{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:49:07Z","timestamp":1793386147866,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["211113\/A\/18\/Z"],"award-info":[{"award-number":["211113\/A\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013963","name":"University Hospitals Birmingham NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000855","name":"University of Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy's and St Thomas' NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ebiom.2023.104778","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:38:26Z","timestamp":1693399106000},"page":"104778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease"],"prefix":"10.1016","volume":"95","author":[{"given":"Trishan","family":"Vaikunthanathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Landmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Marin","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Cellone","family":"Trevelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Corrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jos\u00e9","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Perpinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zoccarato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Edwards-Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reenam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyet-Thin","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Thursz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Newsome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Martinez-Llordella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naina","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Lechler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Sanchez-Fueyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Safinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2023.104778_bib2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and human disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104778_bib3","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.4049\/jimmunol.180.11.7112","article-title":"Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6","volume":"180","author":"Zheng","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.immuni.2008.05.007","article-title":"Molecular antagonism and plasticity of regulatory and inflammatory T cell programs","volume":"29","author":"Yang","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood-2005-11-4567","article-title":"TNF downmodulates the function of human CD4+CD25hi T-regulatory cells","volume":"108","author":"Valencia","year":"2006","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib6","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.4049\/jimmunol.0902070","article-title":"TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function","volume":"184","author":"Nagar","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Dominguez-Villar","year":"2018","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104778_bib8","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.1003224","article-title":"CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game","volume":"187","author":"Long","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib9","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2008-01-133967","article-title":"Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells","volume":"112","author":"Koenen","year":"2008","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104778_bib11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib12","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1172\/JCI97490","article-title":"Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling","volume":"128","author":"Emmerson","year":"2018","journal-title":"J\u00a0Clin Invest"},{"issue":"18","key":"10.1016\/j.ebiom.2023.104778_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149301","article-title":"Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency","volume":"6","author":"Trevelin","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2023.104778_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"17","key":"10.1016\/j.ebiom.2023.104778_bib15","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"13","key":"10.1016\/j.ebiom.2023.104778_bib16","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1074\/jbc.M111.312694","article-title":"Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis","volume":"287","author":"Niture","year":"2012","journal-title":"J\u00a0Biol Chem"},{"issue":"22","key":"10.1016\/j.ebiom.2023.104778_bib17","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib18","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.bcp.2010.07.014","article-title":"Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential","volume":"80","author":"Paine","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"39","key":"10.1016\/j.ebiom.2023.104778_bib19","doi-asserted-by":"crossref","first-page":"24343","DOI":"10.1016\/S0021-9258(19)51088-2","article-title":"Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization","volume":"269","author":"Yamaguchi","year":"1994","journal-title":"J\u00a0Biol Chem"},{"issue":"23","key":"10.1016\/j.ebiom.2023.104778_bib20","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","article-title":"Microsomal heme oxygenase. characterization of the enzyme","volume":"244","author":"Tenhunen","year":"1969","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104778_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85817","article-title":"Heme oxygenase-1 regulates mitochondrial quality control in the heart","volume":"1","author":"Hull","year":"2016","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89676","article-title":"Mitochondrial quality-control dysregulation in conditional HO-1(-\/-) mice","volume":"2","author":"Suliman","year":"2017","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib23","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.18632\/oncotarget.1658","article-title":"Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers","volume":"4","author":"Rotblat","year":"2013","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0006-291X(03)01037-4","article-title":"Differential expressions of heme oxygenase-1 gene in CD25- and CD25+ subsets of human CD4+ T cells","volume":"306","author":"Pae","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104778_bib25","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.12.106","article-title":"Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression","volume":"327","author":"Choi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib26","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2353\/ajpath.2007.070096","article-title":"Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1","volume":"171","author":"Xia","year":"2007","journal-title":"Am J Pathol"},{"issue":"1-2","key":"10.1016\/j.ebiom.2023.104778_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneuroim.2013.10.012","article-title":"Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model","volume":"266","author":"Dey","year":"2014","journal-title":"J\u00a0Neuroimmunol"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jhep.2020.11.048","article-title":"The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis","volume":"74","author":"Arroyo","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"36","key":"10.1016\/j.ebiom.2023.104778_bib29","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.2174\/138161211798764924","article-title":"Mitochondria sentencing about cellular life and death: a matter of oxidative stress","volume":"17","author":"Apostolova","year":"2011","journal-title":"Curr Pharm Des"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104778_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/gast.2002.31474","article-title":"Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more","volume":"122","author":"Lai","year":"2002","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/00365520701559003","article-title":"Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet","volume":"43","author":"Machado","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.ebiom.2023.104778_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5380319","article-title":"Role of TFEB mediated autophagy, oxidative stress, inflammation, and cell death in endotoxin induced myocardial toxicity of young and aged mice","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104778_bib33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41575-021-00520-7","article-title":"Cirrhosis-associated immune dysfunction","volume":"19","author":"Albillos","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104778_bib34","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cgh.2011.02.031","article-title":"Immune dysfunction and infections in patients with cirrhosis","volume":"9","author":"Bonnel","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.20010659","article-title":"Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression","volume":"195","author":"Devadas","year":"2002","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0014-5793(99)00696-1","article-title":"Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY(581\/591)","volume":"453","author":"Pap","year":"1999","journal-title":"FEBS Lett"},{"issue":"34","key":"10.1016\/j.ebiom.2023.104778_bib37","doi-asserted-by":"crossref","first-page":"12831","DOI":"10.1073\/pnas.0604571103","article-title":"T\u00a0cell surface redox levels determine T cell reactivity and arthritis susceptibility","volume":"103","author":"Gelderman","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2023.104778_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2105-15-182","article-title":"Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads","volume":"15","author":"Jiang","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ebiom.2023.104778_bib39","first-page":"11 4 1","article-title":"Mapping RNA-seq reads with STAR","volume":"51","author":"Dobin","year":"2015","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.ebiom.2023.104778_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"10.1016\/j.ebiom.2023.104778_bib41","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2023.104778_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104778_bib44","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1172\/JCI33185","article-title":"Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice","volume":"118","author":"Tsang","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104778_bib45","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/eji.201242909","article-title":"CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function","volume":"43","author":"Smyth","year":"2013","journal-title":"Eur J Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"issue":"14","key":"10.1016\/j.ebiom.2023.104778_bib47","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1182\/blood-2012-08-443473","article-title":"CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines","volume":"121","author":"Pesenacker","year":"2013","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104778_bib48","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1002\/eji.201243296","article-title":"CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner","volume":"43","author":"Afzali","year":"2013","journal-title":"Eur J Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib49","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood-2011-09-377895","article-title":"Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in\u00a0vitro expansion","volume":"119","author":"Kim","year":"2012","journal-title":"Blood"},{"issue":"6258","key":"10.1016\/j.ebiom.2023.104778_bib50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1126\/science.aad0616","article-title":"Stable inhibitory activity of regulatory T cells requires the transcription factor Helios","volume":"350","author":"Kim","year":"2015","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104778_bib51","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/hep.21823","article-title":"A\u00a0high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury","volume":"46","author":"Ma","year":"2007","journal-title":"Hepatology"},{"issue":"1-2","key":"10.1016\/j.ebiom.2023.104778_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cellimm.2014.02.003","article-title":"Increased oxidative stress and the apoptosis of regulatory T cells in obese mice but not resistant mice in response to a high-fat diet","volume":"288","author":"Wang","year":"2014","journal-title":"Cell Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.it.2018.01.005","article-title":"Reactive oxygen species: involvement in T cell signaling and metabolism","volume":"39","author":"Franchina","year":"2018","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem J"},{"issue":"21","key":"10.1016\/j.ebiom.2023.104778_bib55","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ebiom.2023.104778_bib56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.imlet.2020.02.009","article-title":"Beyond bacterial killing: NADPH oxidase 2 is an immunomodulator","volume":"221","author":"Trevelin","year":"2020","journal-title":"Immunol Lett"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib58","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib59","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.tcb.2020.08.008","article-title":"Cristae membrane dynamics\u2013a paradigm change","volume":"30","author":"Kondadi","year":"2020","journal-title":"Trends Cell Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104778_bib60","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cmet.2019.11.021","article-title":"Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function","volume":"31","author":"Field","year":"2020","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib61","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ebiom.2023.104778_bib62","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3389\/fimmu.2019.02839","article-title":"Metabolic pathways involved in regulatory T cell functionality","volume":"10","author":"Kempkes","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi","year":"2012","journal-title":"Cancer Cell"},{"issue":"669","key":"10.1016\/j.ebiom.2023.104778_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo2628","article-title":"Selective decrease of donor-reactive T(regs) after liver transplantation limits T(reg) therapy for promoting allograft tolerance in humans","volume":"14","author":"Tang","year":"2022","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib65","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib66","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104778_bib67","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ni.3868","article-title":"Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor","volume":"18","author":"Maj","year":"2017","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104778_bib68","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cmet.2020.07.001","article-title":"Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity","volume":"32","author":"Alissafi","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.ebiom.2023.104778_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2526174","article-title":"Oxidative stress and Treg and Th17 dysfunction in systemic lupus erythematosus","volume":"2016","author":"Yang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"7851","key":"10.1016\/j.ebiom.2023.104778_bib70","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-021-03326-4","article-title":"CTLA-4 blockade drives loss of T(reg) stability in glycolysis-low tumours","volume":"591","author":"Zappasodi","year":"2021","journal-title":"Nature"},{"issue":"7851","key":"10.1016\/j.ebiom.2023.104778_bib71","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.ebiom.2023.104778_bib72","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1182\/blood-2008-09-181040","article-title":"Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death","volume":"113","author":"Mougiakakos","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104778_bib73","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib74","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/HYPERTENSIONAHA.114.04208","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload","volume":"65","author":"Smyrnias","year":"2015","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104778_bib75","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104778_bib76","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000338597.71702.ad","article-title":"Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1","volume":"103","author":"Piantadosi","year":"2008","journal-title":"Circ Res"},{"issue":"17","key":"10.1016\/j.ebiom.2023.104778_bib77","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/MCB.00677-14","volume":"34","author":"Meakin","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib78","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/BJ20130863","article-title":"Nrf2 affects the efficiency of mitochondrial fatty acid oxidation","volume":"457","author":"Ludtmann","year":"2014","journal-title":"Biochem J"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104778_bib79","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.18632\/oncotarget.6927","article-title":"Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation","volume":"7","author":"Safinia","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104778_bib80","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.CIR.0000048191.75585.60","article-title":"Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin","volume":"107","author":"Visner","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104778_bib81","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jss.2011.10.033","article-title":"Rapamycin induces heme oxygenase-1 in liver but inhibits bile flow recovery after ischemia","volume":"176","author":"Kist","year":"2012","journal-title":"J\u00a0Surg Res"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104778_bib82","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jhep.2021.01.001","article-title":"Systemic inflammation and liver cirrhosis complications: driving or secondary event? How to square the circle?","volume":"74","author":"Samuel","year":"2021","journal-title":"J\u00a0Hepatol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:31:12Z","timestamp":1762457472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423003444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":82,"alternative-id":["S2352396423003444"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104778","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104778"}}