{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:50:32Z","timestamp":1792803032147,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["HHSN268201300005C AM03"],"award-info":[{"award-number":["HHSN268201300005C AM03"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["MOD03"],"award-info":[{"award-number":["MOD03"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007099","name":"San Diego State University","doi-asserted-by":"publisher","award":["HHSN268201300005I \/ N01-HC-65237"],"award-info":[{"award-number":["HHSN268201300005I \/ N01-HC-65237"]}],"id":[{"id":"10.13039\/100007099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007810","name":"University of North Carolina Wilmington","doi-asserted-by":"publisher","award":["HHSN268201300001I \/ N01-HC-65233"],"award-info":[{"award-number":["HHSN268201300001I \/ N01-HC-65233"]}],"id":[{"id":"10.13039\/100007810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL135818"],"award-info":[{"award-number":["R35HL135818"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R21HL145425"],"award-info":[{"award-number":["R21HL145425"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL143221"],"award-info":[{"award-number":["R01HL143221"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"publisher","award":["HHSN268201300003I \/ N01- HC-65236"],"award-info":[{"award-number":["HHSN268201300003I \/ N01- HC-65236"]}],"id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006686","name":"University of Miami","doi-asserted-by":"publisher","award":["HHSN268201300004I \/ N01-HC-65234"],"award-info":[{"award-number":["HHSN268201300004I \/ N01-HC-65234"]}],"id":[{"id":"10.13039\/100006686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine, Yeshiva University","doi-asserted-by":"publisher","award":["HHSN268201300002I \/ N01-HC-65235"],"award-info":[{"award-number":["HHSN268201300002I \/ N01-HC-65235"]}],"id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013981","name":"American Academy of Sleep Medicine Foundation","doi-asserted-by":"publisher","award":["250-SR-21"],"award-info":[{"award-number":["250-SR-21"]}],"id":[{"id":"10.13039\/100013981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ebiom.2022.104288","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:49:55Z","timestamp":1664174995000},"page":"104288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS\/SOL"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-7129","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Elgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuzulul","family":"Kurniansyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neomi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Daviglus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis C.","family":"Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Cade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-8860","authenticated-orcid":false,"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2022.104288_bib0001","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"14","key":"10.1016\/j.ebiom.2022.104288_bib0002","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and management of obstructive sleep apnea: a review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104288_bib0003","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.ijo.0803803","article-title":"Shared genetic basis for obstructive sleep apnea and adiposity measures","volume":"32","author":"Patel","year":"2008","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0004","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1164\/rccm.201309-1735OC","article-title":"Sleep-disordered breathing in Hispanic\/Latino individuals of diverse backgrounds. The Hispanic community health study\/study of Latinos","volume":"189","author":"Redline","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1212\/WNL.0000000000001181","article-title":"Obstructive sleep apnea and neurocognitive function in a Hispanic\/Latino population","volume":"84","author":"Ramos","year":"2015","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0006","first-page":"48","article-title":"Weight loss and OSA and pulmonary function in obesity","volume":"90","author":"Nahmias","year":"1993","journal-title":"Jersey Med"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0007","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s11325-020-02086-1","article-title":"Association between lung function decline and obstructive sleep apnoea: the ALEC study","volume":"25","author":"Emilsson","year":"2021","journal-title":"Sleep Breath\u00a0=\u00a0Schlaf Atmung"},{"key":"10.1016\/j.ebiom.2022.104288_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.smrv.2019.01.004","article-title":"Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis","volume":"45","author":"Zhang","year":"2019","journal-title":"Sleep Med Rev"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104288_bib0009","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41576-019-0137-z","article-title":"Genetic correlations of polygenic disease traits: from theory to practice","volume":"20","author":"van Rheenen","year":"2019","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13073-020-00742-5","article-title":"Polygenic risk scores: from research tools to clinical instruments","volume":"12","author":"Lewis","year":"2020","journal-title":"Genome Med"},{"issue":"19","key":"10.1016\/j.ebiom.2022.104288_bib0011","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104288_bib0012","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03091-2020","article-title":"Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health","volume":"57","author":"Strausz","year":"2021","journal-title":"Eur Respiratory J"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0013","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/hmg\/ddy387","article-title":"Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic\/Latino Americans","volume":"28","author":"Wang","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104288_bib0014","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.annepidem.2010.03.015","article-title":"Design and implementation of the Hispanic community health study\/study of Latinos","volume":"20","author":"Sorlie","year":"2010","journal-title":"Ann Epidemiol"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104288_bib0015","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.annepidem.2010.05.006","article-title":"Sample design and cohort selection in the Hispanic community health study\/study of Latinos","volume":"20","author":"Lavange","year":"2010","journal-title":"Ann Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0016","doi-asserted-by":"crossref","first-page":"547","DOI":"10.18865\/ed.31.4.547","article-title":"Consent for use of genetic data among US Hispanics\/Latinos: results from the hispanic community health study\/study of Latinos","volume":"31","author":"Gonzalez","year":"2021","journal-title":"Ethnicity Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0017","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ajhg.2015.12.001","article-title":"Genetic diversity and association studies in US Hispanic\/Latino populations: applications in the Hispanic community health study\/study of Latinos","volume":"98","author":"Conomos","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104288_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008500","article-title":"Use of >100,000 NHLBI trans-omics for precision medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic\/Latino populations","volume":"15","author":"Kowalski","year":"2019","journal-title":"PLos Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0019","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2022.104288_bib0020","doi-asserted-by":"crossref","unstructured":"Elgart M, Goodman MO, Isasi C, et al. Genetic and environmental correlations between complex phenotypes differ by race\/ethnicity and sex. medRxiv. 2021:2021.09.05.21263126.","DOI":"10.1101\/2021.09.05.21263126"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0021","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/gepi.22188","article-title":"A fully adjusted two-stage procedure for rank-normalization in genetic association studies","volume":"43","author":"Sofer","year":"2019","journal-title":"Genet Epidemiol"},{"issue":"20","key":"10.1016\/j.ebiom.2022.104288_bib0022","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in \u223c700000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0023","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/hmg\/ddy327","article-title":"Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry","volume":"28","author":"Pulit","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0024","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41588-018-0321-7","article-title":"New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries","volume":"51","author":"Shrine","year":"2019","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104288_bib0025","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/ng.2610","article-title":"Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders","volume":"45","author":"den Hoed","year":"2013","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0026","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41588-018-0047-6","article-title":"Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases","volume":"50","author":"Kanai","year":"2018","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104288_bib0027","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104288_bib0028","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","article-title":"Genetics of blood lipids among \u223c300,000 multi-ethnic participants of the Million Veteran Program","volume":"50","author":"Klarin","year":"2018","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104288_bib0029","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41588-021-00852-9","article-title":"The trans-ancestral genomic architecture of glycemic traits","volume":"53","author":"Chen","year":"2021","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ng.520","article-title":"New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk","volume":"42","author":"Dupuis","year":"2010","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0031","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41467-019-08917-4","article-title":"Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates","volume":"10","author":"Dashti","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0032","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41588-019-0361-7","article-title":"Biological and clinical insights from genetics of insomnia symptoms","volume":"51","author":"Lane","year":"2019","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104288_bib0033","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0034","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1165\/rcmb.2017-0237OC","article-title":"Multiethnic meta-analysis identifies RAI1 as a possible obstructive sleep apnea-related quantitative trait locus in men","volume":"58","author":"Chen","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/bib\/bbs038","article-title":"The UCSC genome browser and associated tools","volume":"14","author":"Kuhn","year":"2013","journal-title":"Brief Bioinform"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104288_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput Biol"},{"issue":"22-23","key":"10.1016\/j.ebiom.2022.104288_bib0037","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1093\/bioinformatics\/btaa1029","article-title":"LDpred2: better, faster, stronger","volume":"36","author":"Priv\u00e9","year":"2020","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.ebiom.2022.104288_bib0038","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1093\/bioinformatics\/bty185","article-title":"Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr","volume":"34","author":"Priv\u00e9","year":"2018","journal-title":"Bioinformatics"},{"issue":"6968","key":"10.1016\/j.ebiom.2022.104288_bib0039","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The international hapmap project","volume":"426","author":"The International HapMap Consortium","year":"2003","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.ebiom.2022.104288_bib0040","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1093\/bioinformatics\/btz567","article-title":"Genetic association testing using the GENESIS R\/Bioconductor package","volume":"35","author":"Gogarten","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2022.104288_bib0041","doi-asserted-by":"crossref","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.ebiom.2022.104288_bib0042","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0043","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ije\/dyy101","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"22","key":"10.1016\/j.ebiom.2022.104288_bib0044","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/hmg\/ddab166","article-title":"Genome-wide association study of body fat distribution traits in Hispanics\/Latinos from the HCHS\/SOL","volume":"30","author":"Justice","year":"2021","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12944-017-0591-6","article-title":"Genetic architecture of lipid traits in the Hispanic community health study\/study of Latinos","volume":"16","author":"Graff","year":"2017","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0046","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/gepi.22029","article-title":"A powerful statistical framework for generalization testing in GWAS, with application to the HCHS\/SOL","volume":"41","author":"Sofer","year":"2017","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104288_bib0047","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0048","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1152\/japplphysiol.00587.2005","article-title":"Excess weight and sleep-disordered breathing","volume":"99","author":"Young","year":"2005","journal-title":"J Appl Physiol (Bethesda, Md : 1985)"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104288_bib0049","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.5664\/jcsm.9834","article-title":"Dose-response relationship between weight loss and improvements in obstructive sleep apnea severity after a diet\/lifestyle interventions: secondary analyses of the \u201cMIMOSA\u201d randomized clinical trial","volume":"18","author":"Georgoulis","year":"2022","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104288_bib0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-008222","article-title":"A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses","volume":"5","author":"Esposito","year":"2015","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0051","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/HYPERTENSIONAHA.118.12259","article-title":"Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults","volume":"73","author":"Jennings","year":"2019","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0052","doi-asserted-by":"crossref","first-page":"27010","DOI":"10.1289\/EHP7870","article-title":"Associations of urban environment features with hypertension and blood pressure across 230 latin american cities","volume":"130","author":"Avila-Palencia","year":"2022","journal-title":"Environ Health Perspect"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0053","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12916-017-0901-x","article-title":"Environmental\/lifestyle factors in the pathogenesis and prevention of type 2 diabetes","volume":"15","author":"Kolb","year":"2017","journal-title":"BMC Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0054","first-page":"28","article-title":"Influence of smoking on sleep and obstructive sleep apnea syndrome","volume":"65","author":"Deleanu","year":"2016","journal-title":"Pneumologia"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0055","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jsmc.2020.02.017","article-title":"Sleep, health, and society","volume":"15","author":"Grandner","year":"2020","journal-title":"Sleep Med Clin"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104288_bib0056","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1164\/rccm.201912-2330OC","article-title":"Associations of sleep-disordered breathing and insomnia with incident hypertension and diabetes. The Hispanic community health study\/study of Latinos","volume":"203","author":"Li","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104288_bib0057","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1172\/JCI137560","article-title":"Hypoxia-inducible factors and obstructive sleep apnea","volume":"130","author":"Prabhakar","year":"2020","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0058","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022141","article-title":"Association between arousals during sleep and hypertension among patients with obstructive sleep apnea","volume":"11","author":"Ren","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104288_bib0059","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/dom.14247","article-title":"Benefits of continuous positive airway pressure on glycaemic control and insulin resistance in patients with type 2 diabetes and obstructive sleep apnoea: A meta-analysis","volume":"23","author":"Shang","year":"2021","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.ebiom.2022.104288_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101446","article-title":"Efficacy of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH): systematic review and meta-analysis","volume":"58","author":"Labarca","year":"2021","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.ebiom.2022.104288_bib0061","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.smrv.2015.03.002","article-title":"Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea","volume":"25","author":"Mart\u00ednez-Ceron","year":"2016","journal-title":"Sleep Med Rev"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104288_bib0062","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1378\/chest.13-1115","article-title":"Effect of CPAP on blood pressure in patients with OSA\/hypopnea a systematic review and meta-analysis","volume":"145","author":"Fava","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.ebiom.2022.104288_bib0063","doi-asserted-by":"crossref","first-page":"e13821","DOI":"10.1111\/eci.13821","article-title":"Positive airway pressure therapy in heart failure patients comorbid with obstructive sleep apnea: cardiovascular outcomes and nighttime-duration effect","author":"Lin","year":"2022","journal-title":"Eur J Clin Invest"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104288_bib0064","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.2337\/dc18-0675","article-title":"A Population-based study of the bidirectional association between obstructive sleep apnea and type 2 diabetes in three prospective U.S. cohorts","volume":"41","author":"Huang","year":"2018","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104288_bib0065","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/sleep\/19.10.767","article-title":"Hypotension reduces sleep apneas in Zucker lean and Zucker obese rats","volume":"19","author":"Radulovacki","year":"1996","journal-title":"Sleep"},{"issue":"4 Pt 1","key":"10.1016\/j.ebiom.2022.104288_bib0066","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1164\/ajrccm.162.4.9911033","article-title":"Sleep-disordered respiration in phenotypically normotensive, genetically hypertensive rats","volume":"162","author":"Carley","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0067","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41467-020-14625-1","article-title":"Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank","volume":"11","author":"Campos","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104288_bib0068","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.chest.2020.12.002","article-title":"Sleep apnea and insomnia: emerging evidence for effective clinical management","volume":"159","author":"Ong","year":"2021","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0069","first-page":"105","article-title":"Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records","volume":"13","author":"Veatch","year":"2020","journal-title":"BMC Med Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0070","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1038\/s41467-022-31080-2","article-title":"A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood","volume":"13","author":"Kurniansyah","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104288_bib0071","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s42003-022-03812-z","article-title":"Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations","volume":"5","author":"Elgart","year":"2022","journal-title":"Commun Biol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:35:08Z","timestamp":1778873708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422004704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":71,"alternative-id":["S2352396422004704"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104288","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS\/SOL","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104288","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104288"}}