{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:48Z","timestamp":1790709348330,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ebiom.2022.104100","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T05:02:35Z","timestamp":1654664555000},"page":"104100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway"],"prefix":"10.1016","volume":"81","author":[{"given":"Shirong","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-5811","authenticated-orcid":false,"given":"Larry Ka-Yue","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-7741","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ebiom.2022.104100_bib0001","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41571-021-00524-x","article-title":"Nasopharyngeal carcinoma: an evolving paradigm","volume":"18","author":"Wong","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104100_bib0002","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41591-021-01444-0","article-title":"Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial","volume":"27","author":"Mai","year":"2021","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104100_bib0003","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41571-020-0424-9","article-title":"Chemoradiotherapy improves NPC outcomes","volume":"17","author":"Sidaway","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"issue":"29","key":"10.1016\/j.ebiom.2022.104100_bib0004","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1200\/JCO.21.00396","article-title":"Gemcitabine plus cisplatin versus fluorouracil plus cisplatin as first-line therapy for recurrent or metastatic nasopharyngeal carcinoma: final overall survival analysis of GEM20110714 phase III study","volume":"39","author":"Hong","year":"2021","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104100_bib0005","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/S1470-2045(21)00302-8","article-title":"Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial","volume":"22","author":"Yang","year":"2021","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104100_bib0006","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00330-019-06500-5","article-title":"Nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: clinical outcomes and patterns of failure among subsets of 8th AJCC stage IVa","volume":"30","author":"Huang","year":"2020","journal-title":"Eur Radiol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104100_bib0007","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ijrobp.2006.06.028","article-title":"Radiotherapy-related typing in 842 patients in canton with nasopharyngeal carcinoma","volume":"66","author":"Li","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104100_bib0008","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1200\/JCO.20.03237","article-title":"Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline","volume":"39","author":"Chen","year":"2021","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104100_bib0009","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-2443.2001.00449.x","article-title":"Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65","volume":"6","author":"Yamashita","year":"2001","journal-title":"Genes Cells"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104100_bib0010","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1365-2443.2009.01358.x","article-title":"TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm","volume":"14","author":"Hayano","year":"2009","journal-title":"Genes Cells"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104100_bib0011","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nbt.1759","article-title":"Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes","volume":"29","author":"Bantscheff","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104100_bib0012","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molcel.2011.05.031","article-title":"Pines J. Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery","volume":"43","author":"Pagliuca","year":"2011","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0013","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1038\/s41467-020-17078-8","article-title":"The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure","volume":"11","author":"Turnbull","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0014","article-title":"TdIF1: a putative oncogene in NSCLC tumor progression","volume":"3","author":"Zhang","year":"2018","journal-title":"Signal Transd Target Ther"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104100_bib0015","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41374-018-0070-3","article-title":"Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer","volume":"98","author":"Sawai","year":"2018","journal-title":"Lab Invest"},{"key":"10.1016\/j.ebiom.2022.104100_bib0016","article-title":"A comprehensive analysis of different gene classes in pancreatic cancer: SIGLEC15 may be a promising immunotherapeutic target","author":"Xu","year":"2021","journal-title":"Invest New Drugs"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104100_bib0017","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41388-022-02214-z","article-title":"M(6)A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression","volume":"41","author":"Lv","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.ebiom.2022.104100_bib0018","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2021.12.010","article-title":"EBF3 reactivation by inhibiting the EGR1\/EZH2\/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma","volume":"527","author":"Ding","year":"2022","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ebiom.2022.104100_bib0019","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57519","article-title":"The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth","volume":"9","author":"Mondal","year":"2020","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104100_bib0020","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1158\/1535-7163.MCT-20-0963","article-title":"Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1\/2 inhibitor","volume":"20","author":"Wang","year":"2021","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104100_bib0021","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10555-008-9123-1","article-title":"Dual-specificity MAP kinase phosphatases (MKPs) and cancer","volume":"27","author":"Keyse","year":"2008","journal-title":"Cancer Metastasis Rev"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104100_bib0022","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/annonc\/mdv237","article-title":"Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma","volume":"26","author":"Shi","year":"2015","journal-title":"Ann Oncol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104100_bib0023","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1470-2045(19)30164-0","article-title":"Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"20","author":"Jiang","year":"2019","journal-title":"Lancet Oncol"},{"issue":"7827","key":"10.1016\/j.ebiom.2022.104100_bib0024","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41586-020-2604-2","article-title":"Microbiota-derived metabolite promotes HDAC3 activity in the gut","volume":"586","author":"Wu","year":"2020","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.ebiom.2022.104100_bib0025","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151002","article-title":"Epigenetic modifiers synergize with immune-checkpoint blockade to enhance long-lasting antitumor efficacy","volume":"131","author":"Baretti","year":"2021","journal-title":"J Clin Invest"},{"issue":"17","key":"10.1016\/j.ebiom.2022.104100_bib0026","doi-asserted-by":"crossref","first-page":"9783","DOI":"10.1093\/nar\/gkab737","article-title":"HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis","volume":"49","author":"Yan","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0027","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.stem.2020.12.002","article-title":"UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex","volume":"28","author":"Chagraoui","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"49","key":"10.1016\/j.ebiom.2022.104100_bib0028","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026165118","article-title":"Structural dynamics in the evolution of a bilobed protein scaffold","volume":"118","author":"Gouridis","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0029","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1038\/s41467-021-26574-4","article-title":"Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture","volume":"12","author":"Cha","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104100_bib0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1093\/nar\/gkv068","article-title":"Structural and functional characterization of a cell cycle associated HDAC1\/2 complex reveals the structural basis for complex assembly and nucleosome targeting","volume":"43","author":"Itoh","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0031","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1038\/s41467-020-17610-w","article-title":"A distal regulatory region of a class I human histone deacetylase","volume":"11","author":"Werbeck","year":"2020","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104100_bib0032","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001696","article-title":"Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma","volume":"9","author":"Que","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"33","key":"10.1016\/j.ebiom.2022.104100_bib0033","doi-asserted-by":"crossref","first-page":"39003","DOI":"10.1021\/acsami.1c08290","article-title":"Combination of chidamide-mediated epigenetic modulation with immunotherapy: boosting tumor immunogenicity and response to PD-1\/PD-L1 blockade","volume":"13","author":"Tu","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0034","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13046-020-01792-8","article-title":"Chidamide increases the sensitivity of refractory or relapsed acute myeloid leukemia cells to anthracyclines via regulation of the HDAC3 -AKT-P21-CDK2 signaling pathway","volume":"39","author":"Wang","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"issue":"10054","key":"10.1016\/j.ebiom.2022.104100_bib0035","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/S0140-6736(16)31388-5","article-title":"Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial","volume":"388","author":"Zhang","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104100_bib0036","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41419-021-03417-0","article-title":"HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target","volume":"12","author":"Cheng","year":"2021","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0037","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-021-00702-4","article-title":"Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma","volume":"6","author":"Xie","year":"2021","journal-title":"Signal Transd Target Ther"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104100_bib0038","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/ijc.27439","article-title":"Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma","volume":"131","author":"Hui","year":"2012","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104100_bib0039","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ijc.29698","article-title":"Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir","volume":"138","author":"Hui","year":"2016","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104100_bib0040","doi-asserted-by":"crossref","first-page":"e91325","DOI":"10.1371\/journal.pone.0091325","article-title":"Treatment of nasopharyngeal carcinoma cells with the histone-deacetylase inhibitor abexinostat: cooperative effects with cis-platin and radiotherapy on patient-derived xenografts","volume":"9","author":"Gressette","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104100_bib0041","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1002\/ijc.28924","article-title":"Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism","volume":"135","author":"Hui","year":"2014","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104100_bib0042","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41556-021-00654-5","article-title":"Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling","volume":"23","author":"Ponsioen","year":"2021","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104100_bib0043","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1158\/2159-8290.CD-20-0873","article-title":"durable suppression of acquired MEK inhibitor resistance in cancer by sequestering MEK from ERK and promoting antitumor T-cell immunity","volume":"11","author":"Hong","year":"2021","journal-title":"Cancer Discov"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104100_bib0044","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41556-021-00732-8","article-title":"TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination","volume":"23","author":"Zhu","year":"2021","journal-title":"Nat Cell Biol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104100_bib0045","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.devcel.2021.05.007","article-title":"Collective ERK\/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival","volume":"56","author":"Gagliardi","year":"2021","journal-title":"Dev Cell"},{"issue":"5102","key":"10.1016\/j.ebiom.2022.104100_bib0046","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.7681221","article-title":"PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase","volume":"259","author":"Rohan","year":"1993","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.ebiom.2022.104100_bib0047","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1038\/sj.onc.1210412","article-title":"Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases","volume":"26","author":"Owens","year":"2007","journal-title":"Oncogene"},{"issue":"16","key":"10.1016\/j.ebiom.2022.104100_bib0048","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1158\/0008-5472.CAN-16-2990","article-title":"Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness","volume":"77","author":"Hou","year":"2017","journal-title":"Cancer Res"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642200281X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642200281X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:18:58Z","timestamp":1762456738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642200281X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":48,"alternative-id":["S235239642200281X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104100","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104100"}}