{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:58:03Z","timestamp":1793570283002,"version":"4.5.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ebiom.2022.103985","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T23:42:55Z","timestamp":1649893375000},"page":"103985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Novel role of UHRF1 in the epigenetic repression of the latent HIV-1"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6720","authenticated-orcid":false,"given":"Roxane","family":"Verdikt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Bendoumou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bouchat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Nestola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-4251","authenticated-orcid":false,"given":"Alexander O.","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Darcis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Avettand-Fenoel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Vanhulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"A\u00eft-Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Santangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Plant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin Le","family":"Douce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Delacourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelija","family":"Cicilionyt\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coca","family":"Necsoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Corazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Pereira Bittencourt","family":"Passaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bizet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Fuks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asier","family":"S\u00e1ez-Ciri\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Rouzioux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"De Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Berkhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gautier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Van Lint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2022.103985_bib0001","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3262","article-title":"Towards an HIV cure: a global scientific strategy","volume":"12","author":"Deeks","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0002","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1126\/science.1191047","article-title":"HIV persistence and the prospect of long-term drug-free remissions for hiv-infected individuals","volume":"329","author":"Trono","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2022.103985_bib0003","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/QAD.0b013e328353f3f1","article-title":"HIV reservoirs: pathogenesis and obstacles to viral eradication and cure","volume":"26","author":"Chun","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2022.103985_bib0004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.it.2016.12.003","article-title":"HIV latency: should we shock or lock?","volume":"38","author":"Darcis","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-med-052716-031710","article-title":"Novel latency reversal agents for HIV-1 cure","volume":"69","author":"Spivak","year":"2018","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.ebiom.2022.103985_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102906","article-title":"Shock and kill, but don't miss the target","volume":"58","author":"Herbein","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2022.103985_bib0007","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00281-020-00783-3","article-title":"Epigenetic crosstalk in chronic infection with HIV-1","volume":"42","author":"Lange","year":"2020","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/vaccines9050514","article-title":"Epigenetic mechanisms of HIV-1 persistence","volume":"9","author":"Verdikt","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.ebiom.2022.103985_bib0009","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ymeth.2010.05.009","article-title":"In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus","volume":"53","author":"Chavez","year":"2011","journal-title":"Methods"},{"key":"10.1016\/j.ebiom.2022.103985_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1000495","article-title":"Epigenetic regulation of HIV-1 latency by cytosine methylation","volume":"5","author":"Kauder","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1000554","article-title":"CpG methylation controls reactivation of HIV from latency","volume":"5","author":"Blazkova","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2020.198260","article-title":"Transcriptional behavior of the HIV-1 promoter in context of the BACH2 prominent proviral integration gene","volume":"293","author":"Hamann","year":"2021","journal-title":"Virus Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0013","doi-asserted-by":"crossref","first-page":"13081","DOI":"10.1128\/JVI.01741-12","article-title":"Long-term nonprogressor and elite controller patients who control viremia have a higher percentage of methylation in their HIV-1 proviral promoters than aviremic patients receiving highly active antiretroviral therapy","volume":"86","author":"Palacios","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1010014","article-title":"Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation","volume":"17","author":"Nguyen","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0015","first-page":"1","article-title":"Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy","author":"Blazkova","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0016","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.103985_bib0017","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.virol.2013.11.013","article-title":"Epigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's","volume":"449","author":"Weber","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2022.103985_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/v13050799","article-title":"Cpg methylation profiles of HIV-1 proviral dna in individuals on art","volume":"13","author":"Boltz","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ebiom.2022.103985_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-016-0185-6","article-title":"Development of 5\u2018 LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals","volume":"8","author":"Trejbalova","year":"2016","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.ebiom.2022.103985_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-019-0735-9","article-title":"Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy","volume":"11","author":"Cort\u00e9s-Rubio","year":"2019","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.ebiom.2022.103985_bib0021","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cell.2021.12.011","article-title":"Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses","volume":"185","author":"Einkauf","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.103985_bib0022","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virol.2017.03.002","article-title":"The Human immunodeficiency virus 1 ASP RNA promotes viral latency by recruiting the polycomb repressor complex 2 and promoting nucleosome assembly","volume":"506","author":"Zapata","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2022.103985_bib0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.15252\/emmm.201505557","article-title":"Sequential treatment with 5-aza-2\u2019-deoxycytidine and deacetylase inhibitors reactivates HIV- 1","volume":"8","author":"Bouchat","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ebiom.2022.103985_bib0024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/epi.4.1.7370","article-title":"UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications","volume":"4","author":"Hashimoto","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.ebiom.2022.103985_bib0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bpc.2012.10.002","article-title":"UHRF1 discriminates against binding to fully-methylated CpG-Sites by steric repulsion","volume":"171","author":"Bianchi","year":"2013","journal-title":"Biophys Chem"},{"key":"10.1016\/j.ebiom.2022.103985_bib0026","first-page":"0","article-title":"The Uhrf1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase Dnmt1 by an allosteric mechanism","author":"Bashtrykov","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ebiom.2022.103985_bib0027","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/embor.2009.201","article-title":"Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b,and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells","volume":"10","author":"Meilinger","year":"2009","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ebiom.2022.103985_bib0028","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.stem.2016.03.013","article-title":"Activation of endogenous retroviruses in Dnmt1(\u2212\/\u2212) ESCs involves disruption of SETDB1-mediated repression by NP95 binding to hemimethylated DNA","volume":"19","author":"Sharif","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ebiom.2022.103985_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12455-4","article-title":"UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells","volume":"10","author":"Dong","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2022.103985_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41594-021-00603-8","article-title":"Dnmt1 has de novo activity targeted to transposable elements","author":"Haggerty","year":"2021","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.34655","article-title":"Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells","volume":"7","author":"Battivelli","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ebiom.2022.103985_bib0032","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/nar\/28.5.1053","article-title":"MethTools: a toolbox to visualize and analyze DNA methylation data","volume":"28","author":"Grunau","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0033","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0034","doi-asserted-by":"crossref","first-page":"19434","DOI":"10.1074\/jbc.M110.107607","article-title":"DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein\/CRE modulator\/activation transcription","volume":"285","author":"Pierard","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ebiom.2022.103985_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0019084","article-title":"The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication","volume":"6","author":"Colin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2022.103985_bib0036","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.chom.2013.05.006","article-title":"Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells","volume":"13","author":"Lusic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ebiom.2022.103985_bib0037","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.272.5259.263","article-title":"In vivo gene delivery and stable transduction of post mitotic cells by a lentiviral vector","volume":"272","author":"Naldini","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2022.103985_bib0038","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.emboj.7601516","article-title":"Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing","volume":"26","author":"Marban","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.ebiom.2022.103985_bib0039","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/bib\/bbt054","article-title":"A comprehensive overview of infinium human methylation450 data processing","volume":"15","author":"Dedeurwaerder","year":"2013","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.ebiom.2022.103985_bib0040","first-page":"771","article-title":"Evaluation of the infinium methylation 450K technology report","volume":"3","author":"Dedeurwaerder","year":"2011","journal-title":"Future Med"},{"key":"10.1016\/j.ebiom.2022.103985_bib0041","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2022.103985_bib0042","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/jcm.28.3.495-503.1990","article-title":"Rapid and simple method for purification of nucleic acids","volume":"28","author":"Boom","year":"1990","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0043","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nprot.2008.108","article-title":"A universal real-time PCR assay for the quantification of group-M HIV-1 proviral load","volume":"3","author":"Malnati","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ebiom.2022.103985_bib0044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008490","article-title":"Cellular levels of HIV unspliced RNA from patients on combination antiretroviral therapy with undetectable plasma viremia predict the therapy outcome","volume":"4","author":"Pasternak","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2022.103985_bib0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.21390","article-title":"LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area","volume":"81","author":"Avettand-Fenoel","year":"2009","journal-title":"J Med Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0046","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/emboj\/cdg188","article-title":"HIV reproducibly establishes a latent infection after acute infection of T cells in vitro","volume":"22","author":"Jordan","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.ebiom.2022.103985_bib0047","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/nar\/28.3.663","article-title":"A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter","volume":"28","author":"Pereira","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0048","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1126\/science.3008338","article-title":"Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1","volume":"232","author":"Jones","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2022.103985_bib0049","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1128\/jvi.71.8.6113-6127.1997","article-title":"Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity","volume":"71","author":"Van Lint","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0050","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1073\/pnas.0501076102","article-title":"Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ebiom.2022.103985_bib0051","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1128\/JVI.75.4.1842-1856.2001","article-title":"Interaction between CCAAT \/enhancer binding protein and cyclic AMP response element binding protein 1 regulates human immunodeficiency virus type 1 transcription in cells of the monocyte \/ macrophage lineage","volume":"75","author":"Ross","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0025884","article-title":"A SILAC-based screen for methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence- specific binding protein","volume":"6","author":"Bartels","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2022.103985_bib0053","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/B978-0-12-387685-0.00012-3","article-title":"Biological functions of methyl-CpG-binding proteins","author":"Defossez","year":"2011","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.ebiom.2022.103985_bib0054","first-page":"121","article-title":"ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase II\u03b1 expression","volume":"60","author":"Hopfner","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0088116","article-title":"CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage","volume":"9","author":"Dahiya","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2022.103985_bib0056","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature06397","article-title":"The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA","volume":"450","author":"Sharif","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2022.103985_bib0057","doi-asserted-by":"crossref","first-page":"51946","DOI":"10.18632\/oncotarget.17393","article-title":"The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer","volume":"8","author":"Ashraf","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ebiom.2022.103985_bib0058","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/JCM.00055-08","article-title":"Highly sensitive methods based on seminested real-time reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 unspliced and multiply spliced RNA and proviral DNA","volume":"46","author":"Pasternak","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0059","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2022.103985_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/genes9120600","article-title":"The growing complexity of UHRF1-mediated maintenance DNA methylation","volume":"9","author":"Xie","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.ebiom.2022.103985_bib0061","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1038\/sj.onc.1208053","article-title":"ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain","volume":"23","author":"Unoki","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ebiom.2022.103985_bib0062","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/nar\/gkn961","article-title":"UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells","volume":"37","author":"Kim","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0063","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.3389\/fmicb.2019.03060","article-title":"Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs","volume":"10","author":"Ait-Ammar","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0064","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-virology-091919-103029","article-title":"The current status of latency reversing agents for HIV-1 Remission","volume":"8","author":"Rodari","year":"2021","journal-title":"Annu Rev Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101478","article-title":"Seminars in immunology shocking HIV-1 with immunomodulatory latency reversing agents","volume":"51","author":"Kula-Pacurar","year":"2021","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0066","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbrc.2012.11.087","article-title":"Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1","volume":"430","author":"Achour","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ebiom.2022.103985_bib0067","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0166-3542(01)00189-9","article-title":"Inhibitory effects of (\u2212)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1)","volume":"53","author":"Yamaguchi","year":"2002","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0068","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0069","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/epi.15.114","article-title":"Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences","volume":"8","author":"Moran","year":"2016","journal-title":"Epigenomics"},{"key":"10.1016\/j.ebiom.2022.103985_bib0070","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2006.08.016","article-title":"Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: potential for HIV-1 therapy","volume":"118","author":"Williamson","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0071","doi-asserted-by":"crossref","first-page":"26243","DOI":"10.18632\/oncotarget.25425","article-title":"Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger \u2013 containing 1 (UHRF1) for anti-cancer drug development","volume":"9","author":"Patnaik","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ebiom.2022.103985_bib0072","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ejmech.2016.02.043","article-title":"Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation","volume":"114","author":"Myrianthopoulos","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ebiom.2022.103985_bib0073","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1003834","article-title":"An In-Depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4\u202f+\u202fT cells from aviremic patients","volume":"9","author":"Spina","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0074","first-page":"1","article-title":"CD69 gene is differentially regulated in T and B cells by evolutionary conserved promoter-distal elements","author":"Vazquez","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005063","article-title":"An in-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+JQ1 and ingenol-B+JQ1 to potently reactivate viral gene expression","volume":"11","author":"Darcis","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0076","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/QAI.0000000000001958","article-title":"Heterogeneous HIV-1 reactivation patterns of disulfiram and combined disulfiram\u202f+\u202fromidepsin treatments","volume":"80","author":"Kula","year":"2019","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.ebiom.2022.103985_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0017388","article-title":"Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines","volume":"6","author":"Hagemann","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2022.103985_bib0078","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00002030-200301240-00005","article-title":"Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB\/ATF sites in the LTR","volume":"17","author":"Tanaka","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2022.103985_bib0079","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-4690-6-111","article-title":"Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies","volume":"6","author":"Colin","year":"2009","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2022.103985_bib0080","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01625-21","article-title":"Uhrf1 suppresses HIV-1 transcription and promotes HIV-1 latency by competing with p-tefb for ubiquitination-proteasomal degradation of tat","volume":"12","author":"Liang","year":"2021","journal-title":"MBio"},{"key":"10.1016\/j.ebiom.2022.103985_bib0081","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1742-4690-10-120","article-title":"Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication","volume":"10","author":"Miller","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.ebiom.2022.103985_bib0082","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007498","article-title":"Reiterative enrichment and authentication of CRISPRi targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency","volume":"15","author":"Li","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2022.103985_bib0083","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.coviro.2019.07.004","article-title":"Applications of CRISPR\/Cas9 tools in deciphering the mechanisms of HIV-1 persistence","volume":"38","author":"Verdikt","year":"2019","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0084","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/cr.2015.72","article-title":"DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination","volume":"25","author":"Qin","year":"2015","journal-title":"Cell Res"},{"key":"10.1016\/j.ebiom.2022.103985_bib0085","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molcel.2018.09.029","article-title":"A bifunctional role for the UHRF1 UBL domain in the control of hemi-methylated DNA-dependent histone ubiquitylation","volume":"72","author":"DaRosa","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.ebiom.2022.103985_bib0086","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.molcel.2016.03.019","volume":"62","author":"Gross","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.ebiom.2022.103985_bib0087","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41434-018-0051-6","article-title":"HIV infection alters the human epigenetic landscape","volume":"26","author":"Chen","year":"2019","journal-title":"Gene Ther"},{"key":"10.1016\/j.ebiom.2022.103985_bib0088","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-82164-w","article-title":"Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage","volume":"11","author":"Ait-Ammar","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2022.103985_bib0089","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embr.201949305","article-title":"PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK NF-\u03baB signaling","volume":"21","author":"Yang","year":"2020","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ebiom.2022.103985_bib0090","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1128\/MCB.23.17.6200-6209.2003","article-title":"Potentiation of tumor necrosis factor-induced NF-KB activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of IKBa","volume":"23","author":"Adam","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0091","doi-asserted-by":"crossref","first-page":"11091","DOI":"10.1128\/JVI.76.21.11091-11103.2002","article-title":"Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-KB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies","volume":"76","author":"Quivy","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2022.103985_bib0092","series-title":"HIV Sequence Compendium","author":"Kuiken","year":"2008"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422001694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422001694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:15:43Z","timestamp":1762456543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422001694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":92,"alternative-id":["S2352396422001694"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103985","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.15.448539","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel role of UHRF1 in the epigenetic repression of the latent HIV-1","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.103985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103985"}}