{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:45Z","timestamp":1786987785079,"version":"build-2736575974"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["MG19-8469"],"award-info":[{"award-number":["MG19-8469"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006189","name":"Direkt\u00f6r Albert P\u00e5hlssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M19-0380"],"award-info":[{"award-number":["M19-0380"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-153269"],"award-info":[{"award-number":["PJT-153269"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2021-0112"],"award-info":[{"award-number":["FO2021-0112"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["F 2015\/2112"],"award-info":[{"award-number":["F 2015\/2112"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 4667\/2-1"],"award-info":[{"award-number":["ME 4667\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017-01243"],"award-info":[{"award-number":["2017-01243"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ebiom.2022.104384","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T13:55:20Z","timestamp":1669816520000},"page":"104384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-1347","authenticated-orcid":false,"given":"Lotte","family":"Vanherle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Lidington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska E.","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-1939","authenticated-orcid":false,"given":"Cecilia","family":"Skoug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao M.N.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Ramu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Uller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen-Sebastian","family":"Bolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-7213","authenticated-orcid":false,"given":"Anja","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10053","key":"10.1016\/j.ebiom.2022.104384_bib1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104384_bib2","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/ejhf.1858","article-title":"Epidemiology of heart failure","volume":"22","author":"Groenewegen","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib3","first-page":"46","article-title":"Cognitive impairment in patients with heart failure: an international study","volume":"7","author":"Vellone","year":"2020","journal-title":"ESC Heart Fail"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006086","article-title":"Cognitive domains and postdischarge outcomes in hospitalized patients with heart failure","volume":"12","author":"Huynh","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104384_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/ejhf.1442","article-title":"Cognitive impairment in Asian patients with heart failure: prevalence, biomarkers, clinical correlates, and outcomes","volume":"21","author":"Dong","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ebiom.2022.104384_bib6","article-title":"Cognitive impairment in heart failure: landscape, challenges, and future directions","volume":"8","author":"Yang","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104384_bib7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.neurobiolaging.2008.08.008","article-title":"Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal","volume":"31","author":"Apostolova","year":"2010","journal-title":"Neurobiol Aging"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104384_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/archneur.63.5.693","article-title":"Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps","volume":"63","author":"Apostolova","year":"2006","journal-title":"Arch Neurol"},{"issue":"16","key":"10.1016\/j.ebiom.2022.104384_bib9","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/eurheartj\/ehab003","article-title":"Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure-the COGNITION.MATTERS-HF cohort study","volume":"42","author":"Frey","year":"2021","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104384_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071354","article-title":"Evaluating Alzheimer's disease progression using rate of regional hippocampal atrophy","volume":"8","author":"Franko","year":"2013","journal-title":"PLoS One"},{"issue":"Pt 4","key":"10.1016\/j.ebiom.2022.104384_bib11","first-page":"1067","article-title":"MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers","volume":"132","author":"Schuff","year":"2009","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104384_bib12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1001\/archneurol.2011.167","article-title":"The dynamics of cortical and hippocampal atrophy in Alzheimer disease","volume":"68","author":"Sabuncu","year":"2011","journal-title":"Arch Neurol"},{"issue":"12","key":"10.1016\/j.ebiom.2022.104384_bib13","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.neurobiolaging.2005.10.010","article-title":"Volume reduction of the entorhinal cortex in subjective memory impairment","volume":"27","author":"Jessen","year":"2006","journal-title":"Neurobiol Aging"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104384_bib14","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/archneurol.2009.214","article-title":"Linking hippocampal structure and function to memory performance in an aging population","volume":"66","author":"Reitz","year":"2009","journal-title":"Arch Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib15","first-page":"428","article-title":"Brain volume loss in heart failure and its association with markers of left ventricular function","volume":"129","author":"Wykr\u0119towicz","year":"2019","journal-title":"Pol Arch Intern Med"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104384_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.amjcard.2018.12.035","article-title":"Prognostic importance of hippocampal atrophy in patients with chronic heart failure","volume":"123","author":"Niizeki","year":"2019","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104384_bib17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ejhf.241","article-title":"Regional hippocampal damage in heart failure","volume":"17","author":"Woo","year":"2015","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2017.11.024","article-title":"Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction","volume":"71","author":"Thackeray","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/ijms23020616","article-title":"Neuroinflammation: a potential risk for dementia","volume":"23","author":"Ahmad","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03107-z","article-title":"Effects of exercise training on behavior and brain function after high dose isoproterenol-induced cardiac damage","volume":"11","author":"Toth","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2022.104384_bib21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2010.02.028","article-title":"Microglia activation in the hypothalamic PVN following myocardial infarction","volume":"1326","author":"Rana","year":"2010","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.autneu.2012.04.004","article-title":"Sustained activation of microglia in the hypothalamic PVN following myocardial infarction","volume":"169","author":"Dworak","year":"2012","journal-title":"Auton Neurosci"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104384_bib23","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/ejhf.874","article-title":"Reduced regional cerebral blood flow in patients with heart failure","volume":"19","author":"Roy","year":"2017","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104384_bib24","first-page":"316","article-title":"Cognitive impairment in heart failure patients","volume":"11","author":"Leto","year":"2014","journal-title":"J\u00a0Geriatr Cardiol"},{"issue":"8","key":"10.1016\/j.ebiom.2022.104384_bib25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jacbts.2019.07.004","article-title":"CFTR therapeutics normalize cerebral perfusion deficits in mouse models of heart failure and subarachnoid hemorrhage","volume":"4","author":"Lidington","year":"2019","journal-title":"JACC Basic Transl Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2022.104384_bib26","article-title":"Tumor necrosis factor-alpha underlies loss of cortical dendritic spine density in a mouse model of congestive heart failure","volume":"4","author":"Meissner","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.ebiom.2022.104384_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1744-8069-7-72","article-title":"CFTR mediates noradrenaline-induced ATP efflux from DRG neurons","volume":"7","author":"Kanno","year":"2011","journal-title":"Mol Pain"},{"issue":"11","key":"10.1016\/j.ebiom.2022.104384_bib28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1369\/0022155414546190","article-title":"Cystic fibrosis transmembrane conductance regulator protein (CFTR) expression in the developing human brain: comparative immunohistochemical study between patients with normal and mutated CFTR","volume":"62","author":"Marcorelles","year":"2014","journal-title":"J\u00a0Histochem Cytochem"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1172\/JCI118080","article-title":"Expression and localization of the cystic fibrosis transmembrane conductance regulator mRNA and its protein in rat brain","volume":"96","author":"Mulberg","year":"1995","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/dneu.20855","article-title":"Cystic fibrosis transmembrane conductance regulator modulates synaptic chloride homeostasis in motoneurons of the rat spinal cord during neonatal development","volume":"71","author":"Ostroumov","year":"2011","journal-title":"Dev Neurobiol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib31","doi-asserted-by":"crossref","first-page":"C563","DOI":"10.1152\/ajpcell.1999.277.3.C563","article-title":"CFTR is functionally active in GnRH-expressing GT1-7 hypothalamic neurons.","volume":"277","author":"Weyler","year":"1999","journal-title":"Am J Physiol"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104384_bib32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nchembio.1253","article-title":"Mechanism-based corrector combination restores \u0394F508-CFTR folding and function","volume":"9","author":"Okiyoneda","year":"2013","journal-title":"Nat Chem Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.chest.2018.04.036","article-title":"Ion channel modulators in cystic fibrosis","volume":"154","author":"Gentzsch","year":"2018","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/ijms23020866","article-title":"Therapeutic CFTR correction normalizes systemic and lung-specific S1P level alterations associated with heart failure","volume":"23","author":"Uhl","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2022.104384_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2342-10-1","article-title":"Design and validation of segment--freely available software for cardiovascular image analysis","volume":"10","author":"Heiberg","year":"2010","journal-title":"BMC Med Imaging"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib36","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1152\/jn.00278.2019","article-title":"Object and place information processing by CA1 hippocampal neurons of C57BL\/6J mice","volume":"123","author":"\u00c1sgeirsd\u00f3ttir","year":"2020","journal-title":"J\u00a0Neurophysiol"},{"issue":"17","key":"10.1016\/j.ebiom.2022.104384_bib37","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cub.2013.07.002","article-title":"The rodent hippocampus is essential for nonspatial object memory","volume":"23","author":"Cohen","year":"2013","journal-title":"Curr Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41514-021-00071-w","article-title":"Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia","volume":"7","author":"Don-Doncow","year":"2021","journal-title":"NPJ Aging Mech Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4191","article-title":"Look-locker FAIR TrueFISP for arterial spin labelling on mouse at 9.4 T","volume":"33","author":"Gottschalk","year":"2020","journal-title":"NMR Biomed"},{"key":"10.1016\/j.ebiom.2022.104384_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnana.2016.00038","article-title":"Golgi-Cox staining step by step","volume":"10","author":"Zaqout","year":"2016","journal-title":"Front Neuroanat"},{"issue":"4","key":"10.1016\/j.ebiom.2022.104384_bib41","first-page":"387","article-title":"Dendritic organization in the neurons of the visual and motor cortices of the cat","volume":"87","author":"Sholl","year":"1953","journal-title":"J\u00a0Anat"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104384_bib42","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1007\/s11064-022-03664-3","article-title":"Sphingosine 1-phoshpate receptors are located in synapses and control spontaneous activity of mouse neurons in culture","volume":"47","author":"Skoug","year":"2022","journal-title":"Neurochem Res"},{"issue":"22","key":"10.1016\/j.ebiom.2022.104384_bib43","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1161\/CIRCULATIONAHA.111.047316","article-title":"Tumor necrosis factor-alpha-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure","volume":"125","author":"Meissner","year":"2012","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib44","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/CIRCULATIONAHA.111.039644","article-title":"Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-alpha-dependent activation of sphingosine-1-phosphate signaling","volume":"126","author":"Yang","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2022.104384_bib45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fnbeh.2015.00170","article-title":"Effect of dentate gyrus disruption on remembering what happened where","volume":"9","author":"Kim","year":"2015","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2017.246","article-title":"Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review","volume":"23","author":"Hopperton","year":"2018","journal-title":"Mol Psychiatr"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ebiom.2022.104384_bib48","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2022.104384_bib49","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed","volume":"11","author":"Cherry","year":"2014","journal-title":"J\u00a0Neuroinflammation"},{"issue":"6710","key":"10.1016\/j.ebiom.2022.104384_bib50","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/24790","article-title":"Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein","volume":"396","author":"Migaud","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2022.104384_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108277","article-title":"PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex","volume":"179","author":"McEachern","year":"2020","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000338166","article-title":"Inflammatory cytokines in heart failure: mediators and markers","volume":"122","author":"Gullestad","year":"2012","journal-title":"Cardiology"},{"key":"10.1016\/j.ebiom.2022.104384_bib53","doi-asserted-by":"crossref","DOI":"10.1177\/2050312120965752","article-title":"Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer","volume":"8","author":"Amin","year":"2020","journal-title":"SAGE Open Med"},{"key":"10.1016\/j.ebiom.2022.104384_bib54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fncel.2013.00044","article-title":"Factors regulating microglia activation","volume":"7","author":"Kierdorf","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib55","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s001090050097","article-title":"Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits","volume":"75","author":"Streit","year":"1997","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.ebiom.2022.104384_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174096","article-title":"Ghrelin attenuates depressive-like behavior, heart failure, and neuroinflammation in postmyocardial infarction rat model","volume":"901","author":"Sun","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ebiom.2022.104384_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106652","article-title":"Ginkgolide B attenuates myocardial infarction-induced depression-like behaviors via repressing IL-1\u03b2 in central nervous system","volume":"85","author":"Ge","year":"2020","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib58","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/ijms20030537","article-title":"T-cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis","volume":"20","author":"Don-Doncow","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/cvr\/cvw256","article-title":"Sphingosine-1-phosphate signalling-a key player in the pathogenesis of angiotensin II-induced hypertension","volume":"113","author":"Meissner","year":"2017","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ebiom.2022.104384_bib60","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.phrs.2016.12.032","article-title":"Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension","volume":"116","author":"Dinh","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ebiom.2022.104384_bib61","doi-asserted-by":"crossref","first-page":"113452","DOI":"10.1016\/j.bbr.2021.113452","article-title":"Heart failure impairs mood and memory in male rats and down-regulates the expression of numerous genes important for synaptic plasticity in related brain regions","volume":"414","author":"Parent","year":"2021","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.ebiom.2022.104384_bib62","doi-asserted-by":"crossref","first-page":"7585896","DOI":"10.1155\/2019\/7585896","article-title":"Antineuroinflammatory and neuroprotective effects of gyejibokryeong-hwan in lipopolysaccharide-stimulated BV2 microglia","volume":"2019","author":"Park","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib63","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/acschemneuro.6b00298","article-title":"N-docosahexaenoyl dopamine, an endocannabinoid-like conjugate of dopamine and the n-3 fatty acid docosahexaenoic acid, attenuates lipopolysaccharide-induced activation of microglia and macrophages via COX-2","volume":"8","author":"Wang","year":"2017","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2022.104384_bib64","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.4049\/jimmunol.0803067","article-title":"IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex","volume":"183","author":"Espinassous","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ebiom.2022.104384_bib65","doi-asserted-by":"crossref","first-page":"100048","DOI":"10.1016\/j.cpnec.2021.100048","article-title":"LPS and palmitic acid co-upregulate microglia activation and neuroinflammatory response","volume":"6","author":"Lu","year":"2021","journal-title":"Compr Psychoneuroendocrinol"},{"key":"10.1016\/j.ebiom.2022.104384_bib66","first-page":"5","article-title":"Chemokine interleukin-8 (IL-8) in Alzheimer's and other neurodegenerative diseases","volume":"6","author":"McLarnon","year":"2016","journal-title":"J\u00a0Alzheimers Dis Parkinsonism"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s40478-019-0795-2","article-title":"Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease","volume":"7","author":"Whelan","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ebiom.2022.104384_bib68","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fnmol.2017.00384","article-title":"Adrenomedullin contributes to age-related memory loss in mice and is elevated in aging human brains","volume":"10","author":"Larrayoz","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib69","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-021-01349-z","article-title":"Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease","volume":"11","author":"Lyra e Silva","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.ebiom.2022.104384_bib70","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fcvm.2017.00037","article-title":"Circulating cellular adhesion molecules and cognitive function: the coronary artery risk development in young adults study","volume":"4","author":"Yoon","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ebiom.2022.104384_bib71","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3389\/fimmu.2019.03056","article-title":"Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis","volume":"10","author":"Haghayegh Jahromi","year":"2020","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib72","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/JAD-2007-11307","article-title":"IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons","volume":"11","author":"Thirumangalakudi","year":"2007","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib73","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1750-1326-9-56","article-title":"Interleukin-1\u03b2 causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53","volume":"9","author":"Rossi","year":"2014","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib74","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-020-01939-6","article-title":"Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments","volume":"17","author":"Reverchon","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.bjp.0706943","article-title":"The effects induced by the sulphonylurea glibenclamide on the neonatal rat spinal cord indicate a novel mechanism to control neuronal excitability and inhibitory neurotransmission","volume":"150","author":"Ostroumov","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ebiom.2022.104384_bib76","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2010.12.034","article-title":"The possible additional role of the cystic fibrosis transmembrane regulator to motoneuron inhibition produced by glycine effects","volume":"177","author":"Morales","year":"2011","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib77","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1074\/mcp.D500009-MCP200","article-title":"Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum\u2217S","volume":"5","author":"Cheng","year":"2006","journal-title":"Mol Cell Proteomics"},{"issue":"7","key":"10.1016\/j.ebiom.2022.104384_bib78","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00109-018-1649-2","article-title":"CFTR prevents neuronal apoptosis following cerebral ischemia reperfusion via regulating mitochondrial oxidative stress","volume":"96","author":"Zhang","year":"2018","journal-title":"J\u00a0Mol Med"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib79","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12967-021-03092-x","article-title":"Regional brain tissue changes in patients with cystic fibrosis","volume":"19","author":"Roy","year":"2021","journal-title":"J\u00a0Transl Med"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib80","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000116984","article-title":"Staging of Alzheimer-related cortical destruction","volume":"33","author":"Braak","year":"1993","journal-title":"Eur Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib81","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/S2213-2600(16)30047-9","article-title":"Pilot evaluation of ivacaftor for chronic bronchitis","volume":"4","author":"Solomon","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"20","key":"10.1016\/j.ebiom.2022.104384_bib82","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123467","article-title":"Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis","volume":"3","author":"Brand","year":"2018","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib83","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J\u00a0Cell Mol Med"},{"issue":"10","key":"10.1016\/j.ebiom.2022.104384_bib84","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1017\/S1355617715000697","article-title":"Daily physical activity is associated with subcortical brain volume and cognition in heart failure","volume":"21","author":"Alosco","year":"2015","journal-title":"J\u00a0Int Neuropsychol Soc"},{"issue":"6","key":"10.1016\/j.ebiom.2022.104384_bib85","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/HCR.0b013e3181e1739a","article-title":"Link between change in cognition and left ventricular function following cardiac resynchronization therapy","volume":"30","author":"Hoth","year":"2010","journal-title":"J\u00a0Cardiopulm Rehabil Prev"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib86","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/eurheartj\/ehi058","article-title":"Use of angiotensin-converting enzyme inhibitors and variations in cognitive performance among patients with heart failure","volume":"26","author":"Zuccal\u00e0","year":"2004","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib87","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cell.2021.12.009","article-title":"Mechanism of CFTR correction by type I folding correctors","volume":"185","author":"Fiedorczuk","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2022.104384_bib88","doi-asserted-by":"crossref","first-page":"928300","DOI":"10.3389\/fimmu.2022.928300","article-title":"Cystic fibrosis transmembrane regulator correction attenuates heart failure-induced lung inflammation","volume":"13","author":"Uhl","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2022.104384_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13495","article-title":"Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat\u00a0cardiomyocyte ATP release via pannexin 1 through mitochondrial signalling and caspase activation","volume":"230","author":"Wang","year":"2020","journal-title":"Acta Physiol"},{"issue":"3","key":"10.1016\/j.ebiom.2022.104384_bib90","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/MOP.0000000000000627","article-title":"Cystic fibrosis transmembrane conductance regulator modulators: precision medicine in cystic fibrosis","volume":"30","author":"Burgener","year":"2018","journal-title":"Curr Opin Pediatr"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396422005667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:23:38Z","timestamp":1762457018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396422005667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":90,"alternative-id":["S2352396422005667"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104384","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2022.104384","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104384"}}