{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:19:57Z","timestamp":1790777997283,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ebiom.2022.104249","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T05:04:38Z","timestamp":1662786278000},"page":"104249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity"],"prefix":"10.1016","volume":"84","author":[{"given":"Erin E.","family":"Congdon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Sandusky-Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andie","family":"Dodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hao","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-2681","authenticated-orcid":false,"given":"Xiang-Peng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar M.","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ebiom.2022.104249_bib0001","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s40265-021-01546-6","article-title":"Current status of clinical trials on tau immunotherapies","volume":"81","author":"Ji","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.ebiom.2022.104249_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108104","article-title":"Tau immunotherapies: lessons learned, current status and future considerations","volume":"175","author":"Sandusky-Beltran","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ebiom.2022.104249_bib0003","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcdb.2021.12.002","article-title":"Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly","volume":"126","author":"Congdon","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.ebiom.2022.104249_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104707","article-title":"Advances and considerations in AD tau-targeted immunotherapy","volume":"134","author":"Bittar","year":"2020","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ebiom.2022.104249_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105010","article-title":"Passive immunotherapies targeting Abeta and tau in Alzheimer's disease","volume":"144","author":"Plotkin","year":"2020","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00401-019-02087-9","article-title":"From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy","volume":"139","author":"Colin","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ebiom.2022.104249_bib0007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/bs.pmbts.2019.06.001","article-title":"Alzheimer's therapy development: a few points to consider","volume":"168","author":"Sigurdsson","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0008","first-page":"44","article-title":"A quantitative analysis of brain soluble tau and the tau secretion factor","volume":"76","author":"Han","year":"2017","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0009","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3233\/JAD-150962","article-title":"Differential mass spectrometry profiles of tau protein in the cerebrospinal fluid of patients with Alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies","volume":"51","author":"Barthelemy","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104249_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/acs.jproteome.5b01001","article-title":"Tau protein quantification in human cerebrospinal fluid by targeted mass spectrometry at high sequence coverage provides insights into its primary structure heterogeneity","volume":"15","author":"Barthelemy","year":"2016","journal-title":"J Proteome Res"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104249_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.02.015","article-title":"Tau kinetics in neurons and the human central nervous system","volume":"97","author":"Sato","year":"2018","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0012","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jnnp-2014-308004","article-title":"Divergent CSF tau alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy","volume":"86","author":"Wagshal","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104249_bib0013","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1001\/archneurol.2012.1654","article-title":"Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and\/or parkinsonian disorders","volume":"69","author":"Hall","year":"2012","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0014","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.pneurobio.2011.04.012","article-title":"Biomarkers in frontotemporal lobar degenerations\u2013progress and challenges","volume":"95","author":"Hu","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104249_bib0015","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol"},{"issue":"19 Pt 2","key":"10.1016\/j.ebiom.2022.104249_bib0016","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1212\/01.wnl.0000311445.21321.fc","article-title":"CSF biomarkers in frontotemporal lobar degeneration with known pathology","volume":"70","author":"Bian","year":"2008","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0017","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/ana.20477","article-title":"Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease","volume":"57","author":"Grossman","year":"2005","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104249_bib0018","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.celrep.2016.06.099","article-title":"Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement","volume":"16","author":"Lee","year":"2016","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0019","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40478-020-00948-z","article-title":"Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation","volume":"8","author":"Zilkova","year":"2020","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0020","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1038\/s41598-019-41105-4","article-title":"Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcgamma-receptor binding and functional lysosomes","volume":"9","author":"Andersson","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104249_bib0021","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat Neurosci"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104249_bib0022","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1084\/jem.20190980","article-title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","volume":"216","author":"Shi","year":"2019","journal-title":"J Exp Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104249_bib0023","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1093\/brain\/awz241","article-title":"CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice","volume":"142","author":"Mancuso","year":"2019","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104249_bib0024","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210542","article-title":"Activated microglia mitigate Abeta-associated tau seeding and spreading","volume":"218","author":"Gratuze","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2022.104249_bib0025","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3389\/fnins.2019.01199","article-title":"Neurons expressing pathological tau protein trigger dramatic changes in microglial morphology and dynamics","volume":"13","author":"Hassan-Abdi","year":"2019","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0026","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-021-00440-9","article-title":"Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model","volume":"16","author":"Clayton","year":"2021","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0027","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s41467-022-29552-6","article-title":"Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"issue":"43","key":"10.1016\/j.ebiom.2022.104249_bib0028","doi-asserted-by":"crossref","first-page":"eabg4980","DOI":"10.1126\/sciadv.abg4980","article-title":"Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates","volume":"7","author":"Brelstaff","year":"2021","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0029","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12974-018-1309-z","article-title":"The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease","volume":"15","author":"Hopp","year":"2018","journal-title":"J Neuroinflamm"},{"issue":"593","key":"10.1016\/j.ebiom.2022.104249_bib0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb2639","article-title":"Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer\u2019s disease","volume":"13","author":"Ayalon","year":"2021","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0031","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40478-021-01147-0","article-title":"Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice","volume":"9","author":"Bajracharya","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ebiom.2022.104249_bib0032","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2019.03.033","article-title":"Tau antibody chimerization alters its charge and binding, thereby reduces its cellular uptake and efficacy","volume":"42","author":"Congdon","year":"2019","journal-title":"eBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0033","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13024-016-0126-z","article-title":"Affinity of tau antibodies for solubilized pathological tau species but not their immunogen or insoluble tau aggregates predicts in vivo and ex vivo efficacy","volume":"11","author":"Congdon","year":"2016","journal-title":"Mol Neurodegener"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104249_bib0034","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1007\/s12035-020-02034-w","article-title":"Hyperphosphorylation renders tau prone to aggregate and to cause cell death","volume":"57","author":"Liu","year":"2020","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/mcp.O114.044412","article-title":"Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5\/p25 kinase complex","volume":"14","author":"Sui","year":"2015","journal-title":"Mol Cell Proteomics"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0036","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/78078","article-title":"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein","volume":"25","author":"Lewis","year":"2000","journal-title":"Nat Gen"},{"issue":"Pt 3","key":"10.1016\/j.ebiom.2022.104249_bib0037","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/brain\/awt367","article-title":"Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease","volume":"137","author":"Murphy","year":"2014","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0038","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5115\/acb.2010.43.3.201","article-title":"Combined actions of Na\/K-ATPase, NCX1 and glutamate dependent NMDA receptors in ischemic rat brain penumbra","volume":"43","author":"Park","year":"2010","journal-title":"Anat Cell Biol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0039","doi-asserted-by":"crossref","first-page":"e35921","DOI":"10.1371\/journal.pone.0035921","article-title":"Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis","volume":"7","author":"McKiernan","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104249_bib0040","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.nbd.2007.01.011","article-title":"Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism","volume":"26","author":"Karuppagounder","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ebiom.2022.104249_bib0041","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.1038\/srep08187","article-title":"Truncation and activation of GSK-3beta by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease","volume":"5","author":"Jin","year":"2015","journal-title":"Sci Rep"},{"issue":"47","key":"10.1016\/j.ebiom.2022.104249_bib0042","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1858-12.2012","article-title":"The complex PrP(c)-Fyn couples human oligomeric Abeta with pathological tau changes in Alzheimer's disease","volume":"32","author":"Larson","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.ebiom.2022.104249_bib0043","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fncel.2019.00403","article-title":"Normal and pathological tau uptake mediated by M1\/M3 muscarinic receptors promotes opposite neuronal changes","volume":"13","author":"Morozova","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"33","key":"10.1016\/j.ebiom.2022.104249_bib0044","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1523\/JNEUROSCI.23-33-10662.2003","article-title":"Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes","volume":"23","author":"Yoshiyama","year":"2003","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104249_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ncb1528","article-title":"Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo","volume":"9","author":"Fulga","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0046","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00401-010-0716-8","article-title":"Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo","volume":"120","author":"Cowan","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0047","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00401-007-0207-8","article-title":"Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau","volume":"113","author":"Li","year":"2007","journal-title":"Acta Neuropathol"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104249_bib0048","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1042\/BCJ20190042","article-title":"An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization","volume":"476","author":"Rane","year":"2019","journal-title":"Biochem J"},{"key":"10.1016\/j.ebiom.2022.104249_bib0049","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fnins.2018.00415","article-title":"Imbalanced expression of tau and tubulin induces neuronal dysfunction in C. elegans models of tauopathy","volume":"12","author":"Miyasaka","year":"2018","journal-title":"Front Neurosci"},{"issue":"23","key":"10.1016\/j.ebiom.2022.104249_bib0050","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1073\/pnas.0603214103","article-title":"Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity","volume":"103","author":"Alonso Adel","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"45","key":"10.1016\/j.ebiom.2022.104249_bib0051","doi-asserted-by":"crossref","first-page":"31052","DOI":"10.1074\/jbc.M109.052969","article-title":"Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors","volume":"284","author":"Kim","year":"2009","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0052","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.20131685","article-title":"Neuronal activity regulates extracellular tau in vivo","volume":"211","author":"Yamada","year":"2014","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0053","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1046\/j.1471-4159.2000.0741666.x","article-title":"Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu\/Zn superoxide dismutase","volume":"74","author":"Alexander","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.ebiom.2022.104249_bib0054","doi-asserted-by":"crossref","first-page":"11161","DOI":"10.1038\/srep11161","article-title":"Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody","volume":"5","author":"Luo","year":"2015","journal-title":"Sci Rep"},{"issue":"35","key":"10.1016\/j.ebiom.2022.104249_bib0055","doi-asserted-by":"crossref","first-page":"21652","DOI":"10.1074\/jbc.M115.657924","article-title":"Distinct therapeutic mechanisms of tau antibodies: promoting microglial clearance versus blocking neuronal uptake","volume":"290","author":"Funk","year":"2015","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0056","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/acn3.176","article-title":"Anti-tau antibody reduces insoluble tau and decreases brain atrophy","volume":"2","author":"Yanamandra","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0057","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/alzrt277","article-title":"Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease","volume":"6","author":"Kontsekova","year":"2014","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0058","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/19420862.2017.1323159","article-title":"Affinity of human IgG subclasses to mouse Fc gamma receptors","volume":"9","author":"Dekkers","year":"2017","journal-title":"MAbs"},{"issue":"5753","key":"10.1016\/j.ebiom.2022.104249_bib0059","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1126\/science.1118948","article-title":"Divergent immunoglobulin g subclass activity through selective Fc receptor binding","volume":"310","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2005.05.010","article-title":"FcgammaRIV: a novel FcR with distinct IgG subclass specificity","volume":"23","author":"Nimmerjahn","year":"2005","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0061","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4049\/jimmunol.0902752","article-title":"Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors","volume":"184","author":"Saylor","year":"2010","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104249_bib0062","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.160.1.20","article-title":"Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity","volume":"160","author":"Gavin","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2022.104249_bib0063","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molimm.2020.08.015","article-title":"Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: Antibody deglycosylation only eliminates IgG2b binding","volume":"127","author":"Temming","year":"2020","journal-title":"Mol Immunol"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104249_bib0064","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1084\/jem.191.8.1293","article-title":"Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III","volume":"191","author":"Fossati-Jimack","year":"2000","journal-title":"J Exp Med"},{"issue":"6429","key":"10.1016\/j.ebiom.2022.104249_bib0065","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans","volume":"363","author":"Holth","year":"2019","journal-title":"Science"},{"issue":"49","key":"10.1016\/j.ebiom.2022.104249_bib0066","doi-asserted-by":"crossref","first-page":"35452","DOI":"10.1074\/jbc.M113.491001","article-title":"Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance","volume":"288","author":"Congdon","year":"2013","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104249_bib0067","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.4049\/jimmunol.150.6.2231","article-title":"Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains","volume":"150","author":"Cooper","year":"1993","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104249_bib0068","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1172\/JCI119033","article-title":"Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?","volume":"98","author":"Pritsch","year":"1996","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104249_bib0069","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1002\/1521-4141(2000012)30:12<3387::AID-IMMU3387>3.0.CO;2-K","article-title":"Can isotype switch modulate antigen-binding affinity and influence clonal selection?","volume":"30","author":"Pritsch","year":"2000","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003306","article-title":"IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly gamma-D-glutamic acid capsular antigen of Bacillus anthracis","volume":"9","author":"Hovenden","year":"2013","journal-title":"PLoS Pathog"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104249_bib0071","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02059-20","article-title":"The role of IgG subclass in antibody-mediated protection against carbapenem-resistant Klebsiella pneumoniae","volume":"11","author":"Motley","year":"2020","journal-title":"mBio"},{"issue":"31","key":"10.1016\/j.ebiom.2022.104249_bib0072","doi-asserted-by":"crossref","first-page":"12680","DOI":"10.1073\/pnas.1200024109","article-title":"Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody","volume":"109","author":"Tudor","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1-2","key":"10.1016\/j.ebiom.2022.104249_bib0073","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2013.04.004","article-title":"The constant region affects antigen binding of antibodies to DNA by altering secondary structure","volume":"56","author":"Xia","year":"2013","journal-title":"Mol Immunol"},{"issue":"46","key":"10.1016\/j.ebiom.2022.104249_bib0074","doi-asserted-by":"crossref","first-page":"31366","DOI":"10.1074\/jbc.M806473200","article-title":"Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand","volume":"283","author":"Dam","year":"2008","journal-title":"J Biol Chem"},{"issue":"7-8","key":"10.1016\/j.ebiom.2022.104249_bib0075","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.molimm.2010.02.018","article-title":"Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure","volume":"47","author":"Janda","year":"2010","journal-title":"Mol Immunol"},{"issue":"26","key":"10.1016\/j.ebiom.2022.104249_bib0076","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1021\/bi00240a033","article-title":"Carbon-13 NMR study of switch variant anti-dansyl antibodies: antigen binding and domain-domain interactions","volume":"30","author":"Kato","year":"1991","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0077","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4049\/jimmunol.169.3.1379","article-title":"Isotype can affect the fine specificity of an antibody for a polysaccharide antigen","volume":"169","author":"McLean","year":"2002","journal-title":"J Immunol"},{"issue":"18","key":"10.1016\/j.ebiom.2022.104249_bib0078","doi-asserted-by":"crossref","first-page":"13917","DOI":"10.1074\/jbc.M700661200","article-title":"The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen","volume":"282","author":"Torres","year":"2007","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104249_bib0079","doi-asserted-by":"crossref","first-page":"e1310","DOI":"10.1371\/journal.pone.0001310","article-title":"Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity","volume":"2","author":"Torres","year":"2007","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0080","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.4049\/jimmunol.174.4.2132","article-title":"Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype","volume":"174","author":"Torres","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104249_bib0081","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jaut.2012.06.005","article-title":"The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies","volume":"39","author":"Xia","year":"2012","journal-title":"J Autoimmun"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104249_bib0082","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1128\/IAI.66.3.1057-1062.1998","article-title":"Isotype switching increases efficacy of antibody protection against Cryptococcus neoformans infection in mice","volume":"66","author":"Yuan","year":"1998","journal-title":"Infect Immun"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:19:31Z","timestamp":1762456771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422004315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":82,"alternative-id":["S2352396422004315"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104249","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104249"}}