{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:26:08Z","timestamp":1785878768627,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ebiom.2022.104145","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T22:42:24Z","timestamp":1658184144000},"page":"104145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Same-day confirmation of infection and antimicrobial susceptibility profiling using flow cytometry"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-1339","authenticated-orcid":false,"given":"Kieran","family":"Mulroney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Kopczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teagan","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Inglis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-4187","authenticated-orcid":false,"given":"Aron","family":"Chakera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2022.104145_bib0001","series-title":"Modern Infectious Disease Epidemiology Statistics for Biology and Health","first-page":"3","article-title":"The global burden of infectious diseases","author":"Pinheiro","year":"2009"},{"key":"10.1016\/j.ebiom.2022.104145_bib0002","article-title":"Tackling drug-resistant infections globally: final report and recommendations","author":"O'Neill","year":"2016","journal-title":"Rev Antimicrob Resistance"},{"issue":"10325","key":"10.1016\/j.ebiom.2022.104145_bib0003","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104145_bib0004","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/diagnostics9020049","article-title":"Current and emerging methods of antibiotic susceptibility testing","volume":"9","author":"Khan","year":"2019","journal-title":"Diagnostics"},{"key":"10.1016\/j.ebiom.2022.104145_bib0005","first-page":"62","article-title":"New technologies in clinical microbiology","volume":"49","author":"Wolk","year":"2011","journal-title":"J Clin Microbiol [Internet]. Am Soc Microbiol J"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104145_bib0006","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/jam.14704","article-title":"Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice","volume":"129","author":"Benkova","year":"2020","journal-title":"J Appl Microbiol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104145_bib0007","article-title":"Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection","volume":"5","author":"Anton-Vazquez","year":"2021","journal-title":"Cochrane Database Systemat Rev"},{"key":"10.1016\/j.ebiom.2022.104145_bib0008","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-13-8871-2_1","article-title":"Prevalence and disease burden of chronic kidney disease","author":"Lv","year":"2019"},{"key":"10.1016\/j.ebiom.2022.104145_bib0009","series-title":"The Economic Impact of End-Stage Kidney Disease in Australia - Projections to 2020","author":"Cass","year":"2010"},{"key":"10.1016\/j.ebiom.2022.104145_bib0010","series-title":"Nature Reviews Nephrology","first-page":"90","article-title":"Changes in the worldwide epidemiology of peritoneal dialysis","author":"Li","year":"2017"},{"key":"10.1016\/j.ebiom.2022.104145_bib0011","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2147\/IJNRD.S123618","article-title":"Peritoneal dialysis-related peritonitis: challenges and solutions","volume":"11","author":"Salzer","year":"2018","journal-title":"Int J Nephrol Renovasc Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0012","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.ajkd.2011.12.030","article-title":"Dialysis modality preference of patients with CKD and family caregivers: a discrete-choice study","volume":"60","author":"Morton","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0013","first-page":"17","article-title":"de Paulis a. N. A 15 year-review of peritoneal dialysis-related peritonitis: microbiological trends and patterns of infection in a teaching hospital in Argentina","volume":"40","author":"Santoianni","year":"2008","journal-title":"Rev Argent Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0014","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0971-4065.107188","article-title":"Microbiological aspects of peritonitis in patients on continuous ambulatory peritoneal dialysis","volume":"23","author":"Vikrant","year":"2013","journal-title":"Indian J Nephrol"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104145_bib0015","doi-asserted-by":"crossref","DOI":"10.3747\/pdi.2014.00117","article-title":"Effects of a statewide protocol for the management of peritoneal dialysis-related peritonitis on microbial profiles and antimicrobial susceptibilities: a retrospective five-year review","volume":"35","author":"McGuire","year":"2015","journal-title":"Peritoneal Dialysis Int"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104145_bib0016","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ekir.2016.05.003","article-title":"The relationship between presentation and the time of initial administration of antibiotics with outcomes of peritonitis in peritoneal dialysis patients: the PROMPT study","volume":"1","author":"Muthucumarana","year":"2016","journal-title":"Kidney Int Reports"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104145_bib0017","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.ajkd.2009.11.015","article-title":"Culture-negative peritonitis in peritoneal dialysis patients in Australia: predictors, treatment, and outcomes in 435 cases","volume":"55","author":"Fahim","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ebiom.2022.104145_bib0018","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1099\/mic.0.040618-0","article-title":"Long-term impacts of antibiotic exposure on the human intestinal microbiota","volume":"156","author":"Jernberg","year":"2010","journal-title":"Microbiol. Microbiol (Reading)"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/cpcy.36","article-title":"Fundamentals of acoustic cytometry","volume":"84","author":"Ward","year":"2018","journal-title":"Curr Protocols Cytometry"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104145_bib0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1099\/jmm.0.001092","article-title":"Same-day antimicrobial susceptibility test using acoustic-enhanced flow cytometry visualized with supervised machine learning","volume":"69","author":"Inglis","year":"2020","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0021","first-page":"1903","article-title":"Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae","volume":"7","author":"Mulroney","year":"2017","journal-title":"Sci Reports"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104145_bib0022","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.kint.2020.01.044","article-title":"Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis","volume":"97","author":"Goodlad","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2022.104145_bib0023","unstructured":"The 510(k) Program: Evaluating Substantial Equivalence in Premarket Notifications [510(k)] Guidance for industry and food and drug administration staff [Internet]. [cited 2022 Jul 1]. Available from: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/510k-program-evaluating-substantial-equivalence-premarket-notifications-510k"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12915-014-0087-z","article-title":"Reagent and laboratory contamination can critically impact sequence-based microbiome analyses","volume":"12","author":"Salter","year":"2014","journal-title":"BMC Biology"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104145_bib0025","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1093\/ndt\/gft100","article-title":"Circulating bacterial-derived DNA fragments as a marker of systemic inflammation in peritoneal dialysis","volume":"28","author":"Kwan","year":"2013","journal-title":"Nephrology Dialysis Transplant"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0026","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41579-018-0098-9","article-title":"Developmental roadmap for antimicrobial susceptibility testing systems","volume":"17","author":"van Belkum","year":"2019","journal-title":"Nature Rev Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104145_bib0027","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12866-015-0376-x","article-title":"Critical aspects of using bacterial cell viability assays with the fluorophores SYTO\u00ae 9 and propidium iodide","volume":"15","author":"Stiefel","year":"2015","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ebiom.2022.104145_bib0028","series-title":"M100 - Performance Standards for Antimicrobial Susceptibility Testing","year":"2019"},{"key":"10.1016\/j.ebiom.2022.104145_bib0029","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint Tables for the interpretation of MICs and zone diameters v 10.0. 2020. Available from: https:\/\/www.eucast.org\/clinical_breakpoints\/"},{"key":"10.1016\/j.ebiom.2022.104145_bib0030","unstructured":"ISO - ISO 20776-2:2021 - Clinical laboratory testing and in vitro diagnostic test systems \u2014 Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices \u2014 Part 2: Evaluation of performance of antimicrobial susceptibility test devices against reference broth micro-dilution [Internet]. [cited 2022 May 18]. Available from: https:\/\/www.iso.org\/standard\/79377.html"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422003267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422003267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:16:45Z","timestamp":1762456605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422003267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":30,"alternative-id":["S2352396422003267"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104145","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Same-day confirmation of infection and antimicrobial susceptibility profiling using flow cytometry","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104145"}}