG4-expressing cells in the rat spinal cord injury: an immunoelectron microscopy study","volume":"467","author":"Kabdesh","year":"2021","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103882_bib0025","doi-asserted-by":"crossref","first-page":"e60733","DOI":"10.1371\/journal.pone.0060733","article-title":"Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103882_bib0026","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1007\/s00701-020-04529-w","article-title":"Treatment of posttraumatic syringomyelia: evidence from a systematic review","volume":"162","author":"Kleindienst","year":"2020","journal-title":"Acta Neurochir (Wien)"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0027","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/1673-5374.264446","article-title":"Stem cell therapy for Parkinson's disease: safety and modeling","volume":"15","author":"Stoddard-Bennett","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ebiom.2022.103882_bib0028","doi-asserted-by":"crossref","first-page":"44","DOI":"10.21037\/sci.2019.10.06","article-title":"Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis","volume":"6","author":"Jafarzadeh Bejargafshe","year":"2019","journal-title":"Stem Cell Investig"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103882_bib0029","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s13311-011-0063-z","article-title":"Cell therapy for spinal cord injury by neural stem\/progenitor cells derived from iPS\/ES cells","volume":"8","author":"Tsuji","year":"2011","journal-title":"Neurotherapeutics"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103882_bib0030","doi-asserted-by":"crossref","first-page":"e64160","DOI":"10.1371\/journal.pone.0064160","article-title":"Vector-free and transgene-free human iPS cells differentiate into functional neurons and enhance functional recovery after ischemic stroke in mice","volume":"8","author":"Mohamad","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0031","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s13287-020-01915-0","article-title":"GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells","volume":"11","author":"Vitillo","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103882_bib0032","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/stem.1083","article-title":"Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells","volume":"30","author":"Fujimoto","year":"2012","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0033","doi-asserted-by":"crossref","DOI":"10.1186\/s13041-020-00662-w","article-title":"Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells","volume":"13","author":"Kajikawa","year":"2020","journal-title":"Mol Brain"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103882_bib0034","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1089\/neu.2012.2354","article-title":"The relationship between localized subarachnoid inflammation and parenchymal pathophysiology after spinal cord injury","volume":"29","author":"Austin","year":"2012","journal-title":"J Neurotrauma"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103882_bib0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2014.12.006","article-title":"The role of inflammatory cytokines as key modulators of neurogenesis","volume":"38","author":"Borsini","year":"2015","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.ebiom.2022.103882_bib0036","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2013.03.003","article-title":"Sustained IL-1beta expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells","volume":"32","author":"Wu","year":"2013","journal-title":"Brain Behav Immun"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103882_bib0037","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cnr.2006.09.007","article-title":"Inflammation and spinal cord injury: infiltrating leukocytes as determinants of injury and repair processes","volume":"6","author":"Trivedi","year":"2006","journal-title":"Clin Neurosci Res"},{"key":"10.1016\/j.ebiom.2022.103882_bib0038","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-2094-10-6","article-title":"Absence of IL-1beta positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury","volume":"10","author":"Boato","year":"2013","journal-title":"J Neuroinflammation"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103882_bib0039","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s12031-019-01437-2","article-title":"Modulating pro-inflammatory cytokines, tissue damage magnitude, and motor deficit in spinal cord injury with subventricular zone-derived extracellular vesicles","volume":"70","author":"Ijaz","year":"2020","journal-title":"J Mol Neurosci"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103882_bib0040","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cell.2020.03.037","article-title":"Targeting aquaporin-4 subcellular localization to treat central nervous system edema","volume":"181","author":"Kitchen","year":"2020","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103882_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061681","article-title":"Functional heterogeneity of mouse and human brain OPCs: relevance for preclinical studies in multiple sclerosis","volume":"9","author":"Bribian","year":"2020","journal-title":"J Clin Med"},{"issue":"6512","key":"10.1016\/j.ebiom.2022.103882_bib0042","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb8795","article-title":"A latent lineage potential in resident neural stem cells enables spinal cord repair","volume":"370","author":"Llorens-Bobadilla","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103882_bib0043","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12916-019-1439-x","article-title":"NG2 glia regulate brain innate immunity via TGF-\u03b22\/TGFBR2 axis","volume":"17","author":"Zhang","year":"2019","journal-title":"BMC Med"},{"issue":"7723","key":"10.1016\/j.ebiom.2022.103882_bib0044","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41586-018-0467-6","article-title":"Required growth facilitators propel axon regeneration across complete spinal cord injury","volume":"561","author":"Anderson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2022.103882_bib0045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.expneurol.2019.01.006","article-title":"Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord","volume":"314","author":"Lien","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ebiom.2022.103882_bib0046","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.expneurol.2019.05.007","article-title":"Serotonergic mechanisms in spinal cord injury","volume":"318","author":"Perrin","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ebiom.2022.103882_bib0047","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13287-015-0175-1","article-title":"Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke","volume":"6","author":"Abeysinghe","year":"2015","journal-title":"Stem Cell Res Ther"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:14:54Z","timestamp":1762456494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422000664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"alternative-id":["S2352396422000664"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103882","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103882"}}