{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:26:39Z","timestamp":1790616399885,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010449","name":"Nationales Centrum f\u00fcr Tumorerkrankungen Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2020.100.1"],"award-info":[{"award-number":["2020.100.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","award":["S2TAF-057"],"award-info":[{"award-number":["S2TAF-057"]}],"id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Strategy-EXC 2180\u2014390900677"],"award-info":[{"award-number":["Strategy-EXC 2180\u2014390900677"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","award":["EXC 2180\/10072-1_1"],"award-info":[{"award-number":["EXC 2180\/10072-1_1"]}],"id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ebiom.2023.104644","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T20:11:45Z","timestamp":1686168705000},"page":"104644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases"],"prefix":"10.1016","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-7160","authenticated-orcid":false,"given":"Eftychia","family":"Chatziioannou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Ro\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thazin New","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Niessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Keim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Maria","family":"Serna-Higuita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bonzheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-6929","authenticated-orcid":false,"given":"Luis","family":"Kuhn Cuellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Westphal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Steininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedegund","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oltin Tiberiu","family":"Pop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-2613","authenticated-orcid":false,"given":"Stephan","family":"Forchhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eigentler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"R\u00f6cken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-3327","authenticated-orcid":false,"given":"Tobias","family":"Sinnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1148","key":"10.1016\/j.ebiom.2023.104644_bib1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.3389\/fonc.2019.01148","article-title":"Immune system evasion as hallmark of melanoma progression: the role of dendritic cells","volume":"9","author":"Tucci","year":"2019","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.jid.5700082","article-title":"Heterogeneity of T-cell clones infiltrating primary malignant melanomas","volume":"126","author":"Yazdi","year":"2006","journal-title":"J\u00a0Invest Dermatol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/pcmr.12818","article-title":"Evidence and impact of neutrophil extracellular traps in malignant melanoma","volume":"33","author":"Schedel","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104644_bib4","first-page":"761","article-title":"Role of tumor microenvironment in tumorigenesis","volume":"8","author":"Wang","year":"2017","journal-title":"J\u00a0Cancer"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104644_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/PAP.0000000000000162","volume":"24","author":"Hendry","year":"2017","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.ebiom.2023.104644_bib6","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3389\/fimmu.2020.02105","article-title":"Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma","volume":"11","author":"Maibach","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41698-017-0031-0","article-title":"Immune cell profiling in cancer: molecular approaches to cell-specific identification","volume":"1","author":"Lyons","year":"2017","journal-title":"NPJ Precis Oncol"},{"issue":"24","key":"10.1016\/j.ebiom.2023.104644_bib8","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/jnci\/81.24.1893","article-title":"Model predicting survival in stage I melanoma based on tumor progression","volume":"81","author":"Clark","year":"1989","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104644_bib9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5","article-title":"Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma","volume":"77","author":"Clemente","year":"1996","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pathol.2015.12.006","article-title":"Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy","volume":"48","author":"Lee","year":"2016","journal-title":"Pathology"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104644_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1159\/000505152","article-title":"Prognostic significance of tumor-infiltrating lymphocyte grade in melanoma: a meta-analysis","volume":"236","author":"Sun","year":"2020","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104644_bib12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/pcmr.12757","article-title":"Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor-infiltrating lymphocytes) in superficial spreading and nodular melanoma","volume":"32","author":"N\u011bmejcov\u00e1","year":"2019","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ebiom.2023.104644_bib13","series-title":"AJCC cancer staging manual","author":"Edge","year":"2010"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104644_bib14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1001\/jamadermatol.2019.0440","article-title":"Risk of melanoma recurrence after diagnosis of a high-risk primary tumor","volume":"155","author":"von Schuckmann","year":"2019","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12957-019-1669-6","article-title":"Comparison of seventh and eighth edition of AJCC staging system in melanomas at locoregional stage","volume":"17","author":"Teterycz","year":"2019","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.ebiom.2023.104644_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2147\/CLEP.S99021","article-title":"Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe - a systematic review of the literature","volume":"8","author":"Svedman","year":"2016","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.ebiom.2023.104644_bib17","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.22.00202","article-title":"Prognosis of patients with primary melanoma stage I and II according to American Joint committee on cancer version 8 validated in two independent cohorts: implications for adjuvant treatment","volume":"40","author":"Garbe","year":"2022","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ebiom.2023.104644_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.semcancer.2021.03.036","article-title":"Predictive biomarkers for response to immune checkpoint inhibition","volume":"79","author":"Shum","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib19","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1634\/theoncologist.2019-0244","article-title":"Tumor mutational burden as a predictive biomarker for response to immune checkpoint inhibitors: a review of current evidence","volume":"25","author":"Klempner","year":"2020","journal-title":"Oncologist"},{"key":"10.1016\/j.ebiom.2023.104644_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.748674","article-title":"The predictive value of tumor mutation burden on clinical efficacy of immune checkpoint inhibitors in melanoma: a systematic review and meta-analysis","volume":"13","author":"Ning","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ebiom.2023.104644_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejca.2021.09.019","article-title":"Circulating tumour DNA (ctDNA) in metastatic melanoma, a systematic review and meta-analysis","volume":"158","author":"Gracie","year":"2021","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib22","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/s41467-020-14987-6","article-title":"Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours","volume":"11","author":"Brenner","year":"2020","journal-title":"Nat Commun"},{"issue":"7528","key":"10.1016\/j.ebiom.2023.104644_bib23","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nature13954","article-title":"PD-1 blockade induces responses by inhibiting adaptive immune resistance","volume":"515","author":"Tumeh","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104644_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s40291-020-00459-6","article-title":"Immunoscore\u00ae: a diagnostic assay for clinical management of colon cancer","volume":"24","author":"Blair","year":"2020","journal-title":"Mol Diagn Ther"},{"issue":"20","key":"10.1016\/j.ebiom.2023.104644_bib25","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1158\/1078-0432.CCR-21-0325","article-title":"An open-source, automated tumor-infiltrating lymphocyte algorithm for prognosis in triple-negative breast cancer","volume":"27","author":"Bai","year":"2021","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/jclinpath-2018-205328","article-title":"Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours","volume":"72","author":"Linder","year":"2019","journal-title":"J\u00a0Clin Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib27","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1038\/s41467-019-13043-2","article-title":"An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma","volume":"10","author":"Acs","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib28","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1038\/s41598-021-82305-1","article-title":"Automated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma","volume":"11","author":"Moore","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104644_bib29","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41379-020-00686-6","article-title":"Optimization of an automated tumor-infiltrating lymphocyte algorithm for improved prognostication in primary melanoma","volume":"34","author":"Chou","year":"2021","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib30","first-page":"43","article-title":"Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response","volume":"74","author":"Mihm","year":"1996","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib31","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/s41598-021-81330-4","article-title":"Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600E\/K mutated malignant melanomas","volume":"11","author":"Klein","year":"2021","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104644_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.bjc.6602678","article-title":"REporting recommendations for tumour MARKer prognostic studies (REMARK)","volume":"93","author":"McShane","year":"2005","journal-title":"Br J Cancer"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104644_bib33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/jamasurg.2021.0537","article-title":"TRIPOD reporting guidelines for diagnostic and prognostic studies","volume":"156","author":"Patzer","year":"2021","journal-title":"JAMA Surg"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2023.104644_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cmpb.2019.05.023","article-title":"Evaluate Cutpoints: adaptable continuous data distribution system for determining survival in Kaplan-Meier estimator","volume":"177","author":"Og\u0142uszka","year":"2019","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.ebiom.2023.104644_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104143","article-title":"Objective assessment of tumor infiltrating lymphocytes as a prognostic marker in melanoma using machine learning algorithms","volume":"82","author":"Aung","year":"2022","journal-title":"eBioMedicine"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104644_bib38","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/cas.13101","article-title":"Comparison of tumor-infiltrating lymphocytes between primary and metastatic tumors in breast cancer patients","volume":"107","author":"Ogiya","year":"2016","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ebiom.2023.104644_bib39","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1200\/JCO.2017.35.15_suppl.2049","article-title":"Number of tumor-infiltrating lymphocytes in breast cancer brain metastases compared to matched breast primaries","volume":"35","author":"Narloch","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"issue":"23","key":"10.1016\/j.ebiom.2023.104644_bib40","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.3390\/ijms21238984","article-title":"Overcoming immune evasion in melanoma","volume":"21","author":"Eddy","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jamaoncol.2022.4933","article-title":"Association of machine learning\u2013based assessment of tumor-infiltrating lymphocytes on standard histologic images with outcomes of immunotherapy in patients with NSCLC","volume":"9","author":"Rakaee","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ebiom.2023.104644_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2023.01.040","article-title":"Tumor-infiltrating lymphocytes as a predictive biomarker of cutaneous immune-related adverse events after immune checkpoint blockade in patients with advanced melanoma","author":"Stephens","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104644_bib43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/jdv.16311","article-title":"Cutaneous adverse events: a predictor of tumour response under anti-PD-1 therapy for metastatic melanoma, a cohort analysis of 189 patients","volume":"34","author":"Bottlaender","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104644_bib44","first-page":"720","article-title":"CD8-Targeted pet imaging of tumor-infiltrating T cells in patients with cancer: a phase I first-in-humans study of (89)Zr-Df-IAB22M2C, a radiolabeled anti-CD8 minibody","volume":"63","author":"Farwell","year":"2022","journal-title":"J\u00a0Nucl Med"},{"issue":"27","key":"10.1016\/j.ebiom.2023.104644_bib45","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1200\/JCO.2013.55.0491","article-title":"Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199","volume":"32","author":"Adams","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"18","key":"10.1016\/j.ebiom.2023.104644_bib46","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1158\/0008-5472.CAN-22-0363","article-title":"Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions that predict immunotherapy response","volume":"82","author":"Antoranz","year":"2022","journal-title":"Cancer Res"},{"issue":"6282","key":"10.1016\/j.ebiom.2023.104644_bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41523-021-00346-1","article-title":"The tale of TILs in breast cancer: a report from the international immuno-oncology biomarker working group","volume":"7","author":"El Bairi","year":"2021","journal-title":"NPJ Breast Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib49","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1038\/s41467-021-24343-x","article-title":"The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival","volume":"12","author":"Valpione","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1200\/JCO.22.01763","article-title":"Combination dabrafenib and trametinib versus combination nivolumab and ipilimumab for patients with advanced BRAF-mutant melanoma: the DREAMseq trial\u2014ECOG-ACRIN EA6134","volume":"41","author":"Atkins","year":"2023","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ebiom.2023.104644_bib51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2018.08.019","article-title":"Immunomodulatory effects of BRAF and MEK inhibitors: implications for melanoma therapy","volume":"136","author":"Kuske","year":"2018","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.annonc.2019.10.002","article-title":"Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv600 mutation\u2013positive melanoma receiving adjuvant vemurafenib","volume":"31","author":"Ascierto","year":"2020","journal-title":"Ann Oncol"},{"issue":"23","key":"10.1016\/j.ebiom.2023.104644_bib53","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMoa2210233","article-title":"Tumor-infiltrating lymphocyte therapy or ipilimumab in advanced melanoma","volume":"387","author":"Rohaan","year":"2022","journal-title":"N\u00a0Engl J Med"},{"issue":"10336","key":"10.1016\/j.ebiom.2023.104644_bib54","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/S0140-6736(22)00562-1","article-title":"Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial","volume":"399","author":"Luke","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2023.104644_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.794175","article-title":"Assessing tumor-infiltrating lymphocytes in breast cancer: a proposal for combining immunohistochemistry and gene expression analysis to refine scoring","volume":"13","author":"Locy","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104644_bib56","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1200\/JCO.18.01010","article-title":"Tumor-infiltrating lymphocytes and prognosis: a pooled individual patient analysis of early-stage triple-negative breast cancers","volume":"37","author":"Loi","year":"2019","journal-title":"J\u00a0Clin Oncol"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104644_bib57","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/annonc\/mdu112","article-title":"Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial","volume":"25","author":"Loi","year":"2014","journal-title":"Ann Oncol"},{"issue":"4_Supplement","key":"10.1016\/j.ebiom.2023.104644_bib58","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS19-PD5-03","article-title":"Abstract PD5-03: relationship between tumor-infiltrating lymphocytes (TILs) and outcomes in the KEYNOTE-119 study of pembrolizumab vs chemotherapy for previously treated metastatic triple-negative breast cancer (mTNBC)","volume":"80","author":"Loi","year":"2020","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104644_bib59","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/ejcts\/ezaa098","article-title":"Spatial architecture of tumour-infiltrating lymphocytes as a prognostic parameter in resected non-small-cell lung cancer","volume":"58","author":"Bocchialini","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ebiom.2023.104644_bib60","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.humpath.2018.05.017","article-title":"Evaluation of tumor-infiltrating lymphocytes using routine H&E slides predicts patient survival in resected non\u2013small cell lung cancer","volume":"79","author":"Rakaee","year":"2018","journal-title":"Hum Pathol"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104644_bib61","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/jamaoto.2019.2427","article-title":"Prognostic value of tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma","volume":"145","author":"Spector","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"32","key":"10.1016\/j.ebiom.2023.104644_bib62","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011769","article-title":"Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a systematic review and meta-analysis","volume":"97","author":"Lee","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104644_bib63","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ygyno.2011.09.039","article-title":"Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis","volume":"124","author":"Hwang","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104644_bib64","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s41416-022-01743-4","article-title":"Biomarkers of response to PD-1 pathway blockade","volume":"126","author":"Li","year":"2022","journal-title":"Br J Cancer"},{"issue":"15","key":"10.1016\/j.ebiom.2023.104644_bib65","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1158\/1078-0432.CCR-20-4314","article-title":"Prediction of immunotherapy response in melanoma through combined modeling of neoantigen burden and immune-related resistance mechanisms","volume":"27","author":"Abbott","year":"2021","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99524-1","article-title":"CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer","volume":"11","author":"Gutiontov","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib67","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/s41467-021-25894-9","article-title":"9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy","volume":"12","author":"Han","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2023.104644_bib68","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3389\/fonc.2020.01559","article-title":"Recognition of cutaneous melanoma on digitized histopathological slides via artificial intelligence algorithm","volume":"10","author":"De Logu","year":"2020","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104644_bib69","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12859-022-04584-3","article-title":"A\u00a0data management infrastructure for the integration of imaging and omics data in life sciences","volume":"23","author":"Kuhn Cuellar","year":"2022","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104644_bib70","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.201004104","article-title":"Metadata matters: access to image data in the real world","volume":"189","author":"Linkert","year":"2010","journal-title":"J\u00a0Cell Biol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:26:53Z","timestamp":1762457213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423002098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":70,"alternative-id":["S2352396423002098"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104644","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104644"}}