{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:15:09Z","timestamp":1790766909715,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium fur Bildung und Forschung Dienststelle Bonn","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004563","name":"Bayerische Staatsministerium f\u00fcr Wissenschaft Forschung und Kunst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004563","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ebiom.2022.104294","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T05:41:46Z","timestamp":1664862106000},"page":"104294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-0136","authenticated-orcid":false,"given":"Emanuel","family":"Vogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-3838","authenticated-orcid":false,"given":"Katharina","family":"Kocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-0347","authenticated-orcid":false,"given":"Alina","family":"Priller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-2743","authenticated-orcid":false,"given":"Cho-Chin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Steininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Hung","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-6547","authenticated-orcid":false,"given":"Nina","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Willmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Irrgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-4019","authenticated-orcid":false,"given":"Carolin","family":"Moosmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-9960","authenticated-orcid":false,"given":"Viviane","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Beileke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wytopil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-0344","authenticated-orcid":false,"given":"Sarah","family":"Heringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"Brockhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-2057","authenticated-orcid":false,"given":"Samuel","family":"Jeske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"Mijocevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3950-2481","authenticated-orcid":false,"given":"Catharina","family":"Christa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Tinnefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bogdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Knolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"\u00dcberla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Protzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-9472","authenticated-orcid":false,"given":"Kilian","family":"Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-9056","authenticated-orcid":false,"given":"Matthias","family":"Tenbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.ebiom.2022.104294_bib0001","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa2104840","article-title":"Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination","volume":"384","author":"Greinacher","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2022.104294_bib0002","series-title":"Beschluss der STIKO zur 5. Aktualisierung der COVID-19-Impfempfehlung und die dazugeh\u00f6rige wissenschaftliche Begr\u00fcndung","author":"Vygen-Bonnet","year":"2021"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104294_bib0003","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S2213-2600(21)00357-X","article-title":"Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study","volume":"9","author":"Hillus","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104294_bib0004","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/s41591-021-01449-9","article-title":"Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19\/BNT162b2 vaccination","volume":"27","author":"Barros-Martins","year":"2021","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104294_bib0005","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S1473-3099(21)00420-5","article-title":"Heterologous prime\u2013boost vaccination with ChAdOx1 nCoV-19 and BNT162b2","volume":"21","author":"Tenbusch","year":"2021","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104294_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.medj.2021.12.004","article-title":"Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipients","volume":"3","author":"Khoo","year":"2022","journal-title":"Med"},{"key":"10.1016\/j.ebiom.2022.104294_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103761","article-title":"Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants","volume":"75","author":"Gro\u00df","year":"2022","journal-title":"EBioMedicine"},{"issue":"10305","key":"10.1016\/j.ebiom.2022.104294_bib0008","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(21)01891-2","article-title":"SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S\/BNT162b2 vaccination","volume":"398","author":"Behrens","year":"2021","journal-title":"Lancet"},{"issue":"6584","key":"10.1016\/j.ebiom.2022.104294_bib0009","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.abn2688","article-title":"Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1\/mRNA-1273 vaccination","volume":"375","author":"Kaku","year":"2022","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104294_bib0010","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/s41591-021-01464-w","article-title":"Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19\/mRNA vaccination","volume":"27","author":"Schmidt","year":"2021","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104294_bib0011","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1056\/NEJMc2110716","article-title":"Heterologous ChAdOx1 nCoV-19 and mRNA-1273 vaccination","volume":"385","author":"Normark","year":"2021","journal-title":"N Engl J Med"},{"issue":"10303","key":"10.1016\/j.ebiom.2022.104294_bib0012","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0140-6736(21)01694-9","article-title":"Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial","volume":"398","author":"Liu","year":"2021","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104294_bib0013","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S2213-2600(21)00458-6","article-title":"Waning immunity to SARS-CoV-2: implications for vaccine booster strategies","volume":"9","author":"Altmann","year":"2021","journal-title":"Lancet Respirat Med"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104294_bib0014","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/vaccines10030359","article-title":"Duration of SARS-CoV-2 immune responses up to six months following homologous or heterologous primary immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines","volume":"10","author":"Marking","year":"2022","journal-title":"Vaccines"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104294_bib0015","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3390\/vaccines9101163","article-title":"The effects of heterologous immunization with prime-boost COVID-19 vaccination against SARS-CoV-2","volume":"9","author":"Ho","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.ebiom.2022.104294_bib0016","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41591-022-01715-4","article-title":"Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern","volume":"28","author":"Wratil","year":"2022","journal-title":"Nat Med"},{"issue":"1-2","key":"10.1016\/j.ebiom.2022.104294_bib0017","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jim.2012.09.008","article-title":"Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate","volume":"387","author":"Almanzar","year":"2013","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ebiom.2022.104294_bib0018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2334-4-33","article-title":"A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid","volume":"4","author":"Kneitz","year":"2004","journal-title":"BMC Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104294_bib0019","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10096-020-04072-7","article-title":"Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2","volume":"40","author":"Lapuente","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ebiom.2022.104294_bib0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s10875-021-01190-5","article-title":"Seasonal betacoronavirus antibodies\u2019 expansion Post-BNT161b2 vaccination associates with reduced SARS-CoV-2 VoC neutralization","volume":"42","author":"Dispinseri","year":"2022","journal-title":"J Clin Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104294_bib0021","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1038\/s41467-021-27063-4","article-title":"Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization","volume":"12","author":"Lapuente","year":"2021","journal-title":"Nat Commun"},{"issue":"7833","key":"10.1016\/j.ebiom.2022.104294_bib0022","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2598-9","article-title":"SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19","volume":"587","author":"Braun","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104294_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T cell responses to SARS-CoV-2 Coronavirus in humans with COVID-19 disease and unexposed individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104294_bib0024","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104294_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.01.050","article-title":"Maturation and persistence of the anti-SARS-CoV-2 memory B cell response","volume":"184","author":"Sokal","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.104294_bib0026","first-page":"1","article-title":"Germinal centre-driven maturation of B cell response to mRNA vaccination","author":"Kim","year":"2022","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104294_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.12.026","article-title":"SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans","volume":"185","author":"Mudd","year":"2022","journal-title":"Cell"},{"issue":"7870","key":"10.1016\/j.ebiom.2022.104294_bib0028","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-021-03738-2","article-title":"SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses","volume":"596","author":"Turner","year":"2021","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104294_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.01.018","article-title":"Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination","volume":"185","author":"R\u00f6ltgen","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.104294_bib0030","doi-asserted-by":"crossref","unstructured":"Muecksch F, Wang Z, Cho A, et al. Increased potency and breadth of SARS-CoV-2 neutralizing antibodies after a third mRNA vaccine dose. bioRxiv 2022.","DOI":"10.1101\/2022.02.14.480394"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104294_bib0031","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1473-3099(22)00129-3","article-title":"Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study","volume":"22","author":"Sheward","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104294_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.12.032","article-title":"The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic","volume":"185","author":"Hoffmann","year":"2022","journal-title":"Cell"},{"issue":"7898","key":"10.1016\/j.ebiom.2022.104294_bib0033","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"issue":"10321","key":"10.1016\/j.ebiom.2022.104294_bib0034","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(21)02844-0","article-title":"Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum","volume":"399","author":"Dejnirattisai","year":"2022","journal-title":"Lancet"},{"issue":"6581","key":"10.1016\/j.ebiom.2022.104294_bib0035","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.abn7591","article-title":"Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera","volume":"375","author":"Muik","year":"2022","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104294_bib0036","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1056\/NEJMc2119912","article-title":"SARS-CoV-2 Omicron variant neutralization after mRNA-1273 booster vaccination","volume":"386","author":"Pajon","year":"2022","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104294_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.12.046","article-title":"SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses","volume":"185","author":"Dejnirattisai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.104294_bib0038","first-page":"1","article-title":"mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant","author":"Gruell","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2022.104294_bib0039","first-page":"1","article-title":"Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination","author":"Cheng","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2022.104294_bib0040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41591-022-01705-6","article-title":"Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination","volume":"28","author":"P\u00e9rez-Then","year":"2022","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104294_bib0041","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41591-021-01377-8","article-title":"Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection","volume":"27","author":"Khoury","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2022.104294_bib0042","doi-asserted-by":"crossref","unstructured":"Hansen CH, Schelde AB, Moustsen-Helm IR, et al. Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: a Danish cohort study. medRxiv 2021:2021.12.20.21267966.","DOI":"10.1101\/2021.12.20.21267966"},{"key":"10.1016\/j.ebiom.2022.104294_bib0043","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa2119451","article-title":"Covid-19 vaccine effectiveness against the Omicron (B.1.1.529) variant","volume":"386","author":"Andrews","year":"2022","journal-title":"N Engl J Med"},{"issue":"39","key":"10.1016\/j.ebiom.2022.104294_bib0044","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2021.26.39.2100894","article-title":"Product-specific COVID-19 vaccine effectiveness against secondary infection in close contacts, Navarre, Spain, April to August 2021","volume":"26","author":"Mart\u00ednez-Baz","year":"2021","journal-title":"Euro Surveill"},{"issue":"10327","key":"10.1016\/j.ebiom.2022.104294_bib0045","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0140-6736(22)00089-7","article-title":"Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden","volume":"399","author":"Nordstr\u00f6m","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2022.104294_bib0046","article-title":"Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: a nationwide cohort study","volume":"11","author":"Nordstr\u00f6m","year":"2021","journal-title":"Lancet Reg Health Eur"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104294_bib0047","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41591-022-01721-6","article-title":"Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines","volume":"28","author":"Wei","year":"2022","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104294_bib0048","doi-asserted-by":"crossref","first-page":"e898","DOI":"10.1093\/cid\/ciab915","article-title":"mRNA vaccine-elicited SARS-CoV-2-specific T cells persist at 6 months and recognize the delta variant","volume":"75","author":"Woldemeskel","year":"2022","journal-title":"Clin Infect Dis"},{"issue":"7875","key":"10.1016\/j.ebiom.2022.104294_bib0049","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-021-03841-4","article-title":"Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine","volume":"597","author":"Oberhardt","year":"2021","journal-title":"Nature"},{"issue":"6566","key":"10.1016\/j.ebiom.2022.104294_bib0050","doi-asserted-by":"crossref","first-page":"eabj9853","DOI":"10.1126\/science.abj9853","article-title":"Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells","volume":"374","author":"Mateus","year":"2021","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104294_bib0051","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41590-021-01122-w","article-title":"The T cell immune response against SARS-CoV-2","volume":"23","author":"Moss","year":"2022","journal-title":"Nat Immunol"},{"issue":"66","key":"10.1016\/j.ebiom.2022.104294_bib0052","doi-asserted-by":"crossref","first-page":"eabl5344","DOI":"10.1126\/sciimmunol.abl5344","article-title":"BNT162b2 vaccination induces durable SARS-CoV-2-specific T cells with a stem cell memory phenotype","volume":"6","author":"Guerrera","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.ebiom.2022.104294_bib0053","first-page":"1","article-title":"Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant","author":"Gao","year":"2022","journal-title":"Nat Med"},{"issue":"7901","key":"10.1016\/j.ebiom.2022.104294_bib0054","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41586-022-04460-3","article-title":"T cell responses to SARS-CoV-2 spike cross-recognize Omicron","volume":"603","author":"Keeton","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2022.104294_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.03.022","article-title":"T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals","author":"Naranbhai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.104294_bib0056","doi-asserted-by":"crossref","first-page":"eabo2202","DOI":"10.1126\/sciimmunol.abo2202","article-title":"Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients","author":"GeurtsvanKessel","year":"2022","journal-title":"Sci Immunol"},{"key":"10.1016\/j.ebiom.2022.104294_bib0057","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-022-04465-y","article-title":"Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron","volume":"603","author":"Liu","year":"2022","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104294_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.01.015","article-title":"SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron","volume":"185","author":"Tarke","year":"2022","journal-title":"Cell"},{"issue":"7890","key":"10.1016\/j.ebiom.2022.104294_bib0059","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-021-04120-y","article-title":"Immunogenicity and efficacy of heterologous ChAdOx1-BNT162b2 vaccination","volume":"600","author":"Pozzetto","year":"2021","journal-title":"Nature"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422004765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:20:09Z","timestamp":1762456809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422004765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":59,"alternative-id":["S2352396422004765"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104294","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.23.22272771","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104294"}}