{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:00:31Z","timestamp":1792602031584,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ebiom.2023.104704","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T13:54:18Z","timestamp":1688651658000},"page":"104704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-6052","authenticated-orcid":false,"given":"Lucy A.","family":"Bartho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunda","family":"Nijagal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu'uhevaha J.","family":"Kaitu'u-Lino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2023.104704_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.placenta.2019.02.002","article-title":"The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development","volume":"84","author":"Whigham","year":"2019","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/uog.20117","article-title":"Prediction of pre-eclampsia: review of reviews","volume":"54","author":"Townsend","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ebiom.2023.104704_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2023.104704_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103780","article-title":"Clinical tools and biomarkers to predict preeclampsia","volume":"75","author":"MacDonald","year":"2022","journal-title":"eBioMedicine"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104704_bib5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/metabo12070590","article-title":"Dissecting the roles of lipids in preeclampsia","volume":"12","author":"Yang","year":"2022","journal-title":"Metabolites"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104704_bib6","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s00018-018-2765-4","article-title":"Lipids in the cell: organisation regulates function","volume":"75","author":"Santos","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"7356","key":"10.1016\/j.ebiom.2023.104704_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/bmj.325.7356.157","article-title":"Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?","volume":"325","author":"Sattar","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.ebiom.2023.104704_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.prostaglandins.2018.09.006","article-title":"Role of dyslipidemia in preeclampsia\u2014a review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with preeclampsia","volume":"139","author":"Wojcik-Baszko","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104704_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163972","article-title":"A\u00a0lipidomic analysis of placenta in preeclampsia: evidence for lipid storage","volume":"11","author":"Brown","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-022-02432-y","article-title":"Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study","volume":"20","author":"Mir","year":"2022","journal-title":"BMC Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb3002s98","article-title":"Targeted metabolomics","volume":"98","author":"Roberts","year":"2012","journal-title":"Curr Protoc Mol Biol"},{"key":"10.1016\/j.ebiom.2023.104704_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2021.11.001","article-title":"A\u00a0disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants","volume":"117","author":"Andres","year":"2022","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104704_bib13","doi-asserted-by":"crossref","first-page":"bqad041","DOI":"10.1210\/endocr\/bqad041","article-title":"Circulating chemerin is elevated in women with preeclampsia","volume":"164","author":"Bartho","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.ebiom.2023.104704_bib14","series-title":"Hypertension in pregnancy","year":"2013"},{"key":"10.1016\/j.ebiom.2023.104704_bib15","series-title":"Customised weight centile calculator\u2014GROW-centile v. 5.12\/6.2 2009","author":"Gardosi","year":"2009"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chembiol.2018.10.008","article-title":"High-throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors","volume":"26","author":"Huynh","year":"2019","journal-title":"Cell Chem Biol"},{"issue":"10","key":"10.1016\/j.ebiom.2023.104704_bib17","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1194\/jlr.P035808","article-title":"Plasma lipid profiling in a large population-based cohort [S]","volume":"54","author":"Weir","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.ebiom.2023.104704_bib18","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1007\/s11306-011-0366-4","article-title":"Missing values in mass spectrometry based metabolomics: an undervalued step in the data processing pipeline","volume":"8","author":"Hrydziuszko","year":"2012","journal-title":"Metabolomics"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-10-11","article-title":"Filtering for increased power for microarray data analysis","volume":"10","author":"Hackstadt","year":"2009","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104704_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101176","article-title":"A\u00a0review of published analyses of case-cohort studies and recommendations for future reporting","volume":"9","author":"Sharp","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104704_bib21","doi-asserted-by":"crossref","first-page":"F29","DOI":"10.1083\/jcb.152.5.F29","article-title":"Caveolin, cholesterol, and lipid droplets?","volume":"152","author":"van Meer","year":"2001","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.ebiom.2023.104704_bib22","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1016\/j.placenta.2011.01.011","article-title":"Transport of maternal cholesterol to the fetal circulation","volume":"32","author":"Woollett","year":"2011","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104704_bib23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/antiox11030500","article-title":"Human placental intracellular cholesterol transport: a focus on lysosomal and mitochondrial dysfunction and oxidative stress","volume":"11","author":"Ya\u00f1ez","year":"2022","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104704_bib24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/tra.12709","article-title":"Integrated regulation of the phosphatidylinositol cycle and phosphoinositide-driven lipid transport at ER-PM contact sites","volume":"21","author":"Pemberton","year":"2020","journal-title":"Traffic"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104704_bib25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9378(99)70259-0","article-title":"Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia","volume":"180","author":"Staff","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104704_bib26","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.3390\/ijms14023487","article-title":"Increased placental phospholipid levels in pre-eclamptic pregnancies","volume":"14","author":"Huang","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"17","key":"10.1016\/j.ebiom.2023.104704_bib27","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1002\/sim.6496","article-title":"Positing, fitting, and selecting regression models for pooled biomarker data","volume":"34","author":"Mitchell","year":"2015","journal-title":"Stat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/uog.20168","article-title":"Artificial intelligence and amniotic fluid multiomics: prediction of perinatal outcome in asymptomatic women with short cervix","volume":"54","author":"Bahado-Singh","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104704_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41591-020-0804-9","article-title":"A\u00a0maternal serum metabolite ratio predicts fetal growth restriction at term","volume":"26","author":"Sovio","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib30","first-page":"1","article-title":"Metabolomic biomarkers in midtrimester maternal plasma can accurately predict the development of preeclampsia","volume":"10","author":"Lee","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104704_bib31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1194\/jlr.P064451","article-title":"Detection and confirmation of serum lipid biomarkers for preeclampsia using direct infusion mass spectrometry [S]","volume":"57","author":"Anand","year":"2016","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.ebiom.2023.104704_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100118","article-title":"The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia","volume":"62","author":"He","year":"2021","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.ebiom.2023.104704_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.commatsci.2019.109203","article-title":"Evaluating explorative prediction power of machine learning algorithms for materials discovery using k-fold forward cross-validation","volume":"171","author":"Xiong","year":"2020","journal-title":"Comput Mater Sci"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104704_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091806","article-title":"Plasma and serum lipidomics of healthy white adults shows characteristic profiles by subjects' gender and age","volume":"9","author":"Ishikawa","year":"2014","journal-title":"PLoS One"},{"issue":"4\u20136","key":"10.1016\/j.ebiom.2023.104704_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.plefa.2010.02.017","article-title":"Fatty acid-derived lipid mediators and blood platelet aggregation","volume":"82","author":"Lagarde","year":"2010","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104704_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10565-018-9441-1","article-title":"Is the clinical lipidomics a potential goldmine?","volume":"34","author":"Zhang","year":"2018","journal-title":"Cell Biol Toxicol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104704_bib37","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1186\/s40169-018-0190-9","article-title":"Clinical lipidomics: a new way to diagnose human diseases","volume":"7","author":"Lv","year":"2018","journal-title":"Clin Transl Med"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104704_bib38","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3390\/ijms17121992","article-title":"Advances in lipidomics for cancer biomarkers discovery","volume":"17","author":"Perrotti","year":"2016","journal-title":"Int J Mol Sci"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423002694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:26:21Z","timestamp":1762457181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423002694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":38,"alternative-id":["S2352396423002694"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104704","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104704"}}