{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:10:02Z","timestamp":1792631402342,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Swedish council for Working life and Social research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001861","name":"Forskningsr\u00e5det f\u00f6r Arbetsliv och Socialvetenskap","doi-asserted-by":"publisher","award":["FAS2004\\u20131775"],"award-info":[{"award-number":["FAS2004\\u20131775"]}],"id":[{"id":"10.13039\/501100001861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010805","name":"Forskningsr\u00e5det i Syd\u00f6stra Sverige","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004973","name":"Barndiabetesfondens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2008-69X-20826-01-4"],"award-info":[{"award-number":["K2008-69X-20826-01-4"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2005-72X-11242-11A"],"award-info":[{"award-number":["K2005-72X-11242-11A"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ebiom.2023.104654","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T22:43:51Z","timestamp":1686869031000},"page":"104654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children"],"prefix":"10.1016","volume":"93","author":[{"given":"Erik","family":"Kindgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-7559","authenticated-orcid":false,"given":"Angelica P.","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-4866","authenticated-orcid":false,"given":"Eric W.","family":"Triplett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Ludvigsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2023.104654_bib1","series-title":"The boy with a thorn in his joints","author":"Meadows","year":"2013"},{"key":"10.1016\/j.ebiom.2023.104654_bib2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ng.2614","article-title":"Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis","volume":"45","author":"Hinks","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2023.104654_bib3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jaci.2015.07.040","article-title":"Cesarean section and disease associated with immune function","volume":"137","author":"Kristensen","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/archdischild-2014-308117","article-title":"Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis","volume":"101","author":"Hyrich","year":"2016","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ebiom.2023.104654_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12969-017-0175-z","article-title":"Early feeding and risk of juvenile idiopathic arthritis: a case control study in a prospective birth cohort","volume":"15","author":"Kindgren","year":"2017","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3899\/jrheum.140348","article-title":"Repeated exposure to antibiotics in infancy: a predisposing factor for juvenile idiopathic arthritis or a sign of this group\u2019s greater susceptibility to infections?","volume":"42","author":"Arvonen","year":"2015","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12969-016-0104-6","article-title":"Gut microbiota-host interactions and juvenile idiopathic arthritis","volume":"14","author":"Arvonen","year":"2016","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12969-021-00611-4","article-title":"Infections and antibiotics during fetal life and childhood and their relationship to juvenile idiopathic arthritis: a prospective cohort study","volume":"19","author":"Kindgren","year":"2021","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12969-019-0344-3","article-title":"Heavy metals in fish and its association with autoimmunity in the development of juvenile idiopathic arthritis: a prospective birth cohort study","volume":"17","author":"Kindgren","year":"2019","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad7121","article-title":"Antibiotics, birth mode, and diet shape microbiome maturation during early life","volume":"8","author":"Bokulich","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2023.104654_bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2249.2012.04663.x","article-title":"Altered expression of intestinal human leucocyte antigen D-related and immune signalling molecules in juvenile idiopathic arthritis","volume":"170","author":"Arvonen","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib12","first-page":"773","article-title":"Increased gut permeability in juvenile chronic arthritides. A multivariate analysis of the diagnostic parameters","volume":"18","author":"Picco","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10096-015-2548-x","article-title":"Faecal microbiome in new-onset juvenile idiopathic arthritis","volume":"35","author":"Tejesvi","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ebiom.2023.104654_bib14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/cei.12900","article-title":"Gut microbiome in children with enthesitis-related arthritis in a developing country and the effect of probiotic administration","volume":"187","author":"Aggarwal","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib15","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3389\/fmicb.2016.01703","article-title":"Alteration of fecal microbiota profiles in juvenile idiopathic arthritis. Associations with HLA-B27 allele and disease status","volume":"7","author":"Di Paola","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ebiom.2023.104654_bib16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s13075-014-0486-0","article-title":"Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis","volume":"16","author":"Stoll","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ebiom.2023.104654_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/art.40827","article-title":"Microbiome analytics of the gut microbiota in patients with juvenile idiopathic arthritis: a longitudinal observational cohort study","volume":"71","author":"van Dijkhuizen","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13075-018-1510-6","article-title":"Age and fecal microbial strain-specific differences in patients with spondyloarthritis","volume":"20","author":"Stoll","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ebiom.2023.104654_bib19","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.12998\/wjcc.v7.i18.2734","article-title":"Characterization of microbiota in systemic-onset juvenile idiopathic arthritis with different disease severities","volume":"7","author":"Dong","year":"2019","journal-title":"World J Clin Cases"},{"issue":"Suppl 22","key":"10.1016\/j.ebiom.2023.104654_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/pedi.12327","article-title":"Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity","volume":"17","author":"Ilonen","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.ebiom.2023.104654_bib21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.ebiom.2023.104654_bib22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.ebiom.2023.104654_bib23","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2023.104654_bib25","author":"Oksanen"},{"key":"10.1016\/j.ebiom.2023.104654_bib26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2023.104654_bib27","first-page":"1","article-title":"MatchIt: nonparametric preprocessing for parametric causal inference","volume":"42","author":"Ho","year":"2011","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.ebiom.2023.104654_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/1755-0998.13116","article-title":"pime: a package for discovery of novel differences among microbial communities","volume":"20","author":"Roesch","year":"2020","journal-title":"Mol Ecol Resour"},{"key":"10.1016\/j.ebiom.2023.104654_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12826","article-title":"Microbial orchestra in juvenile idiopathic arthritis: sounds of disarray?","volume":"294","author":"Arvonen","year":"2020","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ebiom.2023.104654_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12969-017-0167-z","article-title":"Juvenile idiopathic arthritis in relation to perinatal and maternal characteristics: a case control study","volume":"15","author":"Bell","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.ebiom.2023.104654_bib31","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/acr2.11485","article-title":"Investigation of inactive disease states among patients with juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance registry","volume":"4","author":"Mannion","year":"2022","journal-title":"ACR Open Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib32","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/acr.22806","article-title":"Environmental risk factors and early life exposures for juvenile idiopathic arthritis; a case: control study","volume":"68","author":"Shenoi","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.ebiom.2023.104654_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12969-021-00629-8","article-title":"Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches","volume":"19","author":"Zaripova","year":"2021","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4274\/balkanmedj.2017.0111","article-title":"Juvenile idiopathic arthritis","volume":"34","author":"Barut","year":"2017","journal-title":"Balkan Med J"},{"key":"10.1016\/j.ebiom.2023.104654_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12016-017-8642-3","article-title":"Sex differences in pediatric rheumatology","volume":"56","author":"Cattalini","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/acr.22471","article-title":"Juvenile idiopathic arthritis in relation to maternal prenatal smoking","volume":"67","author":"Shenoi","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.ebiom.2023.104654_bib37","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/ard.2008.089342","article-title":"Perinatal characteristics, early life infections and later risk of rheumatoid arthritis and juvenile idiopathic arthritis","volume":"68","author":"Carlens","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ebiom.2023.104654_bib38","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/rheumatology\/keab627","article-title":"Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis","volume":"61","author":"Clarke","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.ebiom.2023.104654_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46964-5","article-title":"Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants","volume":"9","author":"Tapiainen","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104654_bib40","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1007\/s00125-023-05895-7","article-title":"Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study","volume":"66","author":"B\u00e9lteky","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2023.104654_bib41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ebiom.2023.104654_bib42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2023.104654_bib43","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/gene.2016.38","article-title":"Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors","volume":"17","author":"Stoll","year":"2016","journal-title":"Genes Immun"},{"key":"10.1016\/j.ebiom.2023.104654_bib44","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12864-020-6703-0","article-title":"Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction","volume":"21","author":"Qian","year":"2020","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ebiom.2023.104654_bib45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2217\/fmb-2016-0130","article-title":"Roseburia spp.: a marker of health?","volume":"12","author":"Tamanai-Shacoori","year":"2017","journal-title":"Future Microbiol"},{"key":"10.1016\/j.ebiom.2023.104654_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12969-021-00542-0","article-title":"Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept","volume":"19","author":"\u00d6man","year":"2021","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn5166","article-title":"Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum","volume":"14","author":"Chriswell","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2023.104654_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104055","article-title":"Gut dysbiosis in rheumatic diseases: a systematic review and meta-analysis of 92 observational studies","volume":"80","author":"Wang","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ebiom.2023.104654_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13075-023-03013-x","article-title":"Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses","volume":"25","author":"Koh","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ebiom.2023.104654_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102913","article-title":"Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells","volume":"58","author":"Takahashi","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2023.104654_bib51","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.1038\/s41467-022-34502-3","article-title":"Gut microbiome-wide association study of depressive symptoms","volume":"13","author":"Radjabzadeh","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2023.104654_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3089303","article-title":"Understanding the impact of omega-3 rich diet on the gut microbiota","volume":"2016","author":"Noriega","year":"2016","journal-title":"Case Rep Med"},{"key":"10.1016\/j.ebiom.2023.104654_bib53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10067-011-1848-5","article-title":"Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-\u03b1), disease activity and response criteria","volume":"31","author":"Gheita","year":"2012","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib54","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s10067-017-3586-9","article-title":"The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity","volume":"36","author":"Gorczyca","year":"2017","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib55","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/RHU.0000000000000563","article-title":"Omega-3 fatty acids in rheumatic diseases: a critical review","volume":"23","author":"Akbar","year":"2017","journal-title":"J\u00a0Clin Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib56","article-title":"The role of the microbiome in rheumatoid arthritis: a review","volume":"7","author":"Tsetseri","year":"2023","journal-title":"Rheumatol Adv Pract"},{"key":"10.1016\/j.ebiom.2023.104654_bib57","doi-asserted-by":"crossref","first-page":"e418","DOI":"10.1016\/S2665-9913(20)30064-3","article-title":"Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study","volume":"2","author":"Wells","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib58","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/eji.202048876","article-title":"Crossing the barriers: revisiting the gut feeling in rheumatoid arthritis","volume":"51","author":"Brandl","year":"2021","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.ebiom.2023.104654_bib60","doi-asserted-by":"crossref","first-page":"e375","DOI":"10.1016\/S2665-9913(20)30090-4","article-title":"Genetics, Prevotella, and the pathogenesis of rheumatoid arthritis","volume":"2","author":"Stoll","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib61","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/art.40003","article-title":"Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis","volume":"69","author":"Pianta","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib62","article-title":"Gut microbiota and rheumatoid arthritis: from pathogenesis to novel therapeutic opportunities","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2023.104654_bib63","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.3899\/jrheum.161589","article-title":"Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis","volume":"44","author":"Fotis","year":"2017","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib64","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1892441","article-title":"Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development","volume":"13","author":"Kim","year":"2021","journal-title":"Gut Microb"},{"key":"10.1016\/j.ebiom.2023.104654_bib65","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41435-018-0024-1","article-title":"Akkermansia muciniphila is permissive to arthritis in the K\/BxN mouse model of arthritis","volume":"20","author":"Stoll","year":"2019","journal-title":"Genes Immun"},{"key":"10.1016\/j.ebiom.2023.104654_bib66","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ebiom.2023.104654_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13567-020-00755-3","article-title":"Akkermansia muciniphila protects intestinal mucosa from damage caused by S.\u00a0pullorum by initiating proliferation of intestinal epithelium","volume":"51","author":"Zhu","year":"2020","journal-title":"Vet Res"},{"key":"10.1016\/j.ebiom.2023.104654_bib68","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2023.104654_bib69","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1007\/s00253-021-11362-3","article-title":"The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets","volume":"105","author":"Hagi","year":"2021","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.ebiom.2023.104654_bib70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12969-022-00689-4","article-title":"In a large juvenile idiopathic arthritis (JIA) cohort, concomitant celiac disease is associated with family history of autoimmunity and a more severe JIA course: a retrospective study","volume":"20","author":"Naddei","year":"2022","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.ebiom.2023.104654_bib71","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1922241","article-title":"Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health","volume":"13","author":"Ezeji","year":"2021","journal-title":"Gut Microb"},{"key":"10.1016\/j.ebiom.2023.104654_bib72","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1177\/0962280214523192","article-title":"Misclassification of outcome in case-control studies: methods for sensitivity analysis","volume":"25","author":"Gilbert","year":"2016","journal-title":"Stat Methods Med Res"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:35:48Z","timestamp":1778873748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423002190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":71,"alternative-id":["S2352396423002190"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104654","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104654","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104654"}}