{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:16:17Z","timestamp":1787807777863,"version":"build-2784847793"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ebiom.2022.104338","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T20:29:53Z","timestamp":1667593793000},"page":"104338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques"],"prefix":"10.1016","volume":"86","author":[{"given":"Natalia","family":"Makarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyana","family":"Singletary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Melissa","family":"Peet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Holder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuong","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Agrahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Heneine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gerardo","family":"Garc\u00eda-Lerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Doncel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib1","doi-asserted-by":"crossref","first-page":"21133","DOI":"10.7448\/IAS.19.1.21133","article-title":"The UNAIDS 90-90-90 target: a clear choice for ending AIDS and for sustainable health and development","volume":"19","author":"Sidib\u00e9","year":"2016","journal-title":"J\u00a0Int AIDS Soc"},{"key":"10.1016\/j.ebiom.2022.104338_bib2","volume":"32","year":"2021"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104338_bib3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2018.1917","article-title":"HIV preexposure prophylaxis: a review","volume":"319","author":"Riddell","year":"2018","journal-title":"JAMA"},{"issue":"27","key":"10.1016\/j.ebiom.2022.104338_bib4","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men","volume":"363","author":"Grant","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.ebiom.2022.104338_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S1473-3099(14)70847-3","article-title":"Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study","volume":"14","author":"Grant","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"10013","key":"10.1016\/j.ebiom.2022.104338_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(15)00056-2","article-title":"Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial","volume":"387","author":"McCormack","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104338_bib7","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1016\/S2352-3018(21)00071-0","article-title":"Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"8","author":"Ogbuagu","year":"2021","journal-title":"Lancet HIV"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104338_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1056\/NEJMoa2101016","article-title":"Cabotegravir for HIV prevention in cisgender men and transgender women","volume":"385","author":"Landovitz","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104338_bib9","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1007\/s10461-017-1969-1","article-title":"Preference of oral tenofovir disoproxil fumarate\/emtricitabine versus rectal tenofovir reduced-glycerin 1% gel regimens for HIV prevention among cisgender men and transgender women who engage in receptive anal intercourse with men","volume":"21","author":"Carballo-Di\u00e9guez","year":"2017","journal-title":"AIDS Behav"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1517\/17425247.2013.860132","article-title":"The development of rectal microbicides for HIV prevention","volume":"11","author":"McGowan","year":"2014","journal-title":"Expert Opin Drug Deliv"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104338_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/pharmaceutics11080374","article-title":"Topical inserts: a versatile delivery form for HIV prevention","volume":"11","author":"Peet","year":"2019","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104338_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11904-020-00497-z","article-title":"PrEP product acceptability and dual process decision-making among men who have sex with men","volume":"17","author":"Bauermeister","year":"2020","journal-title":"Curr HIV AIDS Rep"},{"key":"10.1016\/j.ebiom.2022.104338_bib13","series-title":"Acceptability and choice for 3 placebo products used with receptive anal sex","year":"2021"},{"key":"10.1016\/j.ebiom.2022.104338_bib14","series-title":"One size doesn't fit all when it comes to products for preventing HIV from anal sex","year":"2021"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104338_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/pharmaceutics6040616","article-title":"Evaluation of rapidly disintegrating vaginal tablets of tenofovir, emtricitabine and their combination for HIV-1 prevention","volume":"6","author":"Clark","year":"2014","journal-title":"Pharmaceutics"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104338_bib16","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1128\/AAC.02336-13","article-title":"Pharmacokinetic and safety analyses of tenofovir and tenofovir-emtricitabine vaginal tablets in pigtailed macaques","volume":"58","author":"Pereira","year":"2014","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.ebiom.2022.104338_bib17","series-title":"Pharmacokinetics of tenofovir and emtricitabine delivered by vaginal tablets","year":"2015"},{"key":"10.1016\/j.ebiom.2022.104338_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.antiviral.2015.11.009","article-title":"Tenofovir alafenamide: a novel prodrug of tenofovir for the treatment of human immunodeficiency virus","volume":"125","author":"Ray","year":"2016","journal-title":"Antiviral Res"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104338_bib19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/COH.0b013e328356e91c","article-title":"Pharmacology of HIV integrase inhibitors","volume":"7","author":"Adams","year":"2012","journal-title":"Curr Opin HIV AIDS"},{"issue":"227","key":"10.1016\/j.ebiom.2022.104338_bib20","doi-asserted-by":"crossref","first-page":"227ra235","DOI":"10.1126\/scitranslmed.3007701","article-title":"Postexposure protection of macaques from vaginal SHIV infection by topical integrase inhibitors","volume":"6","author":"Dobard","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2022.104338_bib21","series-title":"A\u00a0phase 1 open label safety and pharmacokinetic study of single dose rectal administration of a tenofovir alafenamide\/elvitegravir insert at two dose levels","year":"2021"},{"key":"10.1016\/j.ebiom.2022.104338_bib22","series-title":"Protection against vaginal SHIV infection with an insert containing TAF and EVG","year":"2019"},{"key":"10.1016\/j.ebiom.2022.104338_bib23","series-title":"On-demand HIV postexposure prophylaxis by TAF\/EVG vaginal inserts in macaques","year":"2020"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104338_bib24","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1371\/journal.pmed.0050028","article-title":"Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir","volume":"5","author":"Garcia-Lerma","year":"2008","journal-title":"PLoS Med"},{"issue":"15","key":"10.1016\/j.ebiom.2022.104338_bib25","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.1128\/JVI.00843-11","article-title":"Protection against rectal transmission of an emtricitabine-resistant simian\/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada","volume":"85C","author":"Cong","year":"2011","journal-title":"J\u00a0Virol"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104338_bib26","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/infdis\/jiz383","article-title":"Efficacy of oral tenofovir alafenamide\/emtricitabine combination or single-agent tenofovir alafenamide against vaginal simian human immunodeficiency virus infection in macaques","volume":"220","author":"Massud","year":"2019","journal-title":"J\u00a0Infect Dis"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104338_bib27","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1371\/journal.pmed.0050157","article-title":"Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel","volume":"5","author":"Cranage","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.ebiom.2022.104338_bib28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12977-015-0195-z","article-title":"Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques","volume":"12","author":"Dobard","year":"2015","journal-title":"Retrovirology"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01644-17","article-title":"Hypo-osmolar formulation of tenofovir (TFV) enema promotes uptake and metabolism of TFV in tissues, leading to prevention of SHIV\/SIV infection","volume":"62","author":"Xiao","year":"2018","journal-title":"Antimicrobial Agents Chemother"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104338_bib30","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1089\/aid.2012.0262","article-title":"RMP-02\/MTN-006: a phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate","volume":"28","author":"Anton","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167696","article-title":"Multicompartmental pharmacokinetic model of tenofovir delivery to the rectal mucosa by an enema","volume":"12","author":"Gao","year":"2017","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104338_bib32","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/10837450.2018.1484766","article-title":"Advances in rectal drug delivery systems","volume":"23","author":"Purohit","year":"2018","journal-title":"Pharm Dev Technol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104338_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.biologicals.2006.08.002","article-title":"Microbicides: a new frontier in HIV prevention","volume":"34","author":"McGowan","year":"2006","journal-title":"Biologicals"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.clpt.6100236","article-title":"Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates","volume":"83","author":"Hendrix","year":"2008","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104338_bib35","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1089\/aid.2016.0167","article-title":"A\u00a0comparative pre-phase I study of the impact of gel vehicle volume on distal colon distribution, user experience, and acceptability","volume":"33","author":"Weld","year":"2017","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1124\/jpet.118.250357","article-title":"MALDI mass spectrometry imaging reveals heterogeneous distribution of tenofovir and tenofovir diphosphate in colorectal tissue of Subjects receiving a tenofovir-containing enema","volume":"367","author":"Seneviratne","year":"2018","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104338_bib37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1086\/426452","article-title":"Multiple vaginal exposures to low doses of R5 simian-human immunodeficiency virus: strategy to study HIV preclinical interventions in nonhuman primates","volume":"191","author":"Otten","year":"2005","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2022.104338_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102894","article-title":"Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques","volume":"58","author":"Massud","year":"2020","journal-title":"EBioMedicine"},{"issue":"14","key":"10.1016\/j.ebiom.2022.104338_bib39","doi-asserted-by":"crossref","first-page":"14ra14","DOI":"10.1126\/scitranslmed.3000391","article-title":"Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection","volume":"2","author":"Garcia-Lerma","year":"2010","journal-title":"Sci Transl Med"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104338_bib40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3390\/pharmaceutics13081110","article-title":"Development, characterization and in\u00a0vivo pharmacokinetic assessment of rectal suppositories containing combination antiretroviral drugs for HIV prevention","volume":"13","author":"Jhunjhunwala","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ebiom.2022.104338_bib41","series-title":"AVMA guidelines for the euthanasia of animals: 2020 edition","year":"2020"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104338_bib42","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s13346-018-0538-0","article-title":"Effects of gel volume on\u00a0pharmacokinetics for vaginal and rectal applications of combination DuoGel-IQB4012, a dual chamber-dual drug HIV microbicide gel, in pigtailed macaques","volume":"8","author":"Pereira","year":"2018","journal-title":"Drug Deliv Transl Res"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104338_bib43","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/infdis\/jiw312","article-title":"Chemoprophylaxis with oral emtricitabine and tenofovir alafenamide combination protects macaques from rectal simian\/human immunodeficiency virus infection","volume":"214","author":"Massud","year":"2016","journal-title":"J\u00a0Infect Dis"},{"issue":"29","key":"10.1016\/j.ebiom.2022.104338_bib44","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1016\/j.jchromb.2009.09.007","article-title":"On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors","volume":"877","author":"Kuklenyik","year":"2009","journal-title":"J\u00a0Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104338_bib45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/JVI.05842-11","article-title":"Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue","volume":"86","author":"Dobard","year":"2012","journal-title":"J\u00a0Virol"},{"issue":"4\u20135","key":"10.1016\/j.ebiom.2022.104338_bib46","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0684.2006.00169.x","article-title":"Repetitive exposures with simian\/human immunodeficiency viruses: strategy to study HIV pre-clinical interventions in non-human primates","volume":"35","author":"Kim","year":"2006","journal-title":"J\u00a0Med Primatol"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104338_bib47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0684.2011.00488.x","article-title":"Development of a pigtail macaque model of sexually transmitted infection\/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3)","volume":"40","author":"Henning","year":"2011","journal-title":"J\u00a0Med Primatol"},{"key":"10.1016\/j.ebiom.2022.104338_bib48","article-title":"Kolmogorov-Smirnov unpared nonparametric test and liner regression analysis","author":"GraphPad","year":"2020"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104338_bib49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jrsm.1401","article-title":"Improved inference for fixed-effects meta-analysis of 2\u00a0\u00d7 2 tables","volume":"11","author":"Qijun Li","year":"2020","journal-title":"Res Synth Methods"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104338_bib50","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1016\/j.csda.2007.02.024","article-title":"Nonconservative exact small-sample inference for discrete data","volume":"51","author":"Agresti","year":"2007","journal-title":"Comput Stat Data Anal"},{"key":"10.1016\/j.ebiom.2022.104338_bib51","series-title":"Base SAS\u00ae 9.4 utilities","year":"2013"},{"key":"10.1016\/j.ebiom.2022.104338_bib52","series-title":"Survival analysis: techniques for censored and truncated data","author":"Klein","year":"1997"},{"key":"10.1016\/j.ebiom.2022.104338_bib53","series-title":"The national academies collection: reports funded by National Institutes of Health. Guide for the care and use of laboratory animals","year":"2011"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104338_bib54","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/infdis\/jiy301","article-title":"Efficacy of vaginally administered gel containing emtricitabine and\u00a0tenofovir against repeated rectal simian human immunodeficiency virus exposures in macaques","volume":"218","author":"Dobard","year":"2018","journal-title":"J\u00a0Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104338_bib55","first-page":"131","article-title":"A\u00a0survey of exact inference for contingency tables","volume":"7","author":"Agresti","year":"1992","journal-title":"Stat Sci"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104338_bib56","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/cpt.1212","article-title":"Current state of microbicide development","volume":"104","author":"Traore","year":"2018","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104338_bib57","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/jac\/dku556","article-title":"Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques","volume":"70","author":"Massud","year":"2015","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104338_bib58","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/infdis\/jiv334","article-title":"Protection against rectal chimeric simian\/human immunodeficiency virus transmission in macaques by rectal-specific gel formulations of maraviroc and tenofovir","volume":"212","author":"Dobard","year":"2015","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2022.104338_bib59","series-title":"Hypo-osmolar rectal enema TFV formulation prevents SHIV acquisition","year":"2018"},{"key":"10.1016\/j.ebiom.2022.104338_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejpb.2018.05.030","article-title":"Development of rectal enema\u00a0as microbicide (DREAM): preclinical progressive selection of a tenofovir prodrug enema","volume":"138","author":"Hoang","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104338_bib61","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1007\/s10461-018-2336-6","article-title":"Rectal douching practices associated with anal intercourse: implications for the development of a behaviorally congruent HIV-prevention rectal microbicide douche","volume":"23","author":"Carballo-Dieguez","year":"2019","journal-title":"AIDS Behav"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104338_bib62","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1007\/s10461-017-1959-3","article-title":"Rectal douching associated with receptive anal intercourse: a literature review","volume":"22","author":"Carballo-Di\u00e9guez","year":"2018","journal-title":"AIDS Behav"},{"key":"10.1016\/j.ebiom.2022.104338_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.923954","article-title":"Comparative pharmacokinetics and local tolerance of tenofovir alafenamide (TAF) from subcutaneous implant in rabbits, dogs, and macaques","volume":"13","author":"Gatto","year":"2022","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104338_bib64","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/aid.2021.0028","article-title":"Tenofovir alafenamide for HIV prevention: review of the proceedings from the Gates Foundation long-acting TAF product development meeting","volume":"37","author":"Romano","year":"2021","journal-title":"AIDS Res Hum Retroviruses"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:19:35Z","timestamp":1762456775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422005205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":64,"alternative-id":["S2352396422005205"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104338","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104338"}}