{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:19:06Z","timestamp":1790767146551,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ebiom.2022.103893","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T18:01:33Z","timestamp":1645639293000},"page":"103893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients"],"prefix":"10.1016","volume":"77","author":[{"given":"Virginie","family":"Montiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Lobysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"G\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Vermeersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perez-Morga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Castelein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Mesland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Collienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gruson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Astrid","family":"van Dievoet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Persu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Beauloye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-1058","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Dechamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00efla","family":"Belkhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-5923","authenticated-orcid":false,"given":"Marc","family":"Derive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Laterre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-3585","authenticated-orcid":false,"given":"A.H.J","family":"Danser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Wittebole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Balligand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12959-021-00284-9","article-title":"Prevalence and risk factors of thrombotic events on patients with COVID-19: a systematic review and meta-analysis","volume":"19","author":"Xiong","year":"2021","journal-title":"Thromb J"},{"key":"10.1016\/j.ebiom.2022.103893_bib0002","article-title":"Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: a systematic review and meta-analysis","volume":"29","author":"Malas","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ebiom.2022.103893_bib0003","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.thromres.2020.09.026","article-title":"Therapeutic versus prophylactic anticoagulation for severe COVID-19: a randomized phase II clinical trial (HESACOVID)","volume":"196","author":"Lemos","year":"2020","journal-title":"Thromb Res"},{"issue":"32","key":"10.1016\/j.ebiom.2022.103893_bib0004","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/eurheartj\/ehaa623","article-title":"COVID-19 is, in the end, an endothelial disease","volume":"41","author":"Libby","year":"2020","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103893_bib0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0006","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13613-020-00680-w","article-title":"Microvascular alterations in patients with SARS-COV-2 severe pneumonia","volume":"10","author":"Damiani","year":"2020","journal-title":"Ann Intensiv Care"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103893_bib0007","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/CCM.0000000000004862","article-title":"Capillary leukocytes, microaggregates, and the response to hypoxemia in the microcirculation of coronavirus disease 2019 patients","volume":"49","author":"Favaron","year":"2021","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0008","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-018-0411-9","article-title":"MicroDAIMON study: microcirculatory daily monitoring in critically ill patients: a prospective observational study","volume":"8","author":"Scorcella","year":"2018","journal-title":"Ann Intensiv Care"},{"key":"10.1016\/j.ebiom.2022.103893_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101982","article-title":"Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19","volume":"43","author":"Dominic","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2022.103893_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2020.07.005","article-title":"Blood nitrate and nitrite modulating nitric oxide bioavailability: potential therapeutic functions in COVID-19","volume":"103","author":"Yamasaki","year":"2020","journal-title":"Nitric Oxide"},{"issue":"4-5","key":"10.1016\/j.ebiom.2022.103893_bib0011","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.micinf.2020.05.006","article-title":"Covid-19 accelerates endothelial dysfunction and nitric oxide deficiency","volume":"22","author":"Green","year":"2020","journal-title":"Microbes Infect"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103893_bib0012","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"issue":"6 Pt 2","key":"10.1016\/j.ebiom.2022.103893_bib0013","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/01.HYP.13.6.658","article-title":"Endothelium and control of vascular function. State of the art lecture","volume":"13","author":"Vanhoutte","year":"1989","journal-title":"Hypertension"},{"issue":"7807","key":"10.1016\/j.ebiom.2022.103893_bib0014","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0015","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103893_bib0016","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11427-020-1643-8","article-title":"Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury","volume":"63","author":"Liu","year":"2020","journal-title":"Sci China Life Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0017","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13054-020-03015-0","article-title":"Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients","volume":"24","author":"Wu","year":"2020","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103893_bib0018","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.pcad.2020.07.006","article-title":"Letter to the editor - circulating plasma levels of angiotensin ii and aldosterone in patients with coronavirus disease 2019 (COVID-19): a preliminary report","volume":"63","author":"Henry","year":"2020","journal-title":"Prog Cardiovasc Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103893_bib0019","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensiv Care Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.103893_bib0020","doi-asserted-by":"crossref","first-page":"e76457","DOI":"10.1371\/journal.pone.0076457","article-title":"Nitrosylated hemoglobin levels in human venous erythrocytes correlate with vascular endothelial function measured by digital reactive hyperemia","volume":"8","author":"Lobysheva","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103893_bib0021","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/HYPERTENSIONAHA.113.02893","article-title":"Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition","volume":"63","author":"Balcarek","year":"2014","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.ebiom.2022.103893_bib0022","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19","volume":"384","author":"Group","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2022.103893_bib0023","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0076-6879(05)96052-7","article-title":"ESR techniques for the detection of nitric oxide in vivo and in tissues","volume":"396","author":"Dikalov","year":"2005","journal-title":"Methods Enzymol"},{"issue":"8","key":"10.1016\/j.ebiom.2022.103893_bib0024","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1016\/S2352-3026(20)30216-7","article-title":"Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study","volume":"7","author":"Goshua","year":"2020","journal-title":"Lancet Haematol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103893_bib0025","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10456-020-09762-6","article-title":"Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality","volume":"24","author":"Philippe","year":"2021","journal-title":"Angiogenesis"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103893_bib0026","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI66843","article-title":"Linking endothelial dysfunction with endothelial cell activation","volume":"123","author":"Liao","year":"2013","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0027","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10456-020-09753-7","article-title":"Microvascular dysfunction in COVID-19: the MYSTIC study","volume":"24","author":"Rovas","year":"2021","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103893_bib0028","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/bjh.17273","article-title":"Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation","volume":"192","author":"Ward","year":"2021","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103893_bib0029","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/jth.15191","article-title":"The ADAMTS13-von Willebrand factor axis in COVID-19 patients","volume":"19","author":"Mancini","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ebiom.2022.103893_bib0030","doi-asserted-by":"crossref","first-page":"m1966","DOI":"10.1136\/bmj.m1966","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study","volume":"369","author":"Petrilli","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ebiom.2022.103893_bib0031","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijid.2020.07.029","article-title":"Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: a systematic review and meta-analysis","volume":"99","author":"Zhou","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0032","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S1056-8727(00)00132-X","article-title":"Diabetes mellitus: a hypercoagulable state","volume":"15","author":"Carr","year":"2001","journal-title":"J Diabetes Complicat"},{"issue":"7","key":"10.1016\/j.ebiom.2022.103893_bib0033","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00004872-199816070-00003","article-title":"Does hypertension confer a hypercoagulable state?","volume":"16","author":"Lip","year":"1998","journal-title":"J Hypertens"},{"issue":"5","key":"10.1016\/j.ebiom.2022.103893_bib0034","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","article-title":"Nitric oxide signalling in cardiovascular health and disease","volume":"15","author":"Farah","year":"2018","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.ebiom.2022.103893_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200352","article-title":"Nitrosyl-hemoglobin formation in rodent and human venous erythrocytes reflects NO formation from the vasculature in vivo","volume":"13","author":"Dei Zotti","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103893_bib0037","doi-asserted-by":"crossref","first-page":"807","DOI":"10.18388\/abp.2003_3672","article-title":"Kinetics of increased generation of (.)NO in endotoxaemic rats as measured by EPR","volume":"50","author":"Plonka","year":"2003","journal-title":"Acta Biochim Pol"},{"issue":"1-3","key":"10.1016\/j.ebiom.2022.103893_bib0038","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/10715769009109680","article-title":"Formation of free radicals and nitric oxide derivative of hemoglobin in rats during shock syndrome","volume":"11","author":"Westenberger","year":"1990","journal-title":"Free Radic Res Commun"},{"issue":"2-3","key":"10.1016\/j.ebiom.2022.103893_bib0039","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0005-2728(99)00020-1","article-title":"Nitric oxide metabolism and breakdown","volume":"1411","author":"Kelm","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ebiom.2022.103893_bib0040","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2021.1545","article-title":"Discriminant accuracy of the SOFA score for determining the probable mortality of patients with COVID-19 pneumonia requiring mechanical ventilation","author":"Raschke","year":"2021","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.ebiom.2022.103893_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228793","article-title":"Endothelial damage in acute respiratory distress syndrome","volume":"21","author":"Vassiliou","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.103893_bib0042","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1172\/JCI114477","article-title":"Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide","volume":"85","author":"Boulanger","year":"1990","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.ebiom.2022.103893_bib0043","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa2103417","article-title":"Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19","volume":"385","author":"Investigators","year":"2021","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ebiom.2022.103893_bib0044","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1165\/rcmb.F278","article-title":"Oxidative stress and acute lung injury","volume":"29","author":"Chow","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ebiom.2022.103893_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103154","article-title":"Metabolomics of exhaled breath in critically ill COVID-19 patients: a pilot study","volume":"63","author":"Grassin-Delyle","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2022.103893_bib0046","article-title":"Total antioxidant capacity as a marker of severity of COVID-19 infection: possible prognostic and therapeutic clinical application","author":"Yaghoubi","year":"2021","journal-title":"J Med Virol"},{"issue":"11","key":"10.1016\/j.ebiom.2022.103893_bib0047","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1089\/ars.2007.1808","article-title":"Sepsis: redox mechanisms and therapeutic opportunities","volume":"9","author":"Biswal","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0048","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/SHK.0b013e318217025a","article-title":"Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis","volume":"36","author":"Ware","year":"2011","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103893_bib0049","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/JLB.3VMA0918-375R","article-title":"TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production","volume":"105","author":"Baruah","year":"2019","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ebiom.2022.103893_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107233","article-title":"Neutrophils and COVID-19: the road so far","volume":"90","author":"Cavalcante-Silva","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.103893_bib0051","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1097\/CCM.0000000000004967","article-title":"Efficacy of serum angiotensin II levels in prognosis of patients with coronavirus disease 2019","volume":"49","author":"Ozkan","year":"2021","journal-title":"Crit Care Med"},{"issue":"34","key":"10.1016\/j.ebiom.2022.103893_bib0052","doi-asserted-by":"crossref","first-page":"30113","DOI":"10.1074\/jbc.M505111200","article-title":"Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)","volume":"280","author":"Lambert","year":"2005","journal-title":"J Biol Chem"},{"issue":"22","key":"10.1016\/j.ebiom.2022.103893_bib0053","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1073\/pnas.0711241105","article-title":"Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry","volume":"105","author":"Haga","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2022.103893_bib0054","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-015-0802-3","article-title":"Angiotensin II in septic shock","volume":"19","author":"Correa","year":"2015","journal-title":"Crit Care"},{"issue":"8","key":"10.1016\/j.ebiom.2022.103893_bib0055","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00004872-199008000-00005","article-title":"An alternative strategy for the radioimmunoassay of angiotensin peptides using amino-terminal-directed antisera: measurement of eight angiotensin peptides in human plasma","volume":"8","author":"Lawrence","year":"1990","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0056","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1186\/s12879-020-05619-x","article-title":"The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019","volume":"20","author":"Zhu","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"16","key":"10.1016\/j.ebiom.2022.103893_bib0057","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1161\/01.CIR.102.16.2011","article-title":"Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injury","volume":"102","author":"Orfanos","year":"2000","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103893_bib0058","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/01.CIR.99.12.1593","article-title":"Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in humans","volume":"99","author":"Orfanos","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2022.103893_bib0059","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yjmcc.2013.11.017","article-title":"Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE\/ADAM-17: a positive feedback mechanism in the RAS","volume":"66","author":"Patel","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.103893_bib0060","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1124\/jpet.105.091728","article-title":"Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta","volume":"315","author":"Loomis","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2022.103893_bib0061","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41467-017-00057-x","article-title":"Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy","volume":"8","author":"To","year":"2017","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.ebiom.2022.103893_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009127","article-title":"Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators","volume":"16","author":"Dias","year":"2020","journal-title":"PLoS Pathog"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:16:04Z","timestamp":1762456564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":62,"alternative-id":["S2352396422000779"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103893","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103893"}}