{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:17:34Z","timestamp":1793078254921,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK109574"],"award-info":[{"award-number":["R01DK109574"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-19-1-0007"],"award-info":[{"award-number":["W81XWH-19-1-0007"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH2110032"],"award-info":[{"award-number":["W81XWH2110032"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18IPA34170220"],"award-info":[{"award-number":["18IPA34170220"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34660279"],"award-info":[{"award-number":["19CDA34660279"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["CA-622265"],"award-info":[{"award-number":["CA-622265"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["R01HL138510"],"award-info":[{"award-number":["R01HL138510"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL133900"],"award-info":[{"award-number":["R01HL133900"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL154720"],"award-info":[{"award-number":["R01HL154720"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL157100"],"award-info":[{"award-number":["R01HL157100"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK122796"],"award-info":[{"award-number":["R01DK122796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012684","name":"Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","award":["1UL1TR003167\u201301"],"award-info":[{"award-number":["1UL1TR003167\u201301"]}],"id":[{"id":"10.13039\/100012684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015366","name":"McGovern Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ebiom.2022.104351","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T19:17:45Z","timestamp":1668194265000},"page":"104351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-7878","authenticated-orcid":false,"given":"Soma S.K.","family":"Jyothula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Shivshankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Yau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet S.","family":"Garcha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Akkanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Collum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Wareing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarajan A.","family":"Thandavarayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-6694","authenticated-orcid":false,"given":"Fernando","family":"Poli de Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan O.","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Maximilian","family":"Buja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger K.","family":"Eltzschig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-9823","authenticated-orcid":false,"given":"Harry","family":"Karmouty-Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ebiom.2022.104351_bib1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S2213-2600(20)30370-2","article-title":"Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study","volume":"8","author":"Grasselli","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104351_bib2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern Med"},{"issue":"20","key":"10.1016\/j.ebiom.2022.104351_bib3","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area","volume":"323","author":"Richardson","year":"2020","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/ALN.0000000000003571","article-title":"Acute respiratory distress syndrome: contemporary management and novel approaches during COVID-19","volume":"134","author":"Williams","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ebiom.2022.104351_bib5","series-title":"COVID-19 pandemic planning scenarios","year":"2020"},{"issue":"18","key":"10.1016\/j.ebiom.2022.104351_bib6","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104351_bib7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMra1608077","article-title":"Acute respiratory distress syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"23","key":"10.1016\/j.ebiom.2022.104351_bib8","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104351_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2022.104351_bib10","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3389\/fimmu.2019.01633","article-title":"Purinergic signaling in pulmonary inflammation","volume":"10","author":"Le","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/ALN.0000000000003571","article-title":"Acute respiratory distress syndrome","volume":"134","author":"Williams","year":"2021","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib12","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1213\/ANE.0000000000005146","article-title":"The role of MicroRNAs in acute respiratory distress syndrome and sepsis, from targets to therapies: a narrative review","volume":"131","author":"Lee","year":"2020","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1213\/ANE.0000000000002288","article-title":"Targeting hypoxia signaling for perioperative organ injury","volume":"126","author":"Yuan","year":"2018","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1183\/09031936.00196412","article-title":"The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance","volume":"43","author":"Burnham","year":"2014","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/thx.2004.030205","article-title":"Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors","volume":"60","author":"Hui","year":"2005","journal-title":"Thorax"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104351_bib16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S2213-2600(20)30222-8","article-title":"Pulmonary fibrosis secondary to COVID-19: a call to arms?","volume":"8","author":"Spagnolo","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104351_bib17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1473-3099(20)30086-4","article-title":"Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study","volume":"20","author":"Shi","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12931-020-01445-6","article-title":"SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis","volume":"21","author":"Xu","year":"2020","journal-title":"Respir Res"},{"issue":"7865","key":"10.1016\/j.ebiom.2022.104351_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03569-1","article-title":"A\u00a0molecular single-cell lung atlas of lethal COVID-19","volume":"595","author":"Melms","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib20","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41467-020-15647-5","article-title":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","volume":"11","author":"Tsukui","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib21","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat Commun"},{"issue":"7536","key":"10.1016\/j.ebiom.2022.104351_bib22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nature13903","article-title":"p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration","volume":"517","author":"Zuo","year":"2015","journal-title":"Nature"},{"issue":"574","key":"10.1016\/j.ebiom.2022.104351_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe4282","article-title":"Lung transplantation for patients with severe COVID-19","volume":"12","author":"Bharat","year":"2020","journal-title":"Sci Transl Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104351_bib24","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S2213-2600(20)30393-3","article-title":"When to consider lung transplantation for COVID-19","volume":"8","author":"Cypel","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104351_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030611","article-title":"Emergency lung transplantation after COVID-19: immunopathological insights on two affected patients","volume":"10","author":"Croci","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104351_bib26","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1165\/rcmb.2015-0145OC","article-title":"Altered hypoxic-adenosine axis and metabolism in group iii pulmonary hypertension","volume":"54","author":"Garcia-Morales","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104351_bib27","first-page":"68","article-title":"Lung transplantation in idiopathic pulmonary fibrosis","volume":"6","author":"Laporta Hernandez","year":"2018","journal-title":"Med Sci (Basel, Switzerland)"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.038711","article-title":"Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema","volume":"12","author":"Collum","year":"2019","journal-title":"Dis Model Mech"},{"issue":"7536","key":"10.1016\/j.ebiom.2022.104351_bib29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S2213-2600(21)00077-1","article-title":"Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries","volume":"9","author":"Bharat","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"21","key":"10.1016\/j.ebiom.2022.104351_bib31","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.3390\/ijms21218081","article-title":"Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets","volume":"21","author":"Karmouty-Quintana","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib32","doi-asserted-by":"crossref","first-page":"L277","DOI":"10.1152\/ajplung.00195.2020","article-title":"Novel insights on the pulmonary vascular consequences of COVID-19","volume":"319","author":"Potus","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"19","key":"10.1016\/j.ebiom.2022.104351_bib33","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra1705751","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"Lederer","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"16","key":"10.1016\/j.ebiom.2022.104351_bib34","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa1013660","article-title":"A\u00a0common MUC5B promoter polymorphism and pulmonary fibrosis","volume":"364","author":"Seibold","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2022.104351_bib35","doi-asserted-by":"crossref","first-page":"103277","DOI":"10.1016\/j.ebiom.2021.103277","article-title":"Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity","volume":"65","author":"Fadista","year":"2021","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib36","doi-asserted-by":"crossref","first-page":"L238","DOI":"10.1152\/ajplung.00142.2016","article-title":"Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and group III pulmonary hypertension","volume":"311","author":"Chen","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104351_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41556-021-00809-4","article-title":"Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5(+) basal cells","volume":"24","author":"Kathiriya","year":"2022","journal-title":"Nat Cell Biol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104351_bib38","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/CM9.0000000000000839","article-title":"Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis","volume":"133","author":"Chen","year":"2020","journal-title":"Chin Med J"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104351_bib39","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S2213-2600(20)30361-1","article-title":"Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient","volume":"8","author":"Lang","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S2213-2600(13)70053-5","article-title":"Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies","volume":"1","author":"Thille","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"20","key":"10.1016\/j.ebiom.2022.104351_bib41","doi-asserted-by":"crossref","first-page":"17435","DOI":"10.1074\/jbc.M110.137273","article-title":"Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity","volume":"286","author":"Heise","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1164\/rccm.201903-0497PP","article-title":"Is progression of pulmonary fibrosis due to ventilation-induced lung injury?","volume":"200","author":"Albert","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"23","key":"10.1016\/j.ebiom.2022.104351_bib43","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1007\/s00018-017-2649-z","article-title":"The role of periostin in lung fibrosis and airway remodeling","volume":"74","author":"O'Dwyer","year":"2017","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104351_bib44","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1183\/09031936.00059810","article-title":"Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias","volume":"37","author":"Okamoto","year":"2011","journal-title":"Eur Respir J"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104351_bib45","doi-asserted-by":"crossref","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","article-title":"Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis","volume":"303","author":"Naik","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104351_bib46","doi-asserted-by":"crossref","first-page":"e0174547","DOI":"10.1371\/journal.pone.0174547","article-title":"The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis","volume":"12","author":"Ohta","year":"2017","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.ebiom.2022.104351_bib47","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s00018-011-0784-5","article-title":"Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell","volume":"68","author":"Kudo","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/mi.2016.61","article-title":"Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis","volume":"10","author":"Ashley","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104351_bib49","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1165\/rcmb.2019-0245OC","article-title":"Cross-talk between\u00a0transforming growth factor-\u03b2 and periostin can be targeted for pulmonary fibrosis","volume":"62","author":"Nanri","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"17","key":"10.1016\/j.ebiom.2022.104351_bib50","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1111\/febs.15609","article-title":"Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID-19 patients","volume":"288","author":"Zeng","year":"2021","journal-title":"FEBS J"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104351_bib51","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","article-title":"Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts","volume":"19","author":"Stein","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2022.104351_bib52","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat Commun"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:25:23Z","timestamp":1762457123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422005333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":52,"alternative-id":["S2352396422005333"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104351","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104351","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104351"}}