{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:43:24Z","timestamp":1784339004907,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ebiom.2022.104084","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T18:51:07Z","timestamp":1654023067000},"page":"104084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Poor ovarian response is associated with air pollutants: A multicentre study in China"],"prefix":"10.1016","volume":"81","author":[{"given":"Shanshan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimin","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-1919","authenticated-orcid":false,"given":"Jichun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2022.104084_bib0001","first-page":"155","article-title":"Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction","author":"Gaskins","year":"2021","journal-title":"Environ Int"},{"issue":"10054","key":"10.1016\/j.ebiom.2022.104084_bib0002","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0140-6736(16)31597-5","article-title":"Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action","volume":"388","author":"Guan","year":"2016","journal-title":"Lancet [Internet]"},{"issue":"xxxx","key":"10.1016\/j.ebiom.2022.104084_bib0003","article-title":"Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms","author":"Mousavi","year":"2021","journal-title":"Sci Total Environ [Internet]"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104084_bib0004","doi-asserted-by":"crossref","first-page":"e470","DOI":"10.1016\/S2468-2667(18)30144-0","article-title":"All-cause mortality risk associated with long-term exposure to ambient PM2\u00b75 in China: a cohort study","volume":"3","author":"Li","year":"2018","journal-title":"Lancet Public Heal [Internet]"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104084_bib0005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41569-020-0371-2","article-title":"Environmental determinants of cardiovascular disease: lessons learned from air pollution","volume":"17","author":"Al-Kindi","year":"2020","journal-title":"Nat Rev Cardiol [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0006","article-title":"Genome-wide DNA methylation analysis reveals significant impact of long-term ambient air pollution exposure on biological functions related to mitochondria and immune response","volume":"264","author":"Wang","year":"2020","journal-title":"Environ Pollut [Internet]"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104084_bib0007","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1164\/rccm.200611-1627OC","article-title":"The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults","volume":"176","author":"Chuang","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ebiom.2022.104084_bib0008","article-title":"Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study","volume":"153","author":"Wu","year":"2021","journal-title":"Environ Int [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0009","article-title":"Association between ambient air pollution and pregnancy outcomes in patients undergoing in vitro fertilization in Shanghai, China: A retrospective cohort study","volume":"148","author":"Shi","year":"2021","journal-title":"Environ Int [Internet]"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104084_bib0010","doi-asserted-by":"crossref","first-page":"e036","DOI":"10.1097\/EE9.0000000000000036","article-title":"Ambient Air Pollution Exposure and Fecundability in Women Undergoing In Vitro Fertilization","volume":"3","author":"Quraishi","year":"2019","journal-title":"Environ Epidemiol"},{"issue":"August 2019","key":"10.1016\/j.ebiom.2022.104084_bib0011","article-title":"Association between Ambient Air Pollution and Pregnancy Outcomes in Patients Undergoing In Vitro Fertilization in Chengdu, China\u00a0: A retrospective study","volume":"184","author":"Zeng","year":"2020","journal-title":"Environ Res [Internet]"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104084_bib0012","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/humrep\/dey386","article-title":"Association between outdoor air pollution during in vitro culture and the outcomes of frozen \u2013 thawed embryo transfer","volume":"34","author":"Wang","year":"2019","journal-title":"Hum Reprod"},{"issue":"December 2018","key":"10.1016\/j.ebiom.2022.104084_bib0013","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.reprotox.2019.07.005","article-title":"Associations between ambient air pollution and pregnancy rate in women who underwent in vitro fertilization in Shenyang, China","volume":"89","author":"Qiu","year":"2019","journal-title":"Reprod Toxicol [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0014","doi-asserted-by":"crossref","unstructured":"Gleicher N, Weghofer A, Barad DH. Defining ovarian reserve to better understand ovarian aging. 2011;1\u201311.","DOI":"10.1186\/1477-7827-9-23"},{"key":"10.1016\/j.ebiom.2022.104084_bib0015","doi-asserted-by":"crossref","unstructured":"Moolhuijsen LME, Visser JA. Anti-M\u00fcllerian Hormone and Ovarian Reserve\u00a0: Update on Assessing Ovarian Function. 2020;105(11):3361\u201373.","DOI":"10.1210\/clinem\/dgaa513"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104084_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12199-021-00942-4","article-title":"Outdoor air pollution and diminished ovarian reserve among infertile Korean women","volume":"26","author":"Kim","year":"2021","journal-title":"Environ Health Prev Med"},{"issue":"April","key":"10.1016\/j.ebiom.2022.104084_bib0017","first-page":"1","article-title":"The influence of fine particulate matter on the association between residential greenness and ovarian reserve","volume":"197","author":"Hood","year":"2021","journal-title":"Environ Res"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104084_bib0018","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/EDE.0000000000001029","article-title":"Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic","volume":"30","author":"Gaskins","year":"2019","journal-title":"Epidemiology"},{"issue":"November 2019","key":"10.1016\/j.ebiom.2022.104084_bib0019","article-title":"Association of exposure to air pollution and green space with ovarian reserve hormones levels","volume":"184","author":"Abareshi","year":"2020","journal-title":"Environ Res [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0020","doi-asserted-by":"crossref","unstructured":"Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients < 38 years old : a quantitative but not qualitative reduction in performance. 2018;(July):1\u201310.","DOI":"10.1093\/humrep\/dey238"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104084_bib0021","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The international glossary on infertility and fertility care, 2017","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104084_bib0022","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/humrep\/deaa336","article-title":"Randomised controlled trial on the effect of clomiphene citrate and gonadotropin dose on ovarian response markers and IVF outcomes in poor responders","volume":"36","author":"Moffat","year":"2021","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104084_bib0023","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.rbmo.2020.07.011","article-title":"The role of diet in unexpected poor response to ovarian stimulation: a cross-sectional study","volume":"41","author":"Noli","year":"2020","journal-title":"Reprod Biomed Online [Internet]"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104084_bib0024","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1530\/REP-17-0157","article-title":"MIR-15a-5p levels correlate with poor ovarian response in human follicular fluid","volume":"154","author":"Zhang","year":"2017","journal-title":"Reproduction"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104084_bib0025","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/humrep\/dey244","article-title":"Ovarian response is associated with anogenital distance in patients undergoing controlled ovarian stimulation for IVF","volume":"33","author":"Fabregues","year":"2018","journal-title":"Hum Reprod"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104084_bib0026","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/humrep\/dex222","article-title":"Ovarian response to controlled ovarian hyperstimulation: What does serum FSH say?","volume":"32","author":"Oudshoorn","year":"2017","journal-title":"Hum Reprod"},{"issue":"July 2019","key":"10.1016\/j.ebiom.2022.104084_bib0027","article-title":"Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice","volume":"135","author":"Liao","year":"2020","journal-title":"Environ Int"},{"issue":"115858","key":"10.1016\/j.ebiom.2022.104084_bib0028","article-title":"Pre-pregnancy exposure to fine particulate matter (PM2.5) increases reactive oxygen species production in oocytes and decrease litter size and weight in mice","volume":"268","author":"Guo","year":"2021","journal-title":"Environ Pollut [Internet]"},{"issue":"undefined","key":"10.1016\/j.ebiom.2022.104084_bib0029","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.reprotox.2017.11.006","article-title":"Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes\u00a0: Potential risks to meiotic maturation","volume":"75","author":"Udagawa","year":"2018","journal-title":"Reprod Toxicol [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejogrb.2016.12.012","article-title":"Influence of air quality on the results of in vitro fertilization attempts: A retrospective study","volume":"210","author":"Carr\u00e9","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol [Internet]"},{"issue":"July","key":"10.1016\/j.ebiom.2022.104084_bib0031","first-page":"1","article-title":"Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic","volume":"127","author":"Gaskins","year":"2019","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ebiom.2022.104084_bib0032","article-title":"Associations of toxic and essential trace elements in serum, follicular fluid, and seminal plasma with In vitro fertilization outcomes","volume":"204","author":"Wu","year":"2020","journal-title":"Ecotoxicol Environ Saf [Internet]"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104084_bib0033","first-page":"370","article-title":"Conventional ovarian stimulation and single embryo transfer for IVF\/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos?","volume":"31","author":"Drakopoulos","year":"2016","journal-title":"Hum Reprod"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104084_bib0034","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1093\/humrep\/dev149","article-title":"Sub-optimal responders following controlled ovarian stimulation: An overlooked group?","volume":"30","author":"Polyzos","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ebiom.2022.104084_bib0035","series-title":"Monitor stations of the China national environmental monitoring Centre","year":"2022"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104084_bib0036","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.rbmo.2009.11.010","article-title":"Anti-M\u00fcllerian hormone follow-up in young women treated by chemotherapy for lymphoma: Preliminary results","volume":"20","author":"Decanter","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ebiom.2022.104084_bib0037","first-page":"1","article-title":"Ethnic Study of","author":"Gao","year":"2022","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104084_bib0038","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/humrep\/dey236","article-title":"Performance of prognostic modeling of high and low ovarian response to ovarian stimulation for IVF","volume":"33","author":"Scheinhardt","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ebiom.2022.104084_bib0039","first-page":"1","article-title":"Untapped Reserves\u00a0: Controlling Primordial Follicle Growth Activation","volume":"xx","author":"Kallen","year":"2018","journal-title":"Trends Mol Med [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0040","article-title":"Association of exposure to ambient air pollution with ovarian reserve among women in Shanxi province of north China *","volume":"278","author":"Feng","year":"2021","journal-title":"Environ Pollut [Internet]"},{"issue":"February","key":"10.1016\/j.ebiom.2022.104084_bib0041","article-title":"Chemosphere Air pollutant spatiotemporal evolution characteristics and effects on human health in North China","volume":"294","author":"Xu","year":"2022","journal-title":"Chemosphere [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0042","doi-asserted-by":"crossref","unstructured":"Sram RJ, Deimek J, Jelinek R, Solanskjq I. Fecundability and Parental Exposure to Ambient Sulfur Dioxide. 2000;108(7):647\u201354.","DOI":"10.1289\/ehp.00108647"},{"key":"10.1016\/j.ebiom.2022.104084_bib0043","doi-asserted-by":"crossref","unstructured":"Yan F, Liu H, Zhang H, Yi L, Wu Y. Association between maternal exposure to gaseous pollutants and atrial septal defect in China: A nationwide population-based study. 2021;200(February).","DOI":"10.1016\/j.envres.2021.111472"},{"issue":"3365","key":"10.1016\/j.ebiom.2022.104084_bib0044","first-page":"1","article-title":"Air Pollution and Preterm Birth\u00a0: Do Air Pollution Changes over Time Influence Risk in Consecutive Pregnancies among Low-Risk Women?","volume":"15","author":"Mendola","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ebiom.2022.104084_bib0045","article-title":"SO2 derivatives induce dysfunction in human trophoblasts via inhibiting ROS\/IL-6\/STAT3 pathway","volume":"210","author":"Hu","year":"2021","journal-title":"Ecotoxicol Environ Saf [Internet]"},{"key":"10.1016\/j.ebiom.2022.104084_bib0046","doi-asserted-by":"crossref","unstructured":"Lim AST, Tsakok MFH. Assisted reproductive technology Age-related. 1997;265\u201371.","DOI":"10.1016\/S0015-0282(97)81513-0"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104084_bib0047","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/humupd\/dmr039","article-title":"Ovarian antral folliculogenesis during the human menstrual cycle\u00a0: a review","volume":"18","author":"Baerwald","year":"2012","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104084_bib0048","first-page":"200","article-title":"Initial and Cyclic Recruitment of Ovarian Follicles *","volume":"21","author":"Hsueh","year":"2000","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104084_bib0049","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/risa.12106","article-title":"Major Factors Influencing the Health Impacts from Controlling Air Pollutants with Nonlinear Chemistry: An Application to China","volume":"34","author":"Zhou","year":"2015","journal-title":"Risk Anal"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104084_bib0050","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/humrep\/deq021","article-title":"Effect of air quality on assisted human reproduction","volume":"25","author":"Legro","year":"2010","journal-title":"Hum Reprod"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104084_bib0051","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/humrep\/dez128","article-title":"Ambient air pollution and in vitro fertilization treatment outcomes","volume":"34","author":"Boulet","year":"2019","journal-title":"Hum Reprod"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422002651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422002651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:15:57Z","timestamp":1762456557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422002651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":51,"alternative-id":["S2352396422002651"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104084","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poor ovarian response is associated with air pollutants: A multicentre study in China","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104084"}}