{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:27:09Z","timestamp":1793863629905,"version":"4.6.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001036","name":"Australian Rotary Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1132604"],"award-info":[{"award-number":["APP1132604"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1140853"],"award-info":[{"award-number":["APP1140853"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.ebiom.2023.104450","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T12:52:30Z","timestamp":1674823950000},"page":"104450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Rates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL 18F-MK6240 PET study"],"prefix":"10.1016","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-2839","authenticated-orcid":false,"given":"Natasha","family":"Krishnadas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne S.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ebiom.2023.104450_bib1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3233\/JAD-200808","article-title":"Relationships between cognition and neuropathological tau in alzheimer's disease assessed by 18F flortaucipir PET","volume":"80","author":"Devous","year":"2021","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"Pt 5","key":"10.1016\/j.ebiom.2023.104450_bib2","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104450_bib3","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1093\/brain\/awx243","article-title":"Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease","volume":"140","author":"Bejanin","year":"2017","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104450_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jamaneurol.2016.5755","article-title":"Association of in\u00a0vivo [18F]AV-1451 tau PET imaging results with cortical atrophy and symptoms in typical and atypical alzheimer disease","volume":"74","author":"Xia","year":"2017","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104450_bib5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jalz.2018.12.001","article-title":"Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease","volume":"15","author":"Mattsson","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104450_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13195-019-0510-3","article-title":"Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer's disease spectrum","volume":"11","author":"Timmers","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.ebiom.2023.104450_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.dadm.2018.02.003","article-title":"Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid \u03b2 positron emission tomography pathology","volume":"10","author":"Gordon","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104450_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and tau with cognition in preclinical alzheimer disease: a longitudinal study","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol"},{"issue":"18","key":"10.1016\/j.ebiom.2023.104450_bib9","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early alzheimer's disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104450_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.14283\/jpad.2022.30","article-title":"Two randomized phase 3 studies of aducanumab in early Alzheimer's disease","volume":"9","author":"Budd Haeberlein","year":"2022","journal-title":"J\u00a0Prev Alzheimers Dis"},{"issue":"10","key":"10.1016\/j.ebiom.2023.104450_bib11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2967\/jnumed.115.171678","article-title":"Preclinical characterization of 18F-MK-6240, a promising PET tracer for in\u00a0vivo quantification of human neurofibrillary tangles","volume":"57","author":"Hostetler","year":"2016","journal-title":"J\u00a0Nucl Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104450_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40478-019-0686-6","article-title":"Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue","volume":"7","author":"Aguero","year":"2019","journal-title":"Acta Neuropathol Commun"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104450_bib13","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1093\/brain\/awab248","article-title":"Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages","volume":"144","author":"Pascoal","year":"2021","journal-title":"Brain"},{"issue":"S9","key":"10.1016\/j.ebiom.2023.104450_bib14","doi-asserted-by":"crossref","first-page":"e044511","DOI":"10.1002\/alz.044511","article-title":"AHEAD 3-45 study design: a global study to evaluate the efficacy and safety of treatment with BAN2401 for 216 weeks in preclinical Alzheimer\u2019s disease with intermediate amyloid (A3 trial) and elevated amyloid (A45 trial)","volume":"16","author":"Aisen","year":"2020","journal-title":"Alzheimers Dementia"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104450_bib15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/S1041610209009405","article-title":"The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease","volume":"21","author":"Ellis","year":"2009","journal-title":"Int Psychogeriatr"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104450_bib16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment--beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment","volume":"256","author":"Winblad","year":"2004","journal-title":"J\u00a0Intern Med"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104450_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch Neurol"},{"key":"10.1016\/j.ebiom.2023.104450_bib18","first-page":"P1269","article-title":"Automated reporting of tau PET quantification on the brain surface","volume":"15","author":"Dore","year":"2019","journal-title":"Alzheimers Dementia"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104450_bib19","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2967\/jnumed.114.149732","article-title":"Improved power for characterizing longitudinal amyloid-beta PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region","volume":"56","author":"Chen","year":"2015","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.ebiom.2023.104450_bib20","first-page":"25","article-title":"The Tau MeTeR composites for the generation of continuous and categorical measures of tau deposits in the brain","volume":"1","author":"Villemagne","year":"2017","journal-title":"J\u00a0Mol Med Ther"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104450_bib21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer's disease","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.ebiom.2023.104450_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuroimage.2018.08.044","article-title":"Implementing the centiloid transformation for (11)C-PiB and beta-amyloid (18)F-PET tracers using CapAIBL","volume":"183","author":"Bourgeat","year":"2018","journal-title":"Neuroimage"},{"issue":"supplement 3","key":"10.1016\/j.ebiom.2023.104450_bib23","first-page":"149","article-title":"Computational analysis of PET by AIBL (CapAIBL): a cloud-based processing pipeline for the quantification of PET images","volume":"56","author":"Bourgeat","year":"2015","journal-title":"J\u00a0Nucl Med"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104450_bib24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"issue":"17","key":"10.1016\/j.ebiom.2023.104450_bib25","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1002\/sim.7300","article-title":"Constructing longitudinal disease progression curves using sparse, short-term individual data with an application to Alzheimer's disease","volume":"36","author":"Budgeon","year":"2017","journal-title":"Stat Med"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104450_bib26","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/brain\/awz090","article-title":"A\u00a0multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia","volume":"142","author":"Pontecorvo","year":"2019","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104450_bib27","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1093\/brain\/awaa327","article-title":"The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects","volume":"143","author":"Smith","year":"2020","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104450_bib28","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2967\/jnumed.118.221697","article-title":"Progressive tau accumulation in Alzheimer disease: 2-year follow-up study","volume":"60","author":"Cho","year":"2019","journal-title":"J\u00a0Nucl Med"},{"issue":"10","key":"10.1016\/j.ebiom.2023.104450_bib29","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1093\/brain\/awaa248","article-title":"Predicting future rates of tau accumulation on PET","volume":"143","author":"Jack","year":"2020","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104450_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ebiom.2023.104450_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101823","article-title":"Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease","volume":"23","author":"Sintini","year":"2019","journal-title":"Neuroimage Clin"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423000154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423000154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:21:41Z","timestamp":1762456901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423000154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":31,"alternative-id":["S2352396423000154"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104450","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.11.22272240","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL 18F-MK6240 PET study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104450","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104450"}}